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The map label for this gene is hisC

Identifier: 78356498

GI number: 78356498

Start: 1476595

End: 1477746

Strand: Reverse

Name: hisC

Synonym: Dde_1453

Alternate gene names: 78356498

Gene position: 1477746-1476595 (Counterclockwise)

Preceding gene: 78356499

Following gene: 78356497

Centisome position: 39.62

GC content: 58.85

Gene sequence:

>1152_bases
ATGACTGAACCCGCAAAGCGGGAAGATTCCGGGCTGCCTGAGGCCGTTACTGCCATACGGCCAGAGGTGGCGGCATTCAA
ACCATACGCGCCCGGCCTTTCCATTGATGAAATCAAGGAACGCTACGGACTTTCCCAGGTCGTGAAAATGGCCAGCAACG
AAAATCCGCTGGGCACCTCGCCGCTGGTTCAGCAGACACTGCGTACCCATGCAGACCTTGCCTTCCGGTATGTCCAGTCC
GGCAATCCCCGGCTGGTCAGCGCCATTGCCCGGTCTTTCGGCGTTGCTGCCGAAAGCGTGGTCACCGGCAACGGCTCTGA
CGAGGTGATAGACCTTATCATACGGGTCAAGGCCCGCCCCGGAAAGCACAACATTGTCGCATTCAATCCCTGCTTCAGCA
TGTACGAGCTGCAGACGCGCTTCTGCGGTGTAGAGTTCCGGCAGGTACCGCTGCGTGCCGACTTCAGTTTCGACTACGAC
GCTTTTGTCGGCGCCGCTGATGCCGACACGGCCGTCGCATTCATCACCACGCCCGACAACCCGTCCGGCTACTGCCCCCC
GGTCGAAGAAATAATCGATCTTGCGCGGCGTCTTCCTTCATCATGTCTGCTGGTAGTGGACGAAGCCTACATGGATTTTG
CCGATGACCCTGCCGCCCACTCTGTTCTGCCGCACCTGACAGAATTTCCCAATGTGGCAGTGCTGCGTACTTTTTCAAAA
AGTTACGGGCTGGCCGGTCTGCGTCTGGGTTTCGGCGTTATGCATCCCGCCCTTGCTGACTATGTAAAAAGGGTGCGGCT
GCCTTTCAGCATCAACATACTGGCAGAGTACGCAGGCATAGCGGCACTGCAGGACACCACATTCCACGCGCAGACCCTGC
GTGTAACCCGCGAAGGCAGAACCTATCTGACCGGCGCGCTGACCGAGGCCGGATGCACGGTGTACCCTTCCGCAGCCAAC
TTCATCATGTTCGCGCTGCCGGAAAACTGCCCGCACGATGCGCGCGCGGTATTCGAGGCACTGCTGCGCCGCGGTATCAT
CATACGTCCGCTAAGCAGCTACAACCTGCCGCAGTGTCTGCGGGTCAGCATAGGCAACAGGCACGAAAACGAGCTGTTCA
TAGCTCAGTTCAAGGAGCTTCTCCGTGGCTGA

Upstream 100 bases:

>100_bases
GGCGCCTTGCCCTGACGCAAAAGGTGGATTATCCAGAGGGGCGGTTCTCACGAACCGTCCCTTTTTTGCTACAGTTCCAT
ACCTGCAAAGGAGCACCCCC

Downstream 100 bases:

>100_bases
ACACATCATTGTCACACTGGACGGCCCCGCCGGAGTGGGTAAAACCACACTGGCCCGCAATATAGCCGAAGAGCTGGGCA
TAGCGTATATGGATACCGGA

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MTEPAKREDSGLPEAVTAIRPEVAAFKPYAPGLSIDEIKERYGLSQVVKMASNENPLGTSPLVQQTLRTHADLAFRYVQS
GNPRLVSAIARSFGVAAESVVTGNGSDEVIDLIIRVKARPGKHNIVAFNPCFSMYELQTRFCGVEFRQVPLRADFSFDYD
AFVGAADADTAVAFITTPDNPSGYCPPVEEIIDLARRLPSSCLLVVDEAYMDFADDPAAHSVLPHLTEFPNVAVLRTFSK
SYGLAGLRLGFGVMHPALADYVKRVRLPFSINILAEYAGIAALQDTTFHAQTLRVTREGRTYLTGALTEAGCTVYPSAAN
FIMFALPENCPHDARAVFEALLRRGIIIRPLSSYNLPQCLRVSIGNRHENELFIAQFKELLRG

Sequences:

>Translated_383_residues
MTEPAKREDSGLPEAVTAIRPEVAAFKPYAPGLSIDEIKERYGLSQVVKMASNENPLGTSPLVQQTLRTHADLAFRYVQS
GNPRLVSAIARSFGVAAESVVTGNGSDEVIDLIIRVKARPGKHNIVAFNPCFSMYELQTRFCGVEFRQVPLRADFSFDYD
AFVGAADADTAVAFITTPDNPSGYCPPVEEIIDLARRLPSSCLLVVDEAYMDFADDPAAHSVLPHLTEFPNVAVLRTFSK
SYGLAGLRLGFGVMHPALADYVKRVRLPFSINILAEYAGIAALQDTTFHAQTLRVTREGRTYLTGALTEAGCTVYPSAAN
FIMFALPENCPHDARAVFEALLRRGIIIRPLSSYNLPQCLRVSIGNRHENELFIAQFKELLRG
>Mature_382_residues
TEPAKREDSGLPEAVTAIRPEVAAFKPYAPGLSIDEIKERYGLSQVVKMASNENPLGTSPLVQQTLRTHADLAFRYVQSG
NPRLVSAIARSFGVAAESVVTGNGSDEVIDLIIRVKARPGKHNIVAFNPCFSMYELQTRFCGVEFRQVPLRADFSFDYDA
FVGAADADTAVAFITTPDNPSGYCPPVEEIIDLARRLPSSCLLVVDEAYMDFADDPAAHSVLPHLTEFPNVAVLRTFSKS
YGLAGLRLGFGVMHPALADYVKRVRLPFSINILAEYAGIAALQDTTFHAQTLRVTREGRTYLTGALTEAGCTVYPSAANF
IMFALPENCPHDARAVFEALLRRGIIIRPLSSYNLPQCLRVSIGNRHENELFIAQFKELLRG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=340, Percent_Identity=30.8823529411765, Blast_Score=142, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322075, Length=384, Percent_Identity=28.90625, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_DESDG (Q311Z4)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387947.1
- ProteinModelPortal:   Q311Z4
- SMR:   Q311Z4
- STRING:   Q311Z4
- GeneID:   3756084
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1453
- NMPDR:   fig|207559.3.peg.660
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   VAFNPCF
- ProtClustDB:   CLSK705005
- BioCyc:   DDES207559:DDE_1453-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42030; Mature: 41899

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPAKREDSGLPEAVTAIRPEVAAFKPYAPGLSIDEIKERYGLSQVVKMASNENPLGTS
CCCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCC
PLVQQTLRTHADLAFRYVQSGNPRLVSAIARSFGVAAESVVTGNGSDEVIDLIIRVKARP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHEEECCCCHHHEEEHHHEECCC
GKHNIVAFNPCFSMYELQTRFCGVEFRQVPLRADFSFDYDAFVGAADADTAVAFITTPDN
CCCCEEEECCCHHHHHHHHHHCCCCCEEECEEECCCCCHHHHCCCCCCCCEEEEEECCCC
PSGYCPPVEEIIDLARRLPSSCLLVVDEAYMDFADDPAAHSVLPHLTEFPNVAVLRTFSK
CCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SYGLAGLRLGFGVMHPALADYVKRVRLPFSINILAEYAGIAALQDTTFHAQTLRVTREGR
HCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCHHEECCCCEEHEEEEEEECCC
TYLTGALTEAGCTVYPSAANFIMFALPENCPHDARAVFEALLRRGIIIRPLSSYNLPQCL
EEEEEEHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHH
RVSIGNRHENELFIAQFKELLRG
HHHCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TEPAKREDSGLPEAVTAIRPEVAAFKPYAPGLSIDEIKERYGLSQVVKMASNENPLGTS
CCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCC
PLVQQTLRTHADLAFRYVQSGNPRLVSAIARSFGVAAESVVTGNGSDEVIDLIIRVKARP
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHEEECCCCHHHEEEHHHEECCC
GKHNIVAFNPCFSMYELQTRFCGVEFRQVPLRADFSFDYDAFVGAADADTAVAFITTPDN
CCCCEEEECCCHHHHHHHHHHCCCCCEEECEEECCCCCHHHHCCCCCCCCEEEEEECCCC
PSGYCPPVEEIIDLARRLPSSCLLVVDEAYMDFADDPAAHSVLPHLTEFPNVAVLRTFSK
CCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
SYGLAGLRLGFGVMHPALADYVKRVRLPFSINILAEYAGIAALQDTTFHAQTLRVTREGR
HCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCHHEECCCCEEHEEEEEEECCC
TYLTGALTEAGCTVYPSAANFIMFALPENCPHDARAVFEALLRRGIIIRPLSSYNLPQCL
EEEEEEHHCCCCEECCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHH
RVSIGNRHENELFIAQFKELLRG
HHHCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA