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The map label for this gene is lon [H]

Identifier: 78357261

GI number: 78357261

Start: 2257812

End: 2260271

Strand: Reverse

Name: lon [H]

Synonym: Dde_2218

Alternate gene names: 78357261

Gene position: 2260271-2257812 (Counterclockwise)

Preceding gene: 78357262

Following gene: 78357260

Centisome position: 60.59

GC content: 54.96

Gene sequence:

>2460_bases
ATGACAGATTTTGATGCAGAATTTTCCGCAGGAAACCCTGAGGGAATCCAGCTTCCGCTTATGTCTCTGCGAGAGGTGGT
CATGTTTCCGCGCTCCATCGTTCCTCTTTTTGTGGGACGTGAAGCGTCTATCAAGGCCATCGACAGCGCCATAGAGCATT
ATGGCAAGACTATTTTTCTGGTGGCGCAGCGCGAGCCTGAACTGGAAAAGCCCGGTCCCGAGGATGTGTTTCCTGTGGGA
ACCGTCAGTAAGATTCTTCAGATTCTCCGCTTGCCCGACGGCACCATAAAGGTGCTTTTTGAAGGTCTGTACCGCGCCCG
CTGGACAGGCGGCGAACTTTCTGTGGAATCTGGTGATTCCGCGTACCCTGTTGTTACGGTGGACCCGCTGGATGACGACG
GCGATGCCGGTCCTGAAGCGGATGCTTTGGTGCGGGCCACACATGAGGCTCTGGAAGAATACAGCAAGACCAACAAAAAG
CTTGCGCAGGAGGCTCTGGCAGCCATTCTGTCGCTGACATCGCCCGGCAAACTGGCAGATGCCGTCATGCCGCACCTTAA
GGTGGAGTATCGTAAAAAGCAGGAAGTGCTGGAAAACACCGACCCCGCTAGCCGTCTGGAAGCCGTGTTTGAAATGCTGC
AGGGCGAGATTGCCATATCGTCCATGGAAAAGCGCATCAAAAACCGTGTGAAAAATCAGATGGAGCGCAACCAGCGCGAG
TACTACCTGAACGAACAGATAAAGGCCATTCACAAGGAAATGGGGCGCGAAGACGACCCGCAGGCCGAAGTGAACGACCT
TGAAGAGCAGCTCAAAGCCAAGGATATGCCTGATGAGGCGCGTGAAAAAGCCTTGCGCGAACTTAAAAAGCTGCGCCAGA
TGCCGCCTTCTTCCGCAGAATACACCGTGGTGCGCAACTATGTGGACTGGATAATCGATCTTCCCTGGAATGCGCTGAAA
GAAACGACCATCGACATAGAAGAAGCCCGCCGCACGCTGGATAATGACCATTACGGTCTGGAAAAGCCCAAAGAGCGTAT
TCTGGAATATCTGGCTGTGCAAAAGCTTGTGAAAAAGCTGAAAGGCCCTATTTTGTGTCTTGTCGGGCCTCCCGGCGTGG
GCAAGACATCGCTTGCCCGTTCGGTGGCCACGGCCACAGGACGGGAGTTTGTGCGGCTTTCGTTGGGCGGCGTGCGTGAC
GAAGCCGAAATCAGAGGGCACCGCCGTACATATGTGGGGGCACTGCCCGGAAAGATTCTGCAGTCGCTCAAGCGGGTAAA
GTTCAACAACCCGCTTTTCTGCCTTGACGAAATAGACAAGATGAGCACCGACTTCCGTGGTGATCCTTCTTCGGCTCTGC
TGGAAGTGCTTGATCCCGAGCAGAACGGCACGTTCGGCGACCATTATCTTGATCTGGACTACGACCTTTCGCAGATCTTT
TTTATAACCACGGCCAACAGCCTGCATTCCATTCCGCTGCCGCTGCAGGACCGCATGGAGATAATCCGGCTGCCCGGCTA
TCTGGAAACGGAAAAGCGCCGTATCGCACGCGATTTTCTGCTGCCCAAGCAGATAGAGCAGCACGGCCTGAAACCGGAAA
ATGTCCGGCTTTCAGACAATGCCCTGCTCGACATTATCCGTTCCTACACGCGTGAAGCAGGTGTACGTAACCTTGAGCGC
GAAATCGCCACCATCTGCCGCAAGTCAGCCATGCAGCTTGTGGAAAAAGATGACATGGACCGAGCAGTGACTGTTTCCAG
ACAGAATCTGGGAACGTTTCTCGGGGTCAAAAAGTACCGGTACGGAGAAAAGGAAAACCAGCCGCAGGTAGGGGTTTCCA
CAGGGCTGGCATGGACGGAGCTTGGCGGAGAACTGCTGCTGGTGGAAACTGCCATCATGCCCGGAACAGGCAAGGTATCC
ATCACCGGAAAGCTGGGTGATGTGATGACGGAATCTGCCAAGGCGGCTCTTTCCTATGTGCGCTCGCGTTCCGACATGTT
CGGTCTGCGTCCTGATTTTCATAAGGAAATAGACATTCATGTGCACGTTCCCGAGGGCGCCACGCCCAAGGACGGCCCTT
CGGCGGGTATCACGCTTGCCACGTCGCTTGTATCTGCGCTGCTGGGCGTACCGGTAAGCGACGAACTGGCCATGACCGGT
GAAATAACGCTGCGGGGCAGGGTGCTGCCCATCGGCGGACTGCGTGAAAAACTGCTGGCTGCGCACCGCGGGCACATTAC
AAAAGTGCTCATTCCCCGTGATAACGAAAAGGATCTGAAGGAAGTGCCTGATGAAATTCTGAAAGGTCTTACCGTGGTTC
CTGTTGATCATGTGGATGATGTGCTGCCCCATGCACTGCTGGCGGAAGCCGATGCCATATTCAACGGTATGGAAGGCCAT
ACCCCGCTTTCCTGTTCTTTGAGAAAAGGGGCGGAGGTTCCGGCTTCCACTCCGCAGTAG

