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The map label for this gene is moeA [C]

Identifier: 78355277

GI number: 78355277

Start: 215881

End: 217146

Strand: Reverse

Name: moeA [C]

Synonym: Dde_0230

Alternate gene names: 78355277

Gene position: 217146-215881 (Counterclockwise)

Preceding gene: 78355278

Following gene: 78355276

Centisome position: 5.82

GC content: 65.4

Gene sequence:

>1266_bases
ATGAAAACAGGTTTTTTCAACGTGCTGGATGTGCAGAGCTTTATAGACCGCCTGCGCGGATTCGACCATCTGCCCGCGCT
GCAGACCCCGCTTGACGAAGCCCACGGCTGCGTGTTGGCCGCGCCTGTGGTTTCGCCCGAAGACCTGCCGGCGGCAGACC
GTTCGTGCATGGACGGCTATGCCGTGCGCGCCGCGGACCTTTTCGGCACCACCGAAGGCAACCCCGCCTACCTTGAATGT
ACGGGCACCGTCAGCATCGAACGCCCCGCAGATTTCAGCATAGCCGCCGGAGAATGCGCTGCCATAGTCACCGGCGCGCT
GCTGCCCCGGGGAGCCGATGCCGTGGTGATGGTGGAGCACACGCAGGAAATGGGCGCGGGCACCGTTGAAATACGCAAAT
CCGTGGCGCCGCACGAACACGTCATGCTGCGGGGCGAAGATGCCGTGCAGGGGCAACCGGCGCTGACCGCCGGTACGCTG
CTGCGCGCGCAGGAAATAGGCCTGCTCGCCGCGCTGGGAGTGCAGACGGTGCATGTGCACCGCCGGCCGCGCGTGGGCAT
TTTTTCCACCGGAGACGAAGTTATTCCGGCCCATGCCACGCCGCGCCCCGGACAGGTGCGCGATGTGAACAGCCACGCGC
TGCAGGCCATGGCCCGTGCCGCAGGAGCCGCCGTAACCTGTTACGGCATTGTGCCGGACGACGAAAAGGCACTGACCGCC
ATGCTGGCGCGCACCACGGCGGAAAACGACATGGTCCTTCTTTCCGGCGGCAGTTCTGTGGGCACCCGCGACCTGACCAT
GGCCGCCCTTGATTCGCTGGACGGAGCCGCTGTCATCAACCACGGCGTTGCCATAAGCCCCGGCAAGCCGCTCATACTGG
CCTCTGCAGACGGCAAAGGTCAGCGCTGCGCCGTCTGGGGGCTGCCCGGGCAGGTCACCTCGGCGCAGGTTGTCATGTTT
GTACTGGGCATCCCTTTTGTTCACTGGCTGGCGGGCAGACGCACGCCGTTTGACCAGTCGGCATGGGCTTCGCGGCGGGC
GGTGCTGGCGCGCAACATTGCTTCCAGACAGGGGCGCGAAGACTACATCCGCGTACGGCTGCATGCAGAAGAGGACGGGC
GGGTCACGGCCACTCCGGTCACAGGCAAGTCCGGACTGCTGCGCACCATGCTGCAGGCACACGGTGTCGTGCGCATACCG
GCACACAGCGAAGGGCTGGACAGCGGTACGCAAGTGGATGTGCTGCTTTTCGGAGGCGGATACTGA

Upstream 100 bases:

>100_bases
GTCTGCCGTCTGTTTTTTTGTACAGCGTCACCTGTGTGCCCTGCGGGTATACCGGCAGCCCGCGGCATGGAAAATCCTCC
CAAGCCATGCGAGTGAAACT

Downstream 100 bases:

>100_bases
TGCGTATACTCATGCTGGGCGACGTGGTGGGCAAGCCGGGCAGACTGGCCCTGCGCGAACATCTGCCGCCGCTGATCAGC
CGGTGCGGTGCAGACTTCAC

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKTGFFNVLDVQSFIDRLRGFDHLPALQTPLDEAHGCVLAAPVVSPEDLPAADRSCMDGYAVRAADLFGTTEGNPAYLEC
TGTVSIERPADFSIAAGECAAIVTGALLPRGADAVVMVEHTQEMGAGTVEIRKSVAPHEHVMLRGEDAVQGQPALTAGTL
LRAQEIGLLAALGVQTVHVHRRPRVGIFSTGDEVIPAHATPRPGQVRDVNSHALQAMARAAGAAVTCYGIVPDDEKALTA
MLARTTAENDMVLLSGGSSVGTRDLTMAALDSLDGAAVINHGVAISPGKPLILASADGKGQRCAVWGLPGQVTSAQVVMF
VLGIPFVHWLAGRRTPFDQSAWASRRAVLARNIASRQGREDYIRVRLHAEEDGRVTATPVTGKSGLLRTMLQAHGVVRIP
AHSEGLDSGTQVDVLLFGGGY

Sequences:

>Translated_421_residues
MKTGFFNVLDVQSFIDRLRGFDHLPALQTPLDEAHGCVLAAPVVSPEDLPAADRSCMDGYAVRAADLFGTTEGNPAYLEC
TGTVSIERPADFSIAAGECAAIVTGALLPRGADAVVMVEHTQEMGAGTVEIRKSVAPHEHVMLRGEDAVQGQPALTAGTL
LRAQEIGLLAALGVQTVHVHRRPRVGIFSTGDEVIPAHATPRPGQVRDVNSHALQAMARAAGAAVTCYGIVPDDEKALTA
MLARTTAENDMVLLSGGSSVGTRDLTMAALDSLDGAAVINHGVAISPGKPLILASADGKGQRCAVWGLPGQVTSAQVVMF
VLGIPFVHWLAGRRTPFDQSAWASRRAVLARNIASRQGREDYIRVRLHAEEDGRVTATPVTGKSGLLRTMLQAHGVVRIP
AHSEGLDSGTQVDVLLFGGGY
>Mature_421_residues
MKTGFFNVLDVQSFIDRLRGFDHLPALQTPLDEAHGCVLAAPVVSPEDLPAADRSCMDGYAVRAADLFGTTEGNPAYLEC
TGTVSIERPADFSIAAGECAAIVTGALLPRGADAVVMVEHTQEMGAGTVEIRKSVAPHEHVMLRGEDAVQGQPALTAGTL
LRAQEIGLLAALGVQTVHVHRRPRVGIFSTGDEVIPAHATPRPGQVRDVNSHALQAMARAAGAAVTCYGIVPDDEKALTA
MLARTTAENDMVLLSGGSSVGTRDLTMAALDSLDGAAVINHGVAISPGKPLILASADGKGQRCAVWGLPGQVTSAQVVMF
VLGIPFVHWLAGRRTPFDQSAWASRRAVLARNIASRQGREDYIRVRLHAEEDGRVTATPVTGKSGLLRTMLQAHGVVRIP
AHSEGLDSGTQVDVLLFGGGY

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=405, Percent_Identity=30.8641975308642, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI66932975, Length=405, Percent_Identity=30.8641975308642, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI1787049, Length=356, Percent_Identity=36.7977528089888, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=310, Percent_Identity=30.9677419354839, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17562606, Length=160, Percent_Identity=28.75, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44229; Mature: 44229

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGFFNVLDVQSFIDRLRGFDHLPALQTPLDEAHGCVLAAPVVSPEDLPAADRSCMDGY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCHHHHCCC
AVRAADLFGTTEGNPAYLECTGTVSIERPADFSIAAGECAAIVTGALLPRGADAVVMVEH
EEEEEHHCCCCCCCCEEEEEEEEEEECCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEEE
TQEMGAGTVEIRKSVAPHEHVMLRGEDAVQGQPALTAGTLLRAQEIGLLAALGVQTVHVH
CHHCCCCEEEHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHCCEEEECCEEEEEEE
RRPRVGIFSTGDEVIPAHATPRPGQVRDVNSHALQAMARAAGAAVTCYGIVPDDEKALTA
CCCCEEEEECCCCEEECCCCCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHHHH
MLARTTAENDMVLLSGGSSVGTRDLTMAALDSLDGAAVINHGVAISPGKPLILASADGKG
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCEEECCCCCEEEEECCCCC
QRCAVWGLPGQVTSAQVVMFVLGIPFVHWLAGRRTPFDQSAWASRRAVLARNIASRQGRE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
DYIRVRLHAEEDGRVTATPVTGKSGLLRTMLQAHGVVRIPAHSEGLDSGTQVDVLLFGGG
CEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEECCC
Y
C
>Mature Secondary Structure
MKTGFFNVLDVQSFIDRLRGFDHLPALQTPLDEAHGCVLAAPVVSPEDLPAADRSCMDGY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCEEEEECCCCCCCCCCCCHHHHCCC
AVRAADLFGTTEGNPAYLECTGTVSIERPADFSIAAGECAAIVTGALLPRGADAVVMVEH
EEEEEHHCCCCCCCCEEEEEEEEEEECCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEEE
TQEMGAGTVEIRKSVAPHEHVMLRGEDAVQGQPALTAGTLLRAQEIGLLAALGVQTVHVH
CHHCCCCEEEHHHCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHCCEEEECCEEEEEEE
RRPRVGIFSTGDEVIPAHATPRPGQVRDVNSHALQAMARAAGAAVTCYGIVPDDEKALTA
CCCCEEEEECCCCEEECCCCCCCCCEEECHHHHHHHHHHHCCCEEEEEEECCCCHHHHHH
MLARTTAENDMVLLSGGSSVGTRDLTMAALDSLDGAAVINHGVAISPGKPLILASADGKG
HHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCEEEECCEEECCCCCEEEEECCCCC
QRCAVWGLPGQVTSAQVVMFVLGIPFVHWLAGRRTPFDQSAWASRRAVLARNIASRQGRE
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
DYIRVRLHAEEDGRVTATPVTGKSGLLRTMLQAHGVVRIPAHSEGLDSGTQVDVLLFGGG
CEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEEEECCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]