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The map label for this gene is dnaX [H]

Identifier: 78224612

GI number: 78224612

Start: 3839009

End: 3840757

Strand: Reverse

Name: dnaX [H]

Synonym: Gmet_3422

Alternate gene names: 78224612

Gene position: 3840757-3839009 (Counterclockwise)

Preceding gene: 78224613

Following gene: 78224611

Centisome position: 96.08

GC content: 65.12

Gene sequence:

>1749_bases
TTGTCCTATCTCGTTCTCGCACGAAAGTGGCGCCCCCAGACCTTCAGCGACCTGACCGGCCAGGAGCATGTCAGCCAGAC
CCTTCAGAACGCCATCGATTCCGGCCGCATCGCCCATGCGTTCCTTTTCACCGGCGCCCGTGGGGTGGGGAAGACCTCGT
CCGCCCGTATTCTGGCCAAGGCCCTGACCTGCGAGCAGGGGATGAGCCCCGAGCCGTGCAATGTCTGTCCCGCCTGTACG
GAGATCACCGCCGGCACCGCCGTGGACGTCCTCGAGATCGACGGCGCCTCCAACACCGGCGTCGACGACATCCGGGAGCT
GCGGGAAAACGTCAAGTACCTCCCGTCCCGGCTCCGCTACAAGATCTTCATCATCGACGAAGTCCACATGCTCTCCACGA
ATGCCTTCAACGCTCTGCTGAAGACCCTGGAAGAGCCCCCTCCCCACGTCAAGTTCATCTTCGCCACCACCGAGCCCCAC
AAGGTGCCGATCACCATTCTCTCCCGCTGTCAGCGGTTCGACTTCCGGCGGATACCGCTCGGCAAGGTGGTGGGGCGTCT
GCGCCACATCGTGGACCAGGAGGGGATCGCCATCAGTGACGCGTCTCTCACCATGGTGGCTCGCAAGGGGGACGGGAGCA
TGCGCGACTCCCTGTCGGTGCTCGACCAGGTCCTCGCTTTCTGTGGCGACCAGGTGCGGGACGAGGAGGTGGTGAGCCTC
CTGGGGGTGGTGGACCGACGGCTTCTTCTCGATGCCACGGCGGCGGTCTTTGGCCGGGATACCCGCACGGTCCTCGACAT
CGTGGCGCGGGTGGACGAGTTCGGCTACAATATGCGACAATTCTGCGGAGAGCTCATCGACCACCTTCGCAACCTCCTGA
TCCTCAAGGCGGTGGGGGATGGCACCGACCTCCTTGACCTTTCCGAGGCGGAACTGGCGACCCTGCGGCAGCAGGCGGAG
AGCGTTCCGCTTGATGACCTCCAGCGGCACTTGACGGTGCTGTTGCGGGCTGACGGGGAACTCGGCCACACATCCTTCCC
CCGGCTCGTGCTGGAGATGGCCCTGGTCAAAATGGCGACTCTGGCACCGGCGGTGCCGGTGGATCAGCTCTTGGAGCGTC
TGAACAAGATTGAAGAAGGGAGCGGGGGCGGCGTTGCCGACGCTCGTGCCCAGTGGCGTGCAACGCCCCCGGCGCCTGCC
GGTTCTCCCACTCCGGCCAGGGCACCTGAACGCACCGCCGCCACTCCACCACCACGGCCGGCCGAGCGGCAGGCTGCACC
CTCTGCTCCCGCGCCGCGCCGCGAGGAGGCGAAGCCCGTTTCGGAGCCTCGCCGGACCGGCGATTCCTGGGCTGATTTCG
TCGCTCTTGTCAAGGGTGCCAAGCCGCGACTCGGTTCGATGCTCGAACAGGGGAGTCCGCTTGTTGTCTCGGCAGACCGG
CTGGAAATCGGTTTCCCGGAAGGCGCCTTCGCCCTGGCCAGCCTCAGGGACAGCGACTCCCAGGCTGCCTTGAAGGAGCT
GGCTCGCCAGTTCTTCTTGGCCGAACCCGTTCTCGTCATGCGTCCCCTTGCTCCTGACGCGGCGGAAGCTCCTCCCAATC
TTCTGGAAAAAAAAAGGGTTGAGAAGGAACAGCAACAGACCGTCCTGAAGCAGGCCGCCACCTCTCATCCCGCGGTTGCC
GACGCGCTCGATGTCTTCGGCGGCACCCTTGCGGAGGTTGAGCCCCTGGAGCGGAAAGAGTCCCGCTAA

Upstream 100 bases:

>100_bases
GGGGAAGCCCAGCTATCAGTTGTGCCCGCAACGCCCCCGTTACACCCTCCCCCCTTTCCGAGCACGCAAGCATCCGACCG
CGTCGTGAGGTGTTGATCCC

Downstream 100 bases:

>100_bases
CAATGTTTTAATTTCAACAAAACTCTTTAATCAAGAGTAAATCTCATCTCACGAAACCACGGAGGAACAGATGTCCAAAG
GTTTGGCAGGTATCATGAAG

Product: DNA polymerase III subunits gamma/tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSYLVLARKWRPQTFSDLTGQEHVSQTLQNAIDSGRIAHAFLFTGARGVGKTSSARILAKALTCEQGMSPEPCNVCPACT
EITAGTAVDVLEIDGASNTGVDDIRELRENVKYLPSRLRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPH
KVPITILSRCQRFDFRRIPLGKVVGRLRHIVDQEGIAISDASLTMVARKGDGSMRDSLSVLDQVLAFCGDQVRDEEVVSL
LGVVDRRLLLDATAAVFGRDTRTVLDIVARVDEFGYNMRQFCGELIDHLRNLLILKAVGDGTDLLDLSEAELATLRQQAE
SVPLDDLQRHLTVLLRADGELGHTSFPRLVLEMALVKMATLAPAVPVDQLLERLNKIEEGSGGGVADARAQWRATPPAPA
GSPTPARAPERTAATPPPRPAERQAAPSAPAPRREEAKPVSEPRRTGDSWADFVALVKGAKPRLGSMLEQGSPLVVSADR
LEIGFPEGAFALASLRDSDSQAALKELARQFFLAEPVLVMRPLAPDAAEAPPNLLEKKRVEKEQQQTVLKQAATSHPAVA
DALDVFGGTLAEVEPLERKESR

Sequences:

>Translated_582_residues
MSYLVLARKWRPQTFSDLTGQEHVSQTLQNAIDSGRIAHAFLFTGARGVGKTSSARILAKALTCEQGMSPEPCNVCPACT
EITAGTAVDVLEIDGASNTGVDDIRELRENVKYLPSRLRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPH
KVPITILSRCQRFDFRRIPLGKVVGRLRHIVDQEGIAISDASLTMVARKGDGSMRDSLSVLDQVLAFCGDQVRDEEVVSL
LGVVDRRLLLDATAAVFGRDTRTVLDIVARVDEFGYNMRQFCGELIDHLRNLLILKAVGDGTDLLDLSEAELATLRQQAE
SVPLDDLQRHLTVLLRADGELGHTSFPRLVLEMALVKMATLAPAVPVDQLLERLNKIEEGSGGGVADARAQWRATPPAPA
GSPTPARAPERTAATPPPRPAERQAAPSAPAPRREEAKPVSEPRRTGDSWADFVALVKGAKPRLGSMLEQGSPLVVSADR
LEIGFPEGAFALASLRDSDSQAALKELARQFFLAEPVLVMRPLAPDAAEAPPNLLEKKRVEKEQQQTVLKQAATSHPAVA
DALDVFGGTLAEVEPLERKESR
>Mature_581_residues
SYLVLARKWRPQTFSDLTGQEHVSQTLQNAIDSGRIAHAFLFTGARGVGKTSSARILAKALTCEQGMSPEPCNVCPACTE
ITAGTAVDVLEIDGASNTGVDDIRELRENVKYLPSRLRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHK
VPITILSRCQRFDFRRIPLGKVVGRLRHIVDQEGIAISDASLTMVARKGDGSMRDSLSVLDQVLAFCGDQVRDEEVVSLL
GVVDRRLLLDATAAVFGRDTRTVLDIVARVDEFGYNMRQFCGELIDHLRNLLILKAVGDGTDLLDLSEAELATLRQQAES
VPLDDLQRHLTVLLRADGELGHTSFPRLVLEMALVKMATLAPAVPVDQLLERLNKIEEGSGGGVADARAQWRATPPAPAG
SPTPARAPERTAATPPPRPAERQAAPSAPAPRREEAKPVSEPRRTGDSWADFVALVKGAKPRLGSMLEQGSPLVVSADRL
EIGFPEGAFALASLRDSDSQAALKELARQFFLAEPVLVMRPLAPDAAEAPPNLLEKKRVEKEQQQTVLKQAATSHPAVAD
ALDVFGGTLAEVEPLERKESR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=237, Percent_Identity=27.4261603375527, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI194306571, Length=240, Percent_Identity=27.0833333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI194306567, Length=240, Percent_Identity=27.0833333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4506491, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI31881687, Length=248, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI31563534, Length=281, Percent_Identity=22.0640569395018, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786676, Length=371, Percent_Identity=43.1266846361186, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI1787341, Length=166, Percent_Identity=31.3253012048193, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=225, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=309, Percent_Identity=25.5663430420712, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17541988, Length=216, Percent_Identity=24.0740740740741, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=243, Percent_Identity=25.5144032921811, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322528, Length=297, Percent_Identity=23.9057239057239, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=227, Percent_Identity=25.1101321585903, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859927, Length=296, Percent_Identity=23.9864864864865, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921076, Length=239, Percent_Identity=27.6150627615063, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17647857, Length=337, Percent_Identity=24.3323442136499, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63361; Mature: 63230

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKWRPQTFSDLTGQEHVSQTLQNAIDSGRIAHAFLFTGARGVGKTSSARILAK
CCEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHH
ALTCEQGMSPEPCNVCPACTEITAGTAVDVLEIDGASNTGVDDIRELRENVKYLPSRLRY
HHHHHCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCE
KIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFRRIPL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCH
GKVVGRLRHIVDQEGIAISDASLTMVARKGDGSMRDSLSVLDQVLAFCGDQVRDEEVVSL
HHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGVVDRRLLLDATAAVFGRDTRTVLDIVARVDEFGYNMRQFCGELIDHLRNLLILKAVGD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEECCC
GTDLLDLSEAELATLRQQAESVPLDDLQRHLTVLLRADGELGHTSFPRLVLEMALVKMAT
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LAPAVPVDQLLERLNKIEEGSGGGVADARAQWRATPPAPAGSPTPARAPERTAATPPPRP
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AERQAAPSAPAPRREEAKPVSEPRRTGDSWADFVALVKGAKPRLGSMLEQGSPLVVSADR
CCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCC
LEIGFPEGAFALASLRDSDSQAALKELARQFFLAEPVLVMRPLAPDAAEAPPNLLEKKRV
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHH
EKEQQQTVLKQAATSHPAVADALDVFGGTLAEVEPLERKESR
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCHHHCCCC
>Mature Secondary Structure 
SYLVLARKWRPQTFSDLTGQEHVSQTLQNAIDSGRIAHAFLFTGARGVGKTSSARILAK
CEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHH
ALTCEQGMSPEPCNVCPACTEITAGTAVDVLEIDGASNTGVDDIRELRENVKYLPSRLRY
HHHHHCCCCCCCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCE
KIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFDFRRIPL
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCH
GKVVGRLRHIVDQEGIAISDASLTMVARKGDGSMRDSLSVLDQVLAFCGDQVRDEEVVSL
HHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
LGVVDRRLLLDATAAVFGRDTRTVLDIVARVDEFGYNMRQFCGELIDHLRNLLILKAVGD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEEECCC
GTDLLDLSEAELATLRQQAESVPLDDLQRHLTVLLRADGELGHTSFPRLVLEMALVKMAT
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LAPAVPVDQLLERLNKIEEGSGGGVADARAQWRATPPAPAGSPTPARAPERTAATPPPRP
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AERQAAPSAPAPRREEAKPVSEPRRTGDSWADFVALVKGAKPRLGSMLEQGSPLVVSADR
CCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCC
LEIGFPEGAFALASLRDSDSQAALKELARQFFLAEPVLVMRPLAPDAAEAPPNLLEKKRV
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHH
EKEQQQTVLKQAATSHPAVADALDVFGGTLAEVEPLERKESR
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]