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The map label for this gene is pgl [H]

Identifier: 78356371

GI number: 78356371

Start: 1344375

End: 1345190

Strand: Reverse

Name: pgl [H]

Synonym: Dde_1324

Alternate gene names: 78356371

Gene position: 1345190-1344375 (Counterclockwise)

Preceding gene: 78356372

Following gene: 78356364

Centisome position: 36.06

GC content: 61.15

Gene sequence:

>816_bases
ATGGCACACGACGTACGGCTCCGGACGGCACATGCCGCCACGGATTACGTCGTAAATCACCATGGGGGTTACATCATGAC
ATTGGTTTCGCATCTTTCGCTGTATATCACACCCGACCCCGATGCCATGGCACGGCAGGCGGCGGAGCTTATAATAGAAC
GCTGCGCCGCGGCAGTGGCCGCGCACGATGCCTTCACCATAGCGCTTTCCGGCGGCAGCACGCCGGTGCCGCTGTTCCGG
CTGCTTGCCGGGCAGGAATACGCAGACCGCATTCCGTGGAATAAAGTCAGCGTATACTGGGTGGACGAACGCTGCGTCCA
CCCCGACCACGAGCAGAGCAACTACCGTGTGGCCCGCGACGAGCTGCTGCACAAGGTGGACGCCACAAAATTCTACCGTA
TGAAAGGAGAAGCACAGCCGGAAATTGCCGCACAGGCATATGAAGAACTGCTGCGCAGGCAGTTCGGGCTGTCAGCGGGT
GAGCTGCCCCGCTTTGACTGCGTGCTGCTGGGAACAGGCGCCGATGGTCATACGGCATCGCTTTTTCCGCACTCCACCGG
ACTGGAGGAGCGCGAAAAACTGGTCATTGACCAGTATGTACCCTCGCTGCACAGCACGCGTCTGACCCTGACCCTGCCGG
TCATCAACAATGCCCGCGATGTCATTGTCATGGCCAGCGGTCACGCGAAACATCCGGTGCTGGCAAAAGCGCTCAACCTG
CTGGAACCACGCCTCCTGCCCATACAGCACATCGCCCCCGCTGCCGGCAGGCTGAGCTGGGTCATTGATCAGGCCGCAGC
GCAGCCGGCAGCCTGA

Upstream 100 bases:

>100_bases
CCGCACCGTCAATGCTTTCAGCGCCTAGCAGCCCCACCGGCGCTGCGCCTTTGCACCGGATGCATCTGCTCTATTCCAAA
ACAACGCAGGGTGTGGCACC

Downstream 100 bases:

>100_bases
GCGTTCTGCAGGCCGCAGCATAACGGTTCCGCTGCGGACGCAGGCATTTGCTAAAAAACAGACGGGAGTACCTGAGCGTA
CTCCCGTCCTTCTGTTTCGT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MAHDVRLRTAHAATDYVVNHHGGYIMTLVSHLSLYITPDPDAMARQAAELIIERCAAAVAAHDAFTIALSGGSTPVPLFR
LLAGQEYADRIPWNKVSVYWVDERCVHPDHEQSNYRVARDELLHKVDATKFYRMKGEAQPEIAAQAYEELLRRQFGLSAG
ELPRFDCVLLGTGADGHTASLFPHSTGLEEREKLVIDQYVPSLHSTRLTLTLPVINNARDVIVMASGHAKHPVLAKALNL
LEPRLLPIQHIAPAAGRLSWVIDQAAAQPAA

Sequences:

>Translated_271_residues
MAHDVRLRTAHAATDYVVNHHGGYIMTLVSHLSLYITPDPDAMARQAAELIIERCAAAVAAHDAFTIALSGGSTPVPLFR
LLAGQEYADRIPWNKVSVYWVDERCVHPDHEQSNYRVARDELLHKVDATKFYRMKGEAQPEIAAQAYEELLRRQFGLSAG
ELPRFDCVLLGTGADGHTASLFPHSTGLEEREKLVIDQYVPSLHSTRLTLTLPVINNARDVIVMASGHAKHPVLAKALNL
LEPRLLPIQHIAPAAGRLSWVIDQAAAQPAA
>Mature_270_residues
AHDVRLRTAHAATDYVVNHHGGYIMTLVSHLSLYITPDPDAMARQAAELIIERCAAAVAAHDAFTIALSGGSTPVPLFRL
LAGQEYADRIPWNKVSVYWVDERCVHPDHEQSNYRVARDELLHKVDATKFYRMKGEAQPEIAAQAYEELLRRQFGLSAGE
LPRFDCVLLGTGADGHTASLFPHSTGLEEREKLVIDQYVPSLHSTRLTLTLPVINNARDVIVMASGHAKHPVLAKALNLL
EPRLLPIQHIAPAAGRLSWVIDQAAAQPAA

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=226, Percent_Identity=38.0530973451327, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI52145310, Length=213, Percent_Identity=38.0281690140845, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI115533058, Length=250, Percent_Identity=27.6, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533060, Length=250, Percent_Identity=27.6, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=35.8139534883721, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319918, Length=213, Percent_Identity=35.6807511737089, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321957, Length=241, Percent_Identity=29.8755186721992, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=251, Percent_Identity=26.6932270916335, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641119, Length=229, Percent_Identity=33.1877729257642, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 29821; Mature: 29690

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDVRLRTAHAATDYVVNHHGGYIMTLVSHLSLYITPDPDAMARQAAELIIERCAAAVA
CCCCEEEEEHHHHHHEEEECCCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHH
AHDAFTIALSGGSTPVPLFRLLAGQEYADRIPWNKVSVYWVDERCVHPDHEQSNYRVARD
HCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
ELLHKVDATKFYRMKGEAQPEIAAQAYEELLRRQFGLSAGELPRFDCVLLGTGADGHTAS
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEE
LFPHSTGLEEREKLVIDQYVPSLHSTRLTLTLPVINNARDVIVMASGHAKHPVLAKALNL
ECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
LEPRLLPIQHIAPAAGRLSWVIDQAAAQPAA
HCCCCCCHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AHDVRLRTAHAATDYVVNHHGGYIMTLVSHLSLYITPDPDAMARQAAELIIERCAAAVA
CCCEEEEEHHHHHHEEEECCCCHHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHH
AHDAFTIALSGGSTPVPLFRLLAGQEYADRIPWNKVSVYWVDERCVHPDHEQSNYRVARD
HCCEEEEEECCCCCCHHHHHHHHCCHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
ELLHKVDATKFYRMKGEAQPEIAAQAYEELLRRQFGLSAGELPRFDCVLLGTGADGHTAS
HHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEE
LFPHSTGLEEREKLVIDQYVPSLHSTRLTLTLPVINNARDVIVMASGHAKHPVLAKALNL
ECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHHH
LEPRLLPIQHIAPAAGRLSWVIDQAAAQPAA
HCCCCCCHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]