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The map label for this gene is norM [H]

Identifier: 78357461

GI number: 78357461

Start: 2439982

End: 2441397

Strand: Reverse

Name: norM [H]

Synonym: Dde_2418

Alternate gene names: 78357461

Gene position: 2441397-2439982 (Counterclockwise)

Preceding gene: 78357464

Following gene: 78357459

Centisome position: 65.45

GC content: 57.42

Gene sequence:

>1416_bases
ATGTTCTTTTCTTCCCTGCGTGCACGTTGGGGCATGCCCAACGGCTATCGCGATGTGCTCGGCGTGGGGTTGCCCCTTGT
TATCAGCATGGCCTCGTCCACTGTGATGCAGTTCACCGACCGGCTTTTTCTGAGCCATTATTCCGTGGACGCCATTGCGG
CCGCATTGCCTGCTGCCATTGTCAACCTGCTGTTTCTGCTGTTTTTTACAGGCGTTGCCGGATATGCCAACGTTTTCATA
GCGCAGTACTGCGGTTCGGCTGCGCCTGCCCGTGTGGGTGCCGCCTTGTGGCAGGCCATTCATTTCAGTCTCATGGGCGG
AGTGCTGCTGGCTCTGCTGTGGTTTGTCGCGCCGTTTATGTTTTCCTTTGCCGGACACCCTGCGCCGGTGGTCAGGCTGG
AGGTGATCTATTTCCGCGTACTGACTGTGGGAGCGGTGTTCATGCTGCTGTCCAGCGCGCTGAGCTGCTTTTTTTCCGGT
CGGGGGCTTACCCGTCCTGTAATGGTGGCCAACATCGCGGCCATGATCATCAACATTCCGCTTGATTACGCGCTGATTTA
CGGTGCGTGGGGGCTGCCTGAACTGGGCATAGCCGGGGCGGGCATTGCCACGGTGGCCGGCTGGGCGCTGACATTTTTCT
TTCTGGCGCTTGCCACGTTTACCCGCCGTCACGATGCCATGTTCGGCGTTCTGCGCAACTGGCGTTTTGAACGGGCGCTT
TTTTTGCGCATGATGCGTTACGGCCTGCCCAGCGGTGTGAACTATTTTTTTGAGATTTTTGCCATTACGTTTTTTGTTTT
TGTCATCGGACGTCTGGGCAGAGTGGAACTGGCGGCAACCAATATCGTGTTTTCCATTGATTCGCTGGCCTTTCTGCCCA
TGCTGGGGCTGAACATAGCAGTCAGCACCATGGTGGGGCAGGCCATCGGCGCGGGCAAACCCGATGCGGCAGGTACCGCC
GCCATGAATACTTTGCATCTGGCGCTGGCGTGGATGCTGTGCATCGGTGTGATGTTCATCATTTTTCCGGGTGTGCTGCT
TGATATGTTCCGGCCGCAGGATGTCAGTGTGCAGGAGTATGTTCCCATTCGCGAAGCCGGTGTGGTGCTGATGCGTTTTG
TGGCGTTCTACTGTCTGTTCGACGCGTTGTCGCTGGTGTTTTTCGGCGCTGTCAAAGGGGCGGGAGACACCTATTTTGTC
ATGTGGGCCATGGTGGTGGGCTGTGCATGCATGGTGGCGGTCATTGTCATCATGCGGCTGTGGTTCGACGCCGGTCTCAT
CGCATTGTGGGTGGTGCTTACCTGTTACGCCGTGGCGCTCAGTCTTTCGGCGCTGCTGCGCTACAGGGGCGGCAAATGGC
GTTCCATGAAAGTGGTTGAAACAGTTCGCCGCAGTCCGGATGCCGGACCCTGCTGA

Upstream 100 bases:

>100_bases
GTTTTGCGGTTGCGAGTGATTGACTTGCCCTGTGAGTGTGATTACACATTCAAGTTCCTTTCCGTACACTAGTCATCTAA
TTCTGTTCCGGAGTATCCTG

Downstream 100 bases:

>100_bases
TACCGTAAAAAAGGCCTTCCCCGTGGAAGGCCTTTTTTGATGCGCGGCTACAGTTTCTGCAGCACGGATTGTGTTTTCTG
TTCCATGCGGGGGCGTGTTC

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MFFSSLRARWGMPNGYRDVLGVGLPLVISMASSTVMQFTDRLFLSHYSVDAIAAALPAAIVNLLFLLFFTGVAGYANVFI
AQYCGSAAPARVGAALWQAIHFSLMGGVLLALLWFVAPFMFSFAGHPAPVVRLEVIYFRVLTVGAVFMLLSSALSCFFSG
RGLTRPVMVANIAAMIINIPLDYALIYGAWGLPELGIAGAGIATVAGWALTFFFLALATFTRRHDAMFGVLRNWRFERAL
FLRMMRYGLPSGVNYFFEIFAITFFVFVIGRLGRVELAATNIVFSIDSLAFLPMLGLNIAVSTMVGQAIGAGKPDAAGTA
AMNTLHLALAWMLCIGVMFIIFPGVLLDMFRPQDVSVQEYVPIREAGVVLMRFVAFYCLFDALSLVFFGAVKGAGDTYFV
MWAMVVGCACMVAVIVIMRLWFDAGLIALWVVLTCYAVALSLSALLRYRGGKWRSMKVVETVRRSPDAGPC

Sequences:

>Translated_471_residues
MFFSSLRARWGMPNGYRDVLGVGLPLVISMASSTVMQFTDRLFLSHYSVDAIAAALPAAIVNLLFLLFFTGVAGYANVFI
AQYCGSAAPARVGAALWQAIHFSLMGGVLLALLWFVAPFMFSFAGHPAPVVRLEVIYFRVLTVGAVFMLLSSALSCFFSG
RGLTRPVMVANIAAMIINIPLDYALIYGAWGLPELGIAGAGIATVAGWALTFFFLALATFTRRHDAMFGVLRNWRFERAL
FLRMMRYGLPSGVNYFFEIFAITFFVFVIGRLGRVELAATNIVFSIDSLAFLPMLGLNIAVSTMVGQAIGAGKPDAAGTA
AMNTLHLALAWMLCIGVMFIIFPGVLLDMFRPQDVSVQEYVPIREAGVVLMRFVAFYCLFDALSLVFFGAVKGAGDTYFV
MWAMVVGCACMVAVIVIMRLWFDAGLIALWVVLTCYAVALSLSALLRYRGGKWRSMKVVETVRRSPDAGPC
>Mature_471_residues
MFFSSLRARWGMPNGYRDVLGVGLPLVISMASSTVMQFTDRLFLSHYSVDAIAAALPAAIVNLLFLLFFTGVAGYANVFI
AQYCGSAAPARVGAALWQAIHFSLMGGVLLALLWFVAPFMFSFAGHPAPVVRLEVIYFRVLTVGAVFMLLSSALSCFFSG
RGLTRPVMVANIAAMIINIPLDYALIYGAWGLPELGIAGAGIATVAGWALTFFFLALATFTRRHDAMFGVLRNWRFERAL
FLRMMRYGLPSGVNYFFEIFAITFFVFVIGRLGRVELAATNIVFSIDSLAFLPMLGLNIAVSTMVGQAIGAGKPDAAGTA
AMNTLHLALAWMLCIGVMFIIFPGVLLDMFRPQDVSVQEYVPIREAGVVLMRFVAFYCLFDALSLVFFGAVKGAGDTYFV
MWAMVVGCACMVAVIVIMRLWFDAGLIALWVVLTCYAVALSLSALLRYRGGKWRSMKVVETVRRSPDAGPC

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=390, Percent_Identity=27.9487179487179, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI226510954, Length=429, Percent_Identity=24.7086247086247, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51381; Mature: 51381

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]