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The map label for this gene is lon

Identifier: 78224405

GI number: 78224405

Start: 3611968

End: 3614439

Strand: Reverse

Name: lon

Synonym: Gmet_3214

Alternate gene names: 78224405

Gene position: 3614439-3611968 (Counterclockwise)

Preceding gene: 78224406

Following gene: 78224404

Centisome position: 90.42

GC content: 63.07

Gene sequence:

>2472_bases
ATGGAAGAAATTGAAGATAAAGAACCCCGGCAGGAGAACGAGGAACTGAAAATCCCCGATGTTTTGCCCCTGTTGCCGGT
GCGGGATGTGGTGGTCTACCCGTACATGATCCTTCCCCTTTTCGTGGGACGCGAGATCTCCATCAACGCGGTGGACCAGG
CTCTCTCCAGGGACCGGCTCATCTTTCTCGCCACCCAGAAGGAGATGGGAGACGAAGAACCGACCCCCGAGGGGATGTAC
ACCGTCGGAACCGTGGCAATGATCATGCGGATGCTGAAGCTTCCCGACGGGCGGGTGAAGGTTCTCGTCCAGGGGCTCGC
CAAGGGGCTTATCACCGAGTTCGTGGAGTCGAAGCCCGCCTATACGGTCCGGATCGAGCGGATCGTGGAGCCCTCGGTCC
CCGAGGAGTCCCTGGAAACCGAGGCTCTCATGAGGGCTGTCAAGGAGCAGTTGACCCAGATCGTCTCCCTCGGCAAGGCC
GTTTCTCCCGAAGTCCTCGTGATTGTGGAGAACATGCAGGAGCCGGGAAGCCTGGCCGACCTCATTGCCAGCAATATCGG
CCTCAAAGTCGATGACGCCCAGGCCCTCCTGGAGATCATCGATCCGGTCCAGCGGCTCCAGAAGGTCAATGAGCATCTCA
ACAAGGAGCACGAGCTCCTCGACATGCAGGTGAAGATCCAGTCGGCCGCCAAGGAGGAGATGGGGAAGAGCCAGCGGGAG
TACTTCCTCCGGGAGCAACTGCGGGCCATCCAGCAGGAGCTGGGGGAGACCGATCCCCGTTCCGAGGAGCTGAACGAGCT
CCGCAAGGCCATCGAGCAGGCCAAGATGCCGCCGGTCGTGGAGAAGGAGGCCTTCAAGCAGTTGGGGCGCCTGGAGCAGA
TGCACCCCGACGCCGCCGAGGCGGGGATGCTCCGCACGTTCCTGGACTGGATGGTGGAGCTTCCCTGGGGCAAGGCGACC
AAGGACGTTCTCGACATCAAGCGGGCCCGGCAGATTCTCGATGAGGACCACTTCTACCTGGAGAAGATCAAGGAGCGGAT
CCTGGAGTTCCTGGCCGTGCGCAAGCTTCGCAAGAAGATGAAGGGGCCGATCCTCTGTTTCGTTGGTCCTCCCGGGGTGG
GCAAGACCTCCCTCGGCAAGTCCATCGCCCGGGCCATGGGGCGGAAGTTCGTCCGCATCTCCTTGGGAGGGGTGCGGGAC
GAGGCCGAGATCCGGGGGCACCGGCGCACCTATGTGGGGGCGCTCCCCGGCCGGATCATCCAGGGGCTCAAGCAGGCCGG
CTCCAACAACCCCGTTTTCATGCTCGACGAGCTGGACAAGCTTGGGGCCGACTTCCGGGGCGATCCCTCCTCGGCTCTGC
TGGAGGTGCTGGACCCGGAGCAGAACCACATGTTCTCGGACCATTACATCAACCTCCCCTTCAACCTGTCCAACGTGATG
TTCATCGCCACCGCCAACCAGATTGACACGGTCCCGGGGCCTCTTCGCGACCGGATGGAGGTGATCCAGCTCTCCGGGTA
CACGGAGGAGGAAAAACTGGAGATCGCCAAACGCTACCTCATCCCTCGGCAGATGAAAGAAAACGGCATTTCGGAGAAGG
AGATCGTCATCAGCGACGAGGCGGTGCGCACCATCATCGCCAAGTATACCCGGGAGGCGGGACTGCGGAACCTGGAGCGG
GAGATCGGCAGTGTCTGCCGCAAGGTGGCCCGCAAGGTGGCCGAGGGGGATGGCCGCCGCTTCCGGATCACCCCGGCCAC
GGTGGCGAAATATCTCGGACCGGCCCGGTTCATCCGGGAGGGGGAGATGGAGAAGAACGAAGTGGGGATCGTTACCGGCC
TTGCCTGGACCCCCGTGGGGGGCGAAGTCCTCTTCGTGGAGGCGACGATCATGAAGGGGAAGGGGGGACTCACCCTCACC
GGGCACCTGGGAGACGTCATGAAGGAGTCGGTTCAGGCGGCCCTTTCCTACATCCGCTCCAAGGCCAAGGAGTTCCACCT
GGCCGAGGATTTCCTCTCCGGGTATGACATCCACGTCCACGTTCCAGCGGGCGCTATCCCCAAGGATGGCCCCTCTGCCG
GCGTTACCATGGCAACGGCCCTTGTCTCGGCCCTGACGCGGGTTCCGGTCCGCAAGGACGTGGCCATGACCGGCGAGATC
ACCCTGCGGGGGAAGGTTCTTCCCATCGGTGGCCTCAAGGAGAAGATGCTCGCCGCCATCCGGGCGGGGATCAAGACCAT
CGTCATCCCCGAGCAGAACGAGAAGGACCTGGAGGAGATTCCCAAACATATCCTCAAGAAGGTGACGGTCGTTTCCGCCA
AGGTCATTGACGACGTTCTCGCGGTGGCTCTGGAAACCTTCCCGCCACCCCCTCCCGCCAGCGAGGGGAAGCCGGCAGCC
ACGGTGAAGGCGCCGCCGCGGCGGGGGATTGCCGCTCCCCGCAAAGGAGCCATGGCCGGGGCAAAGAGTTGA

Upstream 100 bases:

>100_bases
GGGCCTCTTTTCGGCAGGGGGTCCTCACGGTCACCTTTCCCCGTCTCGCGGATCGGGGGAAAATCATCCGCGAGATACCG
ATAGAACAAGGAGACGAGTA

Downstream 100 bases:

>100_bases
GACTTAGGGAGATAGGGGAATTCGGCCTCATCGGACGCATATCTTCCCGGGTCGCCGACGGTGCCGGGGTGCGGATCGGC
ATCGGTGACGACGCTGCCGC

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 823; Mature: 823

Protein sequence:

>823_residues
MEEIEDKEPRQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSRDRLIFLATQKEMGDEEPTPEGMY
TVGTVAMIMRMLKLPDGRVKVLVQGLAKGLITEFVESKPAYTVRIERIVEPSVPEESLETEALMRAVKEQLTQIVSLGKA
VSPEVLVIVENMQEPGSLADLIASNIGLKVDDAQALLEIIDPVQRLQKVNEHLNKEHELLDMQVKIQSAAKEEMGKSQRE
YFLREQLRAIQQELGETDPRSEELNELRKAIEQAKMPPVVEKEAFKQLGRLEQMHPDAAEAGMLRTFLDWMVELPWGKAT
KDVLDIKRARQILDEDHFYLEKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARAMGRKFVRISLGGVRD
EAEIRGHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVM
FIATANQIDTVPGPLRDRMEVIQLSGYTEEEKLEIAKRYLIPRQMKENGISEKEIVISDEAVRTIIAKYTREAGLRNLER
EIGSVCRKVARKVAEGDGRRFRITPATVAKYLGPARFIREGEMEKNEVGIVTGLAWTPVGGEVLFVEATIMKGKGGLTLT
GHLGDVMKESVQAALSYIRSKAKEFHLAEDFLSGYDIHVHVPAGAIPKDGPSAGVTMATALVSALTRVPVRKDVAMTGEI
TLRGKVLPIGGLKEKMLAAIRAGIKTIVIPEQNEKDLEEIPKHILKKVTVVSAKVIDDVLAVALETFPPPPPASEGKPAA
TVKAPPRRGIAAPRKGAMAGAKS

Sequences:

>Translated_823_residues
MEEIEDKEPRQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSRDRLIFLATQKEMGDEEPTPEGMY
TVGTVAMIMRMLKLPDGRVKVLVQGLAKGLITEFVESKPAYTVRIERIVEPSVPEESLETEALMRAVKEQLTQIVSLGKA
VSPEVLVIVENMQEPGSLADLIASNIGLKVDDAQALLEIIDPVQRLQKVNEHLNKEHELLDMQVKIQSAAKEEMGKSQRE
YFLREQLRAIQQELGETDPRSEELNELRKAIEQAKMPPVVEKEAFKQLGRLEQMHPDAAEAGMLRTFLDWMVELPWGKAT
KDVLDIKRARQILDEDHFYLEKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARAMGRKFVRISLGGVRD
EAEIRGHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVM
FIATANQIDTVPGPLRDRMEVIQLSGYTEEEKLEIAKRYLIPRQMKENGISEKEIVISDEAVRTIIAKYTREAGLRNLER
EIGSVCRKVARKVAEGDGRRFRITPATVAKYLGPARFIREGEMEKNEVGIVTGLAWTPVGGEVLFVEATIMKGKGGLTLT
GHLGDVMKESVQAALSYIRSKAKEFHLAEDFLSGYDIHVHVPAGAIPKDGPSAGVTMATALVSALTRVPVRKDVAMTGEI
TLRGKVLPIGGLKEKMLAAIRAGIKTIVIPEQNEKDLEEIPKHILKKVTVVSAKVIDDVLAVALETFPPPPPASEGKPAA
TVKAPPRRGIAAPRKGAMAGAKS
>Mature_823_residues
MEEIEDKEPRQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSRDRLIFLATQKEMGDEEPTPEGMY
TVGTVAMIMRMLKLPDGRVKVLVQGLAKGLITEFVESKPAYTVRIERIVEPSVPEESLETEALMRAVKEQLTQIVSLGKA
VSPEVLVIVENMQEPGSLADLIASNIGLKVDDAQALLEIIDPVQRLQKVNEHLNKEHELLDMQVKIQSAAKEEMGKSQRE
YFLREQLRAIQQELGETDPRSEELNELRKAIEQAKMPPVVEKEAFKQLGRLEQMHPDAAEAGMLRTFLDWMVELPWGKAT
KDVLDIKRARQILDEDHFYLEKIKERILEFLAVRKLRKKMKGPILCFVGPPGVGKTSLGKSIARAMGRKFVRISLGGVRD
EAEIRGHRRTYVGALPGRIIQGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVM
FIATANQIDTVPGPLRDRMEVIQLSGYTEEEKLEIAKRYLIPRQMKENGISEKEIVISDEAVRTIIAKYTREAGLRNLER
EIGSVCRKVARKVAEGDGRRFRITPATVAKYLGPARFIREGEMEKNEVGIVTGLAWTPVGGEVLFVEATIMKGKGGLTLT
GHLGDVMKESVQAALSYIRSKAKEFHLAEDFLSGYDIHVHVPAGAIPKDGPSAGVTMATALVSALTRVPVRKDVAMTGEI
TLRGKVLPIGGLKEKMLAAIRAGIKTIVIPEQNEKDLEEIPKHILKKVTVVSAKVIDDVLAVALETFPPPPPASEGKPAA
TVKAPPRRGIAAPRKGAMAGAKS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=51.063829787234, Blast_Score=595, Evalue=1e-170,
Organism=Homo sapiens, GI21396489, Length=660, Percent_Identity=41.8181818181818, Blast_Score=541, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=768, Percent_Identity=51.3020833333333, Blast_Score=801, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=691, Percent_Identity=37.7713458755427, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17556486, Length=795, Percent_Identity=36.2264150943396, Blast_Score=489, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319449, Length=688, Percent_Identity=39.8255813953488, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=684, Percent_Identity=42.9824561403509, Blast_Score=555, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24666867, Length=684, Percent_Identity=42.9824561403509, Blast_Score=555, Evalue=1e-158,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_GEOMG (Q39QP7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386152.1
- ProteinModelPortal:   Q39QP7
- STRING:   Q39QP7
- MEROPS:   S16.001
- GeneID:   3740969
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3214
- NMPDR:   fig|269799.3.peg.2448
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   VIVENMQ
- PhylomeDB:   Q39QP7
- ProtClustDB:   CLSK829150
- BioCyc:   GMET269799:GMET_3214-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91225; Mature: 91225

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 692-692 ACT_SITE 735-735

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEIEDKEPRQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSRDRL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCE
IFLATQKEMGDEEPTPEGMYTVGTVAMIMRMLKLPDGRVKVLVQGLAKGLITEFVESKPA
EEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
YTVRIERIVEPSVPEESLETEALMRAVKEQLTQIVSLGKAVSPEVLVIVENMQEPGSLAD
EEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHH
LIASNIGLKVDDAQALLEIIDPVQRLQKVNEHLNKEHELLDMQVKIQSAAKEEMGKSQRE
HHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
YFLREQLRAIQQELGETDPRSEELNELRKAIEQAKMPPVVEKEAFKQLGRLEQMHPDAAE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHH
AGMLRTFLDWMVELPWGKATKDVLDIKRARQILDEDHFYLEKIKERILEFLAVRKLRKKM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KGPILCFVGPPGVGKTSLGKSIARAMGRKFVRISLGGVRDEAEIRGHRRTYVGALPGRII
CCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHCCHHHHH
QGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVM
HHHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEE
FIATANQIDTVPGPLRDRMEVIQLSGYTEEEKLEIAKRYLIPRQMKENGISEKEIVISDE
EEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCCCCEEEECHH
AVRTIIAKYTREAGLRNLEREIGSVCRKVARKVAEGDGRRFRITPATVAKYLGPARFIRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCHHHHHHC
GEMEKNEVGIVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGDVMKESVQAALSYIRS
CCCCCCCCEEEEECEECCCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHH
KAKEFHLAEDFLSGYDIHVHVPAGAIPKDGPSAGVTMATALVSALTRVPVRKDVAMTGEI
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEE
TLRGKVLPIGGLKEKMLAAIRAGIKTIVIPEQNEKDLEEIPKHILKKVTVVSAKVIDDVL
EEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVALETFPPPPPASEGKPAATVKAPPRRGIAAPRKGAMAGAKS
HHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEEIEDKEPRQENEELKIPDVLPLLPVRDVVVYPYMILPLFVGREISINAVDQALSRDRL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCE
IFLATQKEMGDEEPTPEGMYTVGTVAMIMRMLKLPDGRVKVLVQGLAKGLITEFVESKPA
EEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
YTVRIERIVEPSVPEESLETEALMRAVKEQLTQIVSLGKAVSPEVLVIVENMQEPGSLAD
EEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHH
LIASNIGLKVDDAQALLEIIDPVQRLQKVNEHLNKEHELLDMQVKIQSAAKEEMGKSQRE
HHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
YFLREQLRAIQQELGETDPRSEELNELRKAIEQAKMPPVVEKEAFKQLGRLEQMHPDAAE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHH
AGMLRTFLDWMVELPWGKATKDVLDIKRARQILDEDHFYLEKIKERILEFLAVRKLRKKM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
KGPILCFVGPPGVGKTSLGKSIARAMGRKFVRISLGGVRDEAEIRGHRRTYVGALPGRII
CCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHCCHHHHH
QGLKQAGSNNPVFMLDELDKLGADFRGDPSSALLEVLDPEQNHMFSDHYINLPFNLSNVM
HHHHHCCCCCCEEEEECHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCCCCEE
FIATANQIDTVPGPLRDRMEVIQLSGYTEEEKLEIAKRYLIPRQMKENGISEKEIVISDE
EEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHCCCCCCEEEECHH
AVRTIIAKYTREAGLRNLEREIGSVCRKVARKVAEGDGRRFRITPATVAKYLGPARFIRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHCHHHHHHC
GEMEKNEVGIVTGLAWTPVGGEVLFVEATIMKGKGGLTLTGHLGDVMKESVQAALSYIRS
CCCCCCCCEEEEECEECCCCCEEEEEEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHH
KAKEFHLAEDFLSGYDIHVHVPAGAIPKDGPSAGVTMATALVSALTRVPVRKDVAMTGEI
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECEE
TLRGKVLPIGGLKEKMLAAIRAGIKTIVIPEQNEKDLEEIPKHILKKVTVVSAKVIDDVL
EEEEEEEECCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVALETFPPPPPASEGKPAATVKAPPRRGIAAPRKGAMAGAKS
HHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA