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The map label for this gene is ahpC [C]

Identifier: 78224377

GI number: 78224377

Start: 3586850

End: 3587455

Strand: Direct

Name: ahpC [C]

Synonym: Gmet_3186

Alternate gene names: 78224377

Gene position: 3586850-3587455 (Clockwise)

Preceding gene: 78224376

Following gene: 78224378

Centisome position: 89.73

GC content: 60.07

Gene sequence:

>606_bases
ATGTGCATGTGTACCCTCGTCACCAAAGAGGCCCCTGATTTCGCAGCCGACGCTGTCCTGCCCGACAACACCTTCGCCAC
CATCAAGCTGTCGAGCTTTCGTGGGAAATACGTGATCCTCTTCTTCTATCCCCTGGACTTCACCTTTGTCTGCCCCTCGG
AAATCCTCGCCTTCAACAAAAAGCTGGACCAGTTCAAGGCCAAAAACTGCGAGGTCATCGGCGTCTCCGTGGATTCGAAG
TTCACCCACCTGGCCTGGAAAAACACGAAGGTGGAAGATGGCGGCATCGGCAACATCCAGTACCCCCTGGTGTCAGACCT
GAAGAAGGAGATCGCCACCCAGTTCGGCGTTCTCTTCGAGAACGGCGGCGTCGCCCTTCGGGGACTCTTTCTCATCGATA
CCAAGGGGATCGTCCGCCACGCTGTCATCAACGACCTCCCCTTGGGTCGGAGCGTTGACGAGGCCCTGCGGATGCTGGAC
GCCCTCCAGTTCGTGGAAACCCACGGCGACCAGGTCTGCCCTGCCAACTGGCGGGAGGGTGACGAGGCCATGAAGCCCAC
GGCCGCCGGCGTTGCCGACTACCTGGCGAAGCATGCCGCAGGGTAG

Upstream 100 bases:

>100_bases
GATTCTTTTTGTCTTTTTCCATTGACAAGGGGCACTGCGGCTGGTATCTCTTTCACTGTCATTGCATTCACACTCGCCGT
ACGAAAGGAGAGACCATTCC

Downstream 100 bases:

>100_bases
CTGCCTCCACGCAGCGAAATGAAAGGCACGGTCCGGCGACCGTGCCTTTTCTGTTTCTCCGAGGATTCCATGGCCGAGCC
CCGCCTCACCGAAAGCCCCC

Product: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFENGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLD
ALQFVETHGDQVCPANWREGDEAMKPTAAGVADYLAKHAAG

Sequences:

>Translated_201_residues
MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFENGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLD
ALQFVETHGDQVCPANWREGDEAMKPTAAGVADYLAKHAAG
>Mature_201_residues
MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSK
FTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFENGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLD
ALQFVETHGDQVCPANWREGDEAMKPTAAGVADYLAKHAAG

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=54.2553191489362, Blast_Score=226, Evalue=7e-60,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=54.2553191489362, Blast_Score=226, Evalue=7e-60,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=54.2553191489362, Blast_Score=226, Evalue=7e-60,
Organism=Homo sapiens, GI32189392, Length=192, Percent_Identity=52.0833333333333, Blast_Score=225, Evalue=2e-59,
Organism=Homo sapiens, GI5802974, Length=196, Percent_Identity=52.0408163265306, Blast_Score=224, Evalue=4e-59,
Organism=Homo sapiens, GI32483377, Length=190, Percent_Identity=52.1052631578947, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=51.8324607329843, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI33188454, Length=80, Percent_Identity=62.5, Blast_Score=111, Evalue=3e-25,
Organism=Homo sapiens, GI4758638, Length=184, Percent_Identity=29.3478260869565, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786822, Length=163, Percent_Identity=32.5153374233129, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=193, Percent_Identity=49.2227979274611, Blast_Score=204, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32565831, Length=193, Percent_Identity=49.2227979274611, Blast_Score=204, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=49.4623655913978, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25153706, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=45.5958549222798, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320661, Length=193, Percent_Identity=43.5233160621762, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319407, Length=200, Percent_Identity=30, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17738015, Length=195, Percent_Identity=52.3076923076923, Blast_Score=220, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24656348, Length=193, Percent_Identity=50.259067357513, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17864676, Length=193, Percent_Identity=50.259067357513, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17157991, Length=178, Percent_Identity=51.685393258427, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24641739, Length=178, Percent_Identity=51.685393258427, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21357347, Length=193, Percent_Identity=45.0777202072539, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17975518, Length=186, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652434, Length=186, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652436, Length=186, Percent_Identity=30.6451612903226, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=29.746835443038, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22051; Mature: 22051

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNK
CEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEECHHHHHHHHH
KLDQFKAKNCEVIGVSVDSKFTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFE
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHHCEEEE
NGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLDALQFVETHGDQVCPANWREG
CCCEEEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEAMKPTAAGVADYLAKHAAG
CHHHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNK
CEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEEEECHHHHHHHHH
KLDQFKAKNCEVIGVSVDSKFTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFE
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHHCEEEE
NGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLDALQFVETHGDQVCPANWREG
CCCEEEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DEAMKPTAAGVADYLAKHAAG
CHHHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]