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The map label for this gene is upp

Identifier: 78356493

GI number: 78356493

Start: 1473172

End: 1473798

Strand: Direct

Name: upp

Synonym: Dde_1448

Alternate gene names: 78356493

Gene position: 1473172-1473798 (Clockwise)

Preceding gene: 78356487

Following gene: 78356494

Centisome position: 39.49

GC content: 55.02

Gene sequence:

>627_bases
GTGGCTGTTTACGCGGTGGACCACCCGCTGGTCAAACATAAACTGGGCAGGCTGCGCCAGAGCGATGTGCCGGTGGCCGA
GTTTCGCGCACTTTCCAACGAAGTGTGCCGGTTGCTTACATATGAAGCAACCAAGGACCTTGAAACGGAAAAGACACAGG
TTGAAGGCTGGGCCGGCCCTGTGGAAGTCGAGCAGATCAAGGGTAAAAAAATTACCGTTGTTCCCATCCTGCGTGCCGGA
CTGGGTATGCTGGACGGGCTGCTTGATATGATTCCCGGCGCAAAGGTCAGCGTTGTGGGCATGTTCCGCAACGAAGAAAC
CCTTGAACCGGTGACGTACTATACCAAGCTCGCCAATAATATCGAAGAGCGTCAGGCTATCATCATCGATCCCATGCTTG
CTACCGGCGGTACGCTGGTGGCAACCATCGACCTGCTGAAAAAAGCAGGCTGCAAACAGATCCGCGGGCTTTTTCTGGTG
GCTGCACCGGAAGGCATCAAGCGTGTGCAGGATGCTCACCCCGACGTGGACATCTATGTGGCCGCAGTGGATGACTGCCT
GAATGAGAACGGTTATATCCTGCCTGGTCTCGGAGATGCCGGTGACAAGATTTTCGGTACCAAATAG

Upstream 100 bases:

>100_bases
ATGTTGTCCTTGACGAAAATCTTTCACCATACTACACATATCCGGATAAAGTTTAAATGCGAACATCTGAACCAACGCAA
TCTCTTTAAGGAGACCGAGA

Downstream 100 bases:

>100_bases
GTATCTGCGCGTCTGAACGCGACAGAGCATTTTTGCAGCGGCGGTGAAAGCCCACCCGTTGCAGAAATGCTCTTTTTTTG
GGCCAAAGGCTGGAATATGA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MAVYAVDHPLVKHKLGRLRQSDVPVAEFRALSNEVCRLLTYEATKDLETEKTQVEGWAGPVEVEQIKGKKITVVPILRAG
LGMLDGLLDMIPGAKVSVVGMFRNEETLEPVTYYTKLANNIEERQAIIIDPMLATGGTLVATIDLLKKAGCKQIRGLFLV
AAPEGIKRVQDAHPDVDIYVAAVDDCLNENGYILPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MAVYAVDHPLVKHKLGRLRQSDVPVAEFRALSNEVCRLLTYEATKDLETEKTQVEGWAGPVEVEQIKGKKITVVPILRAG
LGMLDGLLDMIPGAKVSVVGMFRNEETLEPVTYYTKLANNIEERQAIIIDPMLATGGTLVATIDLLKKAGCKQIRGLFLV
AAPEGIKRVQDAHPDVDIYVAAVDDCLNENGYILPGLGDAGDKIFGTK
>Mature_207_residues
AVYAVDHPLVKHKLGRLRQSDVPVAEFRALSNEVCRLLTYEATKDLETEKTQVEGWAGPVEVEQIKGKKITVVPILRAGL
GMLDGLLDMIPGAKVSVVGMFRNEETLEPVTYYTKLANNIEERQAIIIDPMLATGGTLVATIDLLKKAGCKQIRGLFLVA
APEGIKRVQDAHPDVDIYVAAVDDCLNENGYILPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI57863312, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=68.2692307692308, Blast_Score=307, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=194, Percent_Identity=36.0824742268041, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=29.064039408867, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_DESDG (Q311Z9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387942.1
- HSSP:   Q9WZI0
- ProteinModelPortal:   Q311Z9
- SMR:   Q311Z9
- STRING:   Q311Z9
- GeneID:   3756079
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1448
- NMPDR:   fig|207559.3.peg.655
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   DDES207559:DDE_1448-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22628; Mature: 22496

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYAVDHPLVKHKLGRLRQSDVPVAEFRALSNEVCRLLTYEATKDLETEKTQVEGWAGP
CEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
VEVEQIKGKKITVVPILRAGLGMLDGLLDMIPGAKVSVVGMFRNEETLEPVTYYTKLANN
EEHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHC
IEERQAIIIDPMLATGGTLVATIDLLKKAGCKQIRGLFLVAAPEGIKRVQDAHPDVDIYV
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHCCEEEEECCHHHHHHHHCCCCCEEEE
AAVDDCLNENGYILPGLGDAGDKIFGTK
EEEHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AVYAVDHPLVKHKLGRLRQSDVPVAEFRALSNEVCRLLTYEATKDLETEKTQVEGWAGP
EEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
VEVEQIKGKKITVVPILRAGLGMLDGLLDMIPGAKVSVVGMFRNEETLEPVTYYTKLANN
EEHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHC
IEERQAIIIDPMLATGGTLVATIDLLKKAGCKQIRGLFLVAAPEGIKRVQDAHPDVDIYV
HHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHCCEEEEECCHHHHHHHHCCCCCEEEE
AAVDDCLNENGYILPGLGDAGDKIFGTK
EEEHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA