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The map label for this gene is sppA [H]

Identifier: 78356487

GI number: 78356487

Start: 1466697

End: 1467659

Strand: Direct

Name: sppA [H]

Synonym: Dde_1442

Alternate gene names: 78356487

Gene position: 1466697-1467659 (Clockwise)

Preceding gene: 78356485

Following gene: 78356493

Centisome position: 39.32

GC content: 57.01

Gene sequence:

>963_bases
ATGCGTTATATGGCTGTTTTTATGATTCTTGTGTCATTGCTTGCCACAGGATGCGCATCGGGGGTCAAGCTTTTCGGCGG
CCCCGAAGCTTTAAAAGAATACCAGCTGCAGGGCAGCGGCGATGCAAAGATTGTTGTGCTGCCCGTTGCCGGTGTTATCG
ATAACAAACCGGAACGCGGAATTTTTGCCGACAAGCCCGGTCTGGTGCAGAGTGTCGTAGCCCGCCTGCGTATGGCGGAA
ATGGACCCCGCTGTCCGCGCAGTGATACTTACGGTTGACTCCCCCGGAGGCAGCGTCACCTCAAGCGATGTGCTGTATAA
TGAGATAATGCGCTTCAAACAGCGTACCGGCACCCGTGTGGTGGCCCTGCAAATGGATATGGCCACTTCCGGCGGGTACT
ATGTGTCCATTGCCGCAGACCGTATCATTGCGCATCCGTCGACCATCACCGGCAGCATCGGGACCATTTTCATGCGGCCC
AACGTGACGGGGCTGATGGAAAAGATAGGCGTGCAGGCTGTGACTACAAAGTCCGGGGCGCACAAAGACATCGGTTCGCC
GTTCAGGGAAAACACTCCCGAAGAGCAGGCCATTCTGCAGAATATGGTCACCACGCTCAACAGTCGCTTTATAAAGCTTG
TCAGCGAACGCCGCGAACTGCAGGGCAGGGAATCCAGCTATTCCGACGCCCGCATAATGACAGCGCAGGAAGCCCTTGAA
CTCGGGCTTGTGGACAGCATAGGCTACTTTGACAACGCCGTTGCCGCCGCGCATGAACTGGCCGGTCTTGATGAGGCGTC
TGTGGTTGTGTACCGCCGCGAACCGTTCCCCAACGATACGCCGTACAACACCATCACCGCGCAGGCAGGCAGTGCTCCGC
TTGTGGAGATGCCGCTGGCCCGTCCGCTTAACGTGCCTTCCACAGGGTTTTATTATCTGTGGGCGCCGGAATACGCCCGT
TAA

Upstream 100 bases:

>100_bases
TGCTATTCTCCACAGCAGATATTTGACGCCGATGAACGGGGTGTCAAGGTTAAATCGGCATCACTGCAACTCTCATCTTC
CGTTCTTACAGGAGTTTTAT

Downstream 100 bases:

>100_bases
CAGATTGTACCGTTTATAAAAACAGGCCTGCAGAGCTTCTGCGGGCCTGTTTTTATTTAAGGCATATCCACCCGCTCGCG
GGCGGCGGCATCAGAACAGC

Product: signal peptide peptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRYMAVFMILVSLLATGCASGVKLFGGPEALKEYQLQGSGDAKIVVLPVAGVIDNKPERGIFADKPGLVQSVVARLRMAE
MDPAVRAVILTVDSPGGSVTSSDVLYNEIMRFKQRTGTRVVALQMDMATSGGYYVSIAADRIIAHPSTITGSIGTIFMRP
NVTGLMEKIGVQAVTTKSGAHKDIGSPFRENTPEEQAILQNMVTTLNSRFIKLVSERRELQGRESSYSDARIMTAQEALE
LGLVDSIGYFDNAVAAAHELAGLDEASVVVYRREPFPNDTPYNTITAQAGSAPLVEMPLARPLNVPSTGFYYLWAPEYAR

Sequences:

>Translated_320_residues
MRYMAVFMILVSLLATGCASGVKLFGGPEALKEYQLQGSGDAKIVVLPVAGVIDNKPERGIFADKPGLVQSVVARLRMAE
MDPAVRAVILTVDSPGGSVTSSDVLYNEIMRFKQRTGTRVVALQMDMATSGGYYVSIAADRIIAHPSTITGSIGTIFMRP
NVTGLMEKIGVQAVTTKSGAHKDIGSPFRENTPEEQAILQNMVTTLNSRFIKLVSERRELQGRESSYSDARIMTAQEALE
LGLVDSIGYFDNAVAAAHELAGLDEASVVVYRREPFPNDTPYNTITAQAGSAPLVEMPLARPLNVPSTGFYYLWAPEYAR
>Mature_320_residues
MRYMAVFMILVSLLATGCASGVKLFGGPEALKEYQLQGSGDAKIVVLPVAGVIDNKPERGIFADKPGLVQSVVARLRMAE
MDPAVRAVILTVDSPGGSVTSSDVLYNEIMRFKQRTGTRVVALQMDMATSGGYYVSIAADRIIAHPSTITGSIGTIFMRP
NVTGLMEKIGVQAVTTKSGAHKDIGSPFRENTPEEQAILQNMVTTLNSRFIKLVSERRELQGRESSYSDARIMTAQEALE
LGLVDSIGYFDNAVAAAHELAGLDEASVVVYRREPFPNDTPYNTITAQAGSAPLVEMPLARPLNVPSTGFYYLWAPEYAR

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=238, Percent_Identity=35.2941176470588, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787527, Length=172, Percent_Identity=26.1627906976744, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 34614; Mature: 34614

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYMAVFMILVSLLATGCASGVKLFGGPEALKEYQLQGSGDAKIVVLPVAGVIDNKPERG
CHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCCCEEEEEEECHHHCCCCCCC
IFADKPGLVQSVVARLRMAEMDPAVRAVILTVDSPGGSVTSSDVLYNEIMRFKQRTGTRV
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEE
VALQMDMATSGGYYVSIAADRIIAHPSTITGSIGTIFMRPNVTGLMEKIGVQAVTTKSGA
EEEEEEEECCCCEEEEEECCEEEECCCCCCCCCEEEEECCCHHHHHHHHCCEEEEECCCC
HKDIGSPFRENTPEEQAILQNMVTTLNSRFIKLVSERRELQGRESSYSDARIMTAQEALE
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHH
LGLVDSIGYFDNAVAAAHELAGLDEASVVVYRREPFPNDTPYNTITAQAGSAPLVEMPLA
HCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEECCCC
RPLNVPSTGFYYLWAPEYAR
CCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MRYMAVFMILVSLLATGCASGVKLFGGPEALKEYQLQGSGDAKIVVLPVAGVIDNKPERG
CHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHCCCCCCCCEEEEEEECHHHCCCCCCC
IFADKPGLVQSVVARLRMAEMDPAVRAVILTVDSPGGSVTSSDVLYNEIMRFKQRTGTRV
CCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEE
VALQMDMATSGGYYVSIAADRIIAHPSTITGSIGTIFMRPNVTGLMEKIGVQAVTTKSGA
EEEEEEEECCCCEEEEEECCEEEECCCCCCCCCEEEEECCCHHHHHHHHCCEEEEECCCC
HKDIGSPFRENTPEEQAILQNMVTTLNSRFIKLVSERRELQGRESSYSDARIMTAQEALE
CCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHH
LGLVDSIGYFDNAVAAAHELAGLDEASVVVYRREPFPNDTPYNTITAQAGSAPLVEMPLA
HCCHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEEECCCCCCEEECCCC
RPLNVPSTGFYYLWAPEYAR
CCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]