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The map label for this gene is nuoD

Identifier: 78224542

GI number: 78224542

Start: 3769951

End: 3771123

Strand: Reverse

Name: nuoD

Synonym: Gmet_3352

Alternate gene names: 78224542

Gene position: 3771123-3769951 (Counterclockwise)

Preceding gene: 78224543

Following gene: 78224541

Centisome position: 94.34

GC content: 52.17

Gene sequence:

>1173_bases
ATGGCTAGTACTGAGATTATGACAGTCAACATGGGGCCACAGCATCCGAGTACCCACGGCGTTTTGCGGTTGGTCGTCGA
ACTGGACGGCGAAATCATCCAAAAGATTACGCCGCATATCGGGTATCTGCACCGTGGCGTTGAGAAACTCTCGGAACACC
GCACGTACCACCAGACGATCCCTCTGACCGACCGTCTTGATTACCTTGCACCGATGCACAATAACCTCGGCTATGTGTTG
GCAGTTGAGAAGCTCTTGGGAATTGAGGTTCCTGAACGTGCTCAGACTATACGTGTGATCTTGGCTGAGTTGACCAGGCT
CAAATCTCACCTTGTCTGGGTTGCGTGCCATGCCCTTGATATCGGTGCCATGACCGTGTTCATCTATGCTTTCCGCGAGC
GTGAGATGGTGATGAGCCTTTATGAGAAGATTTCCGGTGCCCGGATGACAAGCAGTTATTTCCGGGTGGGCGGTCTCTCG
TCGGACGTATATGACGGATTCGAAAAAGACGTGAGGGAAATTGTTGACACGTTCCCCGGTCATTTTGATACGTATGAGGG
GCTTCTCACCAAGAACACTATTTGGCTTAACCGCACGGTCGGCAATGGCGTGATATCTGCTGAAGATGCAATTGATTACG
GCATTACCGGGCCTGCGCTGCGTGGCTCGGGTGTTGATTGGGATCTTCGCCGCGACAACCCCTACAGTGGGTACGAGAAG
TACCAGTTCAAGGTTCCAGTGGGGGAGAAGTGTGACACCTTCGACCGTTATAAAGTCAGGCTCGTCGAAATGCGCGAAGC
GGTCAATATCATCCGTCAGGCTCTCGACTCCCTTAAGCCTGGTCCCGTCTTGGCTGATGCACCTCAAGTGACTTATCCGC
CCAAGGAAAATGTTTACAATACGATTGAGGGACTTATCCATCATTTCAAGATAGCCAGCGAAGGATTCCCTGTTCCTGAA
GGTGAAGTATATCAGGGAGTGGAGAACCCCAAGGGAGAGCTTGGCTACTATATCGTCAGCGACGGTGGCAACAAGCCGTA
CCGCATGCGCATACGCCCCCCCTCATTCGTCAACCTTGGGGCCATAGAGAAGATGGCAAAGGGTTCCATGATTGCAGACC
TTGTTGCCGTTATCGGTACGTTGGATATCGTGCTTGGTGAAATCGACCGGTAA

Upstream 100 bases:

>100_bases
GGGGCCTGGTCGTGAGCCTTACAAAGGGCGGTTGTCGTAGCGATACGGATTATTTGAGCGAAATTAACCTACTCTAGAGA
GAAGAATACAGAGGCGCGCA

Downstream 100 bases:

>100_bases
TGCCACTGCGATAAAGGAGAGGGAGTAATGAGCAACGCTCCGGCCGAAGCGACAAATGTTGAGGAAACGCCAGTAGAGGA
AATAGATCTCGGACCGGCGA

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMHNNLGYVL
AVEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALDIGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLS
SDVYDGFEKDVREIVDTFPGHFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEK
YQFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYNTIEGLIHHFKIASEGFPVPE
GEVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR

Sequences:

>Translated_390_residues
MASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMHNNLGYVL
AVEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALDIGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLS
SDVYDGFEKDVREIVDTFPGHFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEK
YQFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYNTIEGLIHHFKIASEGFPVPE
GEVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR
>Mature_389_residues
ASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMHNNLGYVLA
VEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALDIGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLSS
DVYDGFEKDVREIVDTFPGHFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEKY
QFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYNTIEGLIHHFKIASEGFPVPEG
EVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=384, Percent_Identity=50.78125, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI260898743, Length=378, Percent_Identity=50.2645502645503, Blast_Score=399, Evalue=1e-111,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=42.3772609819121, Blast_Score=344, Evalue=5e-96,
Organism=Escherichia coli, GI1789076, Length=387, Percent_Identity=32.5581395348837, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1788832, Length=391, Percent_Identity=28.3887468030691, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=48.9637305699482, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=48.7046632124352, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=49.4845360824742, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=48.6910994764398, Blast_Score=402, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_GEOMG (Q39QB0)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386289.1
- HSSP:   Q56220
- ProteinModelPortal:   Q39QB0
- SMR:   Q39QB0
- STRING:   Q39QB0
- GeneID:   3740667
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3352
- NMPDR:   fig|269799.3.peg.3327
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   MFANEGY
- PhylomeDB:   Q39QB0
- ProtClustDB:   CLSK827764
- BioCyc:   GMET269799:GMET_3352-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 43715; Mature: 43584

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTI
CCCCEEEEEECCCCCCCCHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCC
PLTDRLDYLAPMHNNLGYVLAVEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALD
CCHHHHHHHHHHCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLSSDVYDGFEKDVREIVDTFPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
HFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEK
CCCCHHCCEECCEEEEEEECCCCEEECCHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCE
YQFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHH
TIEGLIHHFKIASEGFPVPEGEVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLG
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHH
AIEKMAKGSMIADLVAVIGTLDIVLGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTI
CCCEEEEEECCCCCCCCHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHCCHHHHCC
PLTDRLDYLAPMHNNLGYVLAVEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALD
CCHHHHHHHHHHCCCCCHHEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLSSDVYDGFEKDVREIVDTFPG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
HFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEK
CCCCHHCCEECCEEEEEEECCCCEEECCHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCE
YQFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHH
TIEGLIHHFKIASEGFPVPEGEVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLG
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCHH
AIEKMAKGSMIADLVAVIGTLDIVLGEIDR
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA