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The map label for this gene is dxs [H]

Identifier: 78357243

GI number: 78357243

Start: 2240122

End: 2242107

Strand: Reverse

Name: dxs [H]

Synonym: Dde_2200

Alternate gene names: 78357243

Gene position: 2242107-2240122 (Counterclockwise)

Preceding gene: 78357244

Following gene: 78357238

Centisome position: 60.11

GC content: 57.35

Gene sequence:

>1986_bases
ATGCACACTGCGTGTCACGTTGTGTGCCGGTTTTCAGGCATTGCCGCAGTGATAACGGGACAGAAGGGAATGAGCCAGAC
AGGCATGACAATAGATAATGTGCTGGATTCGATTCAGCACCCTACGGATGTGGCTAAACTGGATGCCGACCAACTGCGGC
AGCTGGCAGATGAACTGCGCGAACGCATCATCGGCACGGTTTCGCAGAACGGCGGTCATCTGGCGCCTTCGCTCGGAGTG
GTGGAGCTGACGCTGGCGCTGCTGTCGGTTTTCAATCCCGACAAGGACAAATTTGTCTGGGATGTGGGGCATCAGGCCTA
TGCATGGAAGCTGCTGACGGGCAGGCGCGATGAATTTTCCACGCTGCGGCAGTATCAGGGGATCAGCGGTTTTCCCAAAA
TGGCGGAAAGTCCCTACGATCATTTCGGGGTGGGGCATTCTTCCACGTCCATATCGGCTGCGGCGGGCATGGCCATGGCC
CGCGATCTGGCCGGAGATGACAACGATGTCATAGCCATCATCGGTGACGGTTCCATGACCGCGGGGCTGGCTTTTGAAGG
ACTTAATCAGGCGGGGCATCAGGGGCGGCGGCTTCTGGTCATCCTGAATGATAATGAAATGTCCATATCAAAGAATGTCG
GCGCGTTATCTCTTTTTCTCAGCCGTAATCTTTCTTCGCGCTGGGTGCGCCGCATGAAGCGCGATGTGGAAACCTGGCTT
AAGTCGGTACCGGGCATAGGTGAAGAAATGCTCAACTATGCCAAGCGCAGCGAGCACAGCCTGAAAAGCTTTTTTACGCC
CGGTATGTTGTTTGAAGCCTTCCGGTTCAACTATGTGGGACCGGTGGACGGCCATGATGTGCGCAATCTTGCCAAGGTGA
TGCAGATGGCGCGTGCTCTGGATGAGCCGGTGCTGCTGCATGTGCTGACCAAAAAAGGCAAAGGTTATGAACCGGCTGAA
AGCAACCCCACCTATTTTCACGGGGTGGGCCGGTTTGAACTGGAAACCGGTGCCGCGTGTAAATTTGTGGATTCGGATTC
ACTGCCTTCGTATACCGAAGTGTTCGGCAGCACATTGTGCAGTCTGGCGGAAAAAGACGAGCGTGTGATCGCCATTACCG
CCGCCATGCCCGAAGGCACAGGAGTGGGCGAATTCAGCCGACGTTTTCCTGACAGGTTTGTGGATGTGGGCATCTGCGAG
CAGCATGCCGTCACGTTTGCAGCCGGTCTTGCTGCGCAGGGATTCCGGCCCGTGGTGGCCATTTATTCCACTTTTCTCCA
GCGGTCGTATGACCAGATCGTGCATGATGTGTGTCTGCAGAAGCTGCCTGTGACGTTCTGTCTGGACAGAGGCGGGCTTG
TAGGTGAAGACGGTCCGACACACCATGGTGCTTTTGACCTGAGTTATTTGCGGCATATTCCCAATCTGACCATCATTGCC
CCCAAGGACGAGGCCGAATTGCAGCAGGCCATGAAGACGGCTCTGGCCGGTGAAGGACCTGTGGCCATACGCTATCCCCG
CGGCATCGGTGTGGGAGCCTGTCTTTCCGCCGACCCCGGAGTGCTGGAACACGGCAGGGGAGAGCTGCTCAAAAAGGGAG
CGGATGTTGCTGTCATCGCAGTGGGCAGCAGGGTGCATCCCGCGCTGGCGGTGGCCGAAGAAATAGAGCGCTCCACCGGC
AAGGCTGTTTCTGTTTTCAACGCGCGTTTTGTGAAGCCTCTTGACGCGGAGCAGCTTGTGGCGCTGGCCCGCAGCCATGA
CAGCCTGCTGCTGCTTGAAGAGAACACAACAACCGGCGGTTTTTCCTCCGGTGTGCTGGAGCTGCTGGCCGATCACGACT
GTCTTGCCGGCGTGCACGTGCGCCGGTTGGGGTTGCCGGATGATTTTGTGACGCACGGTACTCAGAAACAGCTTCGTAAG
CTCACCGGCATAGACCGCGCGGCCATCCGCCGGACCCTGCTGGAAATGCTCGGGCTTCAGGAGTGA

Upstream 100 bases:

>100_bases
ACAGCGGTGCCCTGTCGTAGCTGAATGCGTACGGCGGCATCTGTTTTTGCGGCATGCGTGGCGCGCATTATCCGTACGGA
GTCTGCGGGGGTACGGATGA

Downstream 100 bases:

>100_bases
GCTGTTTGCCAGCTACGTAAAAAAGTCCCGCCGGATGACGGCGGGACTTTTGCGTTATATGGTGTGCGTCTTTGCGGGCA
TGCGGATTACGGTGCAGGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MHTACHVVCRFSGIAAVITGQKGMSQTGMTIDNVLDSIQHPTDVAKLDADQLRQLADELRERIIGTVSQNGGHLAPSLGV
VELTLALLSVFNPDKDKFVWDVGHQAYAWKLLTGRRDEFSTLRQYQGISGFPKMAESPYDHFGVGHSSTSISAAAGMAMA
RDLAGDDNDVIAIIGDGSMTAGLAFEGLNQAGHQGRRLLVILNDNEMSISKNVGALSLFLSRNLSSRWVRRMKRDVETWL
KSVPGIGEEMLNYAKRSEHSLKSFFTPGMLFEAFRFNYVGPVDGHDVRNLAKVMQMARALDEPVLLHVLTKKGKGYEPAE
SNPTYFHGVGRFELETGAACKFVDSDSLPSYTEVFGSTLCSLAEKDERVIAITAAMPEGTGVGEFSRRFPDRFVDVGICE
QHAVTFAAGLAAQGFRPVVAIYSTFLQRSYDQIVHDVCLQKLPVTFCLDRGGLVGEDGPTHHGAFDLSYLRHIPNLTIIA
PKDEAELQQAMKTALAGEGPVAIRYPRGIGVGACLSADPGVLEHGRGELLKKGADVAVIAVGSRVHPALAVAEEIERSTG
KAVSVFNARFVKPLDAEQLVALARSHDSLLLLEENTTTGGFSSGVLELLADHDCLAGVHVRRLGLPDDFVTHGTQKQLRK
LTGIDRAAIRRTLLEMLGLQE

Sequences:

>Translated_661_residues
MHTACHVVCRFSGIAAVITGQKGMSQTGMTIDNVLDSIQHPTDVAKLDADQLRQLADELRERIIGTVSQNGGHLAPSLGV
VELTLALLSVFNPDKDKFVWDVGHQAYAWKLLTGRRDEFSTLRQYQGISGFPKMAESPYDHFGVGHSSTSISAAAGMAMA
RDLAGDDNDVIAIIGDGSMTAGLAFEGLNQAGHQGRRLLVILNDNEMSISKNVGALSLFLSRNLSSRWVRRMKRDVETWL
KSVPGIGEEMLNYAKRSEHSLKSFFTPGMLFEAFRFNYVGPVDGHDVRNLAKVMQMARALDEPVLLHVLTKKGKGYEPAE
SNPTYFHGVGRFELETGAACKFVDSDSLPSYTEVFGSTLCSLAEKDERVIAITAAMPEGTGVGEFSRRFPDRFVDVGICE
QHAVTFAAGLAAQGFRPVVAIYSTFLQRSYDQIVHDVCLQKLPVTFCLDRGGLVGEDGPTHHGAFDLSYLRHIPNLTIIA
PKDEAELQQAMKTALAGEGPVAIRYPRGIGVGACLSADPGVLEHGRGELLKKGADVAVIAVGSRVHPALAVAEEIERSTG
KAVSVFNARFVKPLDAEQLVALARSHDSLLLLEENTTTGGFSSGVLELLADHDCLAGVHVRRLGLPDDFVTHGTQKQLRK
LTGIDRAAIRRTLLEMLGLQE
>Mature_661_residues
MHTACHVVCRFSGIAAVITGQKGMSQTGMTIDNVLDSIQHPTDVAKLDADQLRQLADELRERIIGTVSQNGGHLAPSLGV
VELTLALLSVFNPDKDKFVWDVGHQAYAWKLLTGRRDEFSTLRQYQGISGFPKMAESPYDHFGVGHSSTSISAAAGMAMA
RDLAGDDNDVIAIIGDGSMTAGLAFEGLNQAGHQGRRLLVILNDNEMSISKNVGALSLFLSRNLSSRWVRRMKRDVETWL
KSVPGIGEEMLNYAKRSEHSLKSFFTPGMLFEAFRFNYVGPVDGHDVRNLAKVMQMARALDEPVLLHVLTKKGKGYEPAE
SNPTYFHGVGRFELETGAACKFVDSDSLPSYTEVFGSTLCSLAEKDERVIAITAAMPEGTGVGEFSRRFPDRFVDVGICE
QHAVTFAAGLAAQGFRPVVAIYSTFLQRSYDQIVHDVCLQKLPVTFCLDRGGLVGEDGPTHHGAFDLSYLRHIPNLTIIA
PKDEAELQQAMKTALAGEGPVAIRYPRGIGVGACLSADPGVLEHGRGELLKKGADVAVIAVGSRVHPALAVAEEIERSTG
KAVSVFNARFVKPLDAEQLVALARSHDSLLLLEENTTTGGFSSGVLELLADHDCLAGVHVRRLGLPDDFVTHGTQKQLRK
LTGIDRAAIRRTLLEMLGLQE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=673, Percent_Identity=23.9227340267459, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI4507521, Length=673, Percent_Identity=23.9227340267459, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI133778974, Length=615, Percent_Identity=23.739837398374, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI225637461, Length=378, Percent_Identity=24.8677248677249, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637459, Length=378, Percent_Identity=24.8677248677249, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI225637463, Length=378, Percent_Identity=24.8677248677249, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI4557353, Length=226, Percent_Identity=22.5663716814159, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI34101272, Length=226, Percent_Identity=22.5663716814159, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=617, Percent_Identity=47.9740680713128, Blast_Score=561, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17539652, Length=407, Percent_Identity=26.5356265356265, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319698, Length=345, Percent_Identity=21.1594202898551, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666278, Length=650, Percent_Identity=26.4615384615385, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI45551847, Length=622, Percent_Identity=25.8842443729904, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45550715, Length=622, Percent_Identity=25.8842443729904, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645119, Length=582, Percent_Identity=25.9450171821306, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI160714832, Length=223, Percent_Identity=24.2152466367713, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI160714828, Length=223, Percent_Identity=24.2152466367713, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 71698; Mature: 71698

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTACHVVCRFSGIAAVITGQKGMSQTGMTIDNVLDSIQHPTDVAKLDADQLRQLADELR
CCCHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
ERIIGTVSQNGGHLAPSLGVVELTLALLSVFNPDKDKFVWDVGHQAYAWKLLTGRRDEFS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCHHHH
TLRQYQGISGFPKMAESPYDHFGVGHSSTSISAAAGMAMARDLAGDDNDVIAIIGDGSMT
HHHHHCCCCCCCHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
AGLAFEGLNQAGHQGRRLLVILNDNEMSISKNVGALSLFLSRNLSSRWVRRMKRDVETWL
HHHHHHHHHHCCCCCCEEEEEECCCCEEHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
KSVPGIGEEMLNYAKRSEHSLKSFFTPGMLFEAFRFNYVGPVDGHDVRNLAKVMQMARAL
HHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
DEPVLLHVLTKKGKGYEPAESNPTYFHGVGRFELETGAACKFVDSDSLPSYTEVFGSTLC
CCCCEEHHHHCCCCCCCCCCCCCCEEECCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
SLAEKDERVIAITAAMPEGTGVGEFSRRFPDRFVDVGICEQHAVTFAAGLAAQGFRPVVA
HHHCCCCEEEEEEEECCCCCCCCHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
IYSTFLQRSYDQIVHDVCLQKLPVTFCLDRGGLVGEDGPTHHGAFDLSYLRHIPNLTIIA
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEC
PKDEAELQQAMKTALAGEGPVAIRYPRGIGVGACLSADPGVLEHGRGELLKKGADVAVIA
CCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCHHHHHCCCCEEEEE
VGSRVHPALAVAEEIERSTGKAVSVFNARFVKPLDAEQLVALARSHDSLLLLEENTTTGG
ECCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCC
FSSGVLELLADHDCLAGVHVRRLGLPDDFVTHGTQKQLRKLTGIDRAAIRRTLLEMLGLQ
CHHHHHHHHHCCCHHHCCHHHCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
E
C
>Mature Secondary Structure
MHTACHVVCRFSGIAAVITGQKGMSQTGMTIDNVLDSIQHPTDVAKLDADQLRQLADELR
CCCHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
ERIIGTVSQNGGHLAPSLGVVELTLALLSVFNPDKDKFVWDVGHQAYAWKLLTGRRDEFS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCHHHH
TLRQYQGISGFPKMAESPYDHFGVGHSSTSISAAAGMAMARDLAGDDNDVIAIIGDGSMT
HHHHHCCCCCCCHHHCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
AGLAFEGLNQAGHQGRRLLVILNDNEMSISKNVGALSLFLSRNLSSRWVRRMKRDVETWL
HHHHHHHHHHCCCCCCEEEEEECCCCEEHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
KSVPGIGEEMLNYAKRSEHSLKSFFTPGMLFEAFRFNYVGPVDGHDVRNLAKVMQMARAL
HHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
DEPVLLHVLTKKGKGYEPAESNPTYFHGVGRFELETGAACKFVDSDSLPSYTEVFGSTLC
CCCCEEHHHHCCCCCCCCCCCCCCEEECCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
SLAEKDERVIAITAAMPEGTGVGEFSRRFPDRFVDVGICEQHAVTFAAGLAAQGFRPVVA
HHHCCCCEEEEEEEECCCCCCCCHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
IYSTFLQRSYDQIVHDVCLQKLPVTFCLDRGGLVGEDGPTHHGAFDLSYLRHIPNLTIIA
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEC
PKDEAELQQAMKTALAGEGPVAIRYPRGIGVGACLSADPGVLEHGRGELLKKGADVAVIA
CCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCHHHHHCCCCEEEEE
VGSRVHPALAVAEEIERSTGKAVSVFNARFVKPLDAEQLVALARSHDSLLLLEENTTTGG
ECCCCCHHHHHHHHHHHHCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCC
FSSGVLELLADHDCLAGVHVRRLGLPDDFVTHGTQKQLRKLTGIDRAAIRRTLLEMLGLQ
CHHHHHHHHHCCCHHHCCHHHCCCCCHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA