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The map label for this gene is zraS [H]

Identifier: 78356727

GI number: 78356727

Start: 1736281

End: 1738026

Strand: Direct

Name: zraS [H]

Synonym: Dde_1684

Alternate gene names: 78356727

Gene position: 1736281-1738026 (Clockwise)

Preceding gene: 78356726

Following gene: 78356728

Centisome position: 46.55

GC content: 56.53

Gene sequence:

>1746_bases
ATGGAAGTAGCTGATTATAAACGTGAACGAAGCACGCTCATCATCGCTGTTCTTACTTTGGTAACGGTGGGACTGAGTCT
TATTGTTTCCACCGGGCAGGTGCTTTCGCAGCAGGAAGAGGCAGGAACCCAGCACCTCATTCTTGCCTCGCGCTCTGTGC
TTCAGGCTGTGGACAGTTCGTTACGGCGCAATATGACGACCGATGCGCAGGGCGGGGCGACATTCGGCGCAGGAGCAGCA
GAATTTTTCCGTGAACTGGAACAGAGCGGAGAAGTGCTGTTTGTCGGGCTTATCGACAAGCACGGCGGGCGCGTGCTCAC
ATCGCGCAGCAGCGGAGAGTCCGGAACCATCCTTTTTCCTCCTGATGCGTTGCGCACTCTGGCACAGACCGGCGAGTGGC
ATGGCAGAGTCGGCTTCGGGCTGGCCAGCGCTTATGTATACGGCAAAAGGATTATTCCCGGTAACACCGGCAGCATGAGT
ATTGCGCGGGCGGAAACCGGCGAGCCTCTACCCGCGTTTCTCGTGGTGGGGCTGGATATGGCCAAGCATCAGGCCATCTA
CCGGAAATTCCGGCAGAATGCTCTTTTTCAGGCTGCCTATATTCTGGGAGCCGCTGTACTGATATGGGCTTTGGCCATGG
GGCTTATCAAACGCAGAGAAATGGCAGGCAAAGCACGTCAGCTTGAGCGTTTTCAGGTAAAGCTGCTGGATAATCTGCCC
GACGGGCTTGTCACCATTGGTGAAAACGGCACCATTCTGGCGGCTAATCCGGCGGCAAACGGCATATTGCAGGCGCGCGG
AGAGGGACTGGCAGGCAAACTGCTGGATGATCTGCCCGACGATATTCTGCGCTGCCTTGCGGCTCCGGAAACGGAAACGG
CAGGGTGGCGTCAGGACAGTGTCCGCGGAGCGCATCTTGAAATTCTGAGTGTACGGATGCCCGGCAGCAGCGAAACAGAC
GATGCTTCGCGCCTTGTGATTATCCGTGACAGAACCCAGATACGTACATTGGAAAAAAGCCTGAGCGATGCTGAAAAACT
GGCTGCAGTGGGAACGCTGGCTGCCGGTGTGGCACATGAAATACGCAACCCGCTGAGCGCGCTGCGCGGGTTTGCCCAGT
ATTTTGCCAAAAAATTCAAGGACAGACATCCGGAAGAAGTTTACGCGCAGACCATGGTGCGCGAGGCTGACCGCCTGAAC
AGGGTCATCACCGATCTTCTGTATCTTGCGCGTCCGCGGCGCGTTACCCCGCGGCTTGTCCGGCTGCGTGCACTTGTTTC
CGAGGTGGAAGATCTGGTCCGCTTTGATCTGGACGAACGCAAGGTCAATATGGTTGTCAGTCTGGGGCCTGAAGAGGTCT
GGGCAGATGAGGATACCCTGAAGCAGGCGGTACTCAATCTGGTACTGAACAGCCTGGACGCGCTGAAGGAAACTGACGGT
GGTGCCCGACAGGTGGATGTGGCATCGGGGCTGGCAAAAGACGGTGTCTGGCTTTTTGTGCGCGACACGGCCAACGGAAT
GACTAAAGAACAGGCCGAACAGGCGTTTGAGCCTTTTTACACCACCAAGAAAAAAGGAACAGGGCTCGGGCTTGCCCTTG
TGCACAAGACCATGCGCGACCATGGCGGCAAGGCGATAATCGATACTGCTCCGGGTCACGGAACCACTGTGGGGTTGTTT
TTTCCCGACCATGACGATGACGTTGCTGACGATACCAATGAAGCTGACGCTGAGAGGGATTCATGA

Upstream 100 bases:

>100_bases
GAGCCATTTTTAATTTTTAATAACAGTATATTATGATGTGCGGTGTTTTGGCACGTGTTTTTCATGTGCTGTGCTTCGAC
ACGTATTGCAGGAAGGCATA

Downstream 100 bases:

>100_bases
TCAAGCGATTGCTGGTTATTGACGACGAGCCCGGCCACCGCCTGATGGTCCGTGCGGTTATGGAAGACAACGGATGGCAG
GTTTTTGAAGCCGCAAGCGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MEVADYKRERSTLIIAVLTLVTVGLSLIVSTGQVLSQQEEAGTQHLILASRSVLQAVDSSLRRNMTTDAQGGATFGAGAA
EFFRELEQSGEVLFVGLIDKHGGRVLTSRSSGESGTILFPPDALRTLAQTGEWHGRVGFGLASAYVYGKRIIPGNTGSMS
IARAETGEPLPAFLVVGLDMAKHQAIYRKFRQNALFQAAYILGAAVLIWALAMGLIKRREMAGKARQLERFQVKLLDNLP
DGLVTIGENGTILAANPAANGILQARGEGLAGKLLDDLPDDILRCLAAPETETAGWRQDSVRGAHLEILSVRMPGSSETD
DASRLVIIRDRTQIRTLEKSLSDAEKLAAVGTLAAGVAHEIRNPLSALRGFAQYFAKKFKDRHPEEVYAQTMVREADRLN
RVITDLLYLARPRRVTPRLVRLRALVSEVEDLVRFDLDERKVNMVVSLGPEEVWADEDTLKQAVLNLVLNSLDALKETDG
GARQVDVASGLAKDGVWLFVRDTANGMTKEQAEQAFEPFYTTKKKGTGLGLALVHKTMRDHGGKAIIDTAPGHGTTVGLF
FPDHDDDVADDTNEADAERDS

Sequences:

>Translated_581_residues
MEVADYKRERSTLIIAVLTLVTVGLSLIVSTGQVLSQQEEAGTQHLILASRSVLQAVDSSLRRNMTTDAQGGATFGAGAA
EFFRELEQSGEVLFVGLIDKHGGRVLTSRSSGESGTILFPPDALRTLAQTGEWHGRVGFGLASAYVYGKRIIPGNTGSMS
IARAETGEPLPAFLVVGLDMAKHQAIYRKFRQNALFQAAYILGAAVLIWALAMGLIKRREMAGKARQLERFQVKLLDNLP
DGLVTIGENGTILAANPAANGILQARGEGLAGKLLDDLPDDILRCLAAPETETAGWRQDSVRGAHLEILSVRMPGSSETD
DASRLVIIRDRTQIRTLEKSLSDAEKLAAVGTLAAGVAHEIRNPLSALRGFAQYFAKKFKDRHPEEVYAQTMVREADRLN
RVITDLLYLARPRRVTPRLVRLRALVSEVEDLVRFDLDERKVNMVVSLGPEEVWADEDTLKQAVLNLVLNSLDALKETDG
GARQVDVASGLAKDGVWLFVRDTANGMTKEQAEQAFEPFYTTKKKGTGLGLALVHKTMRDHGGKAIIDTAPGHGTTVGLF
FPDHDDDVADDTNEADAERDS
>Mature_581_residues
MEVADYKRERSTLIIAVLTLVTVGLSLIVSTGQVLSQQEEAGTQHLILASRSVLQAVDSSLRRNMTTDAQGGATFGAGAA
EFFRELEQSGEVLFVGLIDKHGGRVLTSRSSGESGTILFPPDALRTLAQTGEWHGRVGFGLASAYVYGKRIIPGNTGSMS
IARAETGEPLPAFLVVGLDMAKHQAIYRKFRQNALFQAAYILGAAVLIWALAMGLIKRREMAGKARQLERFQVKLLDNLP
DGLVTIGENGTILAANPAANGILQARGEGLAGKLLDDLPDDILRCLAAPETETAGWRQDSVRGAHLEILSVRMPGSSETD
DASRLVIIRDRTQIRTLEKSLSDAEKLAAVGTLAAGVAHEIRNPLSALRGFAQYFAKKFKDRHPEEVYAQTMVREADRLN
RVITDLLYLARPRRVTPRLVRLRALVSEVEDLVRFDLDERKVNMVVSLGPEEVWADEDTLKQAVLNLVLNSLDALKETDG
GARQVDVASGLAKDGVWLFVRDTANGMTKEQAEQAFEPFYTTKKKGTGLGLALVHKTMRDHGGKAIIDTAPGHGTTVGLF
FPDHDDDVADDTNEADAERDS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=38.2113821138211, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788549, Length=377, Percent_Identity=29.7082228116711, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1790300, Length=348, Percent_Identity=28.735632183908, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=28.0542986425339, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=345, Percent_Identity=25.7971014492754, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=25.764192139738, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63156; Mature: 63156

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVADYKRERSTLIIAVLTLVTVGLSLIVSTGQVLSQQEEAGTQHLILASRSVLQAVDSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHH
LRRNMTTDAQGGATFGAGAAEFFRELEQSGEVLFVGLIDKHGGRVLTSRSSGESGTILFP
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCEEEEC
PDALRTLAQTGEWHGRVGFGLASAYVYGKRIIPGNTGSMSIARAETGEPLPAFLVVGLDM
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHH
AKHQAIYRKFRQNALFQAAYILGAAVLIWALAMGLIKRREMAGKARQLERFQVKLLDNLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGLVTIGENGTILAANPAANGILQARGEGLAGKLLDDLPDDILRCLAAPETETAGWRQDS
CCEEEECCCCEEEEECCCCCCHHHHCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCC
VRGAHLEILSVRMPGSSETDDASRLVIIRDRTQIRTLEKSLSDAEKLAAVGTLAAGVAHE
CCCCEEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRNPLSALRGFAQYFAKKFKDRHPEEVYAQTMVREADRLNRVITDLLYLARPRRVTPRLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RLRALVSEVEDLVRFDLDERKVNMVVSLGPEEVWADEDTLKQAVLNLVLNSLDALKETDG
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
GARQVDVASGLAKDGVWLFVRDTANGMTKEQAEQAFEPFYTTKKKGTGLGLALVHKTMRD
CCEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
HGGKAIIDTAPGHGTTVGLFFPDHDDDVADDTNEADAERDS
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVADYKRERSTLIIAVLTLVTVGLSLIVSTGQVLSQQEEAGTQHLILASRSVLQAVDSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHH
LRRNMTTDAQGGATFGAGAAEFFRELEQSGEVLFVGLIDKHGGRVLTSRSSGESGTILFP
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCCCCCEEEEC
PDALRTLAQTGEWHGRVGFGLASAYVYGKRIIPGNTGSMSIARAETGEPLPAFLVVGLDM
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCEECCCCCCCEEEEECCCCCCCHHHHHHHHHH
AKHQAIYRKFRQNALFQAAYILGAAVLIWALAMGLIKRREMAGKARQLERFQVKLLDNLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DGLVTIGENGTILAANPAANGILQARGEGLAGKLLDDLPDDILRCLAAPETETAGWRQDS
CCEEEECCCCEEEEECCCCCCHHHHCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCC
VRGAHLEILSVRMPGSSETDDASRLVIIRDRTQIRTLEKSLSDAEKLAAVGTLAAGVAHE
CCCCEEEEEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRNPLSALRGFAQYFAKKFKDRHPEEVYAQTMVREADRLNRVITDLLYLARPRRVTPRLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RLRALVSEVEDLVRFDLDERKVNMVVSLGPEEVWADEDTLKQAVLNLVLNSLDALKETDG
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
GARQVDVASGLAKDGVWLFVRDTANGMTKEQAEQAFEPFYTTKKKGTGLGLALVHKTMRD
CCEEEHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
HGGKAIIDTAPGHGTTVGLFFPDHDDDVADDTNEADAERDS
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]