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The map label for this gene is garR [H]

Identifier: 78224204

GI number: 78224204

Start: 3395722

End: 3396585

Strand: Direct

Name: garR [H]

Synonym: Gmet_3011

Alternate gene names: 78224204

Gene position: 3395722-3396585 (Clockwise)

Preceding gene: 78224203

Following gene: 78224206

Centisome position: 84.95

GC content: 65.86

Gene sequence:

>864_bases
ATGCAGAAATTCGGTTTCATCGGCCTCGGCATCATGGGAAGCGCCATGGCTAAGAACCTTGTGAAAGCGGGCTGTTCGGT
GACGATCTGGAACCGTTCCCCGGAGAAGGCGGAGGAACTGGCGGCCTTGGGGGCGGAACGGGCCGCAACCCCCTGCGAAG
TGGTGGAGTCATGCCCCGTGACCTTTGCCATGCTGGCGGACCCAGCTGCGGCGGAGGAGGTTTGCTTCGGCAAGCACGGG
GTGCTGGAGGGGATCGGCGAAGGGCGTGGCTACGTGGACATGTCCACCGTGGACCCGGCCACATCCCAGCGGATCGGCGT
GGCCGTGGTGGCCAAGGGGGGACGGTTCCTGGAGGCGCCCGTGTCGGGGAGCAAAAAGCCGGCCGAGGACGGCACCCTCA
TCATCCTGGCAGCCGGGGACCGGAACCTCTACGACGAGGCAATGCCCGGCTTCGAGAAGATGGGGAAGAAGATCATCCAC
CTTGGTGACGTGGGAAAGGGCGCCGAGATGAAGCTGGTGGTGAACATGGTCATGGGTGGGATGATGGCCTGCTTCTGCGA
GGGACTGGCGTTGGGGGAGAAGGCGGGGCTCGCCACCGACGCCATCCTCGACGTGATCGGCGCCGGCGCCATGGCGAATC
CCATGTTCGCCCTGAAGGGGGGGCTCATCCGCGACCGGAACTTCGCGCCGGCCTTCCCCCTGAAGCATATGCAGAAGGAT
CTGCGGCTGGCGGTTGCCCTGGGTGACCGGGTGGGTCAGCCCCTCGTGGCCTCCGCGGCGGCCAACGAGCTGTTCAAGGG
GGCCAGGGCCGCCGGCTTCGGCGACGAGGATTTCTCCGCCATCTTCAAAACCATCGAGCGGTGA

Upstream 100 bases:

>100_bases
CCCGGGAGGAACTGGAAGGGGCCGAGGACATCTACCTCGTCAACTCGGTTCGGCAGTGGCGCTGGGCGCGGCTGACTTGA
AAAGGAAACGGAGGTAATCC

Downstream 100 bases:

>100_bases
AAGCCCTCCCCCAGGGAGTTCCAGCAGAGCTTACGGCAGTTCCTCGCCCCCAGGCAGGGCCAGTCCGGCCAGGGGGTGCT
GCCGGGGTTCCTCCGGGTTC

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPVTFAMLADPAAAEEVCFGKHG
VLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAPVSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIH
LGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKD
LRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER

Sequences:

>Translated_287_residues
MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPVTFAMLADPAAAEEVCFGKHG
VLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAPVSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIH
LGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKD
LRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER
>Mature_287_residues
MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPVTFAMLADