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The map label for this gene is atoS [H]

Identifier: 78224663

GI number: 78224663

Start: 3900064

End: 3904461

Strand: Reverse

Name: atoS [H]

Synonym: Gmet_3477

Alternate gene names: 78224663

Gene position: 3904461-3900064 (Counterclockwise)

Preceding gene: 78224664

Following gene: 78224662

Centisome position: 97.67

GC content: 59.37

Gene sequence:

>4398_bases
ATGCTAAAGGAATCGGCTACTTTTGCCGATAAGTTAGCTGTAACTATTTTTTTTAAAGGCAAGCACATGCGACCCTTGAG
CCTGAAATCGAAGATGAGCATCACGGTCTTTCTCCTGGTGGCCGTGCTGATGTCCTCTCTGGCATTCTTCTCCTACGGGT
ATTTTGAAGGGGAGTTCAAGCGGTTGATTTGTGCCCAGCAGTTTACGCTGGTATCGTCCCTGGCCGACGAGGTGGACGAC
GAGCTGGCGACCAGCAGCGCCCTCCTCCGGGAGACGGCGAAGCGGATGCCTCTGGACGCATATGGAGACCCACTCAAGGC
CCAGAGATACCTCGACGGCTGCGCGGAAACCCTCTCGGTCTTCGACGACGGCCTCTCCCTCTTCTCTCCGGAGGGAACGC
TCATGGCTGCGACCCCCCATGAGCCGAACCTCCTGGGAAAGGACTATTCTTACCGCGAATACTTCCGCCAGACGGTTGCC
ACCGGCCGCCCCCACATTTCCATCCCTTACTGCACCACCAGGCAGCACCGGAATCCGGCCGTCATGTTCACCGTGCCGCT
CTTCGGGACCGATGGAAAGCTTGCCGGTATCCTGGCCGGGAGCTTTGACCTGCTGAAGGACAATTTCCTGGGAAAGATAG
AAAAGACCAGGGTCGGCAAGACCGGGTATCTCTATACATTCAACGCCGACAGACGACTCATTACCCATCCCGACAGTCCG
CGGATACTGGAGACAGTGCCCGTCGGGAAGAACATCGGCTTCGAGAGGGCACTCCAGGGATTCGAGGGGAGCATGGAGAA
TGTGACGTCCCGTGGAAACAGGGGGATCACATCCTTCAAGAGGCTCAGGAACGCCAGTTGGACCATCGCTGCCCACTATC
CCGTGGATGAGGCCTACGCCCCGGTCCATGCTGTGAAAAAGTACTTACTTGCTGCACTCGTGGGGGCGATTCTTCTGTCG
ATCTTCGTTGTGCGGCTGACCATGGCGTACCTGACCGCCCCGCTCCTTCACTTCACCAGACATGTGGCCAACCTCGGCGA
CATGTCGCCGAAAGGGAGGCGTTTCTCCGCTCCGTCGCGGGACGAGATCGGAACCCTGGCCGAGACCTTCAACGCCATGG
TGGCTAGGCTGGAAAAAAAAGAGGAGGAGCTGAAGCGGAGCAAGGAGCTCTACCAGGTGGTGGCCGATTTCTCCACGGAC
ATGGCGGTCTGGCGGAATTCCGACGGCACGATGGCCTACGTCTCTCCCCACTGCTTCCAGATCACGGGGTACACGGACGC
CGAATTCTATGCCGACCCAGGGCTCATGGACCGGATCATCCATCCCGATGACCGTGACCTGTGGATCGAGCACAAGGAGA
CTGTGGGTACCGAAATCCAGGCAACTCCCCTGGAATTTCGCATCGTCACCAAGGCGAACGAGGTACGTTGGGTCAGCCAT
TTCTGCCGGTTCGTCCACGATGAAGCCGGGGAGCTCATCGGGGTCCGGGGGAGCTTCAGCGATATCTCGGCAAAGAAGAT
GGCCCTTGATGTCGTTATCGCCCAGAAAAACTTCGCGGAAAATCTCATCAGCAGCGCGACAGCCCCCATCTTCGTGCTTG
ACAGCCGGAACCGGATCCTTTTCTGGAACAAGGCGTGCGAAGAGCTGACCGGATACCCGGCGGCCACGATGATCGGCACC
GACCGGCAATGGCAGCCGTTTTATTGCGGCAGGCGGCCCACCCTGGCGGATGTGATCATTGACTGCGGGGAGGAGGCAAC
CCTTTCGGAACTCTATGAGAAATTTTCACCTTCTCAGCTGGCCAAGGAGGGTATGCAGGCCGAGGGGTGGTATTTGGGCC
TCGGCGGCAAGAACCGCTACATCCTCTTCGACGCCGCCCCCATCAGAAATGCCGAGGGGGAGCTGGTGGCGGCCATCGAG
ACGTTCCACGACATCACGGACCGGCAGATCGCCGAGGACAGCGTGGTTCTCCTGAAGGATTTCTACCTCACCCTGTTCGA
GGAGTTTCCGGCCCTCATCTGGCGTTCCGGCACCGATGCGAAATGCAACTATTTCAACAAGACCTGGCTCCAGTTCACCG
GCCGTTCCCTGGAGGAGGAACTGGGGGGCGGGTGGGCCGAAGGGGTCCACCCGGAAGACCTGGAACGGTGCGTCTCCACG
TATCTACGGGCGTTCGACAGTCGCGAACCATTTTCCATGGAATACCGCTTGCGTTGCCACGATGGTGACTACCGGTGGAT
TGTGCACACGGGGAGGCCCTTCCAGGAGCCCGACGGCGCTTTCGCCGGGTATATCGGGGTCTGTTACGACATTACCGACC
GCCGGCGGGCGGCGGAAAAACTCCGCGAAAGTCAGCGGGACCTCGCGCAAAAACACAAGCAACTATCCACCCTGTTCATG
GAGGTTGAAATGGCCAAAAAGGAGTGGGAGCAGACACTAGACTGCATTGGCGACCTGGTGATCCTGACGGACAACGAAGG
ACACATCCGGCGCTGCAACCGGGCCGTCGTCGAGCTTGCCGGTCTTCCCTACCAGGATGTCCTTGGGAGAGAGTGGCGTT
CGATCGTTCTCTCGCCCGAGATGGAGAGGATCCGGTTCACCCAAGAGGGAGGAGAGCTCTTCCACAGGTTGACGGAACGC
TGGTTCTTCTGCGCCATCTACCCCTTCAGACAAAAAAATGAAAGCGGGATGAGTGGGAGCGTCGTCACACTTCACGATAC
CACGGAGCTGAAAAAGGTCGGCGAAGCCCTGGAGAAGGCCTACGGCGAGTTGAAGGAGGCCCAGGGACAGATGCTCCAGC
GGGAAAAAATGGCCTCCATCGGGCAGCTGGCCGCCGGCGTGGCCCATGAGATCAACAATCCCATCGGTTTCATCATGAGC
AACCTCGGAACCCTCGGTAAGTATCTGGGACGGATTCGGGAATTCATCGCCGCCCAGGATGAGACCATCGCCGAACTGGA
AGGGGAAGCGGTGTCGCAGCGCCTCGCCCAAGCAAAAAAGACGCTGAAGATAGAGTACATCATGGGAGACATCGACGGCC
TCATCACCGAATCCCTCGACGGGGCGGAGCGGGTGAAGAAGATCGTGCAGGATCTCAAGGGATTCTCCCGGGTGGATGAG
GCAGAGGTGAAGGTGGTGGATCTGCGCGAGTGCCTCGACAGCACCATCAACATCGTCTGGAACGAGTTGAAGTACAAAGC
GACTCTCAAGAAGGAGTACGGCGACGTCCCTCCCCTGCGGTGCAACCCCCAGCAGCTCAACCAGGTATTCATGAATCTCC
TCGTGAATGCCGGCCATGCCATCGAGAGCCAGGGAGAGATTACCGTCCGGACCTGGCGTGAGGGGGAGGACGCCTTCATT
GCCATTTCCGACACTGGCTGCGGGATTCCCGAGGAGATCAGAGCCCGGATCTTCGAGCCCTTCTTCACCACCAAGGAGGT
GGGAAAGGGGACGGGGCTCGGGCTTTCCATCAGCTACGACATCGTGAAGAAGCACGGCGGCGAGATTACCGTGGAGAGCG
AGCAAGGCCGGGGGACCACCTTCACCGTGCGGTCCCTGTCCGGGAGAGGAACTGATATGGACGAACAGGTACGCATTCTC
TGTGTGGATGATGAGATGAACGTGCTCCGGTCGCTGGGACGGATGTTCCTCGACGACAACTACGACATCCTTACCGCTTC
GTCGGCGGCCGAGGGGCTGGAAATCCTCGAGCGGGAGTCCCCGGTGCAGATCGTTATCTCTGACTACCGGATGCCGGTCA
TGAACGGGGTCGATTTTCTCCGTAAGGTCTGTACCCAGTGGCCCGACACGGTCCGCATCGTCCTGTCGGGGTATGCCGAC
ACGGCCGCCATTGTCGCCGCCATCAACGAGGGGCAGATCTACAAGTTCGTCCCCAAGCCGTGGACCGACGACGAACTCAG
GGTTACAGTGATAAACGCCCTGGAGAAGTACCAGCTCCAAAAGCATAACGCCAAGCTCCTTGATGAGTTGAGCCGGTCCA
ACGAGGAGCTCGTCCTTATGAACGAGAACCTGGAGGCGATCGTTGCCGAACGGACCGAGGAAGTCCTGTTCCGCAACCGG
GCCCTCAGTGCCGCCCAGAACATCCTCGACGCTTTGCCGGTGGGGGTCCTGGGGATGGACACGGAGGGGACGGTGGTCCA
ATGCAACCGGAGTGCGGCGCGGCTTCTGGGGCTCGATGAATACGCAGTCGTCGGTAGAGGCGCAGCCGAAGCCCTGTCGC
CGGAGATCTGTGCGTTCATTGACGAGCTCGCCCGGGAAAAGACCTCCATGTGCCGGCTATTGGCCGGTGTCGCCGGAGTC
CGGAGTCTGGGGGTGTATCTCAAGGAGGGGGAGCAGGAGGGAATCGTTCTTGTCTTCAATGGGGAGGAACCCCTATGA

Upstream 100 bases:

>100_bases
GCCGTCATGCGCTGCTGGCCAGGGGTAGAACGCCGGCTGTTGGCCGTGAACCGGTCATGAGGATGGGCCTCGGTGATACT
TGATGTACGCAGTCTGAAAC

Downstream 100 bases:

>100_bases
GTGCCAAAATTCTGTTCGTGGATGATGAAGAGCATATTCTCAACTCCTTGGAGCGGCTCTCCGCGGATATTTCCGCATTC
AAGAAAAGGGAATTATTGCC

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 1465; Mature: 1465

Protein sequence:

>1465_residues
MLKESATFADKLAVTIFFKGKHMRPLSLKSKMSITVFLLVAVLMSSLAFFSYGYFEGEFKRLICAQQFTLVSSLADEVDD
ELATSSALLRETAKRMPLDAYGDPLKAQRYLDGCAETLSVFDDGLSLFSPEGTLMAATPHEPNLLGKDYSYREYFRQTVA
TGRPHISIPYCTTRQHRNPAVMFTVPLFGTDGKLAGILAGSFDLLKDNFLGKIEKTRVGKTGYLYTFNADRRLITHPDSP
RILETVPVGKNIGFERALQGFEGSMENVTSRGNRGITSFKRLRNASWTIAAHYPVDEAYAPVHAVKKYLLAALVGAILLS
IFVVRLTMAYLTAPLLHFTRHVANLGDMSPKGRRFSAPSRDEIGTLAETFNAMVARLEKKEEELKRSKELYQVVADFSTD
MAVWRNSDGTMAYVSPHCFQITGYTDAEFYADPGLMDRIIHPDDRDLWIEHKETVGTEIQATPLEFRIVTKANEVRWVSH
FCRFVHDEAGELIGVRGSFSDISAKKMALDVVIAQKNFAENLISSATAPIFVLDSRNRILFWNKACEELTGYPAATMIGT
DRQWQPFYCGRRPTLADVIIDCGEEATLSELYEKFSPSQLAKEGMQAEGWYLGLGGKNRYILFDAAPIRNAEGELVAAIE
TFHDITDRQIAEDSVVLLKDFYLTLFEEFPALIWRSGTDAKCNYFNKTWLQFTGRSLEEELGGGWAEGVHPEDLERCVST
YLRAFDSREPFSMEYRLRCHDGDYRWIVHTGRPFQEPDGAFAGYIGVCYDITDRRRAAEKLRESQRDLAQKHKQLSTLFM
EVEMAKKEWEQTLDCIGDLVILTDNEGHIRRCNRAVVELAGLPYQDVLGREWRSIVLSPEMERIRFTQEGGELFHRLTER
WFFCAIYPFRQKNESGMSGSVVTLHDTTELKKVGEALEKAYGELKEAQGQMLQREKMASIGQLAAGVAHEINNPIGFIMS
NLGTLGKYLGRIREFIAAQDETIAELEGEAVSQRLAQAKKTLKIEYIMGDIDGLITESLDGAERVKKIVQDLKGFSRVDE
AEVKVVDLRECLDSTINIVWNELKYKATLKKEYGDVPPLRCNPQQLNQVFMNLLVNAGHAIESQGEITVRTWREGEDAFI
AISDTGCGIPEEIRARIFEPFFTTKEVGKGTGLGLSISYDIVKKHGGEITVESEQGRGTTFTVRSLSGRGTDMDEQVRIL
CVDDEMNVLRSLGRMFLDDNYDILTASSAAEGLEILERESPVQIVISDYRMPVMNGVDFLRKVCTQWPDTVRIVLSGYAD
TAAIVAAINEGQIYKFVPKPWTDDELRVTVINALEKYQLQKHNAKLLDELSRSNEELVLMNENLEAIVAERTEEVLFRNR
ALSAAQNILDALPVGVLGMDTEGTVVQCNRSAARLLGLDEYAVVGRGAAEALSPEICAFIDELAREKTSMCRLLAGVAGV
RSLGVYLKEGEQEGIVLVFNGEEPL

Sequences:

>Translated_1465_residues
MLKESATFADKLAVTIFFKGKHMRPLSLKSKMSITVFLLVAVLMSSLAFFSYGYFEGEFKRLICAQQFTLVSSLADEVDD
ELATSSALLRETAKRMPLDAYGDPLKAQRYLDGCAETLSVFDDGLSLFSPEGTLMAATPHEPNLLGKDYSYREYFRQTVA
TGRPHISIPYCTTRQHRNPAVMFTVPLFGTDGKLAGILAGSFDLLKDNFLGKIEKTRVGKTGYLYTFNADRRLITHPDSP
RILETVPVGKNIGFERALQGFEGSMENVTSRGNRGITSFKRLRNASWTIAAHYPVDEAYAPVHAVKKYLLAALVGAILLS
IFVVRLTMAYLTAPLLHFTRHVANLGDMSPKGRRFSAPSRDEIGTLAETFNAMVARLEKKEEELKRSKELYQVVADFSTD
MAVWRNSDGTMAYVSPHCFQITGYTDAEFYADPGLMDRIIHPDDRDLWIEHKETVGTEIQATPLEFRIVTKANEVRWVSH
FCRFVHDEAGELIGVRGSFSDISAKKMALDVVIAQKNFAENLISSATAPIFVLDSRNRILFWNKACEELTGYPAATMIGT
DRQWQPFYCGRRPTLADVIIDCGEEATLSELYEKFSPSQLAKEGMQAEGWYLGLGGKNRYILFDAAPIRNAEGELVAAIE
TFHDITDRQIAEDSVVLLKDFYLTLFEEFPALIWRSGTDAKCNYFNKTWLQFTGRSLEEELGGGWAEGVHPEDLERCVST
YLRAFDSREPFSMEYRLRCHDGDYRWIVHTGRPFQEPDGAFAGYIGVCYDITDRRRAAEKLRESQRDLAQKHKQLSTLFM
EVEMAKKEWEQTLDCIGDLVILTDNEGHIRRCNRAVVELAGLPYQDVLGREWRSIVLSPEMERIRFTQEGGELFHRLTER
WFFCAIYPFRQKNESGMSGSVVTLHDTTELKKVGEALEKAYGELKEAQGQMLQREKMASIGQLAAGVAHEINNPIGFIMS
NLGTLGKYLGRIREFIAAQDETIAELEGEAVSQRLAQAKKTLKIEYIMGDIDGLITESLDGAERVKKIVQDLKGFSRVDE
AEVKVVDLRECLDSTINIVWNELKYKATLKKEYGDVPPLRCNPQQLNQVFMNLLVNAGHAIESQGEITVRTWREGEDAFI
AISDTGCGIPEEIRARIFEPFFTTKEVGKGTGLGLSISYDIVKKHGGEITVESEQGRGTTFTVRSLSGRGTDMDEQVRIL
CVDDEMNVLRSLGRMFLDDNYDILTASSAAEGLEILERESPVQIVISDYRMPVMNGVDFLRKVCTQWPDTVRIVLSGYAD
TAAIVAAINEGQIYKFVPKPWTDDELRVTVINALEKYQLQKHNAKLLDELSRSNEELVLMNENLEAIVAERTEEVLFRNR
ALSAAQNILDALPVGVLGMDTEGTVVQCNRSAARLLGLDEYAVVGRGAAEALSPEICAFIDELAREKTSMCRLLAGVAGV
RSLGVYLKEGEQEGIVLVFNGEEPL
>Mature_1465_residues
MLKESATFADKLAVTIFFKGKHMRPLSLKSKMSITVFLLVAVLMSSLAFFSYGYFEGEFKRLICAQQFTLVSSLADEVDD
ELATSSALLRETAKRMPLDAYGDPLKAQRYLDGCAETLSVFDDGLSLFSPEGTLMAATPHEPNLLGKDYSYREYFRQTVA
TGRPHISIPYCTTRQHRNPAVMFTVPLFGTDGKLAGILAGSFDLLKDNFLGKIEKTRVGKTGYLYTFNADRRLITHPDSP
RILETVPVGKNIGFERALQGFEGSMENVTSRGNRGITSFKRLRNASWTIAAHYPVDEAYAPVHAVKKYLLAALVGAILLS
IFVVRLTMAYLTAPLLHFTRHVANLGDMSPKGRRFSAPSRDEIGTLAETFNAMVARLEKKEEELKRSKELYQVVADFSTD
MAVWRNSDGTMAYVSPHCFQITGYTDAEFYADPGLMDRIIHPDDRDLWIEHKETVGTEIQATPLEFRIVTKANEVRWVSH
FCRFVHDEAGELIGVRGSFSDISAKKMALDVVIAQKNFAENLISSATAPIFVLDSRNRILFWNKACEELTGYPAATMIGT
DRQWQPFYCGRRPTLADVIIDCGEEATLSELYEKFSPSQLAKEGMQAEGWYLGLGGKNRYILFDAAPIRNAEGELVAAIE
TFHDITDRQIAEDSVVLLKDFYLTLFEEFPALIWRSGTDAKCNYFNKTWLQFTGRSLEEELGGGWAEGVHPEDLERCVST
YLRAFDSREPFSMEYRLRCHDGDYRWIVHTGRPFQEPDGAFAGYIGVCYDITDRRRAAEKLRESQRDLAQKHKQLSTLFM
EVEMAKKEWEQTLDCIGDLVILTDNEGHIRRCNRAVVELAGLPYQDVLGREWRSIVLSPEMERIRFTQEGGELFHRLTER
WFFCAIYPFRQKNESGMSGSVVTLHDTTELKKVGEALEKAYGELKEAQGQMLQREKMASIGQLAAGVAHEINNPIGFIMS
NLGTLGKYLGRIREFIAAQDETIAELEGEAVSQRLAQAKKTLKIEYIMGDIDGLITESLDGAERVKKIVQDLKGFSRVDE
AEVKVVDLRECLDSTINIVWNELKYKATLKKEYGDVPPLRCNPQQLNQVFMNLLVNAGHAIESQGEITVRTWREGEDAFI
AISDTGCGIPEEIRARIFEPFFTTKEVGKGTGLGLSISYDIVKKHGGEITVESEQGRGTTFTVRSLSGRGTDMDEQVRIL
CVDDEMNVLRSLGRMFLDDNYDILTASSAAEGLEILERESPVQIVISDYRMPVMNGVDFLRKVCTQWPDTVRIVLSGYAD
TAAIVAAINEGQIYKFVPKPWTDDELRVTVINALEKYQLQKHNAKLLDELSRSNEELVLMNENLEAIVAERTEEVLFRNR
ALSAAQNILDALPVGVLGMDTEGTVVQCNRSAARLLGLDEYAVVGRGAAEALSPEICAFIDELAREKTSMCRLLAGVAGV
RSLGVYLKEGEQEGIVLVFNGEEPL

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=415, Percent_Identity=26.5060240963855, Blast_Score=129, Evalue=2e-30,
Organism=Escherichia coli, GI1790436, Length=258, Percent_Identity=31.0077519379845, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI87081816, Length=389, Percent_Identity=27.5064267352185, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI145693157, Length=314, Percent_Identity=28.343949044586, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=544, Percent_Identity=25.1838235294118, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI87082128, Length=187, Percent_Identity=31.0160427807487, Blast_Score=80, Evalue=8e-16,
Organism=Escherichia coli, GI1790300, Length=270, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1788713, Length=348, Percent_Identity=25.5747126436782, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=118, Percent_Identity=35.5932203389831, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 164340; Mature: 164340

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKESATFADKLAVTIFFKGKHMRPLSLKSKMSITVFLLVAVLMSSLAFFSYGYFEGEFK
CCCCCCCHHCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RLICAQQFTLVSSLADEVDDELATSSALLRETAKRMPLDAYGDPLKAQRYLDGCAETLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FDDGLSLFSPEGTLMAATPHEPNLLGKDYSYREYFRQTVATGRPHISIPYCTTRQHRNPA
HHCCHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCE
VMFTVPLFGTDGKLAGILAGSFDLLKDNFLGKIEKTRVGKTGYLYTFNADRRLITHPDSP
EEEEEEEECCCCCEEEEECCCHHHHHHHHHCCHHHHCCCCCCEEEEECCCCEEEECCCCC
RILETVPVGKNIGFERALQGFEGSMENVTSRGNRGITSFKRLRNASWTIAAHYPVDEAYA
CEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCHHHC
PVHAVKKYLLAALVGAILLSIFVVRLTMAYLTAPLLHFTRHVANLGDMSPKGRRFSAPSR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
DEIGTLAETFNAMVARLEKKEEELKRSKELYQVVADFSTDMAVWRNSDGTMAYVSPHCFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCEEE
ITGYTDAEFYADPGLMDRIIHPDDRDLWIEHKETVGTEIQATPLEFRIVTKANEVRWVSH
EECCCCCHHCCCCCHHHHCCCCCCCCEEEEEHHHCCCEEEECCEEEEEEECCCHHHHHHH
FCRFVHDEAGELIGVRGSFSDISAKKMALDVVIAQKNFAENLISSATAPIFVLDSRNRIL
HHHHHHHCCCCEEEECCCCCCCCHHHHEEEEEEECHHHHHHHHHCCCCCEEEEECCCEEE
FWNKACEELTGYPAATMIGTDRQWQPFYCGRRPTLADVIIDCGEEATLSELYEKFSPSQL
EECHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHH
AKEGMQAEGWYLGLGGKNRYILFDAAPIRNAEGELVAAIETFHDITDRQIAEDSVVLLKD
HHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHH
FYLTLFEEFPALIWRSGTDAKCNYFNKTWLQFTGRSLEEELGGGWAEGVHPEDLERCVST
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHH
YLRAFDSREPFSMEYRLRCHDGDYRWIVHTGRPFQEPDGAFAGYIGVCYDITDRRRAAEK
HHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEHHEEEEECHHHHHHHHH
LRESQRDLAQKHKQLSTLFMEVEMAKKEWEQTLDCIGDLVILTDNEGHIRRCNRAVVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHC
GLPYQDVLGREWRSIVLSPEMERIRFTQEGGELFHRLTERWFFCAIYPFRQKNESGMSGS
CCCHHHHHHHHHHHEECCCCHHHHEEHHHHHHHHHHHHHCEEEEEEECHHCCCCCCCCCC
VVTLHDTTELKKVGEALEKAYGELKEAQGQMLQREKMASIGQLAAGVAHEINNPIGFIMS
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
NLGTLGKYLGRIREFIAAQDETIAELEGEAVSQRLAQAKKTLKIEYIMGDIDGLITESLD
HHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHCCC
GAERVKKIVQDLKGFSRVDEAEVKVVDLRECLDSTINIVWNELKYKATLKKEYGDVPPLR
HHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
CNPQQLNQVFMNLLVNAGHAIESQGEITVRTWREGEDAFIAISDTGCGIPEEIRARIFEP
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHH
FFTTKEVGKGTGLGLSISYDIVKKHGGEITVESEQGRGTTFTVRSLSGRGTDMDEQVRIL
HHHHHHCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEE
CVDDEMNVLRSLGRMFLDDNYDILTASSAAEGLEILERESPVQIVISDYRMPVMNGVDFL
EECCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
RKVCTQWPDTVRIVLSGYADTAAIVAAINEGQIYKFVPKPWTDDELRVTVINALEKYQLQ
HHHHHCCCCEEEHEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEHHHHHHHHHHHH
KHNAKLLDELSRSNEELVLMNENLEAIVAERTEEVLFRNRALSAAQNILDALPVGVLGMD
HCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
TEGTVVQCNRSAARLLGLDEYAVVGRGAAEALSPEICAFIDELAREKTSMCRLLAGVAGV
CCCCEEEECCHHHHHHCCCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLGVYLKEGEQEGIVLVFNGEEPL
HHHHHHHCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MLKESATFADKLAVTIFFKGKHMRPLSLKSKMSITVFLLVAVLMSSLAFFSYGYFEGEFK
CCCCCCCHHCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RLICAQQFTLVSSLADEVDDELATSSALLRETAKRMPLDAYGDPLKAQRYLDGCAETLSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
FDDGLSLFSPEGTLMAATPHEPNLLGKDYSYREYFRQTVATGRPHISIPYCTTRQHRNPA
HHCCHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCE
VMFTVPLFGTDGKLAGILAGSFDLLKDNFLGKIEKTRVGKTGYLYTFNADRRLITHPDSP
EEEEEEEECCCCCEEEEECCCHHHHHHHHHCCHHHHCCCCCCEEEEECCCCEEEECCCCC
RILETVPVGKNIGFERALQGFEGSMENVTSRGNRGITSFKRLRNASWTIAAHYPVDEAYA
CEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCEEEEEECCCCHHHC
PVHAVKKYLLAALVGAILLSIFVVRLTMAYLTAPLLHFTRHVANLGDMSPKGRRFSAPSR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
DEIGTLAETFNAMVARLEKKEEELKRSKELYQVVADFSTDMAVWRNSDGTMAYVSPHCFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEECCCEEE
ITGYTDAEFYADPGLMDRIIHPDDRDLWIEHKETVGTEIQATPLEFRIVTKANEVRWVSH
EECCCCCHHCCCCCHHHHCCCCCCCCEEEEEHHHCCCEEEECCEEEEEEECCCHHHHHHH
FCRFVHDEAGELIGVRGSFSDISAKKMALDVVIAQKNFAENLISSATAPIFVLDSRNRIL
HHHHHHHCCCCEEEECCCCCCCCHHHHEEEEEEECHHHHHHHHHCCCCCEEEEECCCEEE
FWNKACEELTGYPAATMIGTDRQWQPFYCGRRPTLADVIIDCGEEATLSELYEKFSPSQL
EECHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHCCHHHH
AKEGMQAEGWYLGLGGKNRYILFDAAPIRNAEGELVAAIETFHDITDRQIAEDSVVLLKD
HHCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHHHH
FYLTLFEEFPALIWRSGTDAKCNYFNKTWLQFTGRSLEEELGGGWAEGVHPEDLERCVST
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHH
YLRAFDSREPFSMEYRLRCHDGDYRWIVHTGRPFQEPDGAFAGYIGVCYDITDRRRAAEK
HHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCCEEHHEEEEECHHHHHHHHH
LRESQRDLAQKHKQLSTLFMEVEMAKKEWEQTLDCIGDLVILTDNEGHIRRCNRAVVELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHC
GLPYQDVLGREWRSIVLSPEMERIRFTQEGGELFHRLTERWFFCAIYPFRQKNESGMSGS
CCCHHHHHHHHHHHEECCCCHHHHEEHHHHHHHHHHHHHCEEEEEEECHHCCCCCCCCCC
VVTLHDTTELKKVGEALEKAYGELKEAQGQMLQREKMASIGQLAAGVAHEINNPIGFIMS
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
NLGTLGKYLGRIREFIAAQDETIAELEGEAVSQRLAQAKKTLKIEYIMGDIDGLITESLD
HHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHEEEEEEECCHHHHHHHCCC
GAERVKKIVQDLKGFSRVDEAEVKVVDLRECLDSTINIVWNELKYKATLKKEYGDVPPLR
HHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
CNPQQLNQVFMNLLVNAGHAIESQGEITVRTWREGEDAFIAISDTGCGIPEEIRARIFEP
CCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHH
FFTTKEVGKGTGLGLSISYDIVKKHGGEITVESEQGRGTTFTVRSLSGRGTDMDEQVRIL
HHHHHHCCCCCCCEEEEEHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEE
CVDDEMNVLRSLGRMFLDDNYDILTASSAAEGLEILERESPVQIVISDYRMPVMNGVDFL
EECCHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
RKVCTQWPDTVRIVLSGYADTAAIVAAINEGQIYKFVPKPWTDDELRVTVINALEKYQLQ
HHHHHCCCCEEEHEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEHHHHHHHHHHHH
KHNAKLLDELSRSNEELVLMNENLEAIVAERTEEVLFRNRALSAAQNILDALPVGVLGMD
HCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
TEGTVVQCNRSAARLLGLDEYAVVGRGAAEALSPEICAFIDELAREKTSMCRLLAGVAGV
CCCCEEEECCHHHHHHCCCHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLGVYLKEGEQEGIVLVFNGEEPL
HHHHHHHCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]