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The map label for this gene is pyc [H]

Identifier: 78357124

GI number: 78357124

Start: 2125252

End: 2128968

Strand: Reverse

Name: pyc [H]

Synonym: Dde_2081

Alternate gene names: 78357124

Gene position: 2128968-2125252 (Counterclockwise)

Preceding gene: 78357125

Following gene: 78357123

Centisome position: 57.07

GC content: 55.69

Gene sequence:

>3717_bases
ATGGCTATCAAGACGTTCAATCAGGTTTTGGAAGAGGTGAAAGGCAAGCCTATTCTGGTTGCCAACCGGGGGATTCCCGC
CCGGCGTATCTGCCGTTCTATCCGCGAACGCTTTGATGCGGTCGCCGTGATGACGGCAACCGATATCGACAAGACCTCTC
CGGCCGCTTCCGCAGCGCAGGAGCTTCTGCTGCTCGGATCCGATCCCAGAGCATATCTCGATATTGACAGAATCATCAGA
CTGGCCAAGCAGCGGGGCATCATCGCGATTCATCCGGGCTGGGGATTTTCTTCCGAAGATCCGCGGTTTCCTTCCCGTTG
TGCCGAGGCAGGACTGCTGTATATCGGCTCTACGGCAGAGGCCATGAATCTGCTCGGGAACAAGGTGCAGGTGCGCAGGC
TGGCAAAACAGCTCGGCATTCCTGTTGTTCCCGGTTCGGAAGGCGCCGTTGATGTGCCCACCGGCAGAAAAATAGCTGAA
GAAATCGGCTTTCCCGTCATGCTCAAGGCCGAAGGCGGCGGCGGCGGACGTGGCATATTCCTCATCAAGTCGCAGGATGA
GCTTGAAGACGCTTTTGTGAAAGCGTCGACCATGGCTCAGGCTTCGTTCGGCAACCCCCGGCTGTATGTGGAAAAATACC
TGCCTTCTGTACGGCATATCGAAATTCAGGTTATCGCCGACATGCACGGCAATGTGTTCGCCTTTGACGAACGCGACTGC
ACGGTGCAGCGTAATCACCAGAAGCTTATCGAAATCACTCCTTCTCCGTGGAAGGGCATCACTCCTGAGCTGCGTGCAAG
GCTGAAAGACTACTCGCGTCAGCTTGTGCAGGAAGTAGGCTATTACTCGCTGTGCACGGTGGAGTTTCTGGTTACAGACG
ACGGTACTCCGTATCTTATCGAGGTGAACACCCGCCTGCAGGTGGAGCACGGAATCACCGAATGCCGGTACGGCATCGAT
CTGGTGGAAGAGCAGATTGCTGTAGCCTTCGGTGCGCAGCTGCGTCTTAAAGAAGACGACATGGTTCCCACGCAGCATGC
CATACAGGTGCGCATCAACTGCGAGTCCCCCCAGAACGACTTTGCGCCCAACGCGGGGCTGGTCACGCGGTATGTGTCTC
CGGGCGGTCCCGGCATCCGTCTGGACTCCAACCTTTCCGCCGGATACGAATTCCCCTCGAACTATGATTCTGCCGGTTCA
CTGCTCATCGCATACGGCAAAGGGTGGGAAAAAGCTCTTGCTACCCTTAACCGGGCACTGCGTGAGTATGTTGTGGGCGG
CATCAAGACGACGATTCCGTTTTTCAAGCAGATTGTGAAGCATCCCAAGTTTCTTGATGCGGATTTTGATACCAATTTCA
TTGCCCGCACGCCTGAACTCATGTGTTATACCGATCTGGAGCCGGAAGCCGAACGTCTGGCCCGTCTGGTGGCCGAAATT
TCGGCCAAGGGATATAACCCGCATGTGAAGCTTGACGAGTACCGCACCCGCGAGACTCCGCGCATGCCTGATTTCAGGCC
TGTGCTGCCCGAAATTACATCCAGAGTGCGCAAGACAGCTTCGCCGTATCCTGTGGGAGACAGAGCAGCTCTGCTGGATA
TGGTCAGAGACTCAGGTTATGTGCATTTTACCGACACCACAGCCCGTGACATAACGCAGTCCAACAGCGGCAACCGGTTC
CGTCTTGCGGAAGATGCGCTCATCGGGCCGTATCTTGACAACTGTAATTTCTTCTCGCTTGAAAACGGCGGGGGGGCACA
CTTCCATGTGGCCATGCTGGCCAACATGACCTATCCGTTTACCGAAGCGGCGCACTGGAATCAGTTTGCCCCCAAAACGG
CCAAGCAGATTCTTATCCGCTCGACAAACATTCTGGGGTACAAGCCGCAGCCGCGCAATCTCATGCGTCTGACCGGAGAG
ATGATCTGTGACCACTACCAGATTATCCGGTGTTTTGACTTCCTGAACCATGTCGACAACATGCGTCCGTTTGCGGAAGT
GGCTCTCAACCGTTCCGGCGTGGTTTTCGAACCTGCCATATCTCTTTCCTGGGCCAGAGGCTTCGATGTTCCGCATTATC
TGCAGGTGACGGAAGCCATTTTGCGCATGGTGGCGGACGTGGCGGGGGTAAGCTCTGCCAAGGCTTCTTCCATGATCATT
CTTGGACTGAAGGACATGGCCGGCGTTTGCCCGCCGCGTTTCATGACGGAGCTTGTCACGGCTCTGCGCAAGGCGTGGCC
TCAGCTTGTGCTGCATTATCACCGCCACTTTACGGACGGGCTTTTCGTTCCTGCCGTAGGTGCTGCTGCCAAGGCAGGCG
CGCATATCGTCGATACGGCCATAGGCGCTTCCGTCCGCTGGTACGGTCAGGGTGAGGTGCTGTCCACGGCTGCTTATATT
GAAGACGAACTGGGGCTTAAGACCAATCTCAATAAAGAGATGATCCGCAGCTGCAATTTTGTTCTCAAGCAGATCATGCC
CTATTATGACCGCTACACGGCGCCCTATTTTCAGGGTATCGACTACGATGTGGTGGAACACGCCATGCCCGGCGGCGCCA
CTTCCTCTTCTCAGGAAGGCGCCATGAAGCAGGGCTACATCCATCTGCTGCCGTATATGCTCAAGTTCCTTGCCGGAACC
CGGAAAATAGTGCGGTATCATGATGTGACACCCGGCTCGCAGATTACGTGGAACACCGCGTTTCTGGCGGTAACCAGCGC
CTACAAGCGCGGCGGCGAGCAGGAAGTGCGCTACCTTCTGGAAGTGCTGGACAACGTGACACGTCACAGCGAAGCGGATC
TCTCCTCGGAAATGAAAGAAGCCCGTCTTGCCCTGTATCAGGACAGCAATGACGCTTTCCGTGATTTGCTGATGGGCAAA
TACGGTAAGCTGCCGCTGGGCTTTCCCGCTGACTGGGTGTATCAGAGCGCCTTTGGCAACGAGTGGCAGCGTGCTGTGAA
CTGCCGCACCGAAACTTCTCCGCTGGAGTTTGTGGAAGACATGGATCTTGCCGCTGAAGAGCGGGGGTTTGTGGATATTA
TCCGCCGCAAGCCCACGGATGAAGAGTTCGTCATGTATCTGAACCATCCGGGCGATGCCGTGGCGACCATTCAGCTGCGT
CAGCAGTTCGGCGATCCTAACAATCTGCCGCTGCATGTCTGGTTTGAAGGGATTGAACCGGGCAGAGAGCTGAACTTTAC
CGACTCGCACGGAAAGCCTCACCAGATGACCATTCTCAGCATTTCGCTGCCGGATGAAAGCGGCATGAGCGTTGTGCGCT
ATGTGCTTGATTCGGAAATCATGAGTGTGGACATTCAGGTGGCCGAACCCCATGCCGATGATGTACAGGGGCTGGAAAAG
GCCGACCCCGCCAATGCCTATCATGTGGCTGCGCCTTCCAACGGCGACCTGTGGGTGATGTATGTGCACCCCGGCGACTA
TGTGAAAAAGGGTGAGGAACTGTTCAATATTTCCATCATGAAGCAGGAAAAGGCCGTGCTTGCTCCTGTGGATGGTATGG
TCAGGCGTGTGCTGAGGACCGCCGACTATAAGGAAAACAAGCAGATGGTACCTGTAAAAGGAGGCGAGCTGATTGTCGAG
CTGGGGCCTGTTCCCACGTTGTGTCCCAATGAAAAATGCCGTCATCCCATCACCATAGAGGGTGTCGGTTTTTGTCCCTA
TTGCGGCGACAAGCTTGACTGTGCGTGCAAAGCCTAG

Upstream 100 bases:

>100_bases
TATCATGACACCGTCGTGCCTGAATGAAACTCTAGTGATCGTTGTAACCCCGGTCGTCTATGCAATGGGCTCCGGTTGTT
TTGTTGAGTACGAGGAGTGA

Downstream 100 bases:

>100_bases
GCTTTTGCGTCGCCTCATTGACTGGCAGAGTACCAGCGTATAATGCAGATAAGGTATGGAAAACCGTTCGGCCCGGGCCG
GCGGTTTTCCGCCTTTCAAT

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1238; Mature: 1237

Protein sequence:

>1238_residues
MAIKTFNQVLEEVKGKPILVANRGIPARRICRSIRERFDAVAVMTATDIDKTSPAASAAQELLLLGSDPRAYLDIDRIIR
LAKQRGIIAIHPGWGFSSEDPRFPSRCAEAGLLYIGSTAEAMNLLGNKVQVRRLAKQLGIPVVPGSEGAVDVPTGRKIAE
EIGFPVMLKAEGGGGGRGIFLIKSQDELEDAFVKASTMAQASFGNPRLYVEKYLPSVRHIEIQVIADMHGNVFAFDERDC
TVQRNHQKLIEITPSPWKGITPELRARLKDYSRQLVQEVGYYSLCTVEFLVTDDGTPYLIEVNTRLQVEHGITECRYGID
LVEEQIAVAFGAQLRLKEDDMVPTQHAIQVRINCESPQNDFAPNAGLVTRYVSPGGPGIRLDSNLSAGYEFPSNYDSAGS
LLIAYGKGWEKALATLNRALREYVVGGIKTTIPFFKQIVKHPKFLDADFDTNFIARTPELMCYTDLEPEAERLARLVAEI
SAKGYNPHVKLDEYRTRETPRMPDFRPVLPEITSRVRKTASPYPVGDRAALLDMVRDSGYVHFTDTTARDITQSNSGNRF
RLAEDALIGPYLDNCNFFSLENGGGAHFHVAMLANMTYPFTEAAHWNQFAPKTAKQILIRSTNILGYKPQPRNLMRLTGE
MICDHYQIIRCFDFLNHVDNMRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADVAGVSSAKASSMII
LGLKDMAGVCPPRFMTELVTALRKAWPQLVLHYHRHFTDGLFVPAVGAAAKAGAHIVDTAIGASVRWYGQGEVLSTAAYI
EDELGLKTNLNKEMIRSCNFVLKQIMPYYDRYTAPYFQGIDYDVVEHAMPGGATSSSQEGAMKQGYIHLLPYMLKFLAGT
RKIVRYHDVTPGSQITWNTAFLAVTSAYKRGGEQEVRYLLEVLDNVTRHSEADLSSEMKEARLALYQDSNDAFRDLLMGK
YGKLPLGFPADWVYQSAFGNEWQRAVNCRTETSPLEFVEDMDLAAEERGFVDIIRRKPTDEEFVMYLNHPGDAVATIQLR
QQFGDPNNLPLHVWFEGIEPGRELNFTDSHGKPHQMTILSISLPDESGMSVVRYVLDSEIMSVDIQVAEPHADDVQGLEK
ADPANAYHVAAPSNGDLWVMYVHPGDYVKKGEELFNISIMKQEKAVLAPVDGMVRRVLRTADYKENKQMVPVKGGELIVE
LGPVPTLCPNEKCRHPITIEGVGFCPYCGDKLDCACKA

Sequences:

>Translated_1238_residues
MAIKTFNQVLEEVKGKPILVANRGIPARRICRSIRERFDAVAVMTATDIDKTSPAASAAQELLLLGSDPRAYLDIDRIIR
LAKQRGIIAIHPGWGFSSEDPRFPSRCAEAGLLYIGSTAEAMNLLGNKVQVRRLAKQLGIPVVPGSEGAVDVPTGRKIAE
EIGFPVMLKAEGGGGGRGIFLIKSQDELEDAFVKASTMAQASFGNPRLYVEKYLPSVRHIEIQVIADMHGNVFAFDERDC
TVQRNHQKLIEITPSPWKGITPELRARLKDYSRQLVQEVGYYSLCTVEFLVTDDGTPYLIEVNTRLQVEHGITECRYGID
LVEEQIAVAFGAQLRLKEDDMVPTQHAIQVRINCESPQNDFAPNAGLVTRYVSPGGPGIRLDSNLSAGYEFPSNYDSAGS
LLIAYGKGWEKALATLNRALREYVVGGIKTTIPFFKQIVKHPKFLDADFDTNFIARTPELMCYTDLEPEAERLARLVAEI
SAKGYNPHVKLDEYRTRETPRMPDFRPVLPEITSRVRKTASPYPVGDRAALLDMVRDSGYVHFTDTTARDITQSNSGNRF
RLAEDALIGPYLDNCNFFSLENGGGAHFHVAMLANMTYPFTEAAHWNQFAPKTAKQILIRSTNILGYKPQPRNLMRLTGE
MICDHYQIIRCFDFLNHVDNMRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADVAGVSSAKASSMII
LGLKDMAGVCPPRFMTELVTALRKAWPQLVLHYHRHFTDGLFVPAVGAAAKAGAHIVDTAIGASVRWYGQGEVLSTAAYI
EDELGLKTNLNKEMIRSCNFVLKQIMPYYDRYTAPYFQGIDYDVVEHAMPGGATSSSQEGAMKQGYIHLLPYMLKFLAGT
RKIVRYHDVTPGSQITWNTAFLAVTSAYKRGGEQEVRYLLEVLDNVTRHSEADLSSEMKEARLALYQDSNDAFRDLLMGK
YGKLPLGFPADWVYQSAFGNEWQRAVNCRTETSPLEFVEDMDLAAEERGFVDIIRRKPTDEEFVMYLNHPGDAVATIQLR
QQFGDPNNLPLHVWFEGIEPGRELNFTDSHGKPHQMTILSISLPDESGMSVVRYVLDSEIMSVDIQVAEPHADDVQGLEK
ADPANAYHVAAPSNGDLWVMYVHPGDYVKKGEELFNISIMKQEKAVLAPVDGMVRRVLRTADYKENKQMVPVKGGELIVE
LGPVPTLCPNEKCRHPITIEGVGFCPYCGDKLDCACKA
>Mature_1237_residues
AIKTFNQVLEEVKGKPILVANRGIPARRICRSIRERFDAVAVMTATDIDKTSPAASAAQELLLLGSDPRAYLDIDRIIRL
AKQRGIIAIHPGWGFSSEDPRFPSRCAEAGLLYIGSTAEAMNLLGNKVQVRRLAKQLGIPVVPGSEGAVDVPTGRKIAEE
IGFPVMLKAEGGGGGRGIFLIKSQDELEDAFVKASTMAQASFGNPRLYVEKYLPSVRHIEIQVIADMHGNVFAFDERDCT
VQRNHQKLIEITPSPWKGITPELRARLKDYSRQLVQEVGYYSLCTVEFLVTDDGTPYLIEVNTRLQVEHGITECRYGIDL
VEEQIAVAFGAQLRLKEDDMVPTQHAIQVRINCESPQNDFAPNAGLVTRYVSPGGPGIRLDSNLSAGYEFPSNYDSAGSL
LIAYGKGWEKALATLNRALREYVVGGIKTTIPFFKQIVKHPKFLDADFDTNFIARTPELMCYTDLEPEAERLARLVAEIS
AKGYNPHVKLDEYRTRETPRMPDFRPVLPEITSRVRKTASPYPVGDRAALLDMVRDSGYVHFTDTTARDITQSNSGNRFR
LAEDALIGPYLDNCNFFSLENGGGAHFHVAMLANMTYPFTEAAHWNQFAPKTAKQILIRSTNILGYKPQPRNLMRLTGEM
ICDHYQIIRCFDFLNHVDNMRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADVAGVSSAKASSMIIL
GLKDMAGVCPPRFMTELVTALRKAWPQLVLHYHRHFTDGLFVPAVGAAAKAGAHIVDTAIGASVRWYGQGEVLSTAAYIE
DELGLKTNLNKEMIRSCNFVLKQIMPYYDRYTAPYFQGIDYDVVEHAMPGGATSSSQEGAMKQGYIHLLPYMLKFLAGTR
KIVRYHDVTPGSQITWNTAFLAVTSAYKRGGEQEVRYLLEVLDNVTRHSEADLSSEMKEARLALYQDSNDAFRDLLMGKY
GKLPLGFPADWVYQSAFGNEWQRAVNCRTETSPLEFVEDMDLAAEERGFVDIIRRKPTDEEFVMYLNHPGDAVATIQLRQ
QFGDPNNLPLHVWFEGIEPGRELNFTDSHGKPHQMTILSISLPDESGMSVVRYVLDSEIMSVDIQVAEPHADDVQGLEKA
DPANAYHVAAPSNGDLWVMYVHPGDYVKKGEELFNISIMKQEKAVLAPVDGMVRRVLRTADYKENKQMVPVKGGELIVEL
GPVPTLCPNEKCRHPITIEGVGFCPYCGDKLDCACKA

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1223, Percent_Identity=30.5805396565822, Blast_Score=438, Evalue=1e-122,
Organism=Homo sapiens, GI106049295, Length=1223, Percent_Identity=30.5805396565822, Blast_Score=438, Evalue=1e-122,
Organism=Homo sapiens, GI106049292, Length=1223, Percent_Identity=30.5805396565822, Blast_Score=438, Evalue=1e-122,
Organism=Homo sapiens, GI189095269, Length=458, Percent_Identity=36.8995633187773, Blast_Score=282, Evalue=1e-75,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=37.4717832957111, Blast_Score=282, Evalue=1e-75,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=37.4717832957111, Blast_Score=282, Evalue=2e-75,
Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=34.9206349206349, Blast_Score=278, Evalue=2e-74,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=28.7937743190661, Blast_Score=209, Evalue=1e-53,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=28.7937743190661, Blast_Score=209, Evalue=1e-53,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=28.7937743190661, Blast_Score=209, Evalue=1e-53,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=28.7937743190661, Blast_Score=209, Evalue=2e-53,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=28.7937743190661, Blast_Score=209, Evalue=2e-53,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=28.2306163021869, Blast_Score=194, Evalue=3e-49,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=40.3153153153153, Blast_Score=304, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17562816, Length=1229, Percent_Identity=30.8380797396257, Blast_Score=474, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17567343, Length=466, Percent_Identity=35.4077253218884, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=36.8778280542986, Blast_Score=264, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI133931226, Length=503, Percent_Identity=28.2306163021869, Blast_Score=182, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=26.1811023622047, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=26.1811023622047, Blast_Score=164, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1205, Percent_Identity=30.3734439834025, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1218, Percent_Identity=30.1313628899836, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319685, Length=629, Percent_Identity=29.8887122416534, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=27.4853801169591, Blast_Score=181, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323863, Length=473, Percent_Identity=28.5412262156448, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281363050, Length=1204, Percent_Identity=29.9833887043189, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652224, Length=1204, Percent_Identity=29.9833887043189, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652222, Length=1204, Percent_Identity=29.9833887043189, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652220, Length=1204, Percent_Identity=29.9833887043189, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652218, Length=1204, Percent_Identity=29.9833887043189, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=1192, Percent_Identity=29.8657718120805, Blast_Score=431, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652210, Length=1192, Percent_Identity=29.8657718120805, Blast_Score=431, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652214, Length=1192, Percent_Identity=29.8657718120805, Blast_Score=431, Evalue=1e-120,
Organism=Drosophila melanogaster, GI19921944, Length=1192, Percent_Identity=29.8657718120805, Blast_Score=431, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652216, Length=1192, Percent_Identity=29.8657718120805, Blast_Score=431, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=36.9369369369369, Blast_Score=271, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24651759, Length=389, Percent_Identity=38.0462724935733, Blast_Score=258, Evalue=2e-68,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=28.8306451612903, Blast_Score=194, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24586458, Length=494, Percent_Identity=28.9473684210526, Blast_Score=194, Evalue=3e-49,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=28.8306451612903, Blast_Score=194, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=28.8306451612903, Blast_Score=194, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 137947; Mature: 137816

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS50975 ATP_GRASP ; PS00449 ATPASE_A ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKTFNQVLEEVKGKPILVANRGIPARRICRSIRERFDAVAVMTATDIDKTSPAASAAQ
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHH
ELLLLGSDPRAYLDIDRIIRLAKQRGIIAIHPGWGFSSEDPRFPSRCAEAGLLYIGSTAE
HHEEECCCCCCEECHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCEEEECCHHH
AMNLLGNKVQVRRLAKQLGIPVVPGSEGAVDVPTGRKIAEEIGFPVMLKAEGGGGGRGIF
HHHHHCCHHHHHHHHHHCCCEECCCCCCCEECCCCHHHHHHCCCCEEEEECCCCCCCEEE
LIKSQDELEDAFVKASTMAQASFGNPRLYVEKYLPSVRHIEIQVIADMHGNVFAFDERDC
EEECCHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCEEEEEEEEEECCCCEEEECCCCC
TVQRNHQKLIEITPSPWKGITPELRARLKDYSRQLVQEVGYYSLCTVEFLVTDDGTPYLI
CEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEE
EVNTRLQVEHGITECRYGIDLVEEQIAVAFGAQLRLKEDDMVPTQHAIQVRINCESPQND
EECCEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEECCCCCCC
FAPNAGLVTRYVSPGGPGIRLDSNLSAGYEFPSNYDSAGSLLIAYGKGWEKALATLNRAL
CCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
REYVVGGIKTTIPFFKQIVKHPKFLDADFDTNFIARTPELMCYTDLEPEAERLARLVAEI
HHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHH
SAKGYNPHVKLDEYRTRETPRMPDFRPVLPEITSRVRKTASPYPVGDRAALLDMVRDSGY
HCCCCCCCEECCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCE
VHFTDTTARDITQSNSGNRFRLAEDALIGPYLDNCNFFSLENGGGAHFHVAMLANMTYPF
EEEECCCHHHHHCCCCCCEEEEECCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCC
TEAAHWNQFAPKTAKQILIRSTNILGYKPQPRNLMRLTGEMICDHYQIIRCFDFLNHVDN
CCCCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADVAGVSSAKASSMII
CCHHHHHHHCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LGLKDMAGVCPPRFMTELVTALRKAWPQLVLHYHRHFTDGLFVPAVGAAAKAGAHIVDTA
EEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHCCCHHHHHH
IGASVRWYGQGEVLSTAAYIEDELGLKTNLNKEMIRSCNFVLKQIMPYYDRYTAPYFQGI
HCCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
DYDVVEHAMPGGATSSSQEGAMKQGYIHLLPYMLKFLAGTRKIVRYHDVTPGSQITWNTA
CHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEECHH
FLAVTSAYKRGGEQEVRYLLEVLDNVTRHSEADLSSEMKEARLALYQDSNDAFRDLLMGK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCHHHHHHHHCC
YGKLPLGFPADWVYQSAFGNEWQRAVNCRTETSPLEFVEDMDLAAEERGFVDIIRRKPTD
CCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCC
EEFVMYLNHPGDAVATIQLRQQFGDPNNLPLHVWFEGIEPGRELNFTDSHGKPHQMTILS
CCEEEEEECCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
ISLPDESGMSVVRYVLDSEIMSVDIQVAEPHADDVQGLEKADPANAYHVAAPSNGDLWVM
EECCCCCCHHHHHHHHCCCEEEEEEEEECCCCHHHHCHHCCCCCCEEEEECCCCCCEEEE
YVHPGDYVKKGEELFNISIMKQEKAVLAPVDGMVRRVLRTADYKENKQMVPVKGGELIVE
EECCCHHHHCCCHHEEEEEEECCCCEECCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEE
LGPVPTLCPNEKCRHPITIEGVGFCPYCGDKLDCACKA
ECCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCEECC
>Mature Secondary Structure 
AIKTFNQVLEEVKGKPILVANRGIPARRICRSIRERFDAVAVMTATDIDKTSPAASAAQ
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHH
ELLLLGSDPRAYLDIDRIIRLAKQRGIIAIHPGWGFSSEDPRFPSRCAEAGLLYIGSTAE
HHEEECCCCCCEECHHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHCCCEEEECCHHH
AMNLLGNKVQVRRLAKQLGIPVVPGSEGAVDVPTGRKIAEEIGFPVMLKAEGGGGGRGIF
HHHHHCCHHHHHHHHHHCCCEECCCCCCCEECCCCHHHHHHCCCCEEEEECCCCCCCEEE
LIKSQDELEDAFVKASTMAQASFGNPRLYVEKYLPSVRHIEIQVIADMHGNVFAFDERDC
EEECCHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCEEEEEEEEEECCCCEEEECCCCC
TVQRNHQKLIEITPSPWKGITPELRARLKDYSRQLVQEVGYYSLCTVEFLVTDDGTPYLI
CEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCEEEE
EVNTRLQVEHGITECRYGIDLVEEQIAVAFGAQLRLKEDDMVPTQHAIQVRINCESPQND
EECCEEEECCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEEEEEEECCCCCCC
FAPNAGLVTRYVSPGGPGIRLDSNLSAGYEFPSNYDSAGSLLIAYGKGWEKALATLNRAL
CCCCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
REYVVGGIKTTIPFFKQIVKHPKFLDADFDTNFIARTPELMCYTDLEPEAERLARLVAEI
HHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHH
SAKGYNPHVKLDEYRTRETPRMPDFRPVLPEITSRVRKTASPYPVGDRAALLDMVRDSGY
HCCCCCCCEECCHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCE
VHFTDTTARDITQSNSGNRFRLAEDALIGPYLDNCNFFSLENGGGAHFHVAMLANMTYPF
EEEECCCHHHHHCCCCCCEEEEECCCEECCCCCCCCEEEEECCCCCEEEEEEECCCCCCC
TEAAHWNQFAPKTAKQILIRSTNILGYKPQPRNLMRLTGEMICDHYQIIRCFDFLNHVDN
CCCCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MRPFAEVALNRSGVVFEPAISLSWARGFDVPHYLQVTEAILRMVADVAGVSSAKASSMII
CCHHHHHHHCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LGLKDMAGVCPPRFMTELVTALRKAWPQLVLHYHRHFTDGLFVPAVGAAAKAGAHIVDTA
EEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHCCCHHHHHH
IGASVRWYGQGEVLSTAAYIEDELGLKTNLNKEMIRSCNFVLKQIMPYYDRYTAPYFQGI
HCCCEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
DYDVVEHAMPGGATSSSQEGAMKQGYIHLLPYMLKFLAGTRKIVRYHDVTPGSQITWNTA
CHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCHHEEEEECCCCCCEEEECHH
FLAVTSAYKRGGEQEVRYLLEVLDNVTRHSEADLSSEMKEARLALYQDSNDAFRDLLMGK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCHHHHHHHHCC
YGKLPLGFPADWVYQSAFGNEWQRAVNCRTETSPLEFVEDMDLAAEERGFVDIIRRKPTD
CCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCC
EEFVMYLNHPGDAVATIQLRQQFGDPNNLPLHVWFEGIEPGRELNFTDSHGKPHQMTILS
CCEEEEEECCCCEEEEEEEHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
ISLPDESGMSVVRYVLDSEIMSVDIQVAEPHADDVQGLEKADPANAYHVAAPSNGDLWVM
EECCCCCCHHHHHHHHCCCEEEEEEEEECCCCHHHHCHHCCCCCCEEEEECCCCCCEEEE
YVHPGDYVKKGEELFNISIMKQEKAVLAPVDGMVRRVLRTADYKENKQMVPVKGGELIVE
EECCCHHHHCCCHHEEEEEEECCCCEECCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEE
LGPVPTLCPNEKCRHPITIEGVGFCPYCGDKLDCACKA
ECCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]