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The map label for this gene is hemN [H]

Identifier: 78224718

GI number: 78224718

Start: 3969123

End: 3970274

Strand: Reverse

Name: hemN [H]

Synonym: Gmet_3535

Alternate gene names: 78224718

Gene position: 3970274-3969123 (Counterclockwise)

Preceding gene: 78224726

Following gene: 78224717

Centisome position: 99.32

GC content: 66.93

Gene sequence:

>1152_bases
ATGGACGACACGACAGCCCTCTACATCCACATTCCTTTCTGTGTGCGCAAGTGTCTCTACTGCGCCTTCGCTTCCACGGA
CGAAGCCCCCCTCGCGATCGGGGAGTACACGGCGCTTCTCCTCCGGGAGATGGAACTTCGGGCCGCCGCGCTGGCATCCC
CACTGCGCGCCACCACCCTCTATCTGGGAGGAGGAACCCCGTCGCTGTTGGAGCCCGACCTTGTCGGGAATATCATCGAT
GGCGCCGCCCGCCTCTTCTGGCTCGATCCGTCGGCGGAAATCACCCTCGAAGCCAATCCCGGCACCGTCACGGCCGACTC
CCTCGCGGGGTACCGGGGCGCTGGGGTGAATCGCCTCTCCCTCGGGGTCCAGTCCTTCGACGACCGGATGCTGGAGCGCC
TCGGCCGGGTCCATACGGCCCGGGAAGCGAAGGACGCCTTTGCCCTGGCCCGCCGGGCCGGCTTCGACAATATCGGTATC
GATCTCATCCACGGGCTTCCGGACCAGAGTCTTGACCACTGGCGGGACCAGCTCCGGATGGCGGCAGCCCTTCGGCCGGG
GCACATCTCCGCCTACGGCCTCACGGTGGAGGAGGGAACCCCCTTTGCCCGCCTGGAGGATCAGGGTGTATTGGCGCTTC
CGGACGAGGATGACGCTGCCGCCATGTTCGAGGAGACGGCGGAGGTCCTGGCGGCGGCCGGCTATGAACAGTACGAGATT
GCCAACTTCGCTCTGCCGGGACGCCGCTCCCGCCACAACCAGGTCTACTGGCGGCGGTGGAATTATCTCGGGTTCGGCGC
CGGGGCCCACTCGTTCCTGCGGGAGCCGTTCCCCGGCATCCGCTGGCGCAACCCGGATGATCTCGGCACCTACGGATGCT
CCCTGGCGGATGGGGTTCTGCCCGAGACGGACATTGCCCTTCTTGCGGAAGAGGACGCCATGGCCGAGTGGCTCTTTCTG
GGGCTCAGGATGCTCGAAGGAATCGAGGAAGCGCGGTTTCGGGAGGAATTCGGCCGGCCCCTCATGGAGATCCACGGCAC
CGCCATCGAGGGGTTCTGCGCCGCCGGTCTCCTCGTGCGCGGGGGGGGGCGCCTGCGGCTCACCCGCCGGGGGGTAATCC
TCTCAAACCGGGTCTTCGCGGCCTTTCTCTGA

Upstream 100 bases:

>100_bases
GGTGCCTGCGGAACGCCGTTTAGTGTAGCGGCATACCGGGCCATTTTCAACCAAAGAAGTTTGGACTTCCACGTAAAAAC
TGGCGTATCATCGGCACTAA

Downstream 100 bases:

>100_bases
CCGGTCCCACTGCCGGAAATCTCCGGAAATCTCCTTGACAAAGAAGAGGGGCGTTGTTACCTTTACCCCGTTAGCACTCA
CCAACTCTGAGTGCTAATCT

Product: coproporphyrinogen III oxidase, anaerobic

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTLYLGGGTPSLLEPDLVGNIID
GAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLSLGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGI
DLIHGLPDQSLDHWRDQLRMAAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEI
ANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVLPETDIALLAEEDAMAEWLFL
GLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVRGGGRLRLTRRGVILSNRVFAAFL

Sequences:

>Translated_383_residues
MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTLYLGGGTPSLLEPDLVGNIID
GAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLSLGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGI
DLIHGLPDQSLDHWRDQLRMAAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEI
ANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVLPETDIALLAEEDAMAEWLFL
GLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVRGGGRLRLTRRGVILSNRVFAAFL
>Mature_383_residues
MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTLYLGGGTPSLLEPDLVGNIID
GAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLSLGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGI
DLIHGLPDQSLDHWRDQLRMAAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEI
ANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVLPETDIALLAEEDAMAEWLFL
GLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVRGGGRLRLTRRGVILSNRVFAAFL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=39.7003745318352, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1789325, Length=272, Percent_Identity=44.4852941176471, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082341, Length=245, Percent_Identity=31.0204081632653, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42059; Mature: 42059

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTL
CCCCEEEEEEEHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YLGGGTPSLLEPDLVGNIIDGAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLS
EECCCCCCCCCCHHHHHHHCCCEEEEEECCCCEEEEECCCCEEEHHHHCCCCCCCCCHHH
LGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGIDLIHGLPDQSLDHWRDQLRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHH
AAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEI
HHHCCCCCEEEEEEEEECCCCCEEECCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
ANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVL
EEECCCCCCCCCCCEEEEEECEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCC
PETDIALLAEEDAMAEWLFLGLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVR
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCEEE
GGGRLRLTRRGVILSNRVFAAFL
CCCEEEEEECCEEEECCEEEECC
>Mature Secondary Structure
MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTL
CCCCEEEEEEEHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEE
YLGGGTPSLLEPDLVGNIIDGAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLS
EECCCCCCCCCCHHHHHHHCCCEEEEEECCCCEEEEECCCCEEEHHHHCCCCCCCCCHHH
LGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGIDLIHGLPDQSLDHWRDQLRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHHHH
AAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEI
HHHCCCCCEEEEEEEEECCCCCEEECCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
ANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVL
EEECCCCCCCCCCCEEEEEECEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCC
PETDIALLAEEDAMAEWLFLGLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVR
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCEEE
GGGRLRLTRRGVILSNRVFAAFL
CCCEEEEEECCEEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]