Click here to switch to the map view.

The map label for this gene is murC

Identifier: 78356090

GI number: 78356090

Start: 1071436

End: 1072800

Strand: Direct

Name: murC

Synonym: Dde_1043

Alternate gene names: 78356090

Gene position: 1071436-1072800 (Clockwise)

Preceding gene: 78356089

Following gene: 78356091

Centisome position: 28.72

GC content: 58.53

Gene sequence:

>1365_bases
GTGATCGGAAAAGTTTTCAGAATTCATATGGTCGGCATAGGCGGCACGGGAATGTGCGGCATAGCCGAGGTGCTTCTCAA
TCTCGGTTTCGAAGTGCGCGGCTCCGACATGAATGACAGTCCTTCCGTGCGCCGTCTGCGCCGTCTGGGGGCAGATATTT
TCATCGGCCACGGTGCCGAAAACGTGACGGACGCACAGGTGCTGGTGAAATCGACAGCCGTGAGCATGGATAATCCGGAA
GTGCAGGCCGCGCAGGAAAAGGGCATTCCCATTATTCCGCGTGCCGAAATGCTGGCCGAACTGATGCGGCTGCGCAAGGG
CATAGCCATAGCAGGCACCCATGGCAAAACCACCACCACATCGCTTACGGCAGCCATTTTTGACGAAGCCGGTACCGACC
CCACCGTCATCATCGGGGGCAGACTGAATGCATACGGCTCCAATGCACGGCTGGGAGAAGGCGAATTTCTGCTGGCCGAA
GCTGACGAGTCCGATGGATCGTTCCTGTGTCTGTCGCCGGTGGTCAATGTTGTGACCAATGTGGATCTGGACCATGTGGA
CTTTTATCATGATCAGCAGGCCATCGACACAGCGTTCATCAACTTCATGAACAAGGTGCCTTTTTACGGCATGAACGTGG
TGTGCGGTGATGACGCCGGTGTGCGGCGCCTGCTTCCTCAGATCAAACGGCCTGTGCTTACCTACGGTTTCGGTCCCGAC
AATCAGTTGCGGGCCGAGACTGTAACCTGCGGCGAGACCAGCCGGTTCAGGGTGCTGCTGCATGGCGAAGATCTGGGCGA
AGTGAATCTTGTGCAGCCCGGCAGACACAATGTGCTTAACGCGCTGGCAGCCATAGGTGTGGGGCTGGAAACAGGCATCG
CGGCGGATGTATGTCTGCGCGGACTTGCCAACTTCCGCGGAGTGGGGCGCAGGTTTGAGCGCAAAGGCGAGCGCGGCGGA
GTGCTGGTCGTGGACGACTACGGGCACCATCCGGCGGAGATTGCGGCGACTCTTGCCACGGCGCGCACGTGCTACCCCGG
GCGCAGGCTTGTGGTGGCTTTTCAGCCGCACCGGTTCAGCCGGACCAAGGCGCTGTTCGGCGACTTCTGCAAAGCTTTTG
ACAACGTGGACAAGTTGCTGCTGACGGAAATTTATCCTGCGAGTGAGGCTCCCATACCGGGGGTCAGCGGTCAGAGTCTG
GCGCAGGGAATCCGGCAGGTAAGCAATACCGATGTGGATTACTTTCAGGATTTTGATGCCATGCGTGCCGCACTGCCGGA
AACGCTCCGGCCGGGTGATCTTTTTCTTACTCTTGGCGCCGGCAGCATCTGGACGGTGGGACAGTTTTATCTGGACGGGG
AATAA

Upstream 100 bases:

>100_bases
AGACCCGAGGCTGCAGCCGCCATAGTGAGCGGCGCAAAAGATTTGATAAGGAAAAAGCCCTTAAGGTCGCTGGTGCCTGA
GCGGGAAGGAGAATAACGGC

Downstream 100 bases:

>100_bases
CAGCTGTGAAGCCCGTGATACTTTCTGGTCCGGTGCTGAAAGAGCGCACCACACTCCGGCTGGGCGGACAGGCCCTTGCC
GAAGTGCGTCTGGACGACAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MIGKVFRIHMVGIGGTGMCGIAEVLLNLGFEVRGSDMNDSPSVRRLRRLGADIFIGHGAENVTDAQVLVKSTAVSMDNPE
VQAAQEKGIPIIPRAEMLAELMRLRKGIAIAGTHGKTTTTSLTAAIFDEAGTDPTVIIGGRLNAYGSNARLGEGEFLLAE
ADESDGSFLCLSPVVNVVTNVDLDHVDFYHDQQAIDTAFINFMNKVPFYGMNVVCGDDAGVRRLLPQIKRPVLTYGFGPD
NQLRAETVTCGETSRFRVLLHGEDLGEVNLVQPGRHNVLNALAAIGVGLETGIAADVCLRGLANFRGVGRRFERKGERGG
VLVVDDYGHHPAEIAATLATARTCYPGRRLVVAFQPHRFSRTKALFGDFCKAFDNVDKLLLTEIYPASEAPIPGVSGQSL
AQGIRQVSNTDVDYFQDFDAMRAALPETLRPGDLFLTLGAGSIWTVGQFYLDGE

Sequences:

>Translated_454_residues
MIGKVFRIHMVGIGGTGMCGIAEVLLNLGFEVRGSDMNDSPSVRRLRRLGADIFIGHGAENVTDAQVLVKSTAVSMDNPE
VQAAQEKGIPIIPRAEMLAELMRLRKGIAIAGTHGKTTTTSLTAAIFDEAGTDPTVIIGGRLNAYGSNARLGEGEFLLAE
ADESDGSFLCLSPVVNVVTNVDLDHVDFYHDQQAIDTAFINFMNKVPFYGMNVVCGDDAGVRRLLPQIKRPVLTYGFGPD
NQLRAETVTCGETSRFRVLLHGEDLGEVNLVQPGRHNVLNALAAIGVGLETGIAADVCLRGLANFRGVGRRFERKGERGG
VLVVDDYGHHPAEIAATLATARTCYPGRRLVVAFQPHRFSRTKALFGDFCKAFDNVDKLLLTEIYPASEAPIPGVSGQSL
AQGIRQVSNTDVDYFQDFDAMRAALPETLRPGDLFLTLGAGSIWTVGQFYLDGE
>Mature_454_residues
MIGKVFRIHMVGIGGTGMCGIAEVLLNLGFEVRGSDMNDSPSVRRLRRLGADIFIGHGAENVTDAQVLVKSTAVSMDNPE
VQAAQEKGIPIIPRAEMLAELMRLRKGIAIAGTHGKTTTTSLTAAIFDEAGTDPTVIIGGRLNAYGSNARLGEGEFLLAE
ADESDGSFLCLSPVVNVVTNVDLDHVDFYHDQQAIDTAFINFMNKVPFYGMNVVCGDDAGVRRLLPQIKRPVLTYGFGPD
NQLRAETVTCGETSRFRVLLHGEDLGEVNLVQPGRHNVLNALAAIGVGLETGIAADVCLRGLANFRGVGRRFERKGERGG
VLVVDDYGHHPAEIAATLATARTCYPGRRLVVAFQPHRFSRTKALFGDFCKAFDNVDKLLLTEIYPASEAPIPGVSGQSL
AQGIRQVSNTDVDYFQDFDAMRAALPETLRPGDLFLTLGAGSIWTVGQFYLDGE

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=456, Percent_Identity=48.6842105263158, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI1790680, Length=461, Percent_Identity=31.0195227765727, Blast_Score=191, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_DESDG (Q313Q2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387539.1
- ProteinModelPortal:   Q313Q2
- SMR:   Q313Q2
- STRING:   Q313Q2
- GeneID:   3755468
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1043
- NMPDR:   fig|207559.3.peg.872
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   DDES207559:DDE_1043-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 48952; Mature: 48952

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKVFRIHMVGIGGTGMCGIAEVLLNLGFEVRGSDMNDSPSVRRLRRLGADIFIGHGAE
CCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCEEEEECCCC
NVTDAQVLVKSTAVSMDNPEVQAAQEKGIPIIPRAEMLAELMRLRKGIAIAGTHGKTTTT
CCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCHH
SLTAAIFDEAGTDPTVIIGGRLNAYGSNARLGEGEFLLAEADESDGSFLCLSPVVNVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
VDLDHVDFYHDQQAIDTAFINFMNKVPFYGMNVVCGDDAGVRRLLPQIKRPVLTYGFGPD
CCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCC
NQLRAETVTCGETSRFRVLLHGEDLGEVNLVQPGRHNVLNALAAIGVGLETGIAADVCLR
CCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCHHCCHHHHHHHH
GLANFRGVGRRFERKGERGGVLVVDDYGHHPAEIAATLATARTCYPGRRLVVAFQPHRFS
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
RTKALFGDFCKAFDNVDKLLLTEIYPASEAPIPGVSGQSLAQGIRQVSNTDVDYFQDFDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MRAALPETLRPGDLFLTLGAGSIWTVGQFYLDGE
HHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCC
>Mature Secondary Structure
MIGKVFRIHMVGIGGTGMCGIAEVLLNLGFEVRGSDMNDSPSVRRLRRLGADIFIGHGAE
CCCCEEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHCCCEEEEECCCC
NVTDAQVLVKSTAVSMDNPEVQAAQEKGIPIIPRAEMLAELMRLRKGIAIAGTHGKTTTT
CCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCHH
SLTAAIFDEAGTDPTVIIGGRLNAYGSNARLGEGEFLLAEADESDGSFLCLSPVVNVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHC
VDLDHVDFYHDQQAIDTAFINFMNKVPFYGMNVVCGDDAGVRRLLPQIKRPVLTYGFGPD
CCCCHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCC
NQLRAETVTCGETSRFRVLLHGEDLGEVNLVQPGRHNVLNALAAIGVGLETGIAADVCLR
CCCEEEEEECCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCHHCCHHHHHHHH
GLANFRGVGRRFERKGERGGVLVVDDYGHHPAEIAATLATARTCYPGRRLVVAFQPHRFS
HHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCH
RTKALFGDFCKAFDNVDKLLLTEIYPASEAPIPGVSGQSLAQGIRQVSNTDVDYFQDFDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MRAALPETLRPGDLFLTLGAGSIWTVGQFYLDGE
HHHHCCCCCCCCCEEEEECCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA