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The map label for this gene is uvrB

Identifier: 78357139

GI number: 78357139

Start: 2144920

End: 2146968

Strand: Reverse

Name: uvrB

Synonym: Dde_2096

Alternate gene names: 78357139

Gene position: 2146968-2144920 (Counterclockwise)

Preceding gene: 78357141

Following gene: 78357138

Centisome position: 57.56

GC content: 56.08

Gene sequence:

>2049_bases
ATGCAGGATAGCGTTTTCCGGATAGAGTCGGAGTATGTGCCCAGAGGCGACCAGCCGGAGGCCATCACCCAGTTGAGTGA
CAACATCAGAGCCGGAGTGGCTCATCAGGTACTGCTGGGGGTGACCGGTTCTGGCAAGACGTTCACCATGGCGCATACCA
TAGAACGCTGCCAGCGTCCCGCGCTGATTCTTGCTCCCAACAAGACGCTGGCCGCACAGCTGTATAACGAATTCCGCGCG
CTGTTTCCGCATAATGCCGTGGAATATTTCGTCAGCTACTATGACTACTACCAGCCGGAAGCCTATGTGCCGACTTCCGA
CACCTATATAGAAAAAGACTCTTCCATCAACGACAATATAGACAAGCTGCGCCATGCCGCAACGCACGCCCTGCTTACAC
GACGGGATGTGATCATCATCGCTTCGGTTTCCTGCATCTACGGGCTGGGGTCTCCGGAATACTATGCAAAGATGGTCATA
CCCGTGGAAGCCGGCCAGCACATGAGCATGGACAGCCTGATAGGCAGACTTGTCGATGTGCAGTACGAGCGCAACGACTA
TGATTTTCACCGCGGTACATTCCGTGTCCGGGGAGACGTGCTGGAAGTCATTCCCGCCTATCACCACGAGCGGGCGCTGC
GGCTGGAGTTTTTCGGCGACGAAATTGATTCCATAAAAGAAATCGACCCGTTGACCGGCAATGTGCTGGGCGATGTGGGC
AAAACGGTGATTTATCCTGCAAGCCACTATGTTTCCGACAGAGACAACCTGAACAGAGCCGTTTCCGATATTCGGGAAGA
ACTGCGTCTGCGGCTGGAAGAATACCGGCAGGGGAACAGACTGGTGGAGGCGCAGCGCCTCGAACAGCGAACAATGCTTG
ATCTTGAAATGATTGAGGAAATGGGCTACTGTACCGGTATTGAAAACTATTCCCGCCATCTGGACGGCCGCACGGCGGGA
GAGCCTCCGGCGTGTCTGCTTGATTATTTTCCCGATAATTTCATTCTGTTCGTGGATGAATCGCACATTACCGTTTCACA
GGTGGGCGCCATGTACAAAGGCGACCGGTCGCGCAAGCAGACGCTGGTTGATTTCGGCTTCCGCCTGCCTTCCGCGCTGG
ATAACCGTCCGCTGGAGTTCAGCGAATTTGAAAAGCGGCTCAATCAGGTTGTCTATGTTTCGGCCACACCGTCCAGATGG
GAGCTTGACCGGTCCGAGGGCATTGTTGTCGAGCAGATTATCCGGCCCACAGGTCTGCTTGATCCGCTGACTGAAGTGCG
GCCGACCAAAGGCCAGATGGAAGACCTGATGACCGAGTGCCGCTCCAGAACGGCACGGGATGAGCGGGTGCTTGTAACCA
CGCTGACCAAGCGCATGGCGGAGGACCTGACAGAATACCTGACATCCATGGGCGTGAGTGCGCGGTATCTGCATTCCGAC
ATCGATACCATGGAGCGCATGGCTATTATTCAGGCGCTGCGTCGTAAAGAATTTGATGTGCTTGTGGGTATTAACCTGCT
GCGTGAAGGTCTTGATATTCCGGAAGTTTCTCTGGTTGCCATTCTGGATGCCGACAAAGAGGGCTTTTTGCGCTCCACCG
GATCGCTTATTCAGACATTCGGCCGCGCCGCGCGTAATGTGGACGGCCGCGTTATCATGTATGCCGACAGCGTGACACGT
TCCATGACTGCGGCCATGCAGGAAACGGAACGCAGACGTGAAAAGCAGCGCCTGTATAACGAGGAGCACGGCATAGAGCC
TGTGAGCGTCCGTAAATCGCTTGAGACGCCGTTTGACACGCTGTATTCCGATGCCCGGTCTGCTGCTGCCAAAGGCAGGG
GCAAGGGCAGAGGACGGCAGGCTGCACCGGCCCAGACCGCTGCGGAGGACACCACGGCGTACGGCATCAGCGCAGAGGAA
CTGGGCGGTCTTATCCAGCGTCTTGAACGCGAGATGCGGGAATCGGCGCGCGATCTTGAATTTGAAAAGGCAGCTGAACT
GCGCGACAGAATACGTATGCTGCGCGAGCGGCTGCTGCAGCAGGATTGA

Upstream 100 bases:

>100_bases
GGACAGGCTAAATACCTATGTTTGCAGCAGGCGGATGCGGTGCCGGATGTCCGGCGGGTACAGGGCCGCTGCGGTTCTTT
TTTGATTTTCAGGATGAATC

Downstream 100 bases:

>100_bases
GCTTTTCTGAATCTTTATACGGAACACAGTGCATGGACGAGAAGACGTTACGTGTGCGTATAATACGCCTCCGCAACAGG
GTAGGGACATTCTGGCCGCT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MQDSVFRIESEYVPRGDQPEAITQLSDNIRAGVAHQVLLGVTGSGKTFTMAHTIERCQRPALILAPNKTLAAQLYNEFRA
LFPHNAVEYFVSYYDYYQPEAYVPTSDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIIASVSCIYGLGSPEYYAKMVI
PVEAGQHMSMDSLIGRLVDVQYERNDYDFHRGTFRVRGDVLEVIPAYHHERALRLEFFGDEIDSIKEIDPLTGNVLGDVG
KTVIYPASHYVSDRDNLNRAVSDIREELRLRLEEYRQGNRLVEAQRLEQRTMLDLEMIEEMGYCTGIENYSRHLDGRTAG
EPPACLLDYFPDNFILFVDESHITVSQVGAMYKGDRSRKQTLVDFGFRLPSALDNRPLEFSEFEKRLNQVVYVSATPSRW
ELDRSEGIVVEQIIRPTGLLDPLTEVRPTKGQMEDLMTECRSRTARDERVLVTTLTKRMAEDLTEYLTSMGVSARYLHSD
IDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSTGSLIQTFGRAARNVDGRVIMYADSVTR
SMTAAMQETERRREKQRLYNEEHGIEPVSVRKSLETPFDTLYSDARSAAAKGRGKGRGRQAAPAQTAAEDTTAYGISAEE
LGGLIQRLEREMRESARDLEFEKAAELRDRIRMLRERLLQQD

Sequences:

>Translated_682_residues
MQDSVFRIESEYVPRGDQPEAITQLSDNIRAGVAHQVLLGVTGSGKTFTMAHTIERCQRPALILAPNKTLAAQLYNEFRA
LFPHNAVEYFVSYYDYYQPEAYVPTSDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIIASVSCIYGLGSPEYYAKMVI
PVEAGQHMSMDSLIGRLVDVQYERNDYDFHRGTFRVRGDVLEVIPAYHHERALRLEFFGDEIDSIKEIDPLTGNVLGDVG
KTVIYPASHYVSDRDNLNRAVSDIREELRLRLEEYRQGNRLVEAQRLEQRTMLDLEMIEEMGYCTGIENYSRHLDGRTAG
EPPACLLDYFPDNFILFVDESHITVSQVGAMYKGDRSRKQTLVDFGFRLPSALDNRPLEFSEFEKRLNQVVYVSATPSRW
ELDRSEGIVVEQIIRPTGLLDPLTEVRPTKGQMEDLMTECRSRTARDERVLVTTLTKRMAEDLTEYLTSMGVSARYLHSD
IDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSTGSLIQTFGRAARNVDGRVIMYADSVTR
SMTAAMQETERRREKQRLYNEEHGIEPVSVRKSLETPFDTLYSDARSAAAKGRGKGRGRQAAPAQTAAEDTTAYGISAEE
LGGLIQRLEREMRESARDLEFEKAAELRDRIRMLRERLLQQD
>Mature_682_residues
MQDSVFRIESEYVPRGDQPEAITQLSDNIRAGVAHQVLLGVTGSGKTFTMAHTIERCQRPALILAPNKTLAAQLYNEFRA
LFPHNAVEYFVSYYDYYQPEAYVPTSDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIIASVSCIYGLGSPEYYAKMVI
PVEAGQHMSMDSLIGRLVDVQYERNDYDFHRGTFRVRGDVLEVIPAYHHERALRLEFFGDEIDSIKEIDPLTGNVLGDVG
KTVIYPASHYVSDRDNLNRAVSDIREELRLRLEEYRQGNRLVEAQRLEQRTMLDLEMIEEMGYCTGIENYSRHLDGRTAG
EPPACLLDYFPDNFILFVDESHITVSQVGAMYKGDRSRKQTLVDFGFRLPSALDNRPLEFSEFEKRLNQVVYVSATPSRW
ELDRSEGIVVEQIIRPTGLLDPLTEVRPTKGQMEDLMTECRSRTARDERVLVTTLTKRMAEDLTEYLTSMGVSARYLHSD
IDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSTGSLIQTFGRAARNVDGRVIMYADSVTR
SMTAAMQETERRREKQRLYNEEHGIEPVSVRKSLETPFDTLYSDARSAAAKGRGKGRGRQAAPAQTAAEDTTAYGISAEE
LGGLIQRLEREMRESARDLEFEKAAELRDRIRMLRERLLQQD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=57.0789865871833, Blast_Score=773, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=313, Percent_Identity=24.2811501597444, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_DESDG (Q30ZK3)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388588.1
- ProteinModelPortal:   Q30ZK3
- STRING:   Q30ZK3
- GeneID:   3757104
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2096
- NMPDR:   fig|207559.3.peg.2244
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   DDES207559:DDE_2096-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 77706; Mature: 77706

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDSVFRIESEYVPRGDQPEAITQLSDNIRAGVAHQVLLGVTGSGKTFTMAHTIERCQRP
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHHHCCC
ALILAPNKTLAAQLYNEFRALFPHNAVEYFVSYYDYYQPEAYVPTSDTYIEKDSSINDNI
EEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCCCCH
DKLRHAATHALLTRRDVIIIASVSCIYGLGSPEYYAKMVIPVEAGQHMSMDSLIGRLVDV
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHC
QYERNDYDFHRGTFRVRGDVLEVIPAYHHERALRLEFFGDEIDSIKEIDPLTGNVLGDVG
EECCCCCCCCCCEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCHHHHHCC
KTVIYPASHYVSDRDNLNRAVSDIREELRLRLEEYRQGNRLVEAQRLEQRTMLDLEMIEE
CEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
MGYCTGIENYSRHLDGRTAGEPPACLLDYFPDNFILFVDESHITVSQVGAMYKGDRSRKQ
CCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEEECCCEEHHHHHHHHCCCCHHHH
TLVDFGFRLPSALDNRPLEFSEFEKRLNQVVYVSATPSRWELDRSEGIVVEQIIRPTGLL
HHHHHHHHCCHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
DPLTEVRPTKGQMEDLMTECRSRTARDERVLVTTLTKRMAEDLTEYLTSMGVSARYLHSD
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSTGSLIQTF
HHHHHHHHHHHHHHHCCCHHHEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVDGRVIMYADSVTRSMTAAMQETERRREKQRLYNEEHGIEPVSVRKSLETPFDT
HHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHH
LYSDARSAAAKGRGKGRGRQAAPAQTAAEDTTAYGISAEELGGLIQRLEREMRESARDLE
HHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FEKAAELRDRIRMLRERLLQQD
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQDSVFRIESEYVPRGDQPEAITQLSDNIRAGVAHQVLLGVTGSGKTFTMAHTIERCQRP
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHHHHHCCC
ALILAPNKTLAAQLYNEFRALFPHNAVEYFVSYYDYYQPEAYVPTSDTYIEKDSSINDNI
EEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCCCCH
DKLRHAATHALLTRRDVIIIASVSCIYGLGSPEYYAKMVIPVEAGQHMSMDSLIGRLVDV
HHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHEEEEEEEECCCCCCCHHHHHHHHHHC
QYERNDYDFHRGTFRVRGDVLEVIPAYHHERALRLEFFGDEIDSIKEIDPLTGNVLGDVG
EECCCCCCCCCCEEEECCHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCHHHHHCC
KTVIYPASHYVSDRDNLNRAVSDIREELRLRLEEYRQGNRLVEAQRLEQRTMLDLEMIEE
CEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
MGYCTGIENYSRHLDGRTAGEPPACLLDYFPDNFILFVDESHITVSQVGAMYKGDRSRKQ
CCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEEECCCEEHHHHHHHHCCCCHHHH
TLVDFGFRLPSALDNRPLEFSEFEKRLNQVVYVSATPSRWELDRSEGIVVEQIIRPTGLL
HHHHHHHHCCHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
DPLTEVRPTKGQMEDLMTECRSRTARDERVLVTTLTKRMAEDLTEYLTSMGVSARYLHSD
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IDTMERMAIIQALRRKEFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSTGSLIQTF
HHHHHHHHHHHHHHHCCCHHHEEHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVDGRVIMYADSVTRSMTAAMQETERRREKQRLYNEEHGIEPVSVRKSLETPFDT
HHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHH
LYSDARSAAAKGRGKGRGRQAAPAQTAAEDTTAYGISAEELGGLIQRLEREMRESARDLE
HHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
FEKAAELRDRIRMLRERLLQQD
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA