Click here to switch to the map view.

The map label for this gene is ruvC

Identifier: 78357367

GI number: 78357367

Start: 2341446

End: 2341946

Strand: Reverse

Name: ruvC

Synonym: Dde_2324

Alternate gene names: 78357367

Gene position: 2341946-2341446 (Counterclockwise)

Preceding gene: 78357368

Following gene: 78357366

Centisome position: 62.78

GC content: 59.68

Gene sequence:

>501_bases
ATGACTACGCAGGGTATAACGGTGCTGGGCATAGACCCGGGGTCGAGAACAACGGGCTGGGGTATCGTGCGCGAGGTTTC
CGGCGTGCTGACGCTGGTGGATTGCGGTGCGGTGCGCCCCCGGGGCGATGAATTTTCTGACAGACTCGGCGCTATTTATC
ACGGGCTGCATGAGGTGATTGCCCGGCATATGCCGGACGAAGCATCGGTTGAAAATGTCTTTACCGCCAAAAATGCCGCT
TCTGCTCTTAAACTGGGACAGGCGCGGGGTGCGGCAGTGGCTGCCTGCGCTGCACATCACCTGCCTGTAGCAAGCTATGC
TCCCACAGAAATAAAAAAAACAATTGTGGGAGTGGGCCGTGCCGAAAAAGAGCAGGTCAGCTTTATGGTGGCCCGCCTGC
TGGGCGTGAAAGGCGACTGGGGTCCGGATACGGGCGACGCGCTGGCCGCGGCCATCTGTCATCTGAATATGCGCAGATTG
CGCAGGCTGGCCGCGGGGTAA

Upstream 100 bases:

>100_bases
ATGGAAGACTAGCCTTTACGGCCGGCCGGAATTCTGTTCCGGCCGGCTTGTTCCGCCGGCATGGCGGGGCAGGGCAGACA
TACAAGGCGGCCGGAGCGCA

Downstream 100 bases:

>100_bases
CTTCTGCCTGCCGCTGTGAACCCGGCGCGCAATGCGGACAGCGGCCTTTTATTCTCTGTTCCGTTGATGTACAACCCTAC
TTCAGGAAATCTGCCATGAT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTTQGITVLGIDPGSRTTGWGIVREVSGVLTLVDCGAVRPRGDEFSDRLGAIYHGLHEVIARHMPDEASVENVFTAKNAA
SALKLGQARGAAVAACAAHHLPVASYAPTEIKKTIVGVGRAEKEQVSFMVARLLGVKGDWGPDTGDALAAAICHLNMRRL
RRLAAG

Sequences:

>Translated_166_residues
MTTQGITVLGIDPGSRTTGWGIVREVSGVLTLVDCGAVRPRGDEFSDRLGAIYHGLHEVIARHMPDEASVENVFTAKNAA
SALKLGQARGAAVAACAAHHLPVASYAPTEIKKTIVGVGRAEKEQVSFMVARLLGVKGDWGPDTGDALAAAICHLNMRRL
RRLAAG
>Mature_165_residues
TTQGITVLGIDPGSRTTGWGIVREVSGVLTLVDCGAVRPRGDEFSDRLGAIYHGLHEVIARHMPDEASVENVFTAKNAAS
ALKLGQARGAAVAACAAHHLPVASYAPTEIKKTIVGVGRAEKEQVSFMVARLLGVKGDWGPDTGDALAAAICHLNMRRLR
RLAAG

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=132, Percent_Identity=48.4848484848485, Blast_Score=135, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_DESDG (Q30YX5)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388816.1
- ProteinModelPortal:   Q30YX5
- SMR:   Q30YX5
- STRING:   Q30YX5
- GeneID:   3757335
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2324
- eggNOG:   COG0817
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- ProtClustDB:   PRK00039
- BioCyc:   DDES207559:DDE_2324-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 17435; Mature: 17304

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQGITVLGIDPGSRTTGWGIVREVSGVLTLVDCGAVRPRGDEFSDRLGAIYHGLHEVI
CCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ARHMPDEASVENVFTAKNAASALKLGQARGAAVAACAAHHLPVASYAPTEIKKTIVGVGR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
AEKEQVSFMVARLLGVKGDWGPDTGDALAAAICHLNMRRLRRLAAG
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTQGITVLGIDPGSRTTGWGIVREVSGVLTLVDCGAVRPRGDEFSDRLGAIYHGLHEVI
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ARHMPDEASVENVFTAKNAASALKLGQARGAAVAACAAHHLPVASYAPTEIKKTIVGVGR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCC
AEKEQVSFMVARLLGVKGDWGPDTGDALAAAICHLNMRRLRRLAAG
CHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA