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The map label for this gene is clpX

Identifier: 78357262

GI number: 78357262

Start: 2260437

End: 2261690

Strand: Reverse

Name: clpX

Synonym: Dde_2219

Alternate gene names: 78357262

Gene position: 2261690-2260437 (Counterclockwise)

Preceding gene: 78357263

Following gene: 78357261

Centisome position: 60.63

GC content: 53.67

Gene sequence:

>1254_bases
ATGGATAGAAAAAATGACGGGTCTGCACAGGAGCCCAGATGCTCGTTCTGCCAGAAAGGGCCGGACAGCGTAAAGCGCCT
GATTTCAGGGCCTGATGTTTATATTTGCGATGCATGCGTAGAGCTGTGCAATGAGATCATTGCGCAGGAGCATGTGCAGG
AATCAGTGGATGCGGGCAAGCTGCTCAGCCCTGCGGAAATCAAGGCCAGGCTGGATGAGTATGTCATAGGCCAGCATACG
GCCAAGAAAATTCTGTCAGTTGCTGTGCACAACCACTACAAGCGCGTGTTTTTTGCAGAAACACTTTCTGATGAAGTGGA
ACTGGAAAAAAGCAACATCCTGCTTGTAGGGTCTTCGGGCAGCGGTAAAACCCTGCTGGCTAAAACTCTGGCCCGTGTGC
TTAACGTGCCGTTTGCCATAGCCGACGCCACTACTCTGACAGAGGCCGGATACGTGGGCGAAGATGTTGAAAACATTCTG
GTGCAGCTGCTGCAGAATGCCGATTATGACATCGAAGCCGCTTCCAAGGGTATCGTGTATATTGATGAAATCGACAAAAT
CTCCCGCAAGGGCGACGGTCCTTCCATCACCCGCGATGTTTCCGGCGAAGGCGTGCAGCAGGCGCTGCTTAAAATCATCG
AAGGCACCGAAGCCAATATTCCGCCCAAGGGGGGGCGCAAGCATCCCCAGCAGGAATTCATCCGGCTTGATACGTCAAAT
ATCCTGTTCATCATGGGCGGGGCATTTATCGGGCTGGACAAGATAATCGAGCAGCGGATGCATGGCGGTGCCATGGGCTT
TGGCGTCAAGGTAGCCTCGAAAAAGGAGACCCCGCTTTCCGACCTGCTTGGCAACGTGCATCCCAACGATCTGGTCAAGT
TCGGGCTTATTCCCGAATTCATCGGTCGTATTCCGGTCATTACGCATGTGAATGAACTTGCGGAAGATGACCTTGTGCGC
ATTCTGCAGGAGCCGAAAAATGCCCTGGTGCGCCAGTACCAGAAGTTGTTCGAGCTGGATCACGTGAAGCTGCGCTTTAC
CAGCAATGCACTGCGCGCGGTGGCCCGTCAGGCCATAGAACGCAAAACCGGCGCCCGCGGGCTGCGCAACGTGCTTGAGT
CCGTCATGCTTGAAATTATGTTCAATCTGCCTTCCATGACCGGCGTTAAAGAGTGTGTCATCAACACCGCGGTGGTCGAA
GAAGGCAAGGAGCCTATTTTCCTGTACCAGACGGAAGCCAAAACCGGAACCTGA

Upstream 100 bases:

>100_bases
TTTCATGGGGCCTGAAAATGCAAAGAACTTCGGTATCATTGACCGTATTCTCACATCGCGCAAAGATGTGGAAAAAGACG
GCAAATAACAGGAAGGGCTA

Downstream 100 bases:

>100_bases
TGCCCGCCAGACGGGAATCATCGTTCCGACGGCTCCCGCCGGCCGGGTTCCCGAAAGGGAAACGCCTGCCGGAGAATTGA
CAATTCCGACAGGGGCGTTA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MDRKNDGSAQEPRCSFCQKGPDSVKRLISGPDVYICDACVELCNEIIAQEHVQESVDAGKLLSPAEIKARLDEYVIGQHT
AKKILSVAVHNHYKRVFFAETLSDEVELEKSNILLVGSSGSGKTLLAKTLARVLNVPFAIADATTLTEAGYVGEDVENIL
VQLLQNADYDIEAASKGIVYIDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRLDTSN
ILFIMGGAFIGLDKIIEQRMHGGAMGFGVKVASKKETPLSDLLGNVHPNDLVKFGLIPEFIGRIPVITHVNELAEDDLVR
ILQEPKNALVRQYQKLFELDHVKLRFTSNALRAVARQAIERKTGARGLRNVLESVMLEIMFNLPSMTGVKECVINTAVVE
EGKEPIFLYQTEAKTGT

Sequences:

>Translated_417_residues
MDRKNDGSAQEPRCSFCQKGPDSVKRLISGPDVYICDACVELCNEIIAQEHVQESVDAGKLLSPAEIKARLDEYVIGQHT
AKKILSVAVHNHYKRVFFAETLSDEVELEKSNILLVGSSGSGKTLLAKTLARVLNVPFAIADATTLTEAGYVGEDVENIL
VQLLQNADYDIEAASKGIVYIDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRLDTSN
ILFIMGGAFIGLDKIIEQRMHGGAMGFGVKVASKKETPLSDLLGNVHPNDLVKFGLIPEFIGRIPVITHVNELAEDDLVR
ILQEPKNALVRQYQKLFELDHVKLRFTSNALRAVARQAIERKTGARGLRNVLESVMLEIMFNLPSMTGVKECVINTAVVE
EGKEPIFLYQTEAKTGT
>Mature_417_residues
MDRKNDGSAQEPRCSFCQKGPDSVKRLISGPDVYICDACVELCNEIIAQEHVQESVDAGKLLSPAEIKARLDEYVIGQHT
AKKILSVAVHNHYKRVFFAETLSDEVELEKSNILLVGSSGSGKTLLAKTLARVLNVPFAIADATTLTEAGYVGEDVENIL
VQLLQNADYDIEAASKGIVYIDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRLDTSN
ILFIMGGAFIGLDKIIEQRMHGGAMGFGVKVASKKETPLSDLLGNVHPNDLVKFGLIPEFIGRIPVITHVNELAEDDLVR
ILQEPKNALVRQYQKLFELDHVKLRFTSNALRAVARQAIERKTGARGLRNVLESVMLEIMFNLPSMTGVKECVINTAVVE
EGKEPIFLYQTEAKTGT

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=330, Percent_Identity=49.0909090909091, Blast_Score=302, Evalue=3e-82,
Organism=Escherichia coli, GI1786642, Length=412, Percent_Identity=59.7087378640777, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1790366, Length=106, Percent_Identity=40.5660377358491, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71982905, Length=292, Percent_Identity=47.2602739726027, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71982908, Length=292, Percent_Identity=47.2602739726027, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI71988663, Length=393, Percent_Identity=35.8778625954198, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71988660, Length=251, Percent_Identity=39.4422310756972, Blast_Score=161, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6319704, Length=428, Percent_Identity=39.9532710280374, Blast_Score=272, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24648291, Length=299, Percent_Identity=48.1605351170569, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24648289, Length=299, Percent_Identity=48.1605351170569, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_DESDG (Q30Z80)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388711.1
- ProteinModelPortal:   Q30Z80
- STRING:   Q30Z80
- GeneID:   3757229
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2219
- NMPDR:   fig|207559.3.peg.2181
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   DDES207559:DDE_2219-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45785; Mature: 45785

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRKNDGSAQEPRCSFCQKGPDSVKRLISGPDVYICDACVELCNEIIAQEHVQESVDAGK
CCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
LLSPAEIKARLDEYVIGQHTAKKILSVAVHNHYKRVFFAETLSDEVELEKSNILLVGSSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCC
SGKTLLAKTLARVLNVPFAIADATTLTEAGYVGEDVENILVQLLQNADYDIEAASKGIVY
CCCHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
IDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRLDTSN
EECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEECCCC
ILFIMGGAFIGLDKIIEQRMHGGAMGFGVKVASKKETPLSDLLGNVHPNDLVKFGLIPEF
EEEEECCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHCCCCHHHHHHHCCCHHH
IGRIPVITHVNELAEDDLVRILQEPKNALVRQYQKLFELDHVKLRFTSNALRAVARQAIE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
RKTGARGLRNVLESVMLEIMFNLPSMTGVKECVINTAVVEEGKEPIFLYQTEAKTGT
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MDRKNDGSAQEPRCSFCQKGPDSVKRLISGPDVYICDACVELCNEIIAQEHVQESVDAGK
CCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
LLSPAEIKARLDEYVIGQHTAKKILSVAVHNHYKRVFFAETLSDEVELEKSNILLVGSSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCC
SGKTLLAKTLARVLNVPFAIADATTLTEAGYVGEDVENILVQLLQNADYDIEAASKGIVY
CCCHHHHHHHHHHHCCCHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEE
IDEIDKISRKGDGPSITRDVSGEGVQQALLKIIEGTEANIPPKGGRKHPQQEFIRLDTSN
EECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHEECCCC
ILFIMGGAFIGLDKIIEQRMHGGAMGFGVKVASKKETPLSDLLGNVHPNDLVKFGLIPEF
EEEEECCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHCCCCHHHHHHHCCCHHH
IGRIPVITHVNELAEDDLVRILQEPKNALVRQYQKLFELDHVKLRFTSNALRAVARQAIE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
RKTGARGLRNVLESVMLEIMFNLPSMTGVKECVINTAVVEEGKEPIFLYQTEAKTGT
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA