Click here to switch to the map view.

The map label for this gene is msrA2 [H]

Identifier: 78356049

GI number: 78356049

Start: 1027024

End: 1027527

Strand: Reverse

Name: msrA2 [H]

Synonym: Dde_1002

Alternate gene names: 78356049

Gene position: 1027527-1027024 (Counterclockwise)

Preceding gene: 78356050

Following gene: 78356046

Centisome position: 27.55

GC content: 58.33

Gene sequence:

>504_bases
ATGGAAACAGTAACCGAACGTGCAGTACTGGCCGGAGGATGCTTCTGGGGAATGCAGGAACTCATCAGAAAGCTGCCCGG
CGTGCTTGCCACGCGCACCGGATACACCGGCGGCAACGTGCCGAACGCGACATACAGAAACCACCACGGCCATGCGGAAG
CCGTTGAAATCATCTTTGATCCTGCCGTGCTGTCTTACCGCAGTCTTCTGGAATACTTCTTCCGGATACATGACCCGACG
ACAGCGGACAGACAAGGCAATGATATCGGCAGTTCATACCGTTCGGCCGTTTTTCATACAACGCAGCAGCAGCGCGAAAC
AGCACTGGCAACCATCCGCGACATCAACGCCTCGGGCGTATGGCCTGCAGAGGTGGTGACACAGGTCGAACCCGTTTCCG
ATTTCTGGGAGGCCGAACCGGAGCATCAGGACTATCTGCAGCGTGTTCCGGGCGGATATACATGCCACTACGAACGCCGC
GGCTGGGTGCTGCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CTGTATCAATTCAGCCGCACTGCGTTTTATTCCGGCGGACAAGCTGGAAGAGGAAGGGTACGGCGAATATGCACACCTTT
TCACCACACGGGAGTAGCCC

Downstream 100 bases:

>100_bases
CCGCAGCTCAGGGCTCCGCAGGCGGCTTTGCGTCGCACAGCGCATACAGGCGTACGGTATTGCTGCGCGGAAATTCCTTA
TCAAGCAGCCTGCGGAGCAG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 167; Mature: 167

Protein sequence:

>167_residues
METVTERAVLAGGCFWGMQELIRKLPGVLATRTGYTGGNVPNATYRNHHGHAEAVEIIFDPAVLSYRSLLEYFFRIHDPT
TADRQGNDIGSSYRSAVFHTTQQQRETALATIRDINASGVWPAEVVTQVEPVSDFWEAEPEHQDYLQRVPGGYTCHYERR
GWVLPPR

Sequences:

>Translated_167_residues
METVTERAVLAGGCFWGMQELIRKLPGVLATRTGYTGGNVPNATYRNHHGHAEAVEIIFDPAVLSYRSLLEYFFRIHDPT
TADRQGNDIGSSYRSAVFHTTQQQRETALATIRDINASGVWPAEVVTQVEPVSDFWEAEPEHQDYLQRVPGGYTCHYERR
GWVLPPR
>Mature_167_residues
METVTERAVLAGGCFWGMQELIRKLPGVLATRTGYTGGNVPNATYRNHHGHAEAVEIIFDPAVLSYRSLLEYFFRIHDPT
TADRQGNDIGSSYRSAVFHTTQQQRETALATIRDINASGVWPAEVVTQVEPVSDFWEAEPEHQDYLQRVPGGYTCHYERR
GWVLPPR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=157, Percent_Identity=38.2165605095541, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI6912516, Length=157, Percent_Identity=38.2165605095541, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=38.8888888888889, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=43.421052631579, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=37.0629370629371, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=166, Percent_Identity=36.7469879518072, Blast_Score=106, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=32.6241134751773, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45553131, Length=133, Percent_Identity=32.3308270676692, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18876; Mature: 18876

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVTERAVLAGGCFWGMQELIRKLPGVLATRTGYTGGNVPNATYRNHHGHAEAVEIIFD
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEC
PAVLSYRSLLEYFFRIHDPTTADRQGNDIGSSYRSAVFHTTQQQRETALATIRDINASGV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WPAEVVTQVEPVSDFWEAEPEHQDYLQRVPGGYTCHYERRGWVLPPR
CHHHHHHHHCCHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
METVTERAVLAGGCFWGMQELIRKLPGVLATRTGYTGGNVPNATYRNHHGHAEAVEIIFD
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEC
PAVLSYRSLLEYFFRIHDPTTADRQGNDIGSSYRSAVFHTTQQQRETALATIRDINASGV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WPAEVVTQVEPVSDFWEAEPEHQDYLQRVPGGYTCHYERRGWVLPPR
CHHHHHHHHCCHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12835416 [H]