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The map label for this gene is degP [H]

Identifier: 78224552

GI number: 78224552

Start: 3777508

End: 3778902

Strand: Reverse

Name: degP [H]

Synonym: Gmet_3362

Alternate gene names: 78224552

Gene position: 3778902-3777508 (Counterclockwise)

Preceding gene: 78224565

Following gene: 78224551

Centisome position: 94.53

GC content: 57.35

Gene sequence:

>1395_bases
ATGAAACTGTCTTCACTGCGGTTTTTTAAAGAGATTGTCTTCGCTGCCTGTCTCGCAGTGCTTGCGGTGGGAGAATCCCC
TGCAAAGGTTTTGACGCCCGATTTCGTCGATCTCGCTGAGAAGCTCAAGCCTACGGTCGTCAACATTAGTACCACGAAGA
CGTTAACGCCCCAGTTCCGAATGCGGCGCCAGCCATCTCCATTCCCCGACCCGTTTCAGGACTTTTTCGAGCATTTTTTC
GAGGAAATGCCCCGCCGCCCCCAGCGTGAGCGGAGTCTCGGATCGGGCTTCATCATCAGCAAGCAGGGGTTCATCATTAC
CAATAATCACGTCATTGCCGGGGCTGACGAGATCAAGGTCCGCCTCTCCGACGGCCGTGAATTCAAGGCGGAGGTCAAAG
GCTCCGATGAGAAGCTCGATTTAGCTCTTATCAAGATTGATGCCAAAGAGAATCTCCCCGTGGCTGAACTGGGGGACAGC
GCCCAGATCAAGGTGGGGGAATGGGTCATGGCCATCGGCAACCCCTTCGGCCTGGCTCAGACTGTTACCGCAGGGATTGT
CAGCGCGACGGGGCGCGTTATCGGCAGCGGCCCCTATGACGACTTCATCCAGACTGATGCCTCCATCAATCCGGGGAATT
CCGGTGGTCCCCTCTTCAACGCCGAAGGGAAGGTCATAGGGATCAACACCGCCATTGTGGCTGGCGGACAGGGGATCGGC
TTTGCCATTCCGGTCAATATGGCCAAAGATGTTCTTCCCCAGCTCGAAGAGAAAGGGAAGGTGACGAGGGGATGGCTTGG
CGTTACCATGCAGCCGATGTCACCGGAGTTGGCCAAGTCGTTCGGCCTCGAAGGTGAAAAAGGAGCCCTCATCACGGATG
TTGTCAAGGACGGGCCGGCGGCCAACGCGGGGCTCAGGAGCGGCGACATAATTCTGGAGTTCGATGGGAAAAAGATCAAT
GAGATGAGCGAGCTGCCGCGGCTGGTGGCTGCCGAGCCCATTGGCAAGGCTGTCAAAATCAAGGTTCTCCGGGAGGGGAA
ACCCCGGGAATTCACCGTTTCTGTCGGCCGGCTTGCCGAGTCGGGCGACGAGAACAACCAGAAGACCGCCGGTGATGCGT
TCGGCCTCTCTGCCCGGGAACTGACCAAGGATCTCGCTGCACGGTTGGGGCTGAAGGAGTCCCGGGGGGTGGTCGTCACC
GGTGTGAAGCAGGGGAGCATTGCCGAGCTCGGAGGCTTCCAGTCAGGGGACATAATACTCGAGATTGGCGACAAGGCGGT
TGCGACTGTTATGGATTACGAGAAGCTGATCAAGGAATACGGGAAGGGTGATGTTGTCCGCTTCCTGTTGCGTCGTGGAG
ACTCCAACTACTATCTGGCTTTGCGAATAGAATAG

Upstream 100 bases:

>100_bases
GAAAACACCACCAGAGCGCTATCAACGGGAGGCCCCCATGTTGACAAACCGCTACCCCCTTATTACAGTTATCAGGTTAA
ATCCATTGTCGGAGGTAGCC

Downstream 100 bases:

>100_bases
ATGTTCACGGGGTGCAGGCTGAACTGAACGCACCCCGTTTTTATTCAGGAGGAACTGTTATGAATGCTCGGGTTGTTTTG
CATGATGCCCTGCTCTACCC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFRMRRQPSPFPDPFQDFFEHFF
EEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKVRLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDS
AQIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIG
FAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPAANAGLRSGDIILEFDGKKIN
EMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAESGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVT
GVKQGSIAELGGFQSGDIILEIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE

Sequences:

>Translated_464_residues
MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFRMRRQPSPFPDPFQDFFEHFF
EEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKVRLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDS
AQIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIG
FAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPAANAGLRSGDIILEFDGKKIN
EMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAESGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVT
GVKQGSIAELGGFQSGDIILEIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE
>Mature_464_residues
MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFRMRRQPSPFPDPFQDFFEHFF
EEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKVRLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDS
AQIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIG
FAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPAANAGLRSGDIILEFDGKKIN
EMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAESGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVT
GVKQGSIAELGGFQSGDIILEIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=309, Percent_Identity=38.5113268608414, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI22129776, Length=261, Percent_Identity=41.3793103448276, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI24308541, Length=260, Percent_Identity=40.3846153846154, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI7019477, Length=271, Percent_Identity=38.3763837638376, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=37.9157427937916, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789629, Length=468, Percent_Identity=36.5384615384615, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1789630, Length=274, Percent_Identity=41.6058394160584, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=36.4912280701754, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49934; Mature: 49934

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHH
MRRQPSPFPDPFQDFFEHFFEEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKV
HCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCEEEECCEEEECCCEEEE
RLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDSAQIKVGEWVMAIGNPFGLAQ
EECCCCEEEEEECCCCCEEEEEEEEEECCCCCCHHHCCCCCEEEECEEEEECCCCCCHHH
TVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIG
HHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCCEECCCCCEEEEEEEEEECCCCCE
FAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPA
EEEEHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHCCCCCCCCEEEHHHCCCCC
ANAGLRSGDIILEFDGKKINEMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAE
CCCCCCCCCEEEEECCCCHHHHHHCHHHHHCCCCCCEEEEEEEECCCCCEEEEEHHHHHH
SGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVTGVKQGSIAELGGFQSGDIIL
CCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCCCEEE
EIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE
EECCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure
MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFR
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHH
MRRQPSPFPDPFQDFFEHFFEEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKV
HCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCEEEECCCEEEECCEEEECCCEEEE
RLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDSAQIKVGEWVMAIGNPFGLAQ
EECCCCEEEEEECCCCCEEEEEEEEEECCCCCCHHHCCCCCEEEECEEEEECCCCCCHHH
TVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIG
HHHHHHHHHCCCEECCCCCHHHHCCCCCCCCCCCCCCEECCCCCEEEEEEEEEECCCCCE
FAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPA
EEEEHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHCCCCCCCCEEEHHHCCCCC
ANAGLRSGDIILEFDGKKINEMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAE
CCCCCCCCCEEEEECCCCHHHHHHCHHHHHCCCCCCEEEEEEEECCCCCEEEEEHHHHHH
SGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVTGVKQGSIAELGGFQSGDIIL
CCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCCCEEE
EIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE
EECCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]