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The map label for this gene is tcyB [H]

Identifier: 78357350

GI number: 78357350

Start: 2324230

End: 2325015

Strand: Direct

Name: tcyB [H]

Synonym: Dde_2307

Alternate gene names: 78357350

Gene position: 2324230-2325015 (Clockwise)

Preceding gene: 78357349

Following gene: 78357351

Centisome position: 62.31

GC content: 53.82

Gene sequence:

>786_bases
ATGGCTGATCAAAAAGTCCGCATTGAAGTAACGGACGGCATGCTGATTCCCGACCCGAAAGACCGCAATTTTTTCAATGC
GTGGTCCATCAGCTTCATCGGCGCCATCGGCATCATCATATACCTGTGCGCCAGCCGTCCCGATGTTTACTGGCGGCTGC
TGCAGTATCTGCCCGACGGCATCGCAGTCACGTTCAAAGTCACCATTCTGTCGATTCTCTGCTCCATACCTCTGGGGCTG
CTTACCGGACTGGGCCGCCTGTCACGCAACAAACTCATCAACACCATAGCATCCACATATGTCGAAGTTGTCCGCGGCAT
TCCCCTGCTTGTCCAGCTTTTCTACATATATTATGCACTCGGACGCTTTCTGCAGGTACCCAGCATGGTTGCCGCCGTCA
TTGCCATGAGTGTATGCTACGGCGCATACATGGGCGAGGTTTTCCGCGCGGGCATTGATTCCATAGACAAAGGCCAGACC
GAGGCATCGCGTTCTCTGGGATTCAACAACGTGCAGACCATGTTTCTTGTCATTCTGCCGCAGGCATGGCGCACCATTCT
GCCTCCTGTGGGTAACGAATTCATTGCCATGCTCAAGGACACCTCGCTCGTCTCCATTCTGGCCGTGGCCGACGTGCTGC
GGCGTGGACGCGAGTTTGCAGCGGAGTCCTTTCTGTACTTTGAAACCTACACCATGGTGGCCCTTATCTATCTTGTAATA
ACCCTGCTGCTTTCCAAAGCCGTCAGCATCATGGAAGCGAGGCTGAATTATTATGACCGCGACTGA

Upstream 100 bases:

>100_bases
CAAAAAGTGGATAGGTCAATAGCCGTACGGAAGTCGAATCAACGGGACTGGTGCATCCTGCACCGGTCCTTTCATTTTGC
AAGCACACGGATACACTATC

Downstream 100 bases:

>100_bases
GCCAATCATCAGCATTAAAAACATCTACAAATTCTTCGGTGAACTGACGGCCCTCAATGATGTATCGCTGGACGTGCAGC
CGGGAGAAAAGGTTGTGGTC

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MADQKVRIEVTDGMLIPDPKDRNFFNAWSISFIGAIGIIIYLCASRPDVYWRLLQYLPDGIAVTFKVTILSILCSIPLGL
LTGLGRLSRNKLINTIASTYVEVVRGIPLLVQLFYIYYALGRFLQVPSMVAAVIAMSVCYGAYMGEVFRAGIDSIDKGQT
EASRSLGFNNVQTMFLVILPQAWRTILPPVGNEFIAMLKDTSLVSILAVADVLRRGREFAAESFLYFETYTMVALIYLVI
TLLLSKAVSIMEARLNYYDRD

Sequences:

>Translated_261_residues
MADQKVRIEVTDGMLIPDPKDRNFFNAWSISFIGAIGIIIYLCASRPDVYWRLLQYLPDGIAVTFKVTILSILCSIPLGL
LTGLGRLSRNKLINTIASTYVEVVRGIPLLVQLFYIYYALGRFLQVPSMVAAVIAMSVCYGAYMGEVFRAGIDSIDKGQT
EASRSLGFNNVQTMFLVILPQAWRTILPPVGNEFIAMLKDTSLVSILAVADVLRRGREFAAESFLYFETYTMVALIYLVI
TLLLSKAVSIMEARLNYYDRD
>Mature_260_residues
ADQKVRIEVTDGMLIPDPKDRNFFNAWSISFIGAIGIIIYLCASRPDVYWRLLQYLPDGIAVTFKVTILSILCSIPLGLL
TGLGRLSRNKLINTIASTYVEVVRGIPLLVQLFYIYYALGRFLQVPSMVAAVIAMSVCYGAYMGEVFRAGIDSIDKGQTE
ASRSLGFNNVQTMFLVILPQAWRTILPPVGNEFIAMLKDTSLVSILAVADVLRRGREFAAESFLYFETYTMVALIYLVIT
LLLSKAVSIMEARLNYYDRD

Specific function: Part of the ABC transporter complex tcyABC involved in L-cystine import. Probably responsible for the translocation of the substrate across the membrane (Probable) [H]

COG id: COG0765

COG function: function code E; ABC-type amino acid transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=36.8421052631579, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=36.8421052631579, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786873, Length=210, Percent_Identity=34.7619047619048, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1788646, Length=209, Percent_Identity=30.622009569378, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082239, Length=205, Percent_Identity=30.7317073170732, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787087, Length=229, Percent_Identity=25.3275109170306, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788645, Length=220, Percent_Identity=31.3636363636364, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786874, Length=216, Percent_Identity=23.1481481481481, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI48994930, Length=220, Percent_Identity=28.1818181818182, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787086, Length=227, Percent_Identity=25.9911894273128, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 29213; Mature: 29082

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADQKVRIEVTDGMLIPDPKDRNFFNAWSISFIGAIGIIIYLCASRPDVYWRLLQYLPDG
CCCEEEEEEECCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
IAVTFKVTILSILCSIPLGLLTGLGRLSRNKLINTIASTYVEVVRGIPLLVQLFYIYYAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
GRFLQVPSMVAAVIAMSVCYGAYMGEVFRAGIDSIDKGQTEASRSLGFNNVQTMFLVILP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHH
QAWRTILPPVGNEFIAMLKDTSLVSILAVADVLRRGREFAAESFLYFETYTMVALIYLVI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLLLSKAVSIMEARLNYYDRD
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7551042; 8969502; 9384377 [H]