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The map label for this gene is ade

Identifier: 78355183

GI number: 78355183

Start: 125965

End: 127677

Strand: Reverse

Name: ade

Synonym: Dde_0136

Alternate gene names: 78355183

Gene position: 127677-125965 (Counterclockwise)

Preceding gene: 78355184

Following gene: 78355182

Centisome position: 3.42

GC content: 60.6

Gene sequence:

>1713_bases
ATGAAAAACAATACCATGAACACACTTATCGGCGCGGCGCAGGATGAAAGCCCCGTGGATCTGCTGGTCCGCAACGTCAG
GCTGGTCAACGTGCTTTCCGGCGAAATCCACGACGCGCACATCGCCGTCAAAGACGGCATTGTTGTGGGATTTGAAGAAT
ATGAAGCCCTGCACGTTGTTGAAGGAAACGGACGCCATTGCATTCCCGGTCTGATCGACGGGCATATCCATATTGAATCC
ACCCTGCTGTCACCCGCACGTTTTGCCGCCGCGGCCGCGCCCCACGGCACTGCCGCGGTCATGTGCGACCCCCACGAAAT
AGCAAACGTCATGGGCGCTGAAGGCATTGAATACATGCTGCACGCCAGCGCCGGTCTGCCGTTGTCCGTTTATGTGATGA
TGCCTTCGTGCGTGCCCGCCACACACATGGAAACAGCCGGAGCCACCCTGCGGGCGGAAGACGTGCAGGATTTTCTCTCG
CGCTACCCCGACCGCATGCCCGGACTCGCGGAAATGATGAACTATCCCGGAGTACTTTTCCGCGACGACGAAGTAATGGC
AAAACTGGAGGCAGCAGCTTCTCACGTCATTGACGGCCACGCCCCCCTGCTGCGCGGCAAAGCGCTGAATGCCTATGTGC
TGGGCGGCCCCGCAAGCGATCACGAAACATCCGATGCGGACGAAGCCCGCGAAAAGCTGCGCAAAGGCATGCACCTGATG
ATCCGCGAAGGCGGCTCGCAGGAGCACAACCTCGAAGAGCTGGTCACCGTCCTCAACGAATTCAATACCCAGAATGTCTC
TTTTGTCAGCGACGACAAAGTGGTCAACGACCTGATGGAAAGCGGACACATGGACGACATACTGCGCAAGGCCATGGCTG
CCGGCATTCCCCCTGTCAGAGCCGTGCAGATGGCTTCCATAAACACGGCCCGCTATTTCCGGCTGCACCGTCGCGGTGCG
GTGGCCCCGGGCTATCGCGCAGACTTTGTCCTGCTGGACGACCTGCAGACCATGCGCATCTCCGAATGTTATCTGGGCGG
GCGCAATGTCAAAGAGATCGACTTCACAGGGCACAGCGCAGCCTTCAGCGCCAACACCGTGCATGTGGCCGGTCTGAACA
CGGACTCGCTGCATGTGGCGGCCGGCAACGGCAACCTGCGCGTCATCGGCATAGTGCCGGGACAGGTGATAACCCATGCT
CTGGAACTGCCGCCCACCCTGCGCGAAGGTGCCGCAGTGGCCGATCCTTCCCGCGATCTTGCCAAACTGGCCGTTTTTGA
ACGCCACAAAGGCACCGGCAACGTGGGGCTGGGATTCACCGCCGGTCTGGGGCTGCACAAGGGCGCACTGGCCGGTACCG
TATCGCACGATTCGCACAACCTGATAGTGGCGGGCATGGACGATGCCGACATGATTACCGCCGCGGAAGAAGTGCAGTGC
ATCGGCGGCGGTCTTGCCGTCGCCTGTGACGGCCGCGTGCTGGCATCACTGCCGCTGCCCATTGCCGGACTGATGAGCGA
TGCCCCCGTGGAGGATGTGCTTGCCGGTCTGCGCGGCGTAAACGAAGCCCTTGCCACACTGGGATACAAGCTCAGCAGCC
CCTTTGCCGCGCTGGCGTTCCTCTCTCTTGCCGTTATCCCCTCGCTGAAGCTTACCGACAAGGGCCTTGTGGACGTGCAC
AAATTCGAAATTGTCCCCCTGTGGACAGCCTGA

Upstream 100 bases:

>100_bases
ACCGGCTTCGCTGGGCGTACCCTTCAGCCGGGAAGGCTAGCGGCCCCGCGCCGCGTAACAGACACCGCCGCATACAGCGG
CTGCCGGAGGACAAACAGAC

Downstream 100 bases:

>100_bases
GGCTCCGGCCGCACGGCCGCAGCTGAACAACCTGCCCGCCGGAGATGAAGCAGCCTCCGGCGGGCAGGGAGATGATCTCC
CTGCACCCTCAATACGCCCT

Product: adenine deaminase

Products: NA

Alternate protein names: Adenase; Adenine aminase

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MKNNTMNTLIGAAQDESPVDLLVRNVRLVNVLSGEIHDAHIAVKDGIVVGFEEYEALHVVEGNGRHCIPGLIDGHIHIES
TLLSPARFAAAAAPHGTAAVMCDPHEIANVMGAEGIEYMLHASAGLPLSVYVMMPSCVPATHMETAGATLRAEDVQDFLS
RYPDRMPGLAEMMNYPGVLFRDDEVMAKLEAAASHVIDGHAPLLRGKALNAYVLGGPASDHETSDADEAREKLRKGMHLM
IREGGSQEHNLEELVTVLNEFNTQNVSFVSDDKVVNDLMESGHMDDILRKAMAAGIPPVRAVQMASINTARYFRLHRRGA
VAPGYRADFVLLDDLQTMRISECYLGGRNVKEIDFTGHSAAFSANTVHVAGLNTDSLHVAAGNGNLRVIGIVPGQVITHA
LELPPTLREGAAVADPSRDLAKLAVFERHKGTGNVGLGFTAGLGLHKGALAGTVSHDSHNLIVAGMDDADMITAAEEVQC
IGGGLAVACDGRVLASLPLPIAGLMSDAPVEDVLAGLRGVNEALATLGYKLSSPFAALAFLSLAVIPSLKLTDKGLVDVH
KFEIVPLWTA

Sequences:

>Translated_570_residues
MKNNTMNTLIGAAQDESPVDLLVRNVRLVNVLSGEIHDAHIAVKDGIVVGFEEYEALHVVEGNGRHCIPGLIDGHIHIES
TLLSPARFAAAAAPHGTAAVMCDPHEIANVMGAEGIEYMLHASAGLPLSVYVMMPSCVPATHMETAGATLRAEDVQDFLS
RYPDRMPGLAEMMNYPGVLFRDDEVMAKLEAAASHVIDGHAPLLRGKALNAYVLGGPASDHETSDADEAREKLRKGMHLM
IREGGSQEHNLEELVTVLNEFNTQNVSFVSDDKVVNDLMESGHMDDILRKAMAAGIPPVRAVQMASINTARYFRLHRRGA
VAPGYRADFVLLDDLQTMRISECYLGGRNVKEIDFTGHSAAFSANTVHVAGLNTDSLHVAAGNGNLRVIGIVPGQVITHA
LELPPTLREGAAVADPSRDLAKLAVFERHKGTGNVGLGFTAGLGLHKGALAGTVSHDSHNLIVAGMDDADMITAAEEVQC
IGGGLAVACDGRVLASLPLPIAGLMSDAPVEDVLAGLRGVNEALATLGYKLSSPFAALAFLSLAVIPSLKLTDKGLVDVH
KFEIVPLWTA
>Mature_570_residues
MKNNTMNTLIGAAQDESPVDLLVRNVRLVNVLSGEIHDAHIAVKDGIVVGFEEYEALHVVEGNGRHCIPGLIDGHIHIES
TLLSPARFAAAAAPHGTAAVMCDPHEIANVMGAEGIEYMLHASAGLPLSVYVMMPSCVPATHMETAGATLRAEDVQDFLS
RYPDRMPGLAEMMNYPGVLFRDDEVMAKLEAAASHVIDGHAPLLRGKALNAYVLGGPASDHETSDADEAREKLRKGMHLM
IREGGSQEHNLEELVTVLNEFNTQNVSFVSDDKVVNDLMESGHMDDILRKAMAAGIPPVRAVQMASINTARYFRLHRRGA
VAPGYRADFVLLDDLQTMRISECYLGGRNVKEIDFTGHSAAFSANTVHVAGLNTDSLHVAAGNGNLRVIGIVPGQVITHA
LELPPTLREGAAVADPSRDLAKLAVFERHKGTGNVGLGFTAGLGLHKGALAGTVSHDSHNLIVAGMDDADMITAAEEVQC
IGGGLAVACDGRVLASLPLPIAGLMSDAPVEDVLAGLRGVNEALATLGYKLSSPFAALAFLSLAVIPSLKLTDKGLVDVH
KFEIVPLWTA

Specific function: Unknown

COG id: COG1001

COG function: function code F; Adenine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenine deaminase family

Homologues:

Organism=Escherichia coli, GI1790098, Length=573, Percent_Identity=34.9040139616056, Blast_Score=316, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADEC_DESDG (Q317F9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386632.1
- ProteinModelPortal:   Q317F9
- STRING:   Q317F9
- GeneID:   3756584
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0136
- NMPDR:   fig|207559.3.peg.792
- eggNOG:   COG1001
- HOGENOM:   HBG725357
- OMA:   LHIHYML
- ProtClustDB:   CLSK2503834
- BioCyc:   DDES207559:DDE_0136-MONOMER
- HAMAP:   MF_01518
- InterPro:   IPR006679
- InterPro:   IPR006680
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01178

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.2

Molecular weight: Translated: 60481; Mature: 60481

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNTMNTLIGAAQDESPVDLLVRNVRLVNVLSGEIHDAHIAVKDGIVVGFEEYEALHVV
CCCCCCHHHEECCCCCCCHHHHHHHEEEEEEECCCCCEEEEEEECCEEEEECCCCEEEEE
EGNGRHCIPGLIDGHIHIESTLLSPARFAAAAAPHGTAAVMCDPHEIANVMGAEGIEYML
ECCCCEECCCEECCEEEEEEHHCCHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCEEEE
HASAGLPLSVYVMMPSCVPATHMETAGATLRAEDVQDFLSRYPDRMPGLAEMMNYPGVLF
EECCCCCEEEEEEECCCCCCCCHHCCCCEEEHHHHHHHHHHCCCCCCCHHHHHCCCCEEE
RDDEVMAKLEAAASHVIDGHAPLLRGKALNAYVLGGPASDHETSDADEAREKLRKGMHLM
ECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCEEE
IREGGSQEHNLEELVTVLNEFNTQNVSFVSDDKVVNDLMESGHMDDILRKAMAAGIPPVR
EECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
AVQMASINTARYFRLHRRGAVAPGYRADFVLLDDLQTMRISECYLGGRNVKEIDFTGHSA
EEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCEEEEECCCCC
AFSANTVHVAGLNTDSLHVAAGNGNLRVIGIVPGQVITHALELPPTLREGAAVADPSRDL
EEECCEEEEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHCCCCCCCCCHHH
AKLAVFERHKGTGNVGLGFTAGLGLHKGALAGTVSHDSHNLIVAGMDDADMITAAEEVQC
HHHHHHHHCCCCCCCCCCEECCCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHE
IGGGLAVACDGRVLASLPLPIAGLMSDAPVEDVLAGLRGVNEALATLGYKLSSPFAALAF
ECCCEEEEECCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
LSLAVIPSLKLTDKGLVDVHKFEIVPLWTA
HHHHHCCCCEECCCCCEEEEEEEEEEEECC
>Mature Secondary Structure
MKNNTMNTLIGAAQDESPVDLLVRNVRLVNVLSGEIHDAHIAVKDGIVVGFEEYEALHVV
CCCCCCHHHEECCCCCCCHHHHHHHEEEEEEECCCCCEEEEEEECCEEEEECCCCEEEEE
EGNGRHCIPGLIDGHIHIESTLLSPARFAAAAAPHGTAAVMCDPHEIANVMGAEGIEYML
ECCCCEECCCEECCEEEEEEHHCCHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCEEEE
HASAGLPLSVYVMMPSCVPATHMETAGATLRAEDVQDFLSRYPDRMPGLAEMMNYPGVLF
EECCCCCEEEEEEECCCCCCCCHHCCCCEEEHHHHHHHHHHCCCCCCCHHHHHCCCCEEE
RDDEVMAKLEAAASHVIDGHAPLLRGKALNAYVLGGPASDHETSDADEAREKLRKGMHLM
ECHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCEEE
IREGGSQEHNLEELVTVLNEFNTQNVSFVSDDKVVNDLMESGHMDDILRKAMAAGIPPVR
EECCCCCCCCHHHHHHHHHHCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCHH
AVQMASINTARYFRLHRRGAVAPGYRADFVLLDDLQTMRISECYLGGRNVKEIDFTGHSA
EEEEECCCHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCEEEEECCCCC
AFSANTVHVAGLNTDSLHVAAGNGNLRVIGIVPGQVITHALELPPTLREGAAVADPSRDL
EEECCEEEEEECCCCCEEEEECCCCEEEEEECCHHHHHHHHCCCCCHHCCCCCCCCCHHH
AKLAVFERHKGTGNVGLGFTAGLGLHKGALAGTVSHDSHNLIVAGMDDADMITAAEEVQC
HHHHHHHHCCCCCCCCCCEECCCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHE
IGGGLAVACDGRVLASLPLPIAGLMSDAPVEDVLAGLRGVNEALATLGYKLSSPFAALAF
ECCCEEEEECCEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHH
LSLAVIPSLKLTDKGLVDVHKFEIVPLWTA
HHHHHCCCCEECCCCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA