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The map label for this gene is pdxA

Identifier: 78224594

GI number: 78224594

Start: 3819234

End: 3820253

Strand: Reverse

Name: pdxA

Synonym: Gmet_3404

Alternate gene names: 78224594

Gene position: 3820253-3819234 (Counterclockwise)

Preceding gene: 78224595

Following gene: 78224593

Centisome position: 95.57

GC content: 66.18

Gene sequence:

>1020_bases
ATGCCAAACACTAAACCACGTATTGTCATAACCATGGGGGACCCCACCGGGGTCGGCCCCGAGATCATCGCCGCAACCCT
GGCCGAGCCAGAGGTGCGCCAATGCTGCCGCTTCCTCGTTGTCGGCGACAGCGCGGCCATGGCACGGGGAATCACCGTCG
CAGGCGCCGCGCTCCGGGTAGAGCGGACCGATACCCTGAACTGGGAAGAAAGCAAAGAAGGGGTGCTCCCCCTTTGGGAG
ATTTCGTCCCTCACCGAAGCGGACATGCAGTATGGCTGCCCCACCGTTGCCAGCGGCGACGCCATGTACCGGGCCATCTG
CGAGGCCGCGCGACTCTGCCTTGAAGGAAATGCCGACGCCATGGCGACCGCTCCCATCAGCAAGGAGGCCCTGAACCGGG
CCGGGCATCGGTATCCGGGGCATACGGAACTCCTGGCCGAACTGGCGGGGGCGGAGCGGGTCGTCATGATGCTGGCCGGC
TTCCGGCTCCGGGTCACTCTCGTCACCATCCACGAGGCTTTGGCCGACGTGCCGCGTCTAGTGACCTTCGAGCGGGTGCT
GGAGACAATCCGGATTACCCACCGGGATCTGCACCGCTATTTCAGGAGGAATCCCCGCATCGCGGTCCTGGCCCTCAATC
CCCACTGCGGCGAAGGGGGGATGTTCGGGGACGAGGAGGCGCGCATCATTGCCCCTGCCGTGGCGGCTGCCCGGCAGGAG
GGGATCGATGCGATCGGCCCCCTCTCGGCCGATACGCTTTTCCACTTCGCCGTCCAGGGCGCCTACGACGCGGTGGTCTG
CATGTACCACGACCAGGGACTCATCCCCCTGAAGCTCCTCCACTTCGACGACGGGGTCAACGTGACCCTAGGGCTCCCCA
TTATCCGCACCTCCGTGGACCACGGCACCGCCTACGATCTGGCCGGAACCGGCAGGGCCTCGGCCGAGAGCATGAAGGCG
GCCATCCTCATGGCGGCGGAGATGGCGCGGGTGAAGGGATCGGGAGGCGGAACACCGTGA

Upstream 100 bases:

>100_bases
CACCCGGAAGTAGCGAAAAATCACCACGTACCAAGAAGAGCGGCCTAGCCGCTCTTTTTTTTTCACTGATGCAGGCCCTG
AATCCTGCTATGATCCGACC

Downstream 100 bases:

>100_bases
CCATGAAAAAGATGCTCTATCTGGCCATCGGGGCCGTGGTGGCCTATGGAGCCTACATTGCCCTATCCCTCATGTTCCTT
CCGTCGGTGGAAGAGCTCAA

Product: pyridoxal phosphate biosynthetic protein PdxA

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRVERTDTLNWEESKEGVLPLWE
ISSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADAMATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAG
FRLRVTLVTIHEALADVPRLVTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQE
GIDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGRASAESMKA
AILMAAEMARVKGSGGGTP

Sequences:

>Translated_339_residues
MPNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRVERTDTLNWEESKEGVLPLWE
ISSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADAMATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAG
FRLRVTLVTIHEALADVPRLVTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQE
GIDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGRASAESMKA
AILMAAEMARVKGSGGGTP
>Mature_338_residues
PNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRVERTDTLNWEESKEGVLPLWEI
SSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADAMATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAGF
RLRVTLVTIHEALADVPRLVTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQEG
IDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGRASAESMKAA
ILMAAEMARVKGSGGGTP

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=323, Percent_Identity=39.938080495356, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_GEOMG (Q39Q58)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386341.1
- ProteinModelPortal:   Q39Q58
- SMR:   Q39Q58
- STRING:   Q39Q58
- GeneID:   3741182
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3404
- NMPDR:   fig|269799.3.peg.3379
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   VTLVTIH
- PhylomeDB:   Q39Q58
- ProtClustDB:   CLSK827645
- BioCyc:   GMET269799:GMET_3404-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36281; Mature: 36150

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: BINDING 141-141 BINDING 142-142 BINDING 278-278 BINDING 287-287 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRV
CCCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHEEEECCCHHHHCCEEEECEEEEE
ERTDTLNWEESKEGVLPLWEISSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADA
ECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
MATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAGFRLRVTLVTIHEALADVPRL
EEECCCCHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
VTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHC
GIDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVD
CCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCCCEEEECCEEEEECCC
HGTAYDLAGTGRASAESMKAAILMAAEMARVKGSGGGTP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRV
CCCCCEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHEEEECCCHHHHCCEEEECEEEEE
ERTDTLNWEESKEGVLPLWEISSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADA
ECCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
MATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAGFRLRVTLVTIHEALADVPRL
EEECCCCHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHH
VTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQE
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHC
GIDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVD
CCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEECCCCEEEECCEEEEECCC
HGTAYDLAGTGRASAESMKAAILMAAEMARVKGSGGGTP
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA