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The map label for this gene is pepA [H]

Identifier: 78224551

GI number: 78224551

Start: 3775958

End: 3777448

Strand: Reverse

Name: pepA [H]

Synonym: Gmet_3361

Alternate gene names: 78224551

Gene position: 3777448-3775958 (Counterclockwise)

Preceding gene: 78224552

Following gene: 78224545

Centisome position: 94.5

GC content: 61.1

Gene sequence:

>1491_bases
ATGAATGCTCGGGTTGTTTTGCATGATGCCCTGCTCTACCCCTGCCCGCTGCTTGTTCTGGGCTGCTACGAAGACCGATT
CAGTGAGAACACCCTTCTGGGTTCCGTTGACGATGCATTGGGGCGAGGTCTGTCTGCCATCCGTGAGGCTGGAGAATTTA
CCGGCAAACTCAACAGGACCAAGCTCATCCACACCCTTGGCCGTCTCCCTGCGGAACGGCTTCTCCTTGTCGGGCTGGGC
CAGCGGGATGCGGTTACTCCCGAGCGGGTTCGCCAGGCGGCGGGGAGTGCGGTGAAGGCAGTCCGTGCCACCGGTGTGGT
GCGCTTCGCTACCATCTTGCACCGTTCGGCTGATTCCGTGCCTGGATCACTGGAAGCCTCACTGGAAGGTTATCTTCTTG
GCGGTTACGGTTTCGATATCTACAAGACTACGAAAAATGACGAAGGCACCGTTGAGGAGATGGCCGTCCTTGTGGACGAG
GAAGGCGAACTGGCATCGACCGAGCGCGCGGTGAGCGAGCGCACGACGGTCTGTGATGCGGTAAGCTTTGTCCGCGATCT
GGTTTCCCATCCCTGCAACGTGGCGACCCCCGCATATCTCGCCGACCGAGCCATCGAAATGGCAGGGCGACTCGGCGTCG
CCTGTCGCGTGCTCGAGCGCGAGGATATGGAGCGGCTTTCCATGGAGGGAATCCTGTCCGTGGCCAAGGGATCCCATCAC
TCGCCCCGGTTCATCATTCTCGAATATCTGGCGGGAGACCCCAAGAAACGTCCCGTTGTTCTCGTCGGGAAAGGAGTGAC
GTTCGACTCGGGGGGGATATCCCTCAAGCCGCGGGAGGGGATGGAGAGGATGAAGGACGACATGGCGGGAGCCGCGGCGG
TAATGGGTACCATCAGTGCTGTGTCCGGGCTCCGGATGCCGGTCAACGTTGTCGGCCTCATCCCTGTAGCGGAAAATATG
CCCGGCGGTGGCGCCTATAGGCCTGGCGATGTGGTGCGTACGATGTCAGGGCAAACGGTGGAGATTGTCAACACAGATGC
GGAGGGGAGGATGCTCCTCTGTGACGCCCTTTATTACGCGCAACGCTATCGTCCCGCCGCTCTCATCGACCTGGCTACCC
TCACGGGGGCCTGTCTCGTGGCCCTTGGCACTGTCGCAACAGCGGTCATGGGAAACGATTCGACGCTCATCCGCGCGCTT
ACGACTTCAGGCGAAGCCACGGGGGAGCGGCTCTGGGAGCTTCCCGTCTGGGACGAGTACGGAGAACTCATGAAAAGCGA
CATCGCCGACATGAAAAATGCCGGGGGACCCCATGCCGGCACCATCTCTGCGGCATGGTTTCTCCAACGCTATGTGGGGA
AGGCGAAATGGGCCCACCTCGACATCGCGGGCACCGCGTGGGAGGAGAAGGGGAAGCCTTACCTCCCCAAGGGGGCGACC
GGTGTCGGCGTGAGGCTCCTGGTGGAATATCTGCAGAGAACCTTTGGCTGA

Upstream 100 bases:

>100_bases
GTGGAGACTCCAACTACTATCTGGCTTTGCGAATAGAATAGATGTTCACGGGGTGCAGGCTGAACTGAACGCACCCCGTT
TTTATTCAGGAGGAACTGTT

Downstream 100 bases:

>100_bases
AATTCGGATTGACGGTTGGATAGAGACAAAAAGGGGTGTGCCCACTGGGACACACCCCTTTTGCTCTTTAAGAGATTTGA
AACCGATTACTTCGCGACGG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRTKLIHTLGRLPAERLLLVGLG
QRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSVPGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDE
EGELASTERAVSERTTVCDAVSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHH
SPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISAVSGLRMPVNVVGLIPVAENM
PGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYAQRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRAL
TTSGEATGERLWELPVWDEYGELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGAT
GVGVRLLVEYLQRTFG

Sequences:

>Translated_496_residues
MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRTKLIHTLGRLPAERLLLVGLG
QRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSVPGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDE
EGELASTERAVSERTTVCDAVSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHH
SPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISAVSGLRMPVNVVGLIPVAENM
PGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYAQRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRAL
TTSGEATGERLWELPVWDEYGELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGAT
GVGVRLLVEYLQRTFG
>Mature_496_residues
MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRTKLIHTLGRLPAERLLLVGLG
QRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSVPGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDE
EGELASTERAVSERTTVCDAVSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHH
SPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISAVSGLRMPVNVVGLIPVAENM
PGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYAQRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRAL
TTSGEATGERLWELPVWDEYGELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGAT
GVGVRLLVEYLQRTFG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=493, Percent_Identity=36.7139959432049, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI47155554, Length=351, Percent_Identity=32.4786324786325, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1790710, Length=481, Percent_Identity=41.7879417879418, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=35, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=32.4159021406728, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=257, Percent_Identity=29.9610894941634, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24661038, Length=502, Percent_Identity=30.8764940239044, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=36.1111111111111, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161077148, Length=497, Percent_Identity=30.9859154929577, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20130057, Length=497, Percent_Identity=30.9859154929577, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20129969, Length=467, Percent_Identity=29.7644539614561, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24662227, Length=496, Percent_Identity=28.6290322580645, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI21355645, Length=320, Percent_Identity=31.875, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24662223, Length=320, Percent_Identity=31.875, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19922386, Length=468, Percent_Identity=28.8461538461538, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI20129963, Length=321, Percent_Identity=34.2679127725857, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21357381, Length=354, Percent_Identity=33.0508474576271, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI221379063, Length=354, Percent_Identity=33.0508474576271, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI221379062, Length=354, Percent_Identity=33.0508474576271, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646701, Length=283, Percent_Identity=31.095406360424, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24646703, Length=283, Percent_Identity=31.095406360424, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21358201, Length=283, Percent_Identity=31.095406360424, Blast_Score=102, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53127; Mature: 53127

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRT
CCCEEEEHHHHHHCCHHHHHCCHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCHH
KLIHTLGRLPAERLLLVGLGQRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSV
HHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDEEGELASTERAVSERTTVCDA
CCCEECCCCEEEEECCCEEEEEECCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
VSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISA
CCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
VSGLRMPVNVVGLIPVAENMPGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYA
HCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCEEHHHHHHHH
QRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRALTTSGEATGERLWELPVWDEY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEECCCCHHHH
GELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGAT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCCCCC
GVGVRLLVEYLQRTFG
CHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRT
CCCEEEEHHHHHHCCHHHHHCCHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCHH
KLIHTLGRLPAERLLLVGLGQRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSV
HHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDEEGELASTERAVSERTTVCDA
CCCEECCCCEEEEECCCEEEEEECCCCCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
VSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHH
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISA
CCCEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
VSGLRMPVNVVGLIPVAENMPGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYA
HCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCCEEHHHHHHHH
QRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRALTTSGEATGERLWELPVWDEY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHEECCCCHHHH
GELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGAT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHCCCCCCCCCCC
GVGVRLLVEYLQRTFG
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA