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The map label for this gene is atoC [H]

Identifier: 78356728

GI number: 78356728

Start: 1738023

End: 1739396

Strand: Direct

Name: atoC [H]

Synonym: Dde_1685

Alternate gene names: 78356728

Gene position: 1738023-1739396 (Clockwise)

Preceding gene: 78356727

Following gene: 78356729

Centisome position: 46.59

GC content: 54.95

Gene sequence:

>1374_bases
ATGATCAAGCGATTGCTGGTTATTGACGACGAGCCCGGCCACCGCCTGATGGTCCGTGCGGTTATGGAAGACAACGGATG
GCAGGTTTTTGAAGCCGCAAGCGGAGAAGACGGGCTATCTTTTCTCGGAACCGATTCTGTGCATGTGGTTCTGCTGGATA
TGCGCATGCCGGGTATGGACGGCAAAGAGACGCTGGCCCGTATTCTGGATATCAATCCGCAATTGCCGGTGGTGATGCTT
ACAGCATACGGCACTGTCGGATCTGCTGTTGAAGCCATGAAAAAAGGAGCTTTTGACTACCTGAGCAAGCCCGCGGACAA
TGACGAGCTGGCAGCAGTGCTTGAAAAAGCATGGGAGTATTCGTTGCTGCTGGCAGAAAATCAGAATCTGCGCCAGAAGC
TGGGGCAGGGAGACCCTGTTCAGAAAATTGTGGGTTCAAGCCCCGCCATGCTGCGGGTGCTGGATTTTATCAGACAGGCC
GGTCCCAGCGAGGCTACTGTGCTTGTTATGGGTGAATCCGGAACAGGCAAGGAACTGATTGCCGAAGCCCTGCACGATGC
AAGCCTGCGCCGCGAAAAAACACTGGTGAAAGTCAACTGCGCAGCGTTGCCGGGCAACCTGCTGGAAAGCGAATTGTTCG
GCTATGTCAAGGGCGCTTTTACCGGTGCCGTAAAGGATAAGCCCGGCCGTTTTCAGCTGGCACGCGGTGGCACTCTCTTT
CTGGATGAAATAGGTGAAATGCCTGTTGAACTGCAGGCAAAACTGCTGCGTGCGCTGCAGGAACGGGTTATCGAACCGCT
GGGTTCCGTCCGGCCCGTTGATGTGGATGTGCGCATTGTGGCAGCCACAAACCGCGACCTGCGTAAAGCTATCGAACAGG
GGGATTTCCGCGAAGACCTGTTTTTCCGCCTGAACGTGCTTGAGGTGGTTTCCCCGCCACTGCGTGAACGCATTGATGAT
ATTCCGCTGCTTGTAAGCCGGCTTGTAGATAAACTGAGCCGCAAAAACCGCAAGGAAGTACGCAGCGTCAGTCCGGAGTT
TCTGGATGCACTTATGGCGTACCACTGGCCGGGTAATGTGCGTGAACTGGAAAACGTGCTTGAACGTGCTCTTATTCTGA
GCAGGTCTGATATTCTGGGGCCCGAGTCGTTGCCCGCCCAGTTGCTGCAGGTCGAAGAACGCAGAGACCCCTTACCGCAG
CGCATGGTTTCCACAGCTCTTGTGCCGTCTTTTGACGATGCCGAGCGCGAAACATTGCTCAAGGCGCTGGAAGCGCATAA
CGGACATCGCGAAAAAACAGCCGATGCGCTAGGTATAAGCCGCAGGACACTGCAATATAAGCTTAAGAAGTTCGGTCTGA
CACGGCGCAGCTGA

Upstream 100 bases:

>100_bases
ATACTGCTCCGGGTCACGGAACCACTGTGGGGTTGTTTTTTCCCGACCATGACGATGACGTTGCTGACGATACCAATGAA
GCTGACGCTGAGAGGGATTC

Downstream 100 bases:

>100_bases
TTCAGATTCCGTCATGGGCTGCCCGGCGGCCCATGGCTTGTCCGGATGTGTATTTTTTTGACACGGGGCTTGGTGCGCCA
TGATTGCTGTCCGTGCCTCT

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MIKRLLVIDDEPGHRLMVRAVMEDNGWQVFEAASGEDGLSFLGTDSVHVVLLDMRMPGMDGKETLARILDINPQLPVVML
TAYGTVGSAVEAMKKGAFDYLSKPADNDELAAVLEKAWEYSLLLAENQNLRQKLGQGDPVQKIVGSSPAMLRVLDFIRQA
GPSEATVLVMGESGTGKELIAEALHDASLRREKTLVKVNCAALPGNLLESELFGYVKGAFTGAVKDKPGRFQLARGGTLF
LDEIGEMPVELQAKLLRALQERVIEPLGSVRPVDVDVRIVAATNRDLRKAIEQGDFREDLFFRLNVLEVVSPPLRERIDD
IPLLVSRLVDKLSRKNRKEVRSVSPEFLDALMAYHWPGNVRELENVLERALILSRSDILGPESLPAQLLQVEERRDPLPQ
RMVSTALVPSFDDAERETLLKALEAHNGHREKTADALGISRRTLQYKLKKFGLTRRS

Sequences:

>Translated_457_residues
MIKRLLVIDDEPGHRLMVRAVMEDNGWQVFEAASGEDGLSFLGTDSVHVVLLDMRMPGMDGKETLARILDINPQLPVVML
TAYGTVGSAVEAMKKGAFDYLSKPADNDELAAVLEKAWEYSLLLAENQNLRQKLGQGDPVQKIVGSSPAMLRVLDFIRQA
GPSEATVLVMGESGTGKELIAEALHDASLRREKTLVKVNCAALPGNLLESELFGYVKGAFTGAVKDKPGRFQLARGGTLF
LDEIGEMPVELQAKLLRALQERVIEPLGSVRPVDVDVRIVAATNRDLRKAIEQGDFREDLFFRLNVLEVVSPPLRERIDD
IPLLVSRLVDKLSRKNRKEVRSVSPEFLDALMAYHWPGNVRELENVLERALILSRSDILGPESLPAQLLQVEERRDPLPQ
RMVSTALVPSFDDAERETLLKALEAHNGHREKTADALGISRRTLQYKLKKFGLTRRS
>Mature_457_residues
MIKRLLVIDDEPGHRLMVRAVMEDNGWQVFEAASGEDGLSFLGTDSVHVVLLDMRMPGMDGKETLARILDINPQLPVVML
TAYGTVGSAVEAMKKGAFDYLSKPADNDELAAVLEKAWEYSLLLAENQNLRQKLGQGDPVQKIVGSSPAMLRVLDFIRQA
GPSEATVLVMGESGTGKELIAEALHDASLRREKTLVKVNCAALPGNLLESELFGYVKGAFTGAVKDKPGRFQLARGGTLF
LDEIGEMPVELQAKLLRALQERVIEPLGSVRPVDVDVRIVAATNRDLRKAIEQGDFREDLFFRLNVLEVVSPPLRERIDD
IPLLVSRLVDKLSRKNRKEVRSVSPEFLDALMAYHWPGNVRELENVLERALILSRSDILGPESLPAQLLQVEERRDPLPQ
RMVSTALVPSFDDAERETLLKALEAHNGHREKTADALGISRRTLQYKLKKFGLTRRS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=43.7636761487965, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=45.6375838926174, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=43.2071269487751, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=40.0428265524625, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=45.4810495626822, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI1789087, Length=339, Percent_Identity=44.2477876106195, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=44.478527607362, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=42.9022082018927, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1786524, Length=339, Percent_Identity=41.8879056047198, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=38.4615384615385, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=35.6923076923077, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87081858, Length=306, Percent_Identity=33.6601307189542, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=37.2950819672131, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788222, Length=137, Percent_Identity=31.3868613138686, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786599, Length=114, Percent_Identity=35.9649122807018, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789809, Length=109, Percent_Identity=31.1926605504587, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50793; Mature: 50793

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRLLVIDDEPGHRLMVRAVMEDNGWQVFEAASGEDGLSFLGTDSVHVVLLDMRMPGMD
CCCEEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCCCEEEEEEEECCCCCC
GKETLARILDINPQLPVVMLTAYGTVGSAVEAMKKGAFDYLSKPADNDELAAVLEKAWEY
CHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCE
SLLLAENQNLRQKLGQGDPVQKIVGSSPAMLRVLDFIRQAGPSEATVLVMGESGTGKELI
EEEEECCCHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
AEALHDASLRREKTLVKVNCAALPGNLLESELFGYVKGAFTGAVKDKPGRFQLARGGTLF
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEE
LDEIGEMPVELQAKLLRALQERVIEPLGSVRPVDVDVRIVAATNRDLRKAIEQGDFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCHHHH
FFRLNVLEVVSPPLRERIDDIPLLVSRLVDKLSRKNRKEVRSVSPEFLDALMAYHWPGNV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCH
RELENVLERALILSRSDILGPESLPAQLLQVEERRDPLPQRMVSTALVPSFDDAERETLL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHH
KALEAHNGHREKTADALGISRRTLQYKLKKFGLTRRS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKRLLVIDDEPGHRLMVRAVMEDNGWQVFEAASGEDGLSFLGTDSVHVVLLDMRMPGMD
CCCEEEEEECCCCCEEEEEEEECCCCCEEEECCCCCCCCEEECCCCEEEEEEEECCCCCC
GKETLARILDINPQLPVVMLTAYGTVGSAVEAMKKGAFDYLSKPADNDELAAVLEKAWEY
CHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHCE
SLLLAENQNLRQKLGQGDPVQKIVGSSPAMLRVLDFIRQAGPSEATVLVMGESGTGKELI
EEEEECCCHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
AEALHDASLRREKTLVKVNCAALPGNLLESELFGYVKGAFTGAVKDKPGRFQLARGGTLF
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEE
LDEIGEMPVELQAKLLRALQERVIEPLGSVRPVDVDVRIVAATNRDLRKAIEQGDFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHCCCCHHHH
FFRLNVLEVVSPPLRERIDDIPLLVSRLVDKLSRKNRKEVRSVSPEFLDALMAYHWPGNV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHCCCCCH
RELENVLERALILSRSDILGPESLPAQLLQVEERRDPLPQRMVSTALVPSFDDAERETLL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHH
KALEAHNGHREKTADALGISRRTLQYKLKKFGLTRRS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]