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The map label for this gene is rnd [H]

Identifier: 78224579

GI number: 78224579

Start: 3802794

End: 3803942

Strand: Reverse

Name: rnd [H]

Synonym: Gmet_3389

Alternate gene names: 78224579

Gene position: 3803942-3802794 (Counterclockwise)

Preceding gene: 78224580

Following gene: 78224575

Centisome position: 95.16

GC content: 67.1

Gene sequence:

>1149_bases
TTGCCCGTTCAACCCGTTTCACCCGAGATCATAACCACCCCCGACGGGGTCCGCCGCCTTGCCGACCGCCTCTCCCGGGA
GCCCTATGTGGCCTGCGACCTGGAGGCCGACTCCATGCACCACTACCAGGAGAAGGTCTGCCTGATCCAGTTCACGGTGC
CGGGGCTTGCCGCCATCGTCGACCCCCTGGCGGTTGCCGACCTGGCCCCCTTGGCGCCGGTCTTTGCCAACCCCTCCATC
CGCAAGGTATTCCATGGGGCCGATTACGACATCCGGTCCCTGCACCGGGACTTCGGCATCGAGGTGAATAACCTCTTCGA
CACCATGATCGCGTGCCAGTTTCTGGGGGAGCGGGAGTTCGGCCTGGCGGCGGTGCTCCGGAAGCGTTTCGGAGTGGAGC
TGGACAAGCAGTACCAGCGGGCCGACTGGAGCCGGCGCCCCTTGACGGCGGGGATGATCGAGTATGCGGCGAAGGATACG
ACGCTCCTCATCGAACTCTGCGGGCGGCTGGAGGCGGAACTCCGGGAGAAGGGGCGTATCGGCTGGGTGGAGGAGGAGTG
TGCCCTCCTGGCGCGGGTGCGGGTAGCCCAGCGCTCCGACGGCGAGCCGATGTTCCTCCGCTTCAAGGGAGCCTCGCGGA
TGGCTTCCCGGTCCCTGGCGGTGCTGGAAGAAATCCTCTGCTTCCGGGATCGGCGGGCGCAACAGATGGACGTCCCTCCC
TTCAAAGTGCTGGGCACGGAAACGGTCCGGGAACTGGCCGAGAAGAAGCCCCGATCCCTTGCCGAGTTGACCGGCATTAC
GGGCATCACGGAACGGGTCGTGGAGCGGTGCGGCGAGGGGATAGTGCGGGCCGTGGAGAAGGGGCTGGCGGTGCCGGAGC
AGGAGCTTCCCTTCTTTCCCCGGGAGGAGCGGCGGAAGGTGGGGGGGGACGAGGAGCGGCGCATCAAGGCCCTCAAAGGG
TGGCGTGAGGATAAGGCCCGGCGGTTCGCCGTGGAGCCCGGCTTCCTGGCCAATAACGCCCTTTTGGAGCAGATTGCCCT
GGTCTTTCCCCGGTCGGAGGTGGAACTGGAGGGGATCGCCGGTCTTCGTCCGTGGCAGCGGCGGGAGTTCGGGGCCGAGA
TGGTGGCGGCCCTCCAGGCCAGGCGCTAG

Upstream 100 bases:

>100_bases
AGCCGGCTTCAGGCCTGCCCAGAGAACGACGCTTTATAAAATAATTCGGGAATTTTAGAGTATTTTCCCCTCCCGACAAT
TCTTACGACTGGAGATTTCC

Downstream 100 bases:

>100_bases
CAGGCTGTTGAAAAACTATTGCGGGGCCGGTCTGCGTTGTTTCCGCTCGCTCAAAAGCTCAACGTACCAACGGGTACGCC
TCGCTTTTTCGCTTGCTTGC

Product: 3'-5' exonuclease

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIVDPLAVADLAPLAPVFANPSI
RKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREFGLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDT
TLLIELCGRLEAELREKGRIGWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPP
FKVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFPREERRKVGGDEERRIKALKG
WREDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIAGLRPWQRREFGAEMVAALQARR

Sequences:

>Translated_382_residues
MPVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIVDPLAVADLAPLAPVFANPSI
RKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREFGLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDT
TLLIELCGRLEAELREKGRIGWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPP
FKVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFPREERRKVGGDEERRIKALKG
WREDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIAGLRPWQRREFGAEMVAALQARR
>Mature_381_residues
PVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIVDPLAVADLAPLAPVFANPSIR
KVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREFGLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDTT
LLIELCGRLEAELREKGRIGWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPPF
KVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFPREERRKVGGDEERRIKALKGW
REDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIAGLRPWQRREFGAEMVAALQARR

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=265, Percent_Identity=29.0566037735849, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI50301240, Length=265, Percent_Identity=29.0566037735849, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1788105, Length=290, Percent_Identity=30.3448275862069, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17531757, Length=256, Percent_Identity=33.984375, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564304, Length=107, Percent_Identity=39.2523364485981, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324574, Length=320, Percent_Identity=28.125, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161078302, Length=264, Percent_Identity=29.9242424242424, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43177; Mature: 43046

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIV
CCCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEEECCCHHHHHH
DPLAVADLAPLAPVFANPSIRKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREF
HHHHHHHHHHCCHHHCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCH
GLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDTTLLIELCGRLEAELREKGRI
HHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
GWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPP
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FKVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFP
HHHHCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCC
REERRKVGGDEERRIKALKGWREDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIA
CHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GLRPWQRREFGAEMVAALQARR
CCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIV
CCCCCCCCEEECCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEEECCCHHHHHH
DPLAVADLAPLAPVFANPSIRKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREF
HHHHHHHHHHCCHHHCCCHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCH
GLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDTTLLIELCGRLEAELREKGRI
HHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
GWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPP
CCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FKVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFP
HHHHCHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCC
REERRKVGGDEERRIKALKGWREDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIA
CHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GLRPWQRREFGAEMVAALQARR
CCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]