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The map label for this gene is galE [H]

Identifier: 78357230

GI number: 78357230

Start: 2226869

End: 2227852

Strand: Reverse

Name: galE [H]

Synonym: Dde_2187

Alternate gene names: 78357230

Gene position: 2227852-2226869 (Counterclockwise)

Preceding gene: 78357232

Following gene: 78357224

Centisome position: 59.72

GC content: 58.13

Gene sequence:

>984_bases
ATGCAGCCTCAGAAGGTGCTTGTATGCGGCGGGGCCGGGTATATCGGTTCACATATGGTCAGGGCGCTTATGCGTGCCGG
ACACCTGCCTGTTGTTTTTGACAATCTTTCCACAGGACATCTTGAATCCATCGGGCAGGCGGAATTTGTGCGCGGCGACC
TTTTGGATATGCAGGCCCTGCGGCGCGTGTTCGGTGAATACTGCTTTGATGCGGTTATGCATTTTTCTGCCAAAAGTCTG
GTGGGCGAATCGGTTGTTCATCCCGCCCTGTATTATACCAATAATGTGACGGGCACCTGCAATCTGCTGGAAGCCATGCG
CGAAAGCGGCGTTGGGCGGCTGGTGTTTTCCAGCACGGCGGCCGTGTACGGCGATCCGCAGGCACCTGTCATTGCAGAAG
ATCATCCATGCTTGCCGGTAAACCCCTACGGGCGGTCCAAGCTCATGGTGGAAACCATGCTTGCCGACCATGCGGCCGCC
TATGGCCTGCGTTCTGTCTCTCTGCGGTACTTCAATGCGGCGGGAGCTGACGAGGACGGCGGCATAGGTGAGGCGCATTC
GCCCGAAACCCATCTGCTGCCCAACGTACTGCTGGCGGCATTGGGCAGAAACGACGGCCTGAAGATATTCGGCGATGATT
ATACGACGCCGGACGGGACGTGCGTACGCGACTACATCCATGTGACGGACCTGTGCAGCGCGCATCTGGCGGCGCTGGAG
TATATGACCCTTCATGCCGGTGCCGCAGTGTTCAATCTGGGTAACGGCAACGGTTTTTCCGTGCGCGAAATTCTGGACGC
CGCCTGCCGTGTGACAGGTGTTGATATTCCCTTTACCGTGGAAGGACGCAGGGCTGGCGATCCTCCCATGCTGGTGGCCG
ATGCTGCACGTGCCCGTACCGCGCTGGGATGGACTCCTGTTTATACGGATATAGACCGGATCATTGAAACCGCATGGCGC
TGGCACAGCGACCAGCGTTATTGA

Upstream 100 bases:

>100_bases
GGCAGGCGATGGCGGAAGCGGGGATGCGTACTGTCTGCAGGGGCATTACATCACGCGGCGATTTTACTGACAGATACTAA
TGACAGGGAGACACGAAGCT

Downstream 100 bases:

>100_bases
TTCTGGCTTAAGCGCAATGACGTAACGCCCTGCGATCGTATGACCGCAGGGCGTTTTTGTTGTAACGGAAAGCAGGGCAG
TTCAGACGCGTACAGTAAGG

Product: UDP-galactose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MQPQKVLVCGGAGYIGSHMVRALMRAGHLPVVFDNLSTGHLESIGQAEFVRGDLLDMQALRRVFGEYCFDAVMHFSAKSL
VGESVVHPALYYTNNVTGTCNLLEAMRESGVGRLVFSSTAAVYGDPQAPVIAEDHPCLPVNPYGRSKLMVETMLADHAAA
YGLRSVSLRYFNAAGADEDGGIGEAHSPETHLLPNVLLAALGRNDGLKIFGDDYTTPDGTCVRDYIHVTDLCSAHLAALE
YMTLHAGAAVFNLGNGNGFSVREILDAACRVTGVDIPFTVEGRRAGDPPMLVADAARARTALGWTPVYTDIDRIIETAWR
WHSDQRY

Sequences:

>Translated_327_residues
MQPQKVLVCGGAGYIGSHMVRALMRAGHLPVVFDNLSTGHLESIGQAEFVRGDLLDMQALRRVFGEYCFDAVMHFSAKSL
VGESVVHPALYYTNNVTGTCNLLEAMRESGVGRLVFSSTAAVYGDPQAPVIAEDHPCLPVNPYGRSKLMVETMLADHAAA
YGLRSVSLRYFNAAGADEDGGIGEAHSPETHLLPNVLLAALGRNDGLKIFGDDYTTPDGTCVRDYIHVTDLCSAHLAALE
YMTLHAGAAVFNLGNGNGFSVREILDAACRVTGVDIPFTVEGRRAGDPPMLVADAARARTALGWTPVYTDIDRIIETAWR
WHSDQRY
>Mature_327_residues
MQPQKVLVCGGAGYIGSHMVRALMRAGHLPVVFDNLSTGHLESIGQAEFVRGDLLDMQALRRVFGEYCFDAVMHFSAKSL
VGESVVHPALYYTNNVTGTCNLLEAMRESGVGRLVFSSTAAVYGDPQAPVIAEDHPCLPVNPYGRSKLMVETMLADHAAA
YGLRSVSLRYFNAAGADEDGGIGEAHSPETHLLPNVLLAALGRNDGLKIFGDDYTTPDGTCVRDYIHVTDLCSAHLAALE
YMTLHAGAAVFNLGNGNGFSVREILDAACRVTGVDIPFTVEGRRAGDPPMLVADAARARTALGWTPVYTDIDRIIETAWR
WHSDQRY

Specific function: Can have functions other than metabolism of galactose. It also could be involved in preparation of carbohydrate residues for incorporation into complex polymers, such as exopolysaccharides [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=45.2941176470588, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=45.2941176470588, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=45.2941176470588, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=28.2539682539683, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI7657641, Length=270, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786974, Length=330, Percent_Identity=40.3030303030303, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1788353, Length=342, Percent_Identity=29.8245614035088, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI48994969, Length=339, Percent_Identity=29.4985250737463, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790049, Length=327, Percent_Identity=26.605504587156, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71982035, Length=338, Percent_Identity=36.6863905325444, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI71982038, Length=340, Percent_Identity=36.7647058823529, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17539532, Length=313, Percent_Identity=23.3226837060703, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=41.3489736070381, Blast_Score=244, Evalue=1e-65,
Organism=Drosophila melanogaster, GI19923002, Length=346, Percent_Identity=39.5953757225434, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=25.796178343949, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35356; Mature: 35356

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPQKVLVCGGAGYIGSHMVRALMRAGHLPVVFDNLSTGHLESIGQAEFVRGDLLDMQAL
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHH
RRVFGEYCFDAVMHFSAKSLVGESVVHPALYYTNNVTGTCNLLEAMRESGVGRLVFSSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHCCCCEEEEECCE
AVYGDPQAPVIAEDHPCLPVNPYGRSKLMVETMLADHAAAYGLRSVSLRYFNAAGADEDG
EEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
GIGEAHSPETHLLPNVLLAALGRNDGLKIFGDDYTTPDGTCVRDYIHVTDLCSAHLAALE
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YMTLHAGAAVFNLGNGNGFSVREILDAACRVTGVDIPFTVEGRRAGDPPMLVADAARART
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHEECCCCCEEECCCCCCCCCEEEEHHHHHHH
ALGWTPVYTDIDRIIETAWRWHSDQRY
HCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQPQKVLVCGGAGYIGSHMVRALMRAGHLPVVFDNLSTGHLESIGQAEFVRGDLLDMQAL
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHCCCHHHHHHHHHHHHHH
RRVFGEYCFDAVMHFSAKSLVGESVVHPALYYTNNVTGTCNLLEAMRESGVGRLVFSSTA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHCCCCEEEEECCE
AVYGDPQAPVIAEDHPCLPVNPYGRSKLMVETMLADHAAAYGLRSVSLRYFNAAGADEDG
EEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCC
GIGEAHSPETHLLPNVLLAALGRNDGLKIFGDDYTTPDGTCVRDYIHVTDLCSAHLAALE
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YMTLHAGAAVFNLGNGNGFSVREILDAACRVTGVDIPFTVEGRRAGDPPMLVADAARART
HHHHCCCEEEEECCCCCCCCHHHHHHHHHHEECCCCCEEECCCCCCCCCEEEEHHHHHHH
ALGWTPVYTDIDRIIETAWRWHSDQRY
HCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788721 [H]