Upstream 100 bases:

>100_bases
CTGCCGGAGAATTGACAATTCCGACAGGGGCGTTAGCTTTTGGTCTGACGTCCCTTTCTTTTTCAACGTGCCGGACGTTG
ACCTTCTTCAGGAGGAGTAA

Downstream 100 bases:

>100_bases
ACGAAGGCTTTTGCGCACTGTATCAAACGCCCCGCTGAAAAGCGGGGCGTTTCTTTTATGACGTGCGTTGACTTTGCGTT
ACGAGAAGAGTAGTTACCGT

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MTDFDAEFSAGNPEGIQLPLMSLREVVMFPRSIVPLFVGREASIKAIDSAIEHYGKTIFLVAQREPELEKPGPEDVFPVG
TVSKILQILRLPDGTIKVLFEGLYRARWTGGELSVESGDSAYPVVTVDPLDDDGDAGPEADALVRATHEALEEYSKTNKK
LAQEALAAILSLTSPGKLADAVMPHLKVEYRKKQEVLENTDPASRLEAVFEMLQGEIAISSMEKRIKNRVKNQMERNQRE
YYLNEQIKAIHKEMGREDDPQAEVNDLEEQLKAKDMPDEAREKALRELKKLRQMPPSSAEYTVVRNYVDWIIDLPWNALK
ETTIDIEEARRTLDNDHYGLEKPKERILEYLAVQKLVKKLKGPILCLVGPPGVGKTSLARSVATATGREFVRLSLGGVRD
EAEIRGHRRTYVGALPGKILQSLKRVKFNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNGTFGDHYLDLDYDLSQIF
FITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIARDFLLPKQIEQHGLKPENVRLSDNALLDIIRSYTREAGVRNLER
EIATICRKSAMQLVEKDDMDRAVTVSRQNLGTFLGVKKYRYGEKENQPQVGVSTGLAWTELGGELLLVETAIMPGTGKVS
ITGKLGDVMTESAKAALSYVRSRSDMFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSLVSALLGVPVSDELAMTG
EITLRGRVLPIGGLREKLLAAHRGHITKVLIPRDNEKDLKEVPDEILKGLTVVPVDHVDDVLPHALLAEADAIFNGMEGH
TPLSCSLRKGAEVPASTPQ

Sequences:

>Translated_819_residues
MTDFDAEFSAGNPEGIQLPLMSLREVVMFPRSIVPLFVGREASIKAIDSAIEHYGKTIFLVAQREPELEKPGPEDVFPVG
TVSKILQILRLPDGTIKVLFEGLYRARWTGGELSVESGDSAYPVVTVDPLDDDGDAGPEADALVRATHEALEEYSKTNKK
LAQEALAAILSLTSPGKLADAVMPHLKVEYRKKQEVLENTDPASRLEAVFEMLQGEIAISSMEKRIKNRVKNQMERNQRE
YYLNEQIKAIHKEMGREDDPQAEVNDLEEQLKAKDMPDEAREKALRELKKLRQMPPSSAEYTVVRNYVDWIIDLPWNALK
ETTIDIEEARRTLDNDHYGLEKPKERILEYLAVQKLVKKLKGPILCLVGPPGVGKTSLARSVATATGREFVRLSLGGVRD
EAEIRGHRRTYVGALPGKILQSLKRVKFNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNGTFGDHYLDLDYDLSQIF
FITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIARDFLLPKQIEQHGLKPENVRLSDNALLDIIRSYTREAGVRNLER
EIATICRKSAMQLVEKDDMDRAVTVSRQNLGTFLGVKKYRYGEKENQPQVGVSTGLAWTELGGELLLVETAIMPGTGKVS
ITGKLGDVMTESAKAALSYVRSRSDMFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSLVSALLGVPVSDELAMTG
EITLRGRVLPIGGLREKLLAAHRGHITKVLIPRDNEKDLKEVPDEILKGLTVVPVDHVDDVLPHALLAEADAIFNGMEGH
TPLSCSLRKGAEVPASTPQ
>Mature_818_residues
TDFDAEFSAGNPEGIQLPLMSLREVVMFPRSIVPLFVGREASIKAIDSAIEHYGKTIFLVAQREPELEKPGPEDVFPVGT
VSKILQILRLPDGTIKVLFEGLYRARWTGGELSVESGDSAYPVVTVDPLDDDGDAGPEADALVRATHEALEEYSKTNKKL
AQEALAAILSLTSPGKLADAVMPHLKVEYRKKQEVLENTDPASRLEAVFEMLQGEIAISSMEKRIKNRVKNQMERNQREY
YLNEQIKAIHKEMGREDDPQAEVNDLEEQLKAKDMPDEAREKALRELKKLRQMPPSSAEYTVVRNYVDWIIDLPWNALKE
TTIDIEEARRTLDNDHYGLEKPKERILEYLAVQKLVKKLKGPILCLVGPPGVGKTSLARSVATATGREFVRLSLGGVRDE
AEIRGHRRTYVGALPGKILQSLKRVKFNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNGTFGDHYLDLDYDLSQIFF
ITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIARDFLLPKQIEQHGLKPENVRLSDNALLDIIRSYTREAGVRNLERE
IATICRKSAMQLVEKDDMDRAVTVSRQNLGTFLGVKKYRYGEKENQPQVGVSTGLAWTELGGELLLVETAIMPGTGKVSI
TGKLGDVMTESAKAALSYVRSRSDMFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSLVSALLGVPVSDELAMTGE
ITLRGRVLPIGGLREKLLAAHRGHITKVLIPRDNEKDLKEVPDEILKGLTVVPVDHVDDVLPHALLAEADAIFNGMEGHT
PLSCSLRKGAEVPASTPQ

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=47.4245115452931, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=42.6966292134831, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=55.0257731958763, Blast_Score=849, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=658, Percent_Identity=40.4255319148936, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=787, Percent_Identity=33.2909783989835, Blast_Score=446, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319449, Length=712, Percent_Identity=38.061797752809, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI221513036, Length=624, Percent_Identity=45.3525641025641, Blast_Score=533, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=624, Percent_Identity=45.3525641025641, Blast_Score=533, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90999; Mature: 90868

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFDAEFSAGNPEGIQLPLMSLREVVMFPRSIVPLFVGREASIKAIDSAIEHYGKTIFL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEE
VAQREPELEKPGPEDVFPVGTVSKILQILRLPDGTIKVLFEGLYRARWTGGELSVESGDS
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
AYPVVTVDPLDDDGDAGPEADALVRATHEALEEYSKTNKKLAQEALAAILSLTSPGKLAD
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AVMPHLKVEYRKKQEVLENTDPASRLEAVFEMLQGEIAISSMEKRIKNRVKNQMERNQRE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YYLNEQIKAIHKEMGREDDPQAEVNDLEEQLKAKDMPDEAREKALRELKKLRQMPPSSAE
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
YTVVRNYVDWIIDLPWNALKETTIDIEEARRTLDNDHYGLEKPKERILEYLAVQKLVKKL
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
KGPILCLVGPPGVGKTSLARSVATATGREFVRLSLGGVRDEAEIRGHRRTYVGALPGKIL
CCCEEEEECCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCHHHHCCCCHHEECCCCHHHH
QSLKRVKFNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNGTFGDHYLDLDYDLSQIF
HHHHHHCCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCEEE
FITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIARDFLLPKQIEQHGLKPENVRLSDN
EEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECHH
ALLDIIRSYTREAGVRNLEREIATICRKSAMQLVEKDDMDRAVTVSRQNLGTFLGVKKYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
YGEKENQPQVGVSTGLAWTELGGELLLVETAIMPGTGKVSITGKLGDVMTESAKAALSYV
CCCCCCCCCCCHHCCCHHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHH
RSRSDMFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSLVSALLGVPVSDELAMTG
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
EITLRGRVLPIGGLREKLLAAHRGHITKVLIPRDNEKDLKEVPDEILKGLTVVPVDHVDD
EEEEEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECHHHHH
VLPHALLAEADAIFNGMEGHTPLSCSLRKGAEVPASTPQ
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TDFDAEFSAGNPEGIQLPLMSLREVVMFPRSIVPLFVGREASIKAIDSAIEHYGKTIFL
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCEEEE
VAQREPELEKPGPEDVFPVGTVSKILQILRLPDGTIKVLFEGLYRARWTGGELSVESGDS
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCC
AYPVVTVDPLDDDGDAGPEADALVRATHEALEEYSKTNKKLAQEALAAILSLTSPGKLAD
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AVMPHLKVEYRKKQEVLENTDPASRLEAVFEMLQGEIAISSMEKRIKNRVKNQMERNQRE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YYLNEQIKAIHKEMGREDDPQAEVNDLEEQLKAKDMPDEAREKALRELKKLRQMPPSSAE
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
YTVVRNYVDWIIDLPWNALKETTIDIEEARRTLDNDHYGLEKPKERILEYLAVQKLVKKL
HHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
KGPILCLVGPPGVGKTSLARSVATATGREFVRLSLGGVRDEAEIRGHRRTYVGALPGKIL
CCCEEEEECCCCCCHHHHHHHHHHHHCHHHEEECCCCCCCHHHHCCCCHHEECCCCHHHH
QSLKRVKFNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNGTFGDHYLDLDYDLSQIF
HHHHHHCCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCCEEE
FITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIARDFLLPKQIEQHGLKPENVRLSDN
EEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEECHH
ALLDIIRSYTREAGVRNLEREIATICRKSAMQLVEKDDMDRAVTVSRQNLGTFLGVKKYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
YGEKENQPQVGVSTGLAWTELGGELLLVETAIMPGTGKVSITGKLGDVMTESAKAALSYV
CCCCCCCCCCCHHCCCHHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHH
RSRSDMFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSLVSALLGVPVSDELAMTG
HHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
EITLRGRVLPIGGLREKLLAAHRGHITKVLIPRDNEKDLKEVPDEILKGLTVVPVDHVDD
EEEEEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECHHHHH
VLPHALLAEADAIFNGMEGHTPLSCSLRKGAEVPASTPQ
HHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA