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The map label for this gene is cysG [H]

Identifier: 78357066

GI number: 78357066

Start: 2063048

End: 2063725

Strand: Direct

Name: cysG [H]

Synonym: Dde_2023

Alternate gene names: 78357066

Gene position: 2063048-2063725 (Clockwise)

Preceding gene: 78357063

Following gene: 78357067

Centisome position: 55.31

GC content: 57.52

Gene sequence:

>678_bases
ATGCGATATTACCCCATGTTGCTCAATCTTCAGGGAGCCGCCTGCCTCATCGTCGGCGGCGGGGAAGTAGGCAGGCGCAA
GCTGCAGGCACTGCTGCCCTGCGAGCCCGCCTCCGTTCTTGTGGTCGACCCGCGCACCGCCTCTCCGGATTGGCAGGACT
TGCTATCCGGCGGTACGGTAGTGTACGAATGTCGTCCATTTGATGAAAATGATGTGACCGGTAAGGCGGTTGTATTTGCC
GCTACGGGCAACGCCGCAGTAAACACCGCAGTCGCCCGCGCCTGCAGGCACAACGGCATCCCCTGCAACGTGGCCGATGC
CCCGCAGTCCGGCAGCTTCATTGTTCCCGCGCACTTCACCAGCGGAGACATTCTGGTCGCCCTTTCCACGGGGGGGCACA
GTCCCGCTCTGGCACGGCGCATAAGGTCCGATCTTCAGGAATGGTTCGGAGACAGATATACCGCTCTGGCTGCCTTTATG
GGCAGGGTGCGGCCTCTCATTCTGGATATCGGGCTTGAAACACACCGTAACACGGAAATTTTCAGAAATCTGGTCAATTC
AGACCTCGCAGAAATGCTCCGGCATAACCGCAACACAGAAGCAGAAGCTCTTTTACGGAATCTGCTTCCCGAACAATTGC
ACAACAGAATCGGAGAGTTGCTGAATGAGCTTGCTTAA

Upstream 100 bases:

>100_bases
TAATACCTTTTTTTACTAGCCTATTCCGTCATCAGCGGCAAGAAGACCACACCGGCACTTTCCCCTTTTCCTTTACAGCG
TACAATTGTATAACGCGGCA

Downstream 100 bases:

>100_bases
GCTGCTTACCCTGACCATTATCGTGCTCTACTTTCTGGGCACCTGTGTCGAGCTGTTCGGGCTGGTTACACGCCGCCAGC
GAGTGACAAAGGCGGCATCG

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRYYPMLLNLQGAACLIVGGGEVGRRKLQALLPCEPASVLVVDPRTASPDWQDLLSGGTVVYECRPFDENDVTGKAVVFA
ATGNAAVNTAVARACRHNGIPCNVADAPQSGSFIVPAHFTSGDILVALSTGGHSPALARRIRSDLQEWFGDRYTALAAFM
GRVRPLILDIGLETHRNTEIFRNLVNSDLAEMLRHNRNTEAEALLRNLLPEQLHNRIGELLNELA

Sequences:

>Translated_225_residues
MRYYPMLLNLQGAACLIVGGGEVGRRKLQALLPCEPASVLVVDPRTASPDWQDLLSGGTVVYECRPFDENDVTGKAVVFA
ATGNAAVNTAVARACRHNGIPCNVADAPQSGSFIVPAHFTSGDILVALSTGGHSPALARRIRSDLQEWFGDRYTALAAFM
GRVRPLILDIGLETHRNTEIFRNLVNSDLAEMLRHNRNTEAEALLRNLLPEQLHNRIGELLNELA
>Mature_225_residues
MRYYPMLLNLQGAACLIVGGGEVGRRKLQALLPCEPASVLVVDPRTASPDWQDLLSGGTVVYECRPFDENDVTGKAVVFA
ATGNAAVNTAVARACRHNGIPCNVADAPQSGSFIVPAHFTSGDILVALSTGGHSPALARRIRSDLQEWFGDRYTALAAFM
GRVRPLILDIGLETHRNTEIFRNLVNSDLAEMLRHNRNTEAEALLRNLLPEQLHNRIGELLNELA

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=222, Percent_Identity=31.0810810810811, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 24480; Mature: 24480

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYYPMLLNLQGAACLIVGGGEVGRRKLQALLPCEPASVLVVDPRTASPDWQDLLSGGTV
CCCCCEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHCCCEE
VYECRPFDENDVTGKAVVFAATGNAAVNTAVARACRHNGIPCNVADAPQSGSFIVPAHFT
EEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC
SGDILVALSTGGHSPALARRIRSDLQEWFGDRYTALAAFMGRVRPLILDIGLETHRNTEI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCHHH
FRNLVNSDLAEMLRHNRNTEAEALLRNLLPEQLHNRIGELLNELA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYYPMLLNLQGAACLIVGGGEVGRRKLQALLPCEPASVLVVDPRTASPDWQDLLSGGTV
CCCCCEEEEECCCEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHCCCEE
VYECRPFDENDVTGKAVVFAATGNAAVNTAVARACRHNGIPCNVADAPQSGSFIVPAHFT
EEEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC
SGDILVALSTGGHSPALARRIRSDLQEWFGDRYTALAAFMGRVRPLILDIGLETHRNTEI
CCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCHHH
FRNLVNSDLAEMLRHNRNTEAEALLRNLLPEQLHNRIGELLNELA
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA