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The map label for this gene is dnaA

Identifier: 78357363

GI number: 78357363

Start: 2337250

End: 2338635

Strand: Reverse

Name: dnaA

Synonym: Dde_2320

Alternate gene names: 78357363

Gene position: 2338635-2337250 (Counterclockwise)

Preceding gene: 78357364

Following gene: 78357362

Centisome position: 62.69

GC content: 55.41

Gene sequence:

>1386_bases
ATGATAAACGCTTGGGCGCAAATTGAACATACTCTCCGCGACAATCTGAATCCGGGCCTTTTTAAGGTCTGGATCAAACC
GCTTGCTGCAGAGCAGGCCGGTGACTCTCTTCGTCTTGTCGCGCCCAATGCCTTCGTTGCCAGCTGGGTCCGCGACAGGC
TAATGAACGAAATCGAAAAAGCCGCTGCCTCTGTGCTTGGCAGTGTGCCCACCATTACCGTTGTATCCGGTGAAGAGCCC
GCCGCCGCCCCCAGACCGGTGCAGGTGCCCGCGCAGAAGCGTCCGGCAGCTGCCAGAACCAGCGGTGCCGAGCAGATGGG
GCTGCCCCTGCATTATGCGTCCCGTTCTGCGGACAGCATCAAATGGATGCACAGTTTTGATGAATTTGTTGTGGGGCCAA
GCAACCAGATGGCCTTTGCGGCGTCACAGGATATCTGCCAGCAGTCTTTCCGCAGCGACACTCTTTTTCTCAGCTCCGAC
CCCGGGCTCGGAAAAACACACCTTCTGCATGCCGTGGGGCAGCAGCTTTGCAATATCAGCAACCGTACCCTGCCCCGTGT
GGAGTATCTGACAGCGGAAGAATTTGCCACGCGGCTTATCTGTGCGCTGAAAGCAAAGGAAGTGGACCGCTTTAAAGCCC
GTTACCGCGATGTGGATGTGCTGCTGCTTGAAGATGTCCACTTTCTTCAGGGCAAACAGCGCATGCAGGACGAAGTGCTT
TCCACCGTGAAGGCTTTGCAGTCGCGCGGGGCCAAGGTGCTGTTTTCCAGCTCGTTTGCACCCAAAGACCTGAATGACCT
TGATTCGCAGCTCACCTCGCGTTTCTGTTCAGGATTGCTGGCCGTCATTGAAAAGCCGACATTTGAAACCCGGAAACAGA
TTCTGCGCGAAAAAGCCCGCCTGCACCATGTGCAGCTGCCCGAACAGGTGGCTGATCTGCTGGCAGACAATATCCGCGCC
GATGTGCGTCAGATAGAAAGCTGCCTGCGTAACCTGCTGCTCAAGGCGCGGTTGCTCAACCAGCAGATAACCATGGACAT
GGCGTGGGAGATTATCGGCCACTACGCCAAGCGCGAAGCGGTGCTTGATATTGATGCCATCGTGCGTCAGATATGCAGCG
GGTTTGATATTTCCAAAGAGCAGCTGCAGTCCAGAAGCCGCCGCCGCGAGCTTGTCATAGCGCGCAACACGGCTTTCTTT
CTTGCCCGCAAGCATACCGACCTTTCGCTGGAAGAAATCGGTAAGCGTTTCAACCGCAAGCATTCCACGGTTATCAAAGG
TATAGCCAACATAGAGCGTGAAATGAATAAGGAAACACCGCTGGGCAGACAGGTGGTGAACGCAGTAAATATGGTGGAAC
GCAACGGACGAATTATTCACCCCTGA

Upstream 100 bases:

>100_bases
GAGGCGTACCGTCACTTGGGAAAAACTCGTCGCCGGACTCGTGCCGATGTCCGGTTTTCGATCCTTGCAGCAACCTTAGA
TAGAACGTAATCAACCCGTC

Downstream 100 bases:

>100_bases
CCAGAGTCGGGGCGTGGCCGCTTTATGCGGCGCCGGTTGCAGATAACAAGCAGCTTCAAGGCACGAACCGCTCCGGTTCG
TGCCTTTTTTGCATCCTGCG

Product: DnaA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEKAAASVLGSVPTITVVSGEEP
AAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSIKWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSD
PGLGKTHLLHAVGQQLCNISNRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVL
STVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKARLHHVQLPEQVADLLADNIRA
DVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREAVLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFF
LARKHTDLSLEEIGKRFNRKHSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP

Sequences:

>Translated_461_residues
MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEKAAASVLGSVPTITVVSGEEP
AAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSIKWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSD
PGLGKTHLLHAVGQQLCNISNRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVL
STVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKARLHHVQLPEQVADLLADNIRA
DVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREAVLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFF
LARKHTDLSLEEIGKRFNRKHSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP
>Mature_461_residues
MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEKAAASVLGSVPTITVVSGEEP
AAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSIKWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSD
PGLGKTHLLHAVGQQLCNISNRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVL
STVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKARLHHVQLPEQVADLLADNIRA
DVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREAVLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFF
LARKHTDLSLEEIGKRFNRKHSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=448, Percent_Identity=34.8214285714286, Blast_Score=245, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_DESDG (Q30YX9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388812.1
- ProteinModelPortal:   Q30YX9
- STRING:   Q30YX9
- GeneID:   3757331
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2320
- NMPDR:   fig|207559.3.peg.615
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   WPLCLRR
- ProtClustDB:   CLSK705665
- BioCyc:   DDES207559:DDE_2320-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51836; Mature: 51836

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEK
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
AAASVLGSVPTITVVSGEEPAAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSI
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCHHHHCCCCHHH
KWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSDPGLGKTHLLHAVGQQLCNIS
HHHHHHHHHEECCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
NRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
STVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKAR
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LHHVQLPEQVADLLADNIRADVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFFLARKHTDLSLEEIGKRFNRK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEECCEEEEEECCCCCCHHHHHHHHCHH
HSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MINAWAQIEHTLRDNLNPGLFKVWIKPLAAEQAGDSLRLVAPNAFVASWVRDRLMNEIEK
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
AAASVLGSVPTITVVSGEEPAAAPRPVQVPAQKRPAAARTSGAEQMGLPLHYASRSADSI
HHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHCCCHHHHCCCCHHH
KWMHSFDEFVVGPSNQMAFAASQDICQQSFRSDTLFLSSDPGLGKTHLLHAVGQQLCNIS
HHHHHHHHHEECCCCCEEHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
NRTLPRVEYLTAEEFATRLICALKAKEVDRFKARYRDVDVLLLEDVHFLQGKQRMQDEVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
STVKALQSRGAKVLFSSSFAPKDLNDLDSQLTSRFCSGLLAVIEKPTFETRKQILREKAR
HHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LHHVQLPEQVADLLADNIRADVRQIESCLRNLLLKARLLNQQITMDMAWEIIGHYAKREA
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLDIDAIVRQICSGFDISKEQLQSRSRRRELVIARNTAFFLARKHTDLSLEEIGKRFNRK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHCEEEEECCEEEEEECCCCCCHHHHHHHHCHH
HSTVIKGIANIEREMNKETPLGRQVVNAVNMVERNGRIIHP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA