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The map label for this gene is msrAB [H]

Identifier: 78355751

GI number: 78355751

Start: 722977

End: 723552

Strand: Reverse

Name: msrAB [H]

Synonym: Dde_0704

Alternate gene names: 78355751

Gene position: 723552-722977 (Counterclockwise)

Preceding gene: 78355752

Following gene: 78355750

Centisome position: 19.4

GC content: 52.43

Gene sequence:

>576_bases
ATGAAACCAAACTATATACTTTTACTTGATTTTGCCGCTGTGTTCAGTTATTTGTCATTCGTTACCGGTTCCGCTGCGCA
GTCAGGTGCACATACACCGCAGAACACACCGGCCGTCAGCGGAAAAACATGGCACGGCAGCACCCTGCCGGACAAAGAAG
AACTGAAGGCAAAGCTGAGTCCTCTGCAGTTTGCAGTAACGCAGCATGACGAAACAGAACCGCCGTTTAAAAACGAATAC
TGGGATAACAAACAACCCGGAATTTACGTGGATATAGTTTCCGGAGAACCTTTGTTCAGTTCGACCCACAAGTACGATTC
CGGTACAGGGTGGCCCAGCTTTTACCAGCCGCTTGCAGCCGGACACATTGTGGAAAAAGAAGACCGCGGCCTGTTCTTCA
CCCGTACGGAAGTACGCGGCAGACTGGCCGATTCGCATCTGGGGCATGTTTTCAGCGACGGACCGCCTCCCACGGGCCTG
CGCTACTGCATCAACTCTGCAGCGCTCAGGTTCATACCGGCAGACGCACTCGACAAGGAGTGCTATGGAGAACTCCTGTA
CCTTTTCGACCAATGA

Upstream 100 bases:

>100_bases
TATAACATACTGCAAAAGTACTGTTGCACAGTCAGCATATGCGTCCGGCGGCACAGAATCAGCAGCCTCCATTGCACAAT
ACAACAGCAGGAGAAACAAA

Downstream 100 bases:

>100_bases
GACCGTTAGAAATTCACTTTTGATTTCGGGGCAGAAAATAATCAAAAGTGCAGTCGGGTTTCATTAGTCTTTACATGGCA
GAAAAGTGCAAAGATCCCAT

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKPNYILLLDFAAVFSYLSFVTGSAAQSGAHTPQNTPAVSGKTWHGSTLPDKEELKAKLSPLQFAVTQHDETEPPFKNEY
WDNKQPGIYVDIVSGEPLFSSTHKYDSGTGWPSFYQPLAAGHIVEKEDRGLFFTRTEVRGRLADSHLGHVFSDGPPPTGL
RYCINSAALRFIPADALDKECYGELLYLFDQ

Sequences:

>Translated_191_residues
MKPNYILLLDFAAVFSYLSFVTGSAAQSGAHTPQNTPAVSGKTWHGSTLPDKEELKAKLSPLQFAVTQHDETEPPFKNEY
WDNKQPGIYVDIVSGEPLFSSTHKYDSGTGWPSFYQPLAAGHIVEKEDRGLFFTRTEVRGRLADSHLGHVFSDGPPPTGL
RYCINSAALRFIPADALDKECYGELLYLFDQ
>Mature_191_residues
MKPNYILLLDFAAVFSYLSFVTGSAAQSGAHTPQNTPAVSGKTWHGSTLPDKEELKAKLSPLQFAVTQHDETEPPFKNEY
WDNKQPGIYVDIVSGEPLFSSTHKYDSGTGWPSFYQPLAAGHIVEKEDRGLFFTRTEVRGRLADSHLGHVFSDGPPPTGL
RYCINSAALRFIPADALDKECYGELLYLFDQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=125, Percent_Identity=49.6, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI301336162, Length=125, Percent_Identity=49.6, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI73089054, Length=125, Percent_Identity=49.6, Blast_Score=130, Evalue=7e-31,
Organism=Homo sapiens, GI37620216, Length=125, Percent_Identity=49.6, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI117606353, Length=129, Percent_Identity=47.2868217054264, Blast_Score=117, Evalue=5e-27,
Organism=Escherichia coli, GI1788077, Length=126, Percent_Identity=50.7936507936508, Blast_Score=131, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17553450, Length=124, Percent_Identity=40.3225806451613, Blast_Score=90, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI115532676, Length=124, Percent_Identity=40.3225806451613, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319816, Length=119, Percent_Identity=35.2941176470588, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45553335, Length=126, Percent_Identity=47.6190476190476, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356369, Length=126, Percent_Identity=47.6190476190476, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645799, Length=140, Percent_Identity=44.2857142857143, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221378664, Length=125, Percent_Identity=45.6, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221378662, Length=132, Percent_Identity=43.9393939393939, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645804, Length=137, Percent_Identity=43.7956204379562, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24645801, Length=151, Percent_Identity=41.0596026490066, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 21216; Mature: 21216

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNYILLLDFAAVFSYLSFVTGSAAQSGAHTPQNTPAVSGKTWHGSTLPDKEELKAKLS
CCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
PLQFAVTQHDETEPPFKNEYWDNKQPGIYVDIVSGEPLFSSTHKYDSGTGWPSFYQPLAA
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
GHIVEKEDRGLFFTRTEVRGRLADSHLGHVFSDGPPPTGLRYCINSAALRFIPADALDKE
CCCEECCCCCEEEEHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHEEECCHHCCHH
CYGELLYLFDQ
HHHHHHHEECC
>Mature Secondary Structure
MKPNYILLLDFAAVFSYLSFVTGSAAQSGAHTPQNTPAVSGKTWHGSTLPDKEELKAKLS
CCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHC
PLQFAVTQHDETEPPFKNEYWDNKQPGIYVDIVSGEPLFSSTHKYDSGTGWPSFYQPLAA
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
GHIVEKEDRGLFFTRTEVRGRLADSHLGHVFSDGPPPTGLRYCINSAALRFIPADALDKE
CCCEECCCCCEEEEHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHEEECCHHCCHH
CYGELLYLFDQ
HHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]