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The map label for this gene is thyX

Identifier: 78357364

GI number: 78357364

Start: 2338965

End: 2339711

Strand: Reverse

Name: thyX

Synonym: Dde_2321

Alternate gene names: 78357364

Gene position: 2339711-2338965 (Counterclockwise)

Preceding gene: 78357365

Following gene: 78357363

Centisome position: 62.72

GC content: 58.37

Gene sequence:

>747_bases
ATGCCCAGTAAAGAATGCCGAGTGGAGCTGTTGGCCCATACCCCCGAACCTCTGTCGCTCATCTATGCGGCATTCAGACA
ATGTTATCATGCCGGTTTTGCAGGCGATATGTGGCAGCGGCTGGTGGCCGGCGACATTGACAGGCAGAAACAGGCCGATT
TCATTTCTCAGGTGCTTGAATCCGGCCACGCGAGCCCCATTGAGCATGTCAGCTTTACCTTTGCTGTAGAGGGCGTTTCC
CGCGCTTTGACGCACCAGCTGGTGCGTCACCGGCTTGCCTCTTATTCGCAGCAGAGCCAGCGGTATGTGGATGGAAGTAA
CTTCGAGTATATACTGCCGCCCGCCATTGCCCGTAATCAGGCAGCACGGGCACGTTTCGAGGCCTTTATGGCCGAAGTGG
GCAGTGCCTACCGCGATTTGAAGCAGATTCTGGAGCAGGACGGACGCAAAGGGGCCAAGGCCAATGAGGACGCCCGCTTT
GTCCTGCCGCAGGCTGCCGAGAGCAAAATAGTGCTGACCATGAACTGCAGAGTGCTTCTCCACTTTTTTGAAGAGCGCTG
CTGTTCCCGTGCGCAGTGGGAAATCCGCCATATGGCCGATATGATGCTGGAGCGCTGCCGTGGCGCGCTTCCGGTCATTT
TCCGCCACGCCGGAGCCAAATGTGTGCGTCTGGGCTATTGTCCCGAAGGAGAACGCTTCACCTGCGGCAGGTATCCGCTG
CGTGATGCGGGGCGCGGTCAGCCCTGA

Upstream 100 bases:

>100_bases
CGTATCGCCATATGAATCTGCTTGCGTAATAACAAGACCACCCGCCTCCGGGCGGGTGCACTGATTTCCCCCGCGGGAAG
CCAGACCGGATGGATGTAGT

Downstream 100 bases:

>100_bases
TTCCGAACTGTCGTACATGGCGATTTCTTTTCGCCAGTTCTCAAAAACGCCAAAATAAGAAGTTTTATTAAGCAAAACGC
AGAAAATCGTTCTGTGTCTT

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MPSKECRVELLAHTPEPLSLIYAAFRQCYHAGFAGDMWQRLVAGDIDRQKQADFISQVLESGHASPIEHVSFTFAVEGVS
RALTHQLVRHRLASYSQQSQRYVDGSNFEYILPPAIARNQAARARFEAFMAEVGSAYRDLKQILEQDGRKGAKANEDARF
VLPQAAESKIVLTMNCRVLLHFFEERCCSRAQWEIRHMADMMLERCRGALPVIFRHAGAKCVRLGYCPEGERFTCGRYPL
RDAGRGQP

Sequences:

>Translated_248_residues
MPSKECRVELLAHTPEPLSLIYAAFRQCYHAGFAGDMWQRLVAGDIDRQKQADFISQVLESGHASPIEHVSFTFAVEGVS
RALTHQLVRHRLASYSQQSQRYVDGSNFEYILPPAIARNQAARARFEAFMAEVGSAYRDLKQILEQDGRKGAKANEDARF
VLPQAAESKIVLTMNCRVLLHFFEERCCSRAQWEIRHMADMMLERCRGALPVIFRHAGAKCVRLGYCPEGERFTCGRYPL
RDAGRGQP
>Mature_247_residues
PSKECRVELLAHTPEPLSLIYAAFRQCYHAGFAGDMWQRLVAGDIDRQKQADFISQVLESGHASPIEHVSFTFAVEGVSR
ALTHQLVRHRLASYSQQSQRYVDGSNFEYILPPAIARNQAARARFEAFMAEVGSAYRDLKQILEQDGRKGAKANEDARFV
LPQAAESKIVLTMNCRVLLHFFEERCCSRAQWEIRHMADMMLERCRGALPVIFRHAGAKCVRLGYCPEGERFTCGRYPLR
DAGRGQP

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 28123; Mature: 27991

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKECRVELLAHTPEPLSLIYAAFRQCYHAGFAGDMWQRLVAGDIDRQKQADFISQVLE
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SGHASPIEHVSFTFAVEGVSRALTHQLVRHRLASYSQQSQRYVDGSNFEYILPPAIARNQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHH
AARARFEAFMAEVGSAYRDLKQILEQDGRKGAKANEDARFVLPQAAESKIVLTMNCRVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHH
HFFEERCCSRAQWEIRHMADMMLERCRGALPVIFRHAGAKCVRLGYCPEGERFTCGRYPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCCCCEECCCCCC
RDAGRGQP
CCCCCCCC
>Mature Secondary Structure 
PSKECRVELLAHTPEPLSLIYAAFRQCYHAGFAGDMWQRLVAGDIDRQKQADFISQVLE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SGHASPIEHVSFTFAVEGVSRALTHQLVRHRLASYSQQSQRYVDGSNFEYILPPAIARNQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHH
AARARFEAFMAEVGSAYRDLKQILEQDGRKGAKANEDARFVLPQAAESKIVLTMNCRVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEEEEHHHHHH
HFFEERCCSRAQWEIRHMADMMLERCRGALPVIFRHAGAKCVRLGYCPEGERFTCGRYPL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCCCCCEECCCCCC
RDAGRGQP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA