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The map label for this gene is purH [H]

Identifier: 78355424

GI number: 78355424

Start: 372342

End: 373100

Strand: Reverse

Name: purH [H]

Synonym: Dde_0377

Alternate gene names: 78355424

Gene position: 373100-372342 (Counterclockwise)

Preceding gene: 78355439

Following gene: 78355423

Centisome position: 10.0

GC content: 60.08

Gene sequence:

>759_bases
ATGCCGCGTACGGCCTTTTGGCAAAGGCGGCAGGGCAAGGCCGTGTCAGCCTTTCGACGGCACCGGCACAAACACGTTGC
CCCTGCCGTCAGGTGCGGATACTGTTGCCAAGGGCCGATGTTTCTGGCACTGCCTCAAAAAACCGAATACGGAGGCGATA
TGGATTTTCTGCCCATACGGCGAGCGCTGCTGAGCGTGACCGACAAAAGCGGGCTTGTGGAATTTGCCACGTTTCTCACA
CAGAACGGCGTGGAACTGGTTTCCACCGGCGGCACCCAGCGGACGCTGACCGAAGCGGGACTGGACGTCACCCCTGTGAG
CAAGGTCACCGGCTTTCCTGAAATAATGGGCGGCCGCGTCAAGACCCTGCACCCGCACATCCACGGCGGCATTCTGGCCG
ACAAGGACAACCCCGAACACCTTGCCACTCTCAAGGAGCTGGGAATCCGCACGTTCGACCTCATCTGTGTCAACCTTTAC
AACTTTGCGGATGCCGCCGCCCGCGGTCTTGACCTGCGCGGTGCCGTGGAGGAAGTGGACATCGGCGGGCCGTGCATGCT
GCGCGCCACCGCCAAAAACTTCCATTCCATGCTTGTACTGCCCGACCCTGCCGATTATCAGGCAGCTATGCAGGAAATGC
GCGACAACGACATGCGGGTGGGACTTGCCATGCGTCAGGCCATGGCTGTCAAAACATTCCGCGCCACTTCCGCCTATGAC
GGCATGATTGCCGACTATCTGGGCAGCAAAACGGCTTAA

Upstream 100 bases:

>100_bases
AGAGGCTTCATCAAAATTGAAGAGATCCATGCCGTCTCAAAAAGCAAAAAACAGACCATCGCACCGCAGCCGGACGCAAA
AGCCCGCGCAAGGCCGGTAA

Downstream 100 bases:

>100_bases
ACGCCGGACGGAGACCCGCCATAGCAACCAAGGTTCTCGGCAATACCCAGGGGCTGAAGCCCAGTCAGGTCAAGGCGCTT
TCGCGTCTGTACACACGCCG

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPRTAFWQRRQGKAVSAFRRHRHKHVAPAVRCGYCCQGPMFLALPQKTEYGGDMDFLPIRRALLSVTDKSGLVEFATFLT
QNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLY
NFADAAARGLDLRGAVEEVDIGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDNDMRVGLAMRQAMAVKTFRATSAYD
GMIADYLGSKTA

Sequences:

>Translated_252_residues
MPRTAFWQRRQGKAVSAFRRHRHKHVAPAVRCGYCCQGPMFLALPQKTEYGGDMDFLPIRRALLSVTDKSGLVEFATFLT
QNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLY
NFADAAARGLDLRGAVEEVDIGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDNDMRVGLAMRQAMAVKTFRATSAYD
GMIADYLGSKTA
>Mature_251_residues
PRTAFWQRRQGKAVSAFRRHRHKHVAPAVRCGYCCQGPMFLALPQKTEYGGDMDFLPIRRALLSVTDKSGLVEFATFLTQ
NGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRVKTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYN
FADAAARGLDLRGAVEEVDIGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDNDMRVGLAMRQAMAVKTFRATSAYDG
MIADYLGSKTA

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=192, Percent_Identity=45.3125, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1790439, Length=193, Percent_Identity=53.3678756476684, Blast_Score=200, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71985564, Length=187, Percent_Identity=39.572192513369, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323768, Length=190, Percent_Identity=42.6315789473684, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323056, Length=189, Percent_Identity=41.7989417989418, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24649832, Length=187, Percent_Identity=42.7807486631016, Blast_Score=144, Evalue=4e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 27628; Mature: 27497

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTAFWQRRQGKAVSAFRRHRHKHVAPAVRCGYCCQGPMFLALPQKTEYGGDMDFLPIR
CCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHH
RALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRV
HHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCCCHHHHCCCHHHHCCCE
KTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNFADAAARGLDLRGAVEEVD
EEECCCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
IGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDNDMRVGLAMRQAMAVKTFRATSAYD
CCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHC
GMIADYLGSKTA
CHHHHHHCCCCC
>Mature Secondary Structure 
PRTAFWQRRQGKAVSAFRRHRHKHVAPAVRCGYCCQGPMFLALPQKTEYGGDMDFLPIR
CCCHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHH
RALLSVTDKSGLVEFATFLTQNGVELVSTGGTQRTLTEAGLDVTPVSKVTGFPEIMGGRV
HHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHCCCCCCCHHHHCCCHHHHCCCE
KTLHPHIHGGILADKDNPEHLATLKELGIRTFDLICVNLYNFADAAARGLDLRGAVEEVD
EEECCCCCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCC
IGGPCMLRATAKNFHSMLVLPDPADYQAAMQEMRDNDMRVGLAMRQAMAVKTFRATSAYD
CCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHC
GMIADYLGSKTA
CHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA