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The map label for this gene is ctaB

Identifier: 78356870

GI number: 78356870

Start: 1876193

End: 1877041

Strand: Direct

Name: ctaB

Synonym: Dde_1827

Alternate gene names: 78356870

Gene position: 1876193-1877041 (Clockwise)

Preceding gene: 78356869

Following gene: 78356871

Centisome position: 50.3

GC content: 60.19

Gene sequence:

>849_bases
GTGCTGCGGGCAGCATCCAGCCTGTTCAGGTTCCGCGTGGCGGGCATGGTGGCACTGTCCTGTGTCTTCGGCTATCTGTT
GGCAGCAGGCGCAGCGGGGCCGGACATGGTCACGTCCGCAGCCGGCACCTTTCTGCTGACATGTGCCTGCTCGGTGTTCA
ACCAGATTCAGGAAAAAGATCTGGATGCCCGTATGCCCCGCACCCGCAACCGGCCTGTTGCCTCCGGCAGGCTGCCAACA
ACTGCGGCACGGGCTGTGGGCATGGCGGCACTGCTACCCGCACTGATACTGCTGCATGCGGCGGGCGGCGTCCGTCTGGT
GTTGCTGTCCGCGGCCGTGCTGGCATTATACAATGGCGTATACACCCCGATGAAAAAATACACGGCTTTTTCGCTGCTTG
CCGGGGCAGTACCGGGTGCTCTGCCTCCTGTGTTCGGCTGGCTGGCGGCAGGTGGTAATCTTTATTCACCCGAGATAGCG
CTGCTTTTCATCGTGTATTATCTGTGGCAGGTCCCGCACTTCTGGCTGCGGGCAGAACGCGACCGCCAGTCGTACCTTGC
GGCCGGTCTTCCCTTACCTTCTGTCGAGCTGCCGCACAGGTATCATGCACTGCTGCGGCTGTGGTATGCGTCATACATGG
TGGCGCTGCTTCTGTTGCCCGTATTCCCCTTCATAGCCGAAACAGCGGTGCGCATTGCCGTGTGCCTTGCCGGTATCACC
GGTCTGGCAGCCTCGGGCTATCTGCTGGCGTCGCCTGTAAGGGGATTTCATGCCGTCAATGTCAGCATGCTTTTTGTCAT
GCTTCTGCTGGTCGTAGACCGGCTTGTCACTTCCGGTATTATTACCTGA

Upstream 100 bases:

>100_bases
ATGATCCCGTTATGCCGCCGTACGAGATGGACGAAGAGAGGCTGAACGCTCTTGTGGAATATATGAAGAGCCTGTCCGAC
AAAAACGGGAAGGCGCAATA

Downstream 100 bases:

>100_bases
AAGGAGGATTACATGCCGAGCATGTGGATTCATCCGGCACTCCAGCTGTTCGCCACCATTGCTGGCGGATATGTTTTTTA
TCTCGGCATCAGACGATTCA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLRAASSLFRFRVAGMVALSCVFGYLLAAGAAGPDMVTSAAGTFLLTCACSVFNQIQEKDLDARMPRTRNRPVASGRLPT
TAARAVGMAALLPALILLHAAGGVRLVLLSAAVLALYNGVYTPMKKYTAFSLLAGAVPGALPPVFGWLAAGGNLYSPEIA
LLFIVYYLWQVPHFWLRAERDRQSYLAAGLPLPSVELPHRYHALLRLWYASYMVALLLLPVFPFIAETAVRIAVCLAGIT
GLAASGYLLASPVRGFHAVNVSMLFVMLLLVVDRLVTSGIIT

Sequences:

>Translated_282_residues
MLRAASSLFRFRVAGMVALSCVFGYLLAAGAAGPDMVTSAAGTFLLTCACSVFNQIQEKDLDARMPRTRNRPVASGRLPT
TAARAVGMAALLPALILLHAAGGVRLVLLSAAVLALYNGVYTPMKKYTAFSLLAGAVPGALPPVFGWLAAGGNLYSPEIA
LLFIVYYLWQVPHFWLRAERDRQSYLAAGLPLPSVELPHRYHALLRLWYASYMVALLLLPVFPFIAETAVRIAVCLAGIT
GLAASGYLLASPVRGFHAVNVSMLFVMLLLVVDRLVTSGIIT
>Mature_282_residues
MLRAASSLFRFRVAGMVALSCVFGYLLAAGAAGPDMVTSAAGTFLLTCACSVFNQIQEKDLDARMPRTRNRPVASGRLPT
TAARAVGMAALLPALILLHAAGGVRLVLLSAAVLALYNGVYTPMKKYTAFSLLAGAVPGALPPVFGWLAAGGNLYSPEIA
LLFIVYYLWQVPHFWLRAERDRQSYLAAGLPLPSVELPHRYHALLRLWYASYMVALLLLPVFPFIAETAVRIAVCLAGIT
GLAASGYLLASPVRGFHAVNVSMLFVMLLLVVDRLVTSGIIT

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=31.7708333333333, Blast_Score=85, Evalue=7e-17,
Organism=Escherichia coli, GI1786631, Length=261, Percent_Identity=26.4367816091954, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71998235, Length=189, Percent_Identity=34.9206349206349, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325085, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921064, Length=198, Percent_Identity=29.7979797979798, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_DESDG (Q310M2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388319.1
- STRING:   Q310M2
- GeneID:   3756830
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1827
- NMPDR:   fig|207559.3.peg.1154
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   PHFWLRA
- ProtClustDB:   CLSK705424
- BioCyc:   DDES207559:DDE_1827-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 30194; Mature: 30194

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10c885e8)-; HASH(0x11d0a280)-; HASH(0x11ee72ec)-; HASH(0x11ee7c40)-; HASH(0x120b3538)-; HASH(0xeec9330)-; HASH(0x11e8128c)-; HASH(0x123a7830)-; HASH(0x12042220)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure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HHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA