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The map label for this gene is lexA

Identifier: 78355940

GI number: 78355940

Start: 921657

End: 922280

Strand: Reverse

Name: lexA

Synonym: Dde_0893

Alternate gene names: 78355940

Gene position: 922280-921657 (Counterclockwise)

Preceding gene: 78355955

Following gene: 78355939

Centisome position: 24.72

GC content: 51.92

Gene sequence:

>624_bases
ATGGGCAGAAACAGAGAAGACGACATTACGCCGTTGCAGCAGGAAACACTTGATGAAATATGCCGGTACGTTTCAGCCAA
AGGGTATCCGCCGACGGTTAAGGAAATGAGCGAAACATTTGGAATCAGTCACGCCAGTGTGCATGACCGGATCAACCAGC
TGGTTCGCAAAGGTTATTTGAAAAGAGAGGAAGGTAAGGCTCGCGGTCTGACCGTGACCAAGCATCCTCAGACAAACGCG
GTCGCCCTTGTGGCGGTTCCGATTGTCGGCACGGTTGCAGCCGGTCATCCGATTTTCGCTCATGAGAACATCACGGGCGA
GGTTCTGGTGGAAGCATCCGTTGTCGGATCAGGCAAGTGCTTTGCCTTGTACACACAGGGCGACAGTATGATCGATGCCG
GAATAAACGACGGCGACCTGATCATTGTGAGGCGTCAGCCAATTGCCGAAGACGGTGATATCGTTATTGCGCTGCTTGAC
GATGAAGCCACGGTCAAAAGGCTGAAAATTGATAATGAGCTCATCGAGCTGGTCCCGGAGAATCCGAGGCTGAAACCGAT
CAGGGTCAAACCTGAAGATGAATTGAGGATTCTCGGCAAAGTGGTGGGCCGTAAACGAATTTGA

Upstream 100 bases:

>100_bases
TATTTATAAGATTTCTTGACCTGATGGATATAAGGTCGTATATTTATGTGTTATTCGGCCCAAACTGGGGCTCTCTGTCT
TTTAAAGGAAGGAGGACGCT

Downstream 100 bases:

>100_bases
GAGAACACTATGTAAGGACAGCTATAAGCTAAAAAAAACAGGAGAAATTAATGGCAACTTTAAACCTTCGCCGCTTTTCG
AAGCCGGAAATGCTCCGGAA

Product: SOS-response transcriptional repressor, LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MGRNREDDITPLQQETLDEICRYVSAKGYPPTVKEMSETFGISHASVHDRINQLVRKGYLKREEGKARGLTVTKHPQTNA
VALVAVPIVGTVAAGHPIFAHENITGEVLVEASVVGSGKCFALYTQGDSMIDAGINDGDLIIVRRQPIAEDGDIVIALLD
DEATVKRLKIDNELIELVPENPRLKPIRVKPEDELRILGKVVGRKRI

Sequences:

>Translated_207_residues
MGRNREDDITPLQQETLDEICRYVSAKGYPPTVKEMSETFGISHASVHDRINQLVRKGYLKREEGKARGLTVTKHPQTNA
VALVAVPIVGTVAAGHPIFAHENITGEVLVEASVVGSGKCFALYTQGDSMIDAGINDGDLIIVRRQPIAEDGDIVIALLD
DEATVKRLKIDNELIELVPENPRLKPIRVKPEDELRILGKVVGRKRI
>Mature_206_residues
GRNREDDITPLQQETLDEICRYVSAKGYPPTVKEMSETFGISHASVHDRINQLVRKGYLKREEGKARGLTVTKHPQTNAV
ALVAVPIVGTVAAGHPIFAHENITGEVLVEASVVGSGKCFALYTQGDSMIDAGINDGDLIIVRRQPIAEDGDIVIALLDD
EATVKRLKIDNELIELVPENPRLKPIRVKPEDELRILGKVVGRKRI

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=182, Percent_Identity=37.3626373626374, Blast_Score=116, Evalue=8e-28,
Organism=Escherichia coli, GI1787431, Length=77, Percent_Identity=48.0519480519481, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_DESDG (Q314F2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387389.1
- ProteinModelPortal:   Q314F2
- SMR:   Q314F2
- STRING:   Q314F2
- MEROPS:   S24.001
- GeneID:   3755621
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0893
- NMPDR:   fig|207559.3.peg.308
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   VGVWRGY
- ProtClustDB:   CLSK770545
- BioCyc:   DDES207559:DDE_0893-MONOMER
- GO:   GO:0005622
- GO:   GO:0006508
- HAMAP:   MF_00015
- InterPro:   IPR019885
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 22763; Mature: 22631

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00519 HTH_ASNC_1

Important sites: ACT_SITE 129-129 ACT_SITE 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNREDDITPLQQETLDEICRYVSAKGYPPTVKEMSETFGISHASVHDRINQLVRKGYL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
KREEGKARGLTVTKHPQTNAVALVAVPIVGTVAAGHPIFAHENITGEVLVEASVVGSGKC
CCCCCCCCCEEEEECCCCCEEEEEEECHHHHHCCCCCEEEECCCCEEEEEEEEEECCCCE
FALYTQGDSMIDAGINDGDLIIVRRQPIAEDGDIVIALLDDEATVKRLKIDNELIELVPE
EEEEECCCCEEECCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHCCHHHHHCCC
NPRLKPIRVKPEDELRILGKVVGRKRI
CCCEEEEEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GRNREDDITPLQQETLDEICRYVSAKGYPPTVKEMSETFGISHASVHDRINQLVRKGYL
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
KREEGKARGLTVTKHPQTNAVALVAVPIVGTVAAGHPIFAHENITGEVLVEASVVGSGKC
CCCCCCCCCEEEEECCCCCEEEEEEECHHHHHCCCCCEEEECCCCEEEEEEEEEECCCCE
FALYTQGDSMIDAGINDGDLIIVRRQPIAEDGDIVIALLDDEATVKRLKIDNELIELVPE
EEEEECCCCEEECCCCCCCEEEEECCCCCCCCCEEEEEECCCCHHHHHHHCCHHHHHCCC
NPRLKPIRVKPEDELRILGKVVGRKRI
CCCEEEEEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA