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The map label for this gene is czcD [H]

Identifier: 78224263

GI number: 78224263

Start: 3469679

End: 3470683

Strand: Direct

Name: czcD [H]

Synonym: Gmet_3071

Alternate gene names: 78224263

Gene position: 3469679-3470683 (Clockwise)

Preceding gene: 78224250

Following gene: 78224264

Centisome position: 86.8

GC content: 65.97

Gene sequence:

>1005_bases
ATGCACGCCGAAACGCACCTTGACCAGAGCATCACCGGACGCTTCAAGTATGCCATCATCCTGACGACCTTCACCCTGGT
GGCCGAGGTCGCGGGTGGGATCTGGACCAACTCCCTGGCCCTCCTGTCGGACGCGGCCCACGTCTTTCTCGACCTCTTCG
CCCTGATCCTGTCGCTGGCGGCCATCAAGCTCGCCGGCTACCCCGCCTCCGACACCCGCACCTTCGGCTGGCACCGGACC
GAGGTCTTCGCCTCTTTCATCAACGGCGCCACGGTCTTCCTCATGGCCATCGGCATCTTCTACGAGGCCTGGGAGCGGCT
GCGCCACCCGGTGGAGGTCAAGAGCCTCCCGATGCTGGTCATCGCCGCGGTGGGCCTCGTCATGAACCTCGTCGCCGCCT
CGGCCCTCCACAGCCACTCCCACGACGATCTGAACGTGCGCAGCGCCTTTCTCCACGTCATCGGCGACGCGGCCGCCTCG
GTGGGGGTCATCATCGGCGGCGTCATCATGTACTACACCAGCTGGTACCTCCTGGACGCCATCATCTCCGCCGGGATCGG
CTGCGTCATCTTCTGGGGGTCGTGGCGGGTGATCCGGGAGTCGTCCCACATCCTCATGGAGGGGGTCCCCCGGGGGATGA
GCACCCGGGAAGTGGCCATTGCCATGCAGGAAGTGGAGGGGGTGAACACGGTCCACCACCTGAACATCTGGACCATCTGC
TCCCACATCCTGGCCCTGTCGGCCCACGTGGATGTGGAGCCCGAGCACAAGGAGCGGCAGGCGGATGTGCTCAGGCGGCT
CGAAGAGCTGCTCTTCGAGCGCTACCACATCTCCCACACCACCCTCCAGGCCGAGTGCACCCGGTGCGCGGAAACACCGC
CGATCATAAAGGAGCTACGCCACCGCCCCCGCCACGGCCAGCACCACGACCATCACGGCCACGACCATGGGCACGGCCAT
GACCACCACGGGCACGACCACGACCACTGCCACCATGACCACTAG

Upstream 100 bases:

>100_bases
ACTCCGGAAATGCAAGGGGGGAGCGGTTCTTTCCGTTTGACCCGCCAAAGGGGCATCTGCTACAGTGAACCCCTGACGGG
AAGGGGGGACGAAGCCGACC

Downstream 100 bases:

>100_bases
CAACCCCACGGAGAACCGATGCTCCCCTACACCCTGATCCAGGAAGCGTCAGACCGCCTCAAAAAGCGGGTCCGGCGCAC
CGAGCTGATCCACTCCCACC

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLAAIKLAGYPASDTRTFGWHRT
EVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLVIAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAAS
VGVIIGGVIMYYTSWYLLDAIISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTIC
SHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELRHRPRHGQHHDHHGHDHGHGH
DHHGHDHDHCHHDH

Sequences:

>Translated_334_residues
MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLAAIKLAGYPASDTRTFGWHRT
EVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLVIAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAAS
VGVIIGGVIMYYTSWYLLDAIISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTIC
SHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELRHRPRHGQHHDHHGHDHGHGH
DHHGHDHDHCHHDH
>Mature_334_residues
MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLAAIKLAGYPASDTRTFGWHRT
EVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLVIAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAAS
VGVIIGGVIMYYTSWYLLDAIISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTIC
SHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELRHRPRHGQHHDHHGHDHGHGH
DHHGHDHDHCHHDH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=322, Percent_Identity=27.639751552795, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI52352805, Length=273, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI21361112, Length=315, Percent_Identity=30.1587301587302, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI64762489, Length=271, Percent_Identity=30.9963099630996, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI289803013, Length=271, Percent_Identity=30.9963099630996, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI289803009, Length=271, Percent_Identity=30.9963099630996, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI289803007, Length=271, Percent_Identity=30.9963099630996, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI289803003, Length=271, Percent_Identity=30.9963099630996, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI20070323, Length=321, Percent_Identity=24.9221183800623, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI222080086, Length=319, Percent_Identity=25.3918495297806, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI40255009, Length=319, Percent_Identity=25.3918495297806, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=28.8990825688073, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI52351208, Length=158, Percent_Identity=27.2151898734177, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=35.2517985611511, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193210990, Length=300, Percent_Identity=28.3333333333333, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17555794, Length=298, Percent_Identity=29.5302013422819, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=298, Percent_Identity=29.5302013422819, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32564488, Length=282, Percent_Identity=27.3049645390071, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320411, Length=187, Percent_Identity=34.2245989304813, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=181, Percent_Identity=28.1767955801105, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=163, Percent_Identity=31.2883435582822, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24583858, Length=377, Percent_Identity=28.1167108753316, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24656728, Length=328, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656724, Length=328, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656720, Length=328, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656715, Length=328, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357035, Length=328, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574430, Length=156, Percent_Identity=31.4102564102564, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24584409, Length=156, Percent_Identity=31.4102564102564, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24645863, Length=109, Percent_Identity=39.4495412844037, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24585900, Length=152, Percent_Identity=29.6052631578947, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585898, Length=152, Percent_Identity=29.6052631578947, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585896, Length=152, Percent_Identity=29.6052631578947, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921672, Length=152, Percent_Identity=29.6052631578947, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 37318; Mature: 37318

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLA
CCCHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKLAGYPASDTRTFGWHRTEVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAASVGVIIGGVIMYYTSWYLLDA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTIC
HHHCCCCEEEEECCCCEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
SHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HRPRHGQHHDHHGHDHGHGHDHHGHDHDHCHHDH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLA
CCCHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIKLAGYPASDTRTFGWHRTEVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLV
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAASVGVIIGGVIMYYTSWYLLDA
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTIC
HHHCCCCEEEEECCCCEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
SHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HRPRHGQHHDHHGHDHGHGHDHHGHDHDHCHHDH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]