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The map label for this gene is ispA [C]

Identifier: 78357244

GI number: 78357244

Start: 2242216

End: 2243130

Strand: Reverse

Name: ispA [C]

Synonym: Dde_2201

Alternate gene names: 78357244

Gene position: 2243130-2242216 (Counterclockwise)

Preceding gene: 78357245

Following gene: 78357243

Centisome position: 60.13

GC content: 60.0

Gene sequence:

>915_bases
ATGTCTCATGCGGACGAAATGACACCGCAGGCCATGAAGCAGCGGCTTGCGGCGGAAGCGCTGGAAGTGGAAGCGTATCT
TGGCGGGTGCCTTAAAGGGCGGGGAATACCCTGTGATCTTCTGAAGGCCATGGATTACAGCCTGCTTGCCGGCGGTAAGC
GTCTGCGACCCGTGCTGTGCCTTACCACGGCCGGTCTTTTCGGTCTGGCGCGCGATGCGGTGCTGCCTTTTGCCGCGGCC
ATCGAGCTTATTCATACATATTCTCTGGTGCACGACGACCTGCCCGCCATGGATGATGACGACCTGCGGCGCGGCATGCC
ATCGAATCATAAAAAATTCGGCGAGGCCACAGCCATACTGGCCGGTGACGGCCTGCTTACCGAAGCGTTTTGCCTGATGG
CATCGGCGGGAGCTGCTGTGGAAGCCTCCAGAGTGCTTTCCGCCCTGTCTGTGGTGGCTGCTGCGGCAGGCGCCGGAGGC
ATGGTGGGAGGTCAGATGCTGGATATGGAGTACACCGGCCGCGCTGATGTGTCTTTGGACATGCTTCGCGGTATGCACGC
CATGAAAACAGGTGCGCTCATCCGCTGTTCGTGTCTTGCCGGAGCCCTGCTTGCAGGCGCACCGCATGAAGATGCCGAAC
GGATATCCCACTATGGAGAAGCCATTGGAGCCGCTTTTCAGATTGTTGATGACATTCTTGATGAAACCGGCGACGAGGCG
ACACTGGGCAAGCCGGTGGGCAGTGACAGCGGGCAGGGCAAGAACACATATCCGAGCCTGCTGGGGCTTGAGCGCAGCAG
AGAGCTGGCGCAGCAGCAGGTGGATGCCGCCGTGGCCTGCCTGTCGGGGTATGAAGGTGAAAATGCGCTTTTCCTCAGGG
CACTTGCACAGTACATTGCCGATCGGGCCATGTGA

Upstream 100 bases:

>100_bases
ATTCTCCGGCGGCGGATGACTGAATCTGTGTGCGCCGGCAGGTTTTTTGCGTTCTGCAGCGGCAGGCGACGGACAGCAAC
TTTTACACAGGGACGTGAAC

Downstream 100 bases:

>100_bases
TTTTTTTAACAGCGGTGCCCTGTCGTAGCTGAATGCGTACGGCGGCATCTGTTTTTGCGGCATGCGTGGCGCGCATTATC
CGTACGGAGTCTGCGGGGGT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSHADEMTPQAMKQRLAAEALEVEAYLGGCLKGRGIPCDLLKAMDYSLLAGGKRLRPVLCLTTAGLFGLARDAVLPFAAA
IELIHTYSLVHDDLPAMDDDDLRRGMPSNHKKFGEATAILAGDGLLTEAFCLMASAGAAVEASRVLSALSVVAAAAGAGG
MVGGQMLDMEYTGRADVSLDMLRGMHAMKTGALIRCSCLAGALLAGAPHEDAERISHYGEAIGAAFQIVDDILDETGDEA
TLGKPVGSDSGQGKNTYPSLLGLERSRELAQQQVDAAVACLSGYEGENALFLRALAQYIADRAM

Sequences:

>Translated_304_residues
MSHADEMTPQAMKQRLAAEALEVEAYLGGCLKGRGIPCDLLKAMDYSLLAGGKRLRPVLCLTTAGLFGLARDAVLPFAAA
IELIHTYSLVHDDLPAMDDDDLRRGMPSNHKKFGEATAILAGDGLLTEAFCLMASAGAAVEASRVLSALSVVAAAAGAGG
MVGGQMLDMEYTGRADVSLDMLRGMHAMKTGALIRCSCLAGALLAGAPHEDAERISHYGEAIGAAFQIVDDILDETGDEA
TLGKPVGSDSGQGKNTYPSLLGLERSRELAQQQVDAAVACLSGYEGENALFLRALAQYIADRAM
>Mature_303_residues
SHADEMTPQAMKQRLAAEALEVEAYLGGCLKGRGIPCDLLKAMDYSLLAGGKRLRPVLCLTTAGLFGLARDAVLPFAAAI
ELIHTYSLVHDDLPAMDDDDLRRGMPSNHKKFGEATAILAGDGLLTEAFCLMASAGAAVEASRVLSALSVVAAAAGAGGM
VGGQMLDMEYTGRADVSLDMLRGMHAMKTGALIRCSCLAGALLAGAPHEDAERISHYGEAIGAAFQIVDDILDETGDEAT
LGKPVGSDSGQGKNTYPSLLGLERSRELAQQQVDAAVACLSGYEGENALFLRALAQYIADRAM

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=238, Percent_Identity=31.5126050420168, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=49.063670411985, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1789578, Length=242, Percent_Identity=31.8181818181818, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=192, Percent_Identity=32.8125, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651612, Length=191, Percent_Identity=31.413612565445, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31776; Mature: 31645

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHADEMTPQAMKQRLAAEALEVEAYLGGCLKGRGIPCDLLKAMDYSLLAGGKRLRPVLC
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCHHCHHHH
LTTAGLFGLARDAVLPFAAAIELIHTYSLVHDDLPAMDDDDLRRGMPSNHKKFGEATAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCHHEEE
AGDGLLTEAFCLMASAGAAVEASRVLSALSVVAAAAGAGGMVGGQMLDMEYTGRADVSLD
ECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHH
MLRGMHAMKTGALIRCSCLAGALLAGAPHEDAERISHYGEAIGAAFQIVDDILDETGDEA
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLGKPVGSDSGQGKNTYPSLLGLERSRELAQQQVDAAVACLSGYEGENALFLRALAQYIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DRAM
HCCC
>Mature Secondary Structure 
SHADEMTPQAMKQRLAAEALEVEAYLGGCLKGRGIPCDLLKAMDYSLLAGGKRLRPVLC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCHHCHHHH
LTTAGLFGLARDAVLPFAAAIELIHTYSLVHDDLPAMDDDDLRRGMPSNHKKFGEATAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHCCHHEEE
AGDGLLTEAFCLMASAGAAVEASRVLSALSVVAAAAGAGGMVGGQMLDMEYTGRADVSLD
ECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHH
MLRGMHAMKTGALIRCSCLAGALLAGAPHEDAERISHYGEAIGAAFQIVDDILDETGDEA
HHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLGKPVGSDSGQGKNTYPSLLGLERSRELAQQQVDAAVACLSGYEGENALFLRALAQYIA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
DRAM
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]