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The map label for this gene is mvaB [H]

Identifier: 78224484

GI number: 78224484

Start: 3706595

End: 3707524

Strand: Direct

Name: mvaB [H]

Synonym: Gmet_3293

Alternate gene names: 78224484

Gene position: 3706595-3707524 (Clockwise)

Preceding gene: 78224483

Following gene: 78224485

Centisome position: 92.72

GC content: 65.81

Gene sequence:

>930_bases
ATGCCAATGCCGACGCGGGTGAAGATGGTGGAGGTGGGGCCCCGGGACGGTCTCCAGAACGAGAAGGCGATCATCCCGGC
CGAGGTAAAGATCGCCCTTATCGATAAGCTGTCGGAGGCGGGGCTTCCGGCGATCGAGGTCACGAGCTTCGTCTCTCCCA
CCTGGGTCCCCCAGATGGCCGACAACGCCCAGGTCATGACCGGAATCGCCCGCCGGGAGGGTGTCGCCTATCCGGTTCTC
GTCCCTAACCGAAAGGGGCTGGAAGCGGCCATTGCCGCCGGCGCGGCCGAAATCGCCATATTCGCCGCCGCCTCGGAGTC
CTTCTCCCGAAAGAACATCAACTGCTCCATTGCCGAGAGTCTGGAACGCTTCGCCGAGGTCATCACCGTGGCCAGGGTCC
AGGGGTTGCGGGTGCGGGGGTATGTCTCCTGCGTCCTCGGCTGCCCCTACGAGGGTGAGGTGAGCTTCGACGTGGTGGCA
GGGGTGGCAGGGCAGCTCCTGCAGCTCGGCTGCTACGAGATATCTCTTGGCGACACCATCGGCGTGGGCACCCCCGGCCG
GGCGCAGACCATGGTGGATGTGGTGTCGAGACTGGTGCCGCGGGAGAAACTGGCAGTCCATTTCCACGATACCTACGGCC
AGGCCCTGGCCAACATCCTGGCAGTCCTCGAACGGGGCATCGCCACCGTCGACAGCTCCGTGGCCGGCCTCGGCGGCTGT
CCTTACGCCGCCGGCGCCTCGGGCAACGTTGCCAGCGAGGATCTTCTTTACATGCTGAACGGCCTCGGCATCGAGACCGG
GGTCGACCTGGAACACCTCATGGCCGCCGGAAACTACATCTCCGGCCACTTGGGCCGCCCGTCGGGCTCCCGTGTGGCTC
GGGCCATGGGGTGCTCTCCACACCAGATAACGACGACGGCAAACGCCTGA

Upstream 100 bases:

>100_bases
CCCCGGGACGGACTCGTGGCCCGGCTCAACTTCACCGTCGGCTCCCTGGTGAGCGATGGGGCGGAACTTCTGGCCCTTGC
CGACGAAGAGGGGGTCTGAG

Downstream 100 bases:

>100_bases
ACTAAAACAATACAGGAGGATTGACCATGAATAATGCAGCATTGGCCGTATCCCGATACGAACAGGAATATCAGCAGAAG
CTCTCCACCGCCGAAGAGGT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMADNAQVMTGIARREGVAYPVL
VPNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAESLERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVA
GVAGQLLQLGCYEISLGDTIGVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGC
PYAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSPHQITTTANA

Sequences:

>Translated_309_residues
MPMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMADNAQVMTGIARREGVAYPVL
VPNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAESLERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVA
GVAGQLLQLGCYEISLGDTIGVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGC
PYAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSPHQITTTANA
>Mature_308_residues
PMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMADNAQVMTGIARREGVAYPVLV
PNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAESLERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVAG
VAGQLLQLGCYEISLGDTIGVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGCP
YAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSPHQITTTANA

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=62.7986348122867, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=60.7508532423208, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=60.7508532423208, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI260654708, Length=136, Percent_Identity=62.5, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17510563, Length=293, Percent_Identity=55.9726962457338, Blast_Score=341, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24582381, Length=291, Percent_Identity=60.4810996563574, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32232; Mature: 32101

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMA
CCCCCEEEEEEECCCCCCCCCCEECCHHEEEHHHHHHHHCCCCCEEHHHHCCCCCCCCCC
DNAQVMTGIARREGVAYPVLVPNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAES
CCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCCHHHEEEEEECCCCHHCCCCCCHHHHH
LERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVAGVAGQLLQLGCYEISLGDTI
HHHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEECCCEE
GVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGC
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PYAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCC
HQITTTANA
CEEEECCCC
>Mature Secondary Structure 
PMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMA
CCCCEEEEEEECCCCCCCCCCEECCHHEEEHHHHHHHHCCCCCEEHHHHCCCCCCCCCC
DNAQVMTGIARREGVAYPVLVPNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAES
CCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHCCHHHEEEEEECCCCHHCCCCCCHHHHH
LERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVAGVAGQLLQLGCYEISLGDTI
HHHHHHHHHHHHHCCEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEECCCEE
GVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGC
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PYAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSP
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCHHCCCCCCCCHHHHHHHHCCCC
HQITTTANA
CEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]