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The map label for this gene is ddlB [C]

Identifier: 78355465

GI number: 78355465

Start: 416344

End: 417579

Strand: Reverse

Name: ddlB [C]

Synonym: Dde_0418

Alternate gene names: 78355465

Gene position: 417579-416344 (Counterclockwise)

Preceding gene: 78355466

Following gene: 78355464

Centisome position: 11.19

GC content: 63.75

Gene sequence:

>1236_bases
ATGAAACCCTGCATACTGATAGTGGGCGCGGGCCCCAACCAGCTGCCCGCCATAGAAAAAGCCCTTGAGCGCGGATACGA
GGTGGCCGCGACGGACATGAATCCGCAGGCACCGGGGCTGCGCAAAGCCACATATGCAGGCATCGCCGACACACGCAGTC
CGCAACAGACCGTGGCGTTCGCCCTCAGCCTGCATGACCGCAGACCGCTGAACGGCGTGATGACCATCGCATCGGAAAGC
GCCGTCACCGTGGCCGCCGTGGCCGAAGCCCTCGGCCTGCCCGGCACAGGTACCGCGGCCGCCATGAAGGCCACCAACAA
AGTGCTGCGGCAGGAAGCTTTTGCCGCGGCGGGCGTACCCGCCCCTTTGTACGCACGGGCACAAAACGCCGCACAGGCAT
GCGCTGCCGCGCAAAGACTGGGCTGGCCCGTGGTGGTCAAACCGGCCGACAGTGCCGGAGCACGCGGCGTGCGCAAAGTG
CCGCACCCGGATGCCATGGACGATGCCGTGGCGGAGATACGCCGCATTTCGCAACGGCCTGAATTTCTGGTGGAAGAATT
TCTTACCGGCACCGAACACAGCATCGAAGGCATTGTACTGGACGGACGCATACACTGGACGGGTTTTTCTGACAGAAACT
ATGACCGCAAGGAACTGTATCCGCCCTATTTTCTGGAAGACGGAGACACCCTGCCGACCATTCTTGCCCCGCAGACTCTG
GCAGCTGTGCACCGCGCCGCGGACATGGCGGTACGCGCACTGGGTATCACCTGCGGCCCTGTCAAAGGCGATATTCTTGT
CGATGCCGCGGGGCCGCGTGTTCTGGAAATGGCTGCACGTCTTTCCGGTGATTATTTCTGCAGCGAAACCGTGCCGCTGC
ACAACGGAGTCCGCCTGCTGGACATGGTGATGGATCAGGCGCTGGGGCTGCCGGTGGATTCCGCACGCCTGATACCGGAC
CGCTGCAACGGCGTGGCCCTGCGGTATGTCTGGCCGCGTCCGGGCAGAGTGACCGCGGTGACAGGTCTGGAAGAGGCCCG
GAGCATGCCGGGCGTATACGCCGTGCGCTTTGAACCGCACTGGCAGAACCTGACCACCGGCACTGTGATTTCTCCCGCCA
CATGCATGGGAGAGCGTGTTGCCTCCGTCATGGCCACGGGCGATACACGGCAGCAGGCCGTCAGCCGCGCCGAAGCGGCC
GTGCGGTGCATCCGCATTGAAACAGAACCGGTGTGA

Upstream 100 bases:

>100_bases
GCGACCACATGCTGCACCGTATAGAACAGCTGCAACAGCAGCTTGCAGGCTACATCGACATTGCGGCAGCACTTGCCGCC
CCTGCCGGAGACCACACTCC

Downstream 100 bases:

>100_bases
CCGGACGCAGAATCCCGCACCGCAGCACCACACTTTTTTTGAACAACGGACGGTACCGCTGCCGTCCTCAGGAGAACATA
TGGCCCCGCAATTCTGCACA

Product: hypothetical protein

Products: pyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKPCILIVGAGPNQLPAIEKALERGYEVAATDMNPQAPGLRKATYAGIADTRSPQQTVAFALSLHDRRPLNGVMTIASES
AVTVAAVAEALGLPGTGTAAAMKATNKVLRQEAFAAAGVPAPLYARAQNAAQACAAAQRLGWPVVVKPADSAGARGVRKV
PHPDAMDDAVAEIRRISQRPEFLVEEFLTGTEHSIEGIVLDGRIHWTGFSDRNYDRKELYPPYFLEDGDTLPTILAPQTL
AAVHRAADMAVRALGITCGPVKGDILVDAAGPRVLEMAARLSGDYFCSETVPLHNGVRLLDMVMDQALGLPVDSARLIPD
RCNGVALRYVWPRPGRVTAVTGLEEARSMPGVYAVRFEPHWQNLTTGTVISPATCMGERVASVMATGDTRQQAVSRAEAA
VRCIRIETEPV

Sequences:

>Translated_411_residues
MKPCILIVGAGPNQLPAIEKALERGYEVAATDMNPQAPGLRKATYAGIADTRSPQQTVAFALSLHDRRPLNGVMTIASES
AVTVAAVAEALGLPGTGTAAAMKATNKVLRQEAFAAAGVPAPLYARAQNAAQACAAAQRLGWPVVVKPADSAGARGVRKV
PHPDAMDDAVAEIRRISQRPEFLVEEFLTGTEHSIEGIVLDGRIHWTGFSDRNYDRKELYPPYFLEDGDTLPTILAPQTL
AAVHRAADMAVRALGITCGPVKGDILVDAAGPRVLEMAARLSGDYFCSETVPLHNGVRLLDMVMDQALGLPVDSARLIPD
RCNGVALRYVWPRPGRVTAVTGLEEARSMPGVYAVRFEPHWQNLTTGTVISPATCMGERVASVMATGDTRQQAVSRAEAA
VRCIRIETEPV
>Mature_411_residues
MKPCILIVGAGPNQLPAIEKALERGYEVAATDMNPQAPGLRKATYAGIADTRSPQQTVAFALSLHDRRPLNGVMTIASES
AVTVAAVAEALGLPGTGTAAAMKATNKVLRQEAFAAAGVPAPLYARAQNAAQACAAAQRLGWPVVVKPADSAGARGVRKV
PHPDAMDDAVAEIRRISQRPEFLVEEFLTGTEHSIEGIVLDGRIHWTGFSDRNYDRKELYPPYFLEDGDTLPTILAPQTL
AAVHRAADMAVRALGITCGPVKGDILVDAAGPRVLEMAARLSGDYFCSETVPLHNGVRLLDMVMDQALGLPVDSARLIPD
RCNGVALRYVWPRPGRVTAVTGLEEARSMPGVYAVRFEPHWQNLTTGTVISPATCMGERVASVMATGDTRQQAVSRAEAA
VRCIRIETEPV

Specific function: Cell Wall Formation. [C]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI261245046, Length=262, Percent_Identity=28.2442748091603, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI148839342, Length=262, Percent_Identity=28.2442748091603, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005479 [H]

Pfam domain/function: PF02786 CPSase_L_D2 [H]

EC number: 1.1.1.27

Molecular weight: Translated: 43829; Mature: 43829

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50975 ATP_GRASP ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPCILIVGAGPNQLPAIEKALERGYEVAATDMNPQAPGLRKATYAGIADTRSPQQTVAF
CCCEEEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCCCCCHHHHHEE
ALSLHDRRPLNGVMTIASESAVTVAAVAEALGLPGTGTAAAMKATNKVLRQEAFAAAGVP
EEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
APLYARAQNAAQACAAAQRLGWPVVVKPADSAGARGVRKVPHPDAMDDAVAEIRRISQRP
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCH
EFLVEEFLTGTEHSIEGIVLDGRIHWTGFSDRNYDRKELYPPYFLEDGDTLPTILAPQTL
HHHHHHHHCCCCCCCCEEEEECEEEEECCCCCCCCHHHCCCCEEECCCCCCCHHCCHHHH
AAVHRAADMAVRALGITCGPVKGDILVDAAGPRVLEMAARLSGDYFCSETVPLHNGVRLL
HHHHHHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCHHHH
DMVMDQALGLPVDSARLIPDRCNGVALRYVWPRPGRVTAVTGLEEARSMPGVYAVRFEPH
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHCCCCEEEEEECCC
WQNLTTGTVISPATCMGERVASVMATGDTRQQAVSRAEAAVRCIRIETEPV
CCCCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEECCCC
>Mature Secondary Structure
MKPCILIVGAGPNQLPAIEKALERGYEVAATDMNPQAPGLRKATYAGIADTRSPQQTVAF
CCCEEEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCCCCCCCHHHHHEE
ALSLHDRRPLNGVMTIASESAVTVAAVAEALGLPGTGTAAAMKATNKVLRQEAFAAAGVP
EEECCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
APLYARAQNAAQACAAAQRLGWPVVVKPADSAGARGVRKVPHPDAMDDAVAEIRRISQRP
CHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCH
EFLVEEFLTGTEHSIEGIVLDGRIHWTGFSDRNYDRKELYPPYFLEDGDTLPTILAPQTL
HHHHHHHHCCCCCCCCEEEEECEEEEECCCCCCCCHHHCCCCEEECCCCCCCHHCCHHHH
AAVHRAADMAVRALGITCGPVKGDILVDAAGPRVLEMAARLSGDYFCSETVPLHNGVRLL
HHHHHHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCHHHH
DMVMDQALGLPVDSARLIPDRCNGVALRYVWPRPGRVTAVTGLEEARSMPGVYAVRFEPH
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHCCCCEEEEEECCC
WQNLTTGTVISPATCMGERVASVMATGDTRQQAVSRAEAAVRCIRIETEPV
CCCCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-lactate; NAD+

Specific reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]