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The map label for this gene is hdrA2 [H]

Identifier: 78356256

GI number: 78356256

Start: 1235877

End: 1237859

Strand: Direct

Name: hdrA2 [H]

Synonym: Dde_1209

Alternate gene names: 78356256

Gene position: 1235877-1237859 (Clockwise)

Preceding gene: 78356255

Following gene: 78356257

Centisome position: 33.13

GC content: 59.05

Gene sequence:

>1983_bases
ATGCGCATAGGCGTTTTCGTCTGCCACTGCGGGAGCAACATCGCCGCCACCGTCGACTGTCCTTCGGTTGCGGAGACGGC
ACGGATGTTCCCCGATGTGGTGTATTCCACCGATACCATGTACGCCTGTTCCGAACCGGGGCAGGAGGGTATAGTGCAGT
CCATTGCCGAGCATAATCTGGACGGCGTGGTGGTGGCTTCCTGTTCGCCCCGCATGCACGAACCCACCTTCCGGCGCGCG
CTGGAGCGTGCCGGGCTGAACCGCTACATGCTGGAAATGGCAAACATCCGCGAACATGTTTCGTGGATCGGCAAAGATAT
CAGACGCAACACGGTCAAGGCCTCGGACCTGATACGTATGGCCGTGGAAAAGCTGCGCCATAACGCTCCCCTTACGCCCA
AGCACTTCGAGGTGACCCGCAGAGCGCTGGTCATCGGCGGCGGCGTGGCGGGCATTCAGGCCGCGCTGGACTGTGCCGAT
GCAGGCATAGAAGTGATCATGGTGGAGCGCGAACCCAGCATAGGCGGCAAAATGGCCAAGCTGGACAAGACGTTTCCCAC
TGTGGACTGTTCGTCCTGCATTCTCGGTCCCAAGATGGTGGACGTGGCTCAGCATCCCAACATCACGCTGTACGCCGCTG
CCGAAGTGGACGAGATAAGCGGCTATGTGGGTAACTTTGAGGTCAAAATCCGCCGCAGGCAGACCTATGTTGACTGGTCC
AAATGTACCGGTTGCGGCCTGTGCATGGAAAAATGCCCCAGCAAAAAAAGCTTCGACCGCTTTAACGAAGGGGTGGCCAC
AACCACGGCCATCAATATACCCTTTCCGCAGGCCATTCCCAAAAAGGCTTCCATCGATCCCGACTACTGCCGCAAGCTGC
AGGGTAAAAAATGCGGCGTGTGTGAAAAGTTCTGCCCCATGGGCTGCATCGATTTCGAGCAGCAGGAGACCGTGGTCACC
GAAAAAGTGGGCGCCATTGTGGCGGCCACGGGGTACGATCTTTTTGACTACACGGTGTACGGCCAGTACGGCGCCGGAAA
ATACCCCGATGTCATCACATCGCTGCAGTACGAACGCCTGATGAATGCCTCCGGCCCCACCGGCGGCCACATCAAGCGTC
CTTCGGACGGCAGGGAACCCAAGGAAGTGGTTTTCATCCAGTGCGTGGGGTCGCGCGACCCCGCCGTGGGCAGACCCTAC
TGCAGCGGATTCTGCTGCATGTATACCGCCAAACAGGCGGTGCTGACCAAAGACCACATCCCCGATTCCAACTCCTATGT
TTTTTACATGGATATCCGCGCCCCCGGCAAAGGATACGACGAGTTTACGCGGCGCGCTCAGGAACAGTACGACGTGCAGT
ATGTGCGCGGCCGTGTTTCCATGATTTTCCCGCGCGGCGACAAGCTGGTGGTACGCGGTGCCGACACGCTGGCAGGCACG
CAGGTAGAGGTTGAAGCCGACCTTGTGGTGCTGGCCGTGGGGGTTGAGGCTGCTCATGGTGCGCCTCAGCTGGCCGAAAA
ACTGCGTATTTCCTACGATCAGTACGGCTTTTTCATGGAATCGCACCCCAAGCTGAAACCCGTGGAAACCAACACCGCCG
GTGTGTATCTGGCCGGAGCCTGTCAGGGCGCCAAGGATATTCCCACATCAGTGGGACAGGGCAGTGCCGCGGCTTCCAAG
GTGCTGACACTGTTCTCGCGTGAAATGCTTGAGTCGGACCCGCAGGTTGCCAAGGTTGATACGGCGCGCTGCGTGGGCTG
CATGAAGTGCGCCATGACATGTCCTTTCGGCGCGGTGCGTGAAACGCAGGACCGTGCAGGCAATGTGAAGGCGGACGTGC
TGGAAACCGTGTGTCAGGGCTGCGGCATTTGCACGGCAACCTGTCCGCACGGGGCCATTCAGCTGCAGCATTTCACAGAC
AACCAGATTCTTGCGGAGGTTAATGCCTTATGTCCGCCCCTGATGGACGAGAGCTTCGAATAG

Upstream 100 bases:

>100_bases
CGGTCTTGCACCGGCGGACGTGGGCCTTGCCAAGCTGGTTGTGGACCCCGGCCCCTGCCTCCGCGCGGCAGGCGTGCTCT
AACGCCAAGGAGATGAAACC

Downstream 100 bases:

>100_bases
TCGGCTTTCTTTGCAACTGGTGCTCCTACGGGGGGGCGGATACCGCGGGTGTGGGCCGTTTTGTGCAGCCCACCGACCTG
CGCATTGTCCGTGTTCCCTG

Product: heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MRIGVFVCHCGSNIAATVDCPSVAETARMFPDVVYSTDTMYACSEPGQEGIVQSIAEHNLDGVVVASCSPRMHEPTFRRA
LERAGLNRYMLEMANIREHVSWIGKDIRRNTVKASDLIRMAVEKLRHNAPLTPKHFEVTRRALVIGGGVAGIQAALDCAD
AGIEVIMVEREPSIGGKMAKLDKTFPTVDCSSCILGPKMVDVAQHPNITLYAAAEVDEISGYVGNFEVKIRRRQTYVDWS
KCTGCGLCMEKCPSKKSFDRFNEGVATTTAINIPFPQAIPKKASIDPDYCRKLQGKKCGVCEKFCPMGCIDFEQQETVVT
EKVGAIVAATGYDLFDYTVYGQYGAGKYPDVITSLQYERLMNASGPTGGHIKRPSDGREPKEVVFIQCVGSRDPAVGRPY
CSGFCCMYTAKQAVLTKDHIPDSNSYVFYMDIRAPGKGYDEFTRRAQEQYDVQYVRGRVSMIFPRGDKLVVRGADTLAGT
QVEVEADLVVLAVGVEAAHGAPQLAEKLRISYDQYGFFMESHPKLKPVETNTAGVYLAGACQGAKDIPTSVGQGSAAASK
VLTLFSREMLESDPQVAKVDTARCVGCMKCAMTCPFGAVRETQDRAGNVKADVLETVCQGCGICTATCPHGAIQLQHFTD
NQILAEVNALCPPLMDESFE

Sequences:

>Translated_660_residues
MRIGVFVCHCGSNIAATVDCPSVAETARMFPDVVYSTDTMYACSEPGQEGIVQSIAEHNLDGVVVASCSPRMHEPTFRRA
LERAGLNRYMLEMANIREHVSWIGKDIRRNTVKASDLIRMAVEKLRHNAPLTPKHFEVTRRALVIGGGVAGIQAALDCAD
AGIEVIMVEREPSIGGKMAKLDKTFPTVDCSSCILGPKMVDVAQHPNITLYAAAEVDEISGYVGNFEVKIRRRQTYVDWS
KCTGCGLCMEKCPSKKSFDRFNEGVATTTAINIPFPQAIPKKASIDPDYCRKLQGKKCGVCEKFCPMGCIDFEQQETVVT
EKVGAIVAATGYDLFDYTVYGQYGAGKYPDVITSLQYERLMNASGPTGGHIKRPSDGREPKEVVFIQCVGSRDPAVGRPY
CSGFCCMYTAKQAVLTKDHIPDSNSYVFYMDIRAPGKGYDEFTRRAQEQYDVQYVRGRVSMIFPRGDKLVVRGADTLAGT
QVEVEADLVVLAVGVEAAHGAPQLAEKLRISYDQYGFFMESHPKLKPVETNTAGVYLAGACQGAKDIPTSVGQGSAAASK
VLTLFSREMLESDPQVAKVDTARCVGCMKCAMTCPFGAVRETQDRAGNVKADVLETVCQGCGICTATCPHGAIQLQHFTD
NQILAEVNALCPPLMDESFE
>Mature_660_residues
MRIGVFVCHCGSNIAATVDCPSVAETARMFPDVVYSTDTMYACSEPGQEGIVQSIAEHNLDGVVVASCSPRMHEPTFRRA
LERAGLNRYMLEMANIREHVSWIGKDIRRNTVKASDLIRMAVEKLRHNAPLTPKHFEVTRRALVIGGGVAGIQAALDCAD
AGIEVIMVEREPSIGGKMAKLDKTFPTVDCSSCILGPKMVDVAQHPNITLYAAAEVDEISGYVGNFEVKIRRRQTYVDWS
KCTGCGLCMEKCPSKKSFDRFNEGVATTTAINIPFPQAIPKKASIDPDYCRKLQGKKCGVCEKFCPMGCIDFEQQETVVT
EKVGAIVAATGYDLFDYTVYGQYGAGKYPDVITSLQYERLMNASGPTGGHIKRPSDGREPKEVVFIQCVGSRDPAVGRPY
CSGFCCMYTAKQAVLTKDHIPDSNSYVFYMDIRAPGKGYDEFTRRAQEQYDVQYVRGRVSMIFPRGDKLVVRGADTLAGT
QVEVEADLVVLAVGVEAAHGAPQLAEKLRISYDQYGFFMESHPKLKPVETNTAGVYLAGACQGAKDIPTSVGQGSAAASK
VLTLFSREMLESDPQVAKVDTARCVGCMKCAMTCPFGAVRETQDRAGNVKADVLETVCQGCGICTATCPHGAIQLQHFTD
NQILAEVNALCPPLMDESFE

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 71924; Mature: 71924

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVFVCHCGSNIAATVDCPSVAETARMFPDVVYSTDTMYACSEPGQEGIVQSIAEHNL
CEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHCCCCCEEEECCCCHHHHHHHHHHCCC
DGVVVASCSPRMHEPTFRRALERAGLNRYMLEMANIREHVSWIGKDIRRNTVKASDLIRM
CEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVEKLRHNAPLTPKHFEVTRRALVIGGGVAGIQAALDCADAGIEVIMVEREPSIGGKMAK
HHHHHHCCCCCCCHHHHHHEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHH
LDKTFPTVDCSSCILGPKMVDVAQHPNITLYAAAEVDEISGYVGNFEVKIRRRQTYVDWS
HCCCCCCCCCHHHHCCCHHHHHHCCCCEEEEEECCHHHHCCCCCCEEEEEEECCCCCCHH
KCTGCGLCMEKCPSKKSFDRFNEGVATTTAINIPFPQAIPKKASIDPDYCRKLQGKKCGV
HCCCCHHHHHHCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCC
CEKFCPMGCIDFEQQETVVTEKVGAIVAATGYDLFDYTVYGQYGAGKYPDVITSLQYERL
HHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
MNASGPTGGHIKRPSDGREPKEVVFIQCVGSRDPAVGRPYCSGFCCMYTAKQAVLTKDHI
HCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCEEEEHHHHHHHHHHCCC
PDSNSYVFYMDIRAPGKGYDEFTRRAQEQYDVQYVRGRVSMIFPRGDKLVVRGADTLAGT
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCC
QVEVEADLVVLAVGVEAAHGAPQLAEKLRISYDQYGFFMESHPKLKPVETNTAGVYLAGA
EEEEECCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCEECCCCCCCCCCCCCCCEEEEEC
CQGAKDIPTSVGQGSAAASKVLTLFSREMLESDPQVAKVDTARCVGCMKCAMTCPFGAVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCHHH
ETQDRAGNVKADVLETVCQGCGICTATCPHGAIQLQHFTDNQILAEVNALCPPLMDESFE
HHHHHCCCCHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRIGVFVCHCGSNIAATVDCPSVAETARMFPDVVYSTDTMYACSEPGQEGIVQSIAEHNL
CEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHCCCCCEEEECCCCHHHHHHHHHHCCC
DGVVVASCSPRMHEPTFRRALERAGLNRYMLEMANIREHVSWIGKDIRRNTVKASDLIRM
CEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVEKLRHNAPLTPKHFEVTRRALVIGGGVAGIQAALDCADAGIEVIMVEREPSIGGKMAK
HHHHHHCCCCCCCHHHHHHEEEEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHH
LDKTFPTVDCSSCILGPKMVDVAQHPNITLYAAAEVDEISGYVGNFEVKIRRRQTYVDWS
HCCCCCCCCCHHHHCCCHHHHHHCCCCEEEEEECCHHHHCCCCCCEEEEEEECCCCCCHH
KCTGCGLCMEKCPSKKSFDRFNEGVATTTAINIPFPQAIPKKASIDPDYCRKLQGKKCGV
HCCCCHHHHHHCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCC
CEKFCPMGCIDFEQQETVVTEKVGAIVAATGYDLFDYTVYGQYGAGKYPDVITSLQYERL
HHHHCCCCCCCCCCHHHHHHHHHCEEEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
MNASGPTGGHIKRPSDGREPKEVVFIQCVGSRDPAVGRPYCSGFCCMYTAKQAVLTKDHI
HCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHCCEEEEHHHHHHHHHHCCC
PDSNSYVFYMDIRAPGKGYDEFTRRAQEQYDVQYVRGRVSMIFPRGDKLVVRGADTLAGT
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCEEEEECCCCCCCC
QVEVEADLVVLAVGVEAAHGAPQLAEKLRISYDQYGFFMESHPKLKPVETNTAGVYLAGA
EEEEECCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCEECCCCCCCCCCCCCCCEEEEEC
CQGAKDIPTSVGQGSAAASKVLTLFSREMLESDPQVAKVDTARCVGCMKCAMTCPFGAVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCCHHH
ETQDRAGNVKADVLETVCQGCGICTATCPHGAIQLQHFTDNQILAEVNALCPPLMDESFE
HHHHHCCCCHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]