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The map label for this gene is coxM [H]

Identifier: 78356869

GI number: 78356869

Start: 1874967

End: 1876193

Strand: Direct

Name: coxM [H]

Synonym: Dde_1826

Alternate gene names: 78356869

Gene position: 1874967-1876193 (Clockwise)

Preceding gene: 78356868

Following gene: 78356870

Centisome position: 50.26

GC content: 53.14

Gene sequence:

>1227_bases
ATGTTTCCGCAATCACTCAGCCCTGTGCAACAGGTTGATCTGGCTTTCTATGTCATCTTCGGCATTTCAATAGCAATTCT
GGTATGCATAACCGCCTGTATGCTGTGGTTCGCATGGCGCTATCACCACACGCGCAACCCCAAACCGGCGCGCTTCGACG
GCAACGTGACAGCAGAAGTGCTGTGGACCGTTATTCCATCCCTGCTTGTGATGGGCATGTTCTATTACGGCTGGATAGGT
TTCAAGGCACTTCGCTCTGTTCCTGCCAATGCCATGGAAGTCAAAGTGACTGCACGCATGTGGTCATGGGTTTTTGAATA
CCCCAACGGCAAACGGGCAAACACCCTCTATGTGCCGGTCAACAAGGCAATACGGCTTGATATGACCTCAGCAGATGTTT
TGCACAGCTTTTATGTACCTGCCTTCCGCATCAAGATGGACACAGTTCCGGGTATGGACACCTACGCTTGGTTCAAGGCG
GAACGGACAGGAGAATATGACATCCTGTGTGCGGAATACTGCGGGTTAAAGCACGCCAACATGCTTTCTACGGTGGCCGT
AATGCCGGAAAAAGACTTCGAAGACTGGCTGAATGCCACCGAACAGACCGATGACGAGGCCAAGGCGCTGGCACTGCTGG
AAACTCACGGCTGCATTTCATGCCACTCGCTGGACGGCAGCCCCGGTCTGGGACCGACGCTTAAAGATATCTACGGTGCC
GAGCGCCCGATTATTATGCCCGACGGTACAAAGACAACCATGGTGGCCGACGAACAGTACCTGCGCCGCGCACTGCTGCA
GCCCAACGCCGAGGTGGTGGAAGGCTATGACCCCATGATGCCCTCGTATCAGGACAGTGTCCCCCCCGGCGAAATAGACT
TGATGGTGGGCTGGATGCTTAACCGCAACCAGTCTGCGATAAGTGCAGGCCGCAAGCTGATGCAGGAAGAAGGCTGCATT
TCCTGTCACTCTACGGACGGTTCCGAAATTATGGGCCCCAGTGTTAAAAACCTGTACGGCTATCAGCGTCTGGTCATAGA
AGATGGTACAGAAAGGACTGTCACGGCAGACGAGAGCTATCTTATTGAAAGCATAATCAATCCTTCTGAAAAGCTGACCA
AGGGATATGATCCCGTTATGCCGCCGTACGAGATGGACGAAGAGAGGCTGAACGCTCTTGTGGAATATATGAAGAGCCTG
TCCGACAAAAACGGGAAGGCGCAATAG

Upstream 100 bases:

>100_bases
GAGGGCAATCTTATCCGCCTGATGGTTTTCATTGCCTTTGCAATTCTTGCCATCGCCATAGGATTCACATTTTTTGACGT
AGCCTACAGGTGAGGTGCCT

Downstream 100 bases:

>100_bases
TGCTGCGGGCAGCATCCAGCCTGTTCAGGTTCCGCGTGGCGGGCATGGTGGCACTGTCCTGTGTCTTCGGCTATCTGTTG
GCAGCAGGCGCAGCGGGGCC

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide II; Cytochrome BB3 subunit 2; Oxidase BB(3) subunit 2 [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MFPQSLSPVQQVDLAFYVIFGISIAILVCITACMLWFAWRYHHTRNPKPARFDGNVTAEVLWTVIPSLLVMGMFYYGWIG
FKALRSVPANAMEVKVTARMWSWVFEYPNGKRANTLYVPVNKAIRLDMTSADVLHSFYVPAFRIKMDTVPGMDTYAWFKA
ERTGEYDILCAEYCGLKHANMLSTVAVMPEKDFEDWLNATEQTDDEAKALALLETHGCISCHSLDGSPGLGPTLKDIYGA
ERPIIMPDGTKTTMVADEQYLRRALLQPNAEVVEGYDPMMPSYQDSVPPGEIDLMVGWMLNRNQSAISAGRKLMQEEGCI
SCHSTDGSEIMGPSVKNLYGYQRLVIEDGTERTVTADESYLIESIINPSEKLTKGYDPVMPPYEMDEERLNALVEYMKSL
SDKNGKAQ

Sequences:

>Translated_408_residues
MFPQSLSPVQQVDLAFYVIFGISIAILVCITACMLWFAWRYHHTRNPKPARFDGNVTAEVLWTVIPSLLVMGMFYYGWIG
FKALRSVPANAMEVKVTARMWSWVFEYPNGKRANTLYVPVNKAIRLDMTSADVLHSFYVPAFRIKMDTVPGMDTYAWFKA
ERTGEYDILCAEYCGLKHANMLSTVAVMPEKDFEDWLNATEQTDDEAKALALLETHGCISCHSLDGSPGLGPTLKDIYGA
ERPIIMPDGTKTTMVADEQYLRRALLQPNAEVVEGYDPMMPSYQDSVPPGEIDLMVGWMLNRNQSAISAGRKLMQEEGCI
SCHSTDGSEIMGPSVKNLYGYQRLVIEDGTERTVTADESYLIESIINPSEKLTKGYDPVMPPYEMDEERLNALVEYMKSL
SDKNGKAQ
>Mature_408_residues
MFPQSLSPVQQVDLAFYVIFGISIAILVCITACMLWFAWRYHHTRNPKPARFDGNVTAEVLWTVIPSLLVMGMFYYGWIG
FKALRSVPANAMEVKVTARMWSWVFEYPNGKRANTLYVPVNKAIRLDMTSADVLHSFYVPAFRIKMDTVPGMDTYAWFKA
ERTGEYDILCAEYCGLKHANMLSTVAVMPEKDFEDWLNATEQTDDEAKALALLETHGCISCHSLDGSPGLGPTLKDIYGA
ERPIIMPDGTKTTMVADEQYLRRALLQPNAEVVEGYDPMMPSYQDSVPPGEIDLMVGWMLNRNQSAISAGRKLMQEEGCI
SCHSTDGSEIMGPSVKNLYGYQRLVIEDGTERTVTADESYLIESIINPSEKLTKGYDPVMPPYEMDEERLNALVEYMKSL
SDKNGKAQ

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A ce

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=165, Percent_Identity=28.4848484848485, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786635, Length=208, Percent_Identity=25.4807692307692, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6226540, Length=226, Percent_Identity=24.7787610619469, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 45884; Mature: 45884

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPQSLSPVQQVDLAFYVIFGISIAILVCITACMLWFAWRYHHTRNPKPARFDGNVTAEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
LWTVIPSLLVMGMFYYGWIGFKALRSVPANAMEVKVTARMWSWVFEYPNGKRANTLYVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCCEEEEEC
NKAIRLDMTSADVLHSFYVPAFRIKMDTVPGMDTYAWFKAERTGEYDILCAEYCGLKHAN
CCEEEEECCHHHHHHHHCCCEEEEEECCCCCCCHHHEEEECCCCCEEEEEHHHCCCCCCH
MLSTVAVMPEKDFEDWLNATEQTDDEAKALALLETHGCISCHSLDGSPGLGPTLKDIYGA
HHHHHEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCC
ERPIIMPDGTKTTMVADEQYLRRALLQPNAEVVEGYDPMMPSYQDSVPPGEIDLMVGWML
CCCEECCCCCCEEEECCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEE
NRNQSAISAGRKLMQEEGCISCHSTDGSEIMGPSVKNLYGYQRLVIEDGTERTVTADESY
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCEEEEEECCCCCEEECCHHH
LIESIINPSEKLTKGYDPVMPPYEMDEERLNALVEYMKSLSDKNGKAQ
HHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFPQSLSPVQQVDLAFYVIFGISIAILVCITACMLWFAWRYHHTRNPKPARFDGNVTAEV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
LWTVIPSLLVMGMFYYGWIGFKALRSVPANAMEVKVTARMWSWVFEYPNGKRANTLYVPV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCCCCCEEEEEC
NKAIRLDMTSADVLHSFYVPAFRIKMDTVPGMDTYAWFKAERTGEYDILCAEYCGLKHAN
CCEEEEECCHHHHHHHHCCCEEEEEECCCCCCCHHHEEEECCCCCEEEEEHHHCCCCCCH
MLSTVAVMPEKDFEDWLNATEQTDDEAKALALLETHGCISCHSLDGSPGLGPTLKDIYGA
HHHHHEECCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHCCC
ERPIIMPDGTKTTMVADEQYLRRALLQPNAEVVEGYDPMMPSYQDSVPPGEIDLMVGWML
CCCEECCCCCCEEEECCHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEE
NRNQSAISAGRKLMQEEGCISCHSTDGSEIMGPSVKNLYGYQRLVIEDGTERTVTADESY
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHCCEEEEEECCCCCEEECCHHH
LIESIINPSEKLTKGYDPVMPPYEMDEERLNALVEYMKSLSDKNGKAQ
HHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]