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The map label for this gene is hisB

Identifier: 78356512

GI number: 78356512

Start: 1487844

End: 1488434

Strand: Reverse

Name: hisB

Synonym: Dde_1467

Alternate gene names: 78356512

Gene position: 1488434-1487844 (Counterclockwise)

Preceding gene: 78356513

Following gene: 78356511

Centisome position: 39.9

GC content: 57.7

Gene sequence:

>591_bases
ATGACCCGACGCGCTGCGACTGTGACGCGCACCACGACAGAAACTGCCATTTCCCTTTCGCTTACAGTGGACGGCAAGGG
CGAAGTATCGGTAACAACCGGTCACGGATTTACCGATCATATGCTTACTCTGCTCGGCTTCTGGGCGGGCTTTGACCTGA
CCCTGACCTGCAACGGCGACACGCATGTGGACGCCCACCATACGGTGGAAGATGCAGGGCTCTGTCTGGGGCAGGCTTTT
GCACAGGCGCTGGGTGACAGAAAAGGCATAGCGCGGGTAGGCAACGCACGGGTACCCATGGATGAAGCGCTGACGGAAGT
CGATCTGGATATTTCCGGACGCCCCTATCTGGTTTACCGCGGCGACGAACTGCTGCCGCCGGTCATTGCCGGTGACGAGG
CAGACCTGTGGCGCGAGTTTTTCAAATCATTTGCCAACGGTGCCAGAATCAATCTGCACATATCATTGCTTTACGGCAAA
AACGGTCATCATCTGTTAGAATCCGCGTTCAAAGGTCTGGGGCTTGCTCTGCGCCGGGCCGCGGCTTGTGAACGCGAAGC
ACTGCTCAGCACCAAGGGGAGTCTCGACTGA

Upstream 100 bases:

>100_bases
TTTCGGCCGGTCCGCCAAAGCCGGCGGGCAGGATGAAGATGAAAACGATGAGCAGGAAGAAACAGCGTAGCCGCTTTTTT
TCCGGCTTTCAGGAGACACC

Downstream 100 bases:

>100_bases
TGCGCAAACTCTGCATAAAAATCCTGCTGGTCACGGCGGCGGCCGCGCTGCTGCTTACCGGCTGTTACAGCCCTGTCCAA
GGTCCCATGCCGTTGCCCGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTRRAATVTRTTTETAISLSLTVDGKGEVSVTTGHGFTDHMLTLLGFWAGFDLTLTCNGDTHVDAHHTVEDAGLCLGQAF
AQALGDRKGIARVGNARVPMDEALTEVDLDISGRPYLVYRGDELLPPVIAGDEADLWREFFKSFANGARINLHISLLYGK
NGHHLLESAFKGLGLALRRAAACEREALLSTKGSLD

Sequences:

>Translated_196_residues
MTRRAATVTRTTTETAISLSLTVDGKGEVSVTTGHGFTDHMLTLLGFWAGFDLTLTCNGDTHVDAHHTVEDAGLCLGQAF
AQALGDRKGIARVGNARVPMDEALTEVDLDISGRPYLVYRGDELLPPVIAGDEADLWREFFKSFANGARINLHISLLYGK
NGHHLLESAFKGLGLALRRAAACEREALLSTKGSLD
>Mature_195_residues
TRRAATVTRTTTETAISLSLTVDGKGEVSVTTGHGFTDHMLTLLGFWAGFDLTLTCNGDTHVDAHHTVEDAGLCLGQAFA
QALGDRKGIARVGNARVPMDEALTEVDLDISGRPYLVYRGDELLPPVIAGDEADLWREFFKSFANGARINLHISLLYGKN
GHHLLESAFKGLGLALRRAAACEREALLSTKGSLD

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=42.1875, Blast_Score=143, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324776, Length=222, Percent_Identity=39.1891891891892, Blast_Score=141, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_DESDG (Q311Y0)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387961.1
- HSSP:   P34047
- ProteinModelPortal:   Q311Y0
- SMR:   Q311Y0
- STRING:   Q311Y0
- GeneID:   3756098
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1467
- NMPDR:   fig|207559.3.peg.674
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   CLSK705015
- BioCyc:   DDES207559:DDE_1467-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21094; Mature: 20963

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRAATVTRTTTETAISLSLTVDGKGEVSVTTGHGFTDHMLTLLGFWAGFDLTLTCNGD
CCCCCCEEEEECCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCC
THVDAHHTVEDAGLCLGQAFAQALGDRKGIARVGNARVPMDEALTEVDLDISGRPYLVYR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCEEEEEC
GDELLPPVIAGDEADLWREFFKSFANGARINLHISLLYGKNGHHLLESAFKGLGLALRRA
CCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
AACEREALLSTKGSLD
HHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRRAATVTRTTTETAISLSLTVDGKGEVSVTTGHGFTDHMLTLLGFWAGFDLTLTCNGD
CCCCCEEEEECCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCC
THVDAHHTVEDAGLCLGQAFAQALGDRKGIARVGNARVPMDEALTEVDLDISGRPYLVYR
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCEEEEEC
GDELLPPVIAGDEADLWREFFKSFANGARINLHISLLYGKNGHHLLESAFKGLGLALRRA
CCCCCCCEEECCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
AACEREALLSTKGSLD
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA