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The map label for this gene is ppiB [H]

Identifier: 78355256

GI number: 78355256

Start: 188690

End: 189199

Strand: Reverse

Name: ppiB [H]

Synonym: Dde_0209

Alternate gene names: 78355256

Gene position: 189199-188690 (Counterclockwise)

Preceding gene: 78355258

Following gene: 78355255

Centisome position: 5.07

GC content: 53.53

Gene sequence:

>510_bases
ATGAGCAATCCCATGGTGCTGCTGGAAACATCTTCCGGCGATATGCTGATAGAACTCTATGCCGACAAGGCCCCTGAAAC
CGTGAAAAACTTTCTGCGCTATGTGGAGGAAGGTTTTTACGAAAACACCATCTTCCACCGTGTCATTAAAAATTTCATGA
TTCAGGGCGGTGGCGTTACCATGCGCATGGAAGACAAAAAAGGCCACGAACCCATTGCCAACGAGGCAGGCAACGGCCTT
AAAAACGTCCGCGGCACCATTGCCATGGCGCGCACCGCAGCCCCCCACAGCGCGACTTCACAGTTTTTCATCAACCTTGT
GGACAACCCCGACCTTGACCATCAGGACGATTCCGATGCCGGATTCGGCTACTGCGTTTTCGGTGCCGTGGTTGAAGGCA
TGGACGTGGTTGATGCCATAGGCAAGCTGAAAACCAAACCCATGGGTGAGCACGATGATGTTCCCGTGGATTCGGTGGTC
ATCACCGGCGCAGGCCTTTTCGACCTGTAG

Upstream 100 bases:

>100_bases
CATACCACATCGGCAGAACGGTGCAAGGCCGCTTGCCTTTTTCCCGCAGGCGGGGCAAACACGGCGGATATTACTCCCAT
CATTCAAGGAAGGAACGCAC

Downstream 100 bases:

>100_bases
GCAGGCACCTGACGGCAGACATCCGCCGCAGCGGTGCCGCAGCGCAGAAATACCGCCCCGCCTCAGCGCGGACGGTAACG
GACGCGCTTCTGCCTGCATG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSNPMVLLETSSGDMLIELYADKAPETVKNFLRYVEEGFYENTIFHRVIKNFMIQGGGVTMRMEDKKGHEPIANEAGNGL
KNVRGTIAMARTAAPHSATSQFFINLVDNPDLDHQDDSDAGFGYCVFGAVVEGMDVVDAIGKLKTKPMGEHDDVPVDSVV
ITGAGLFDL

Sequences:

>Translated_169_residues
MSNPMVLLETSSGDMLIELYADKAPETVKNFLRYVEEGFYENTIFHRVIKNFMIQGGGVTMRMEDKKGHEPIANEAGNGL
KNVRGTIAMARTAAPHSATSQFFINLVDNPDLDHQDDSDAGFGYCVFGAVVEGMDVVDAIGKLKTKPMGEHDDVPVDSVV
ITGAGLFDL
>Mature_168_residues
SNPMVLLETSSGDMLIELYADKAPETVKNFLRYVEEGFYENTIFHRVIKNFMIQGGGVTMRMEDKKGHEPIANEAGNGLK
NVRGTIAMARTAAPHSATSQFFINLVDNPDLDHQDDSDAGFGYCVFGAVVEGMDVVDAIGKLKTKPMGEHDDVPVDSVVI
TGAGLFDL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=37.8048780487805, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI19557636, Length=159, Percent_Identity=35.8490566037736, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=33.9393939393939, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=33.9393939393939, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=33.9393939393939, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI24308049, Length=161, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI64276486, Length=136, Percent_Identity=36.7647058823529, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI4758950, Length=161, Percent_Identity=36.6459627329193, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI10863927, Length=158, Percent_Identity=33.5443037974684, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27735045, Length=166, Percent_Identity=31.3253012048193, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI6631100, Length=148, Percent_Identity=33.7837837837838, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310110104, Length=148, Percent_Identity=33.7837837837838, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI4505991, Length=165, Percent_Identity=35.1515151515151, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=157, Percent_Identity=61.7834394904459, Blast_Score=196, Evalue=9e-52,
Organism=Escherichia coli, GI1789763, Length=166, Percent_Identity=57.2289156626506, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17532641, Length=173, Percent_Identity=36.4161849710983, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=145, Percent_Identity=38.6206896551724, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=38.6206896551724, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=144, Percent_Identity=34.7222222222222, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997782, Length=167, Percent_Identity=35.3293413173653, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=173, Percent_Identity=31.2138728323699, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=175, Percent_Identity=34.2857142857143, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551282, Length=180, Percent_Identity=30, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=180, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=163, Percent_Identity=36.8098159509202, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=161, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=161, Percent_Identity=35.4037267080745, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=152, Percent_Identity=36.1842105263158, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=36.1963190184049, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922912, Length=163, Percent_Identity=34.9693251533742, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=31.6770186335404, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=173, Percent_Identity=27.7456647398844, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357249, Length=152, Percent_Identity=32.2368421052632, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549139, Length=147, Percent_Identity=36.0544217687075, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18400; Mature: 18269

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPMVLLETSSGDMLIELYADKAPETVKNFLRYVEEGFYENTIFHRVIKNFMIQGGGVT
CCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
MRMEDKKGHEPIANEAGNGLKNVRGTIAMARTAAPHSATSQFFINLVDNPDLDHQDDSDA
EEECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCC
GFGYCVFGAVVEGMDVVDAIGKLKTKPMGEHDDVPVDSVVITGAGLFDL
CCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
SNPMVLLETSSGDMLIELYADKAPETVKNFLRYVEEGFYENTIFHRVIKNFMIQGGGVT
CCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEE
MRMEDKKGHEPIANEAGNGLKNVRGTIAMARTAAPHSATSQFFINLVDNPDLDHQDDSDA
EEECCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCC
GFGYCVFGAVVEGMDVVDAIGKLKTKPMGEHDDVPVDSVVITGAGLFDL
CCHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]