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The map label for this gene is gabT [H]

Identifier: 78355464

GI number: 78355464

Start: 414867

End: 416264

Strand: Reverse

Name: gabT [H]

Synonym: Dde_0417

Alternate gene names: 78355464

Gene position: 416264-414867 (Counterclockwise)

Preceding gene: 78355465

Following gene: 78355463

Centisome position: 11.16

GC content: 63.23

Gene sequence:

>1398_bases
ATGGCCCCGCAATTCTGCACAACCCCTGTGCCGGTACCGCCTGTACACACAGGCTACAGACATATCGCCACACCGCTGCC
GGTGCCGGAATCCCTTGCACTGCTGGAAGAAATGCGCGCCTGCGAACCCCGTTCGGTTGACTGCCAGCCGCCGCTGGTCT
GGCACGGCGCACAGGGCGTGCAGGTATACGACCCCTACGGCAACATCTGGCTTGATTTCACCTCGGGCGTGCTTGTGACC
AACATCGGCCACTGCCAGCCCGAAATGGTGCAGGCCGCCCGGGCAGAACTGGATGCACACCGTTTTTTTTCGTACTGCTT
TGCCACTGAACCGCGTATCCGGCTGGCCCGCAGACTGGTGGACATGCTGCAACCGCACATAGGTACGGCATGCAAAGCCT
TCATCATGAGCACCGGTTCCGAGGCAACGGAAAACGCCCTGAAACTCGCACGGGCACACGGCCGCAGCCTGCATCCCGAA
AAAAACGTCATCGTCAGCTTTGACCGCGCCTTTCACGGGCGCACGCTGGGCGCGCAGCAGATGGGCGGGTACCCCGCAGC
CAAAAGCTGGATAGGCAACCTTGATCCGGCATTTGTACAGGTGCCCTTTCCCGACGGACTGCACTGCACGGACACGTCAT
TCAACCTTTTCAGCCGGCGGCTGGCGCAGCTGGGCATCGCCCCGCAACGCGTGGCCGGTGTTATCATGGAAAGCTATCAG
GGCGGCGGGGCCAGTTTTGCCCCCGAAGAATACGTACGCGAACTGCGCAGTTTCTGCTCCCGCCACGAGGCACTGCTCAT
CATGGATGAAGTGCAGTCCGGATTCGGCCGTACCGGCAGGTTGTTCGCCTTTGAACATTACGGCATCGCGCCGGACCTTG
TCTGTCTGGGCAAGGCCGTAAGCGGCGGGCTGCCCGTTTCCGCCGTGGCAGGCAGGGCCGATGTGCTGGACATGCATGAC
CCCGGTTCCATGACCAGCACGCACGGCGGCAACCCCGTCGCCTGCGCATCGGCAGCGGCCAATCTGGAGGTGCTGCTGCG
TGACGGACTGACAGAAGCTGCCGCCGCCACAGGGCACATTCTGCGGCAGGGTCTGGAAGGTCTGCGGCAGCGGCATGCGG
GGCACATAATGGCCATACACGGCAGGGGCATGGTACAGGGCATCCACGTGGGCCGGACAGAACCGGACGGCACCCCCTGT
CCGGACGGGGCGCTGGCTTTTGACGTGACAGAGCGGGCATTCCGCAAGGGCCTGCTGCTGTTCGCTCCCGTGGGCACAGG
CGGCGCAACCATCAAAATATGCCCCCCGCTGATCATGCAGCCGGACGCCGTGCTCGAGGGGATCGACGTACTGACACAAT
GCTTTGATGAAGCCCTGTCCGCCGAGACAGACCGCTGA

Upstream 100 bases:

>100_bases
ATTGAAACAGAACCGGTGTGACCGGACGCAGAATCCCGCACCGCAGCACCACACTTTTTTTGAACAACGGACGGTACCGC
TGCCGTCCTCAGGAGAACAT

Downstream 100 bases:

>100_bases
GGAACATTCATGCATCCACAGACAGAAAACAGCGGCAGTCTGCTGTACCGCGGCTGCGGGCGTGCGGGTCTGCACTGGGC
CGTCACTCCGCAGAACGCGC

Product: aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MAPQFCTTPVPVPPVHTGYRHIATPLPVPESLALLEEMRACEPRSVDCQPPLVWHGAQGVQVYDPYGNIWLDFTSGVLVT
NIGHCQPEMVQAARAELDAHRFFSYCFATEPRIRLARRLVDMLQPHIGTACKAFIMSTGSEATENALKLARAHGRSLHPE
KNVIVSFDRAFHGRTLGAQQMGGYPAAKSWIGNLDPAFVQVPFPDGLHCTDTSFNLFSRRLAQLGIAPQRVAGVIMESYQ
GGGASFAPEEYVRELRSFCSRHEALLIMDEVQSGFGRTGRLFAFEHYGIAPDLVCLGKAVSGGLPVSAVAGRADVLDMHD
PGSMTSTHGGNPVACASAAANLEVLLRDGLTEAAAATGHILRQGLEGLRQRHAGHIMAIHGRGMVQGIHVGRTEPDGTPC
PDGALAFDVTERAFRKGLLLFAPVGTGGATIKICPPLIMQPDAVLEGIDVLTQCFDEALSAETDR

Sequences:

>Translated_465_residues
MAPQFCTTPVPVPPVHTGYRHIATPLPVPESLALLEEMRACEPRSVDCQPPLVWHGAQGVQVYDPYGNIWLDFTSGVLVT
NIGHCQPEMVQAARAELDAHRFFSYCFATEPRIRLARRLVDMLQPHIGTACKAFIMSTGSEATENALKLARAHGRSLHPE
KNVIVSFDRAFHGRTLGAQQMGGYPAAKSWIGNLDPAFVQVPFPDGLHCTDTSFNLFSRRLAQLGIAPQRVAGVIMESYQ
GGGASFAPEEYVRELRSFCSRHEALLIMDEVQSGFGRTGRLFAFEHYGIAPDLVCLGKAVSGGLPVSAVAGRADVLDMHD
PGSMTSTHGGNPVACASAAANLEVLLRDGLTEAAAATGHILRQGLEGLRQRHAGHIMAIHGRGMVQGIHVGRTEPDGTPC
PDGALAFDVTERAFRKGLLLFAPVGTGGATIKICPPLIMQPDAVLEGIDVLTQCFDEALSAETDR
>Mature_464_residues
APQFCTTPVPVPPVHTGYRHIATPLPVPESLALLEEMRACEPRSVDCQPPLVWHGAQGVQVYDPYGNIWLDFTSGVLVTN
IGHCQPEMVQAARAELDAHRFFSYCFATEPRIRLARRLVDMLQPHIGTACKAFIMSTGSEATENALKLARAHGRSLHPEK
NVIVSFDRAFHGRTLGAQQMGGYPAAKSWIGNLDPAFVQVPFPDGLHCTDTSFNLFSRRLAQLGIAPQRVAGVIMESYQG
GGASFAPEEYVRELRSFCSRHEALLIMDEVQSGFGRTGRLFAFEHYGIAPDLVCLGKAVSGGLPVSAVAGRADVLDMHDP
GSMTSTHGGNPVACASAAANLEVLLRDGLTEAAAATGHILRQGLEGLRQRHAGHIMAIHGRGMVQGIHVGRTEPDGTPCP
DGALAFDVTERAFRKGLLLFAPVGTGGATIKICPPLIMQPDAVLEGIDVLTQCFDEALSAETDR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=412, Percent_Identity=32.5242718446602, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=34.7692307692308, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI13994255, Length=450, Percent_Identity=26.8888888888889, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI37574042, Length=433, Percent_Identity=28.4064665127021, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=461, Percent_Identity=27.9826464208243, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=28.6069651741293, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI226442705, Length=433, Percent_Identity=27.7136258660508, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI188536080, Length=472, Percent_Identity=23.9406779661017, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI38679950, Length=472, Percent_Identity=23.9406779661017, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI38679946, Length=472, Percent_Identity=23.9406779661017, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1789016, Length=431, Percent_Identity=33.4106728538283, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1787560, Length=426, Percent_Identity=35.4460093896714, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789759, Length=324, Percent_Identity=36.1111111111111, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=31.1392405063291, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI145693181, Length=413, Percent_Identity=30.7506053268765, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786349, Length=363, Percent_Identity=29.7520661157025, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=29.3706293706294, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=28.6764705882353, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=432, Percent_Identity=29.8611111111111, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=314, Percent_Identity=29.6178343949045, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=25.9953161592506, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=471, Percent_Identity=23.5668789808917, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=416, Percent_Identity=31.7307692307692, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=410, Percent_Identity=27.3170731707317, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=348, Percent_Identity=26.7241379310345, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=421, Percent_Identity=24.4655581947743, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357415, Length=415, Percent_Identity=29.3975903614458, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574759, Length=441, Percent_Identity=26.530612244898, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=26.2443438914027, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI21356575, Length=428, Percent_Identity=29.6728971962617, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281366494, Length=412, Percent_Identity=24.2718446601942, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667139, Length=412, Percent_Identity=24.2718446601942, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667143, Length=412, Percent_Identity=24.2718446601942, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 49969; Mature: 49838

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPQFCTTPVPVPPVHTGYRHIATPLPVPESLALLEEMRACEPRSVDCQPPLVWHGAQGV
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCC
QVYDPYGNIWLDFTSGVLVTNIGHCQPEMVQAARAELDAHRFFSYCFATEPRIRLARRLV
EEECCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DMLQPHIGTACKAFIMSTGSEATENALKLARAHGRSLHPEKNVIVSFDRAFHGRTLGAQQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHH
MGGYPAAKSWIGNLDPAFVQVPFPDGLHCTDTSFNLFSRRLAQLGIAPQRVAGVIMESYQ
HCCCCHHHHHCCCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GGGASFAPEEYVRELRSFCSRHEALLIMDEVQSGFGRTGRLFAFEHYGIAPDLVCLGKAV
CCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
SGGLPVSAVAGRADVLDMHDPGSMTSTHGGNPVACASAAANLEVLLRDGLTEAAAATGHI
CCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCEEHHHHHCCHHHHHHCCCHHHHHHHHHH
LRQGLEGLRQRHAGHIMAIHGRGMVQGIHVGRTEPDGTPCPDGALAFDVTERAFRKGLLL
HHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCEEE
FAPVGTGGATIKICPPLIMQPDAVLEGIDVLTQCFDEALSAETDR
EEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
APQFCTTPVPVPPVHTGYRHIATPLPVPESLALLEEMRACEPRSVDCQPPLVWHGAQGV
CCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCC
QVYDPYGNIWLDFTSGVLVTNIGHCQPEMVQAARAELDAHRFFSYCFATEPRIRLARRLV
EEECCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
DMLQPHIGTACKAFIMSTGSEATENALKLARAHGRSLHPEKNVIVSFDRAFHGRTLGAQQ
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHH
MGGYPAAKSWIGNLDPAFVQVPFPDGLHCTDTSFNLFSRRLAQLGIAPQRVAGVIMESYQ
HCCCCHHHHHCCCCCCCEEEECCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCC
GGGASFAPEEYVRELRSFCSRHEALLIMDEVQSGFGRTGRLFAFEHYGIAPDLVCLGKAV
CCCCCCCHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
SGGLPVSAVAGRADVLDMHDPGSMTSTHGGNPVACASAAANLEVLLRDGLTEAAAATGHI
CCCCCHHHHCCCCCEEECCCCCCCCCCCCCCCEEHHHHHCCHHHHHHCCCHHHHHHHHHH
LRQGLEGLRQRHAGHIMAIHGRGMVQGIHVGRTEPDGTPCPDGALAFDVTERAFRKGLLL
HHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHCCEEE
FAPVGTGGATIKICPPLIMQPDAVLEGIDVLTQCFDEALSAETDR
EEECCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]