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The map label for this gene is lytS [H]

Identifier: 78355207

GI number: 78355207

Start: 146349

End: 148052

Strand: Reverse

Name: lytS [H]

Synonym: Dde_0160

Alternate gene names: 78355207

Gene position: 148052-146349 (Counterclockwise)

Preceding gene: 78355208

Following gene: 78355204

Centisome position: 3.97

GC content: 57.63

Gene sequence:

>1704_bases
ATGACAACGGGCATTCTGCTCATAACGCTTATCGAGCGTTTCGGCCTCATGGTTGCCGGAGCGTTTATGCTGCTGTCCAT
CAGTCCCGTGCAGAAACTGCGCCGCGACACCAATTCACCCCTGCAAAAAAGTTTCTGTATTCTTTTTTTCGGGTTATTTG
GCATTCTGGGGACTTACAGCGGTAACGCCATCTTTGAGTCAGTGGCAAACCTGCGGGCCATGGCTGTCATAACGGCAGGC
TTGTTCGGCGGACCGGCCGTGGGACTGGGTGCCGGACTCATGGCGGGACTGCACCGCAACATCATCGACCCCGGCGGCTT
CAGCGCGTTGCCGTGCGGTCTTGCCACCGTGCTCGAAGGGCTTTTTGCCGGGCTGGTGGCATGGCGGGTCAAGGAAAGCA
TGGACTGGCGGCTGGCTGCCATGCTGGGTCTGGTAGGCGAAACCGTTCACATGATTCTGGTGCTGGCTCTGTCGCGCCCG
TTTCCGCAGGCGGTGGAACTGGTCAAAGTCATCGGCATGCCCATGATTGTGGTCAACTCGCTGGGCGCCGCACTGTTTGT
ACAAATCATCAATCTGGTATCCAAAGGGCGTGAACGCCGCGAATCAAGCCATGCGGAACAGATTCTTTCCATTGCCAACC
AGACGGTGAGCCATCTGCGCAGCGGTCTTAACAGAGAAACGGCTGCCGCCACGGCGCGCATAATCTACGACAATATCCCC
CTGGCCGCTGTGAGCATTACAGACACGGAAACCGTGCTGGCACACATAGGAGCAGGCGACACACATCATCTGGTGGACAA
ACCCATCCAGACCGAAGCCACACGACGTGTACTGCATTCCGGTCAGCCGACATTTCTCAGCGGCAAACGGCAGATTGCCT
GCGGACATCCGGGCTGTCCGCTCAACTCCGCCATTATCATCCCCCTGCGCAAAGGCGATACAGTCACCGGCACGCTCAAA
TTTTACGGCAGCCAGAGCGAGCCGCTGGACAGTATCCGCTTTGAAATCGCCAAAGGGCTGGGCGGACTGTTTTCCACCCA
GCTGGAACTGGAAGACATTCATCTGAAAGCGCGCATGCTGGCCCATGCAGAAATCCGCAGACTGCAGGCACAGATAAACC
CGCACTTTCTTTTCAACTCGCTCAATACCATCGCTTCTTTCTGCCGGACAAACCCTGACAAAGCGCGCGAGCTGCTGCTT
GACCTTTCAAGGTATATGCGTCGCAGCCTCGACAGCAGCAGGGGGTTTGTCCCCTTGTACGAAGAGCTTGAGCAGGTGGC
CTCGTACCTTGCCATTGAACAGGCACGGTTCGGCGACAGGGTAAGAGTGGATGTGACCATAGAACCGGACTGCACCGACT
GGCCTATCCCGCCGCTGATAATCCAGCCCATTGTGGAAAACGGTGTACGGCACGGCATTGCACGGCGTGAAGAAGGCGGC
GTAATCACCCTGCAGGTGGGCAGAGACGGCGACGAACTGGCCGTACGCGTTGCCGACAACGGTGTGGGTATGGACGAACA
GCAGGTACAAAGACTGCTTGCCCGCCATCAGACCGACTCCCATTCCTCCGGCATCGGCGTAACCAATTGCAGACAGCGGC
TGGAGCAGATTTTCGGCCCCCGCTATACGCTGAACATCCACAGCCGCCCCGGAGAAGGCACCGAGGTGGCCTTCAGAGTC
CCTAAAATACCGATGGTGCAATAA

Upstream 100 bases:

>100_bases
GAAATCACCGTCAACCGCAGCAGGGTCAAAGATTTCAAGGAACGGCTGGGGCTGGTCTGATAGCGGTGACCGCCCCGTAT
TGCCGCAGCGGAGAAACAGC

Downstream 100 bases:

>100_bases
CGCCTGGGCCGCAGGGCACACGCTGCGGCTGTGGCCGGTATGTGCCCCGGCTGCAGCCGGTATGCACCTTGAAACAAGGG
ACGGACCTGCTGCCCGTGCA

Product: ATP-binding region, ATPase-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MTTGILLITLIERFGLMVAGAFMLLSISPVQKLRRDTNSPLQKSFCILFFGLFGILGTYSGNAIFESVANLRAMAVITAG
LFGGPAVGLGAGLMAGLHRNIIDPGGFSALPCGLATVLEGLFAGLVAWRVKESMDWRLAAMLGLVGETVHMILVLALSRP
FPQAVELVKVIGMPMIVVNSLGAALFVQIINLVSKGRERRESSHAEQILSIANQTVSHLRSGLNRETAAATARIIYDNIP
LAAVSITDTETVLAHIGAGDTHHLVDKPIQTEATRRVLHSGQPTFLSGKRQIACGHPGCPLNSAIIIPLRKGDTVTGTLK
FYGSQSEPLDSIRFEIAKGLGGLFSTQLELEDIHLKARMLAHAEIRRLQAQINPHFLFNSLNTIASFCRTNPDKARELLL
DLSRYMRRSLDSSRGFVPLYEELEQVASYLAIEQARFGDRVRVDVTIEPDCTDWPIPPLIIQPIVENGVRHGIARREEGG
VITLQVGRDGDELAVRVADNGVGMDEQQVQRLLARHQTDSHSSGIGVTNCRQRLEQIFGPRYTLNIHSRPGEGTEVAFRV
PKIPMVQ

Sequences:

>Translated_567_residues
MTTGILLITLIERFGLMVAGAFMLLSISPVQKLRRDTNSPLQKSFCILFFGLFGILGTYSGNAIFESVANLRAMAVITAG
LFGGPAVGLGAGLMAGLHRNIIDPGGFSALPCGLATVLEGLFAGLVAWRVKESMDWRLAAMLGLVGETVHMILVLALSRP
FPQAVELVKVIGMPMIVVNSLGAALFVQIINLVSKGRERRESSHAEQILSIANQTVSHLRSGLNRETAAATARIIYDNIP
LAAVSITDTETVLAHIGAGDTHHLVDKPIQTEATRRVLHSGQPTFLSGKRQIACGHPGCPLNSAIIIPLRKGDTVTGTLK
FYGSQSEPLDSIRFEIAKGLGGLFSTQLELEDIHLKARMLAHAEIRRLQAQINPHFLFNSLNTIASFCRTNPDKARELLL
DLSRYMRRSLDSSRGFVPLYEELEQVASYLAIEQARFGDRVRVDVTIEPDCTDWPIPPLIIQPIVENGVRHGIARREEGG
VITLQVGRDGDELAVRVADNGVGMDEQQVQRLLARHQTDSHSSGIGVTNCRQRLEQIFGPRYTLNIHSRPGEGTEVAFRV
PKIPMVQ
>Mature_566_residues
TTGILLITLIERFGLMVAGAFMLLSISPVQKLRRDTNSPLQKSFCILFFGLFGILGTYSGNAIFESVANLRAMAVITAGL
FGGPAVGLGAGLMAGLHRNIIDPGGFSALPCGLATVLEGLFAGLVAWRVKESMDWRLAAMLGLVGETVHMILVLALSRPF
PQAVELVKVIGMPMIVVNSLGAALFVQIINLVSKGRERRESSHAEQILSIANQTVSHLRSGLNRETAAATARIIYDNIPL
AAVSITDTETVLAHIGAGDTHHLVDKPIQTEATRRVLHSGQPTFLSGKRQIACGHPGCPLNSAIIIPLRKGDTVTGTLKF
YGSQSEPLDSIRFEIAKGLGGLFSTQLELEDIHLKARMLAHAEIRRLQAQINPHFLFNSLNTIASFCRTNPDKARELLLD
LSRYMRRSLDSSRGFVPLYEELEQVASYLAIEQARFGDRVRVDVTIEPDCTDWPIPPLIIQPIVENGVRHGIARREEGGV
ITLQVGRDGDELAVRVADNGVGMDEQQVQRLLARHQTDSHSSGIGVTNCRQRLEQIFGPRYTLNIHSRPGEGTEVAFRVP
KIPMVQ

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=562, Percent_Identity=34.3416370106762, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1788446, Length=529, Percent_Identity=34.9716446124764, Blast_Score=306, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61825; Mature: 61693

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTGILLITLIERFGLMVAGAFMLLSISPVQKLRRDTNSPLQKSFCILFFGLFGILGTYS
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
GNAIFESVANLRAMAVITAGLFGGPAVGLGAGLMAGLHRNIIDPGGFSALPCGLATVLEG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LFAGLVAWRVKESMDWRLAAMLGLVGETVHMILVLALSRPFPQAVELVKVIGMPMIVVNS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
LGAALFVQIINLVSKGRERRESSHAEQILSIANQTVSHLRSGLNRETAAATARIIYDNIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEECCC
LAAVSITDTETVLAHIGAGDTHHLVDKPIQTEATRRVLHSGQPTFLSGKRQIACGHPGCP
EEEEEECCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCEECCCCEEECCCCCCC
LNSAIIIPLRKGDTVTGTLKFYGSQSEPLDSIRFEIAKGLGGLFSTQLELEDIHLKARML
CCCEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCEEHHHHHHHHHHH
AHAEIRRLQAQINPHFLFNSLNTIASFCRTNPDKARELLLDLSRYMRRSLDSSRGFVPLY
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EELEQVASYLAIEQARFGDRVRVDVTIEPDCTDWPIPPLIIQPIVENGVRHGIARREEGG
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
VITLQVGRDGDELAVRVADNGVGMDEQQVQRLLARHQTDSHSSGIGVTNCRQRLEQIFGP
EEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
RYTLNIHSRPGEGTEVAFRVPKIPMVQ
CEEEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TTGILLITLIERFGLMVAGAFMLLSISPVQKLRRDTNSPLQKSFCILFFGLFGILGTYS
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
GNAIFESVANLRAMAVITAGLFGGPAVGLGAGLMAGLHRNIIDPGGFSALPCGLATVLEG
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LFAGLVAWRVKESMDWRLAAMLGLVGETVHMILVLALSRPFPQAVELVKVIGMPMIVVNS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
LGAALFVQIINLVSKGRERRESSHAEQILSIANQTVSHLRSGLNRETAAATARIIYDNIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEECCC
LAAVSITDTETVLAHIGAGDTHHLVDKPIQTEATRRVLHSGQPTFLSGKRQIACGHPGCP
EEEEEECCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCEECCCCEEECCCCCCC
LNSAIIIPLRKGDTVTGTLKFYGSQSEPLDSIRFEIAKGLGGLFSTQLELEDIHLKARML
CCCEEEEEEECCCEEEEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCEEHHHHHHHHHHH
AHAEIRRLQAQINPHFLFNSLNTIASFCRTNPDKARELLLDLSRYMRRSLDSSRGFVPLY
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
EELEQVASYLAIEQARFGDRVRVDVTIEPDCTDWPIPPLIIQPIVENGVRHGIARREEGG
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
VITLQVGRDGDELAVRVADNGVGMDEQQVQRLLARHQTDSHSSGIGVTNCRQRLEQIFGP
EEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
RYTLNIHSRPGEGTEVAFRVPKIPMVQ
CEEEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]