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The map label for this gene is appC [H]

Identifier: 78355320

GI number: 78355320

Start: 263801

End: 264721

Strand: Reverse

Name: appC [H]

Synonym: Dde_0273

Alternate gene names: 78355320

Gene position: 264721-263801 (Counterclockwise)

Preceding gene: 78355321

Following gene: 78355319

Centisome position: 7.1

GC content: 56.89

Gene sequence:

>921_bases
ATGCTGGCCAGACTGAAACAATTGCGCGATTCGGATTTTCTGTATCACTTCGTACGCGACAAAATAGCGCTGACCAGCTT
CATCGTGGTTGCCGTGCTGGTGCTTTCAGCCGCGTTTGCGCCGCTGCTCACCTCGCACAACCCGTATGACGGTGCCAGCA
TCGACGTAATGAACGCCGAAACGCCTCCCTCGTGGAAAGCCGGCGGTTCCGCCGAATTTCTGCTGGGTACCGATGCGCAG
GGACGCGACATGTTTTCCGCCATCCTGTACGGCATGCGCGTGTCCATTCTTATCGGCATGGGCGCCGTGGCGCTGCAGGC
TTCGCTGGGCATTCTCATCGGGCTTATGGCCGGATACGGCTCCAAGCGGCTGGACAGCCTGCTGATGCGTGTTACCGACG
TACAGCTTTCATTTTCTTCATACATGGTTGCCATCTTCTTCGGTGCGGTCATTCAGGCAGCTTTCGGCGTGGCCAAATTT
GCCGAAATCGCCGTACCGTTCATCGTGCTGGTCATCGGTCTTTCCGAATGGCCCCAGTATGCCCGTACCGTGCGTGCATC
GGTACTGGCCGAAAAGAAAAAAGAATATGTAGAAGCGGCACGCGTCATCGGGTTGAAACCGCGGCGCATCATGTGGCGGC
ATATCCTGCCAAACACGCTTACTCCGGTGCTGGTTATTTCCACCGTGCAGGTGGCAAACGCCATCATGAGCGAAGCAGCC
CTGTCTTTTCTGGGACTGGGCATGCCCGTTAACCAGCCCTCGCTCGGTTCGCTCATCAAGTCAGGCTTCGAGTACATTTT
CAGCGGCAGCTGGTGGATCACCCTGTTCCCCGGTGTGGTGCTGGTGCTGCTTGTGCTCACCATAAACCTGCTGGGCGACT
GGCTGCGGGATTATCTCAATCCCAAACTCTACAAGGACTAG

Upstream 100 bases:

>100_bases
CATGGTTTTCGTGGGGGCTCTTTTCGTGGTGGTGAATACGGTGGTGGACATCATATACGGACTGGTGAACCCCATGGTCC
GCGTCGCGGGGAGGAAATAG

Downstream 100 bases:

>100_bases
ACCATGAGCACGCTGCTTGAAGTCAAAAACATGACCGTCCAGTTCGCCATGCGCGACACGCAGCTCACAGCGGTCGACAA
TGTTTCGTTTTCCCTGAACA

Product: oligopeptide/dipeptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLARLKQLRDSDFLYHFVRDKIALTSFIVVAVLVLSAAFAPLLTSHNPYDGASIDVMNAETPPSWKAGGSAEFLLGTDAQ
GRDMFSAILYGMRVSILIGMGAVALQASLGILIGLMAGYGSKRLDSLLMRVTDVQLSFSSYMVAIFFGAVIQAAFGVAKF
AEIAVPFIVLVIGLSEWPQYARTVRASVLAEKKKEYVEAARVIGLKPRRIMWRHILPNTLTPVLVISTVQVANAIMSEAA
LSFLGLGMPVNQPSLGSLIKSGFEYIFSGSWWITLFPGVVLVLLVLTINLLGDWLRDYLNPKLYKD

Sequences:

>Translated_306_residues
MLARLKQLRDSDFLYHFVRDKIALTSFIVVAVLVLSAAFAPLLTSHNPYDGASIDVMNAETPPSWKAGGSAEFLLGTDAQ
GRDMFSAILYGMRVSILIGMGAVALQASLGILIGLMAGYGSKRLDSLLMRVTDVQLSFSSYMVAIFFGAVIQAAFGVAKF
AEIAVPFIVLVIGLSEWPQYARTVRASVLAEKKKEYVEAARVIGLKPRRIMWRHILPNTLTPVLVISTVQVANAIMSEAA
LSFLGLGMPVNQPSLGSLIKSGFEYIFSGSWWITLFPGVVLVLLVLTINLLGDWLRDYLNPKLYKD
>Mature_306_residues
MLARLKQLRDSDFLYHFVRDKIALTSFIVVAVLVLSAAFAPLLTSHNPYDGASIDVMNAETPPSWKAGGSAEFLLGTDAQ
GRDMFSAILYGMRVSILIGMGAVALQASLGILIGLMAGYGSKRLDSLLMRVTDVQLSFSSYMVAIFFGAVIQAAFGVAKF
AEIAVPFIVLVIGLSEWPQYARTVRASVLAEKKKEYVEAARVIGLKPRRIMWRHILPNTLTPVLVISTVQVANAIMSEAA
LSFLGLGMPVNQPSLGSLIKSGFEYIFSGSWWITLFPGVVLVLLVLTINLLGDWLRDYLNPKLYKD

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=295, Percent_Identity=36.6101694915254, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1787054, Length=305, Percent_Identity=33.4426229508197, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787760, Length=301, Percent_Identity=32.2259136212625, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789889, Length=260, Percent_Identity=31.9230769230769, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787498, Length=287, Percent_Identity=33.7979094076655, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787549, Length=236, Percent_Identity=32.2033898305085, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788505, Length=246, Percent_Identity=28.8617886178862, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33437; Mature: 33437

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure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CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]