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The map label for this gene is pdxA [H]

Identifier: 78355174

GI number: 78355174

Start: 118545

End: 119558

Strand: Reverse

Name: pdxA [H]

Synonym: Dde_0127

Alternate gene names: 78355174

Gene position: 119558-118545 (Counterclockwise)

Preceding gene: 78355175

Following gene: 78355172

Centisome position: 3.21

GC content: 60.36

Gene sequence:

>1014_bases
GTGAAACTGCCTGTTTTAGCGCTGACCATGGGTGACCCTGCGGGAATCGGACCGGAAATAACAGCCAAGGCCCTCGGACG
CGATGAAATTCACACCATGTGCATACCGCTTGTGGTGGGCGATATGGCGCTTATGCAGGCGCACGAACGATATATGAACG
GCCGCAGGTGCATACTTGTGGACGGAGTGGAAGCGCTGGATACGCTGCCTGCTGACGGTGTGGCCGTTTTTCAGCCGCAC
GGACCTTTACGCGGCGTTGTGGCGGGTACGCTGTCAGCGGAAGCAGGCCGCGCAGCTGCGGCCTATGTGTACGGAGCCAT
AGAACTGGCCAAACGCGGCGACATTCAGGGCATAGTGACTGCCCCGCTGAACAAGGAAGCGCTGCATATGGGCGGCGACA
CCCACCCCGGACACACGGAACTGCTGGCAGAAAGCTTCGGAGTGCGCAACTATGCCATGGTGCTGGCCGCGGAAGACAGA
TATGTGTTTCATGTGACCACACATCAGTCGCTGCGTTCCGCCATTGATTCACTTACCGTGGATGCCGTGTACCAGCGCAT
CAGGCTGGCCCATCTGCTGGCGACGGCACTGGGCACACCGCAGGAGACGGTGGCAGTGGCCGGAGTCAATCCGCACGCCG
GAGAAGGCGGCATGTTCGGCACGGAAGAACGCGACATCATAACCCCCGCTGTACAGAAGGCCGTGGCGGAGGGCATACCG
GCTGAAGGTCCGGTTCCGGCCGATGTGCTGTTCCCGCGCATGGTACGCGGTCAGTACCGGTTTGCCATCGCCATGTATCA
CGATCAGGGGCACGCCGTTTTCAAATCGCTGTATTTCGACACCGGCGTCAACATCACCATAGGGCTGCCGGTCATCCGCA
CCTCTGTTGACCACGGCACGGCCTTTGATATTGCGGGCAAAGGCATTGCCAGCGAAGAAAGCATGATCGAAGCGGTCCGC
GCAGCAGCCCGTCTGGGCAACAGCTGGGCACATATAAGCCGCAGCGCCATGTGA

Upstream 100 bases:

>100_bases
AGGCCGTGCGCACCCTGCGTGAACTGGACTGACAATACAGCCGGGCAGCCCGCCGCTGACGGGGCTGCCCGCCATACCAT
ACAGAACCAAGGAGCAGAGA

Downstream 100 bases:

>100_bases
TGCCGCGGGCGCAAAGCCCGCAGGAACACCGCAACGACATAACATTCCGCCGCACCCACGGCGTCAGAAACCCCGCCGGA
AAAACGGAGCGTCCGTCCGG

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKLPVLALTMGDPAGIGPEITAKALGRDEIHTMCIPLVVGDMALMQAHERYMNGRRCILVDGVEALDTLPADGVAVFQPH
GPLRGVVAGTLSAEAGRAAAAYVYGAIELAKRGDIQGIVTAPLNKEALHMGGDTHPGHTELLAESFGVRNYAMVLAAEDR
YVFHVTTHQSLRSAIDSLTVDAVYQRIRLAHLLATALGTPQETVAVAGVNPHAGEGGMFGTEERDIITPAVQKAVAEGIP
AEGPVPADVLFPRMVRGQYRFAIAMYHDQGHAVFKSLYFDTGVNITIGLPVIRTSVDHGTAFDIAGKGIASEESMIEAVR
AAARLGNSWAHISRSAM

Sequences:

>Translated_337_residues
MKLPVLALTMGDPAGIGPEITAKALGRDEIHTMCIPLVVGDMALMQAHERYMNGRRCILVDGVEALDTLPADGVAVFQPH
GPLRGVVAGTLSAEAGRAAAAYVYGAIELAKRGDIQGIVTAPLNKEALHMGGDTHPGHTELLAESFGVRNYAMVLAAEDR
YVFHVTTHQSLRSAIDSLTVDAVYQRIRLAHLLATALGTPQETVAVAGVNPHAGEGGMFGTEERDIITPAVQKAVAEGIP
AEGPVPADVLFPRMVRGQYRFAIAMYHDQGHAVFKSLYFDTGVNITIGLPVIRTSVDHGTAFDIAGKGIASEESMIEAVR
AAARLGNSWAHISRSAM
>Mature_337_residues
MKLPVLALTMGDPAGIGPEITAKALGRDEIHTMCIPLVVGDMALMQAHERYMNGRRCILVDGVEALDTLPADGVAVFQPH
GPLRGVVAGTLSAEAGRAAAAYVYGAIELAKRGDIQGIVTAPLNKEALHMGGDTHPGHTELLAESFGVRNYAMVLAAEDR
YVFHVTTHQSLRSAIDSLTVDAVYQRIRLAHLLATALGTPQETVAVAGVNPHAGEGGMFGTEERDIITPAVQKAVAEGIP
AEGPVPADVLFPRMVRGQYRFAIAMYHDQGHAVFKSLYFDTGVNITIGLPVIRTSVDHGTAFDIAGKGIASEESMIEAVR
AAARLGNSWAHISRSAM

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=322, Percent_Identity=36.0248447204969, Blast_Score=171, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35701; Mature: 35701

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPVLALTMGDPAGIGPEITAKALGRDEIHTMCIPLVVGDMALMQAHERYMNGRRCILV
CCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
DGVEALDTLPADGVAVFQPHGPLRGVVAGTLSAEAGRAAAAYVYGAIELAKRGDIQGIVT
ECHHHHHCCCCCCEEEECCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
APLNKEALHMGGDTHPGHTELLAESFGVRNYAMVLAAEDRYVFHVTTHQSLRSAIDSLTV
CCCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECHHHHHHHHHHHHH
DAVYQRIRLAHLLATALGTPQETVAVAGVNPHAGEGGMFGTEERDIITPAVQKAVAEGIP
HHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
AEGPVPADVLFPRMVRGQYRFAIAMYHDQGHAVFKSLYFDTGVNITIGLPVIRTSVDHGT
CCCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCEEEECCCCCC
AFDIAGKGIASEESMIEAVRAAARLGNSWAHISRSAM
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MKLPVLALTMGDPAGIGPEITAKALGRDEIHTMCIPLVVGDMALMQAHERYMNGRRCILV
CCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
DGVEALDTLPADGVAVFQPHGPLRGVVAGTLSAEAGRAAAAYVYGAIELAKRGDIQGIVT
ECHHHHHCCCCCCEEEECCCCCCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
APLNKEALHMGGDTHPGHTELLAESFGVRNYAMVLAAEDRYVFHVTTHQSLRSAIDSLTV
CCCCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCEEEEEECHHHHHHHHHHHHH
DAVYQRIRLAHLLATALGTPQETVAVAGVNPHAGEGGMFGTEERDIITPAVQKAVAEGIP
HHHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
AEGPVPADVLFPRMVRGQYRFAIAMYHDQGHAVFKSLYFDTGVNITIGLPVIRTSVDHGT
CCCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCEEEECCCCCC
AFDIAGKGIASEESMIEAVRAAARLGNSWAHISRSAM
EEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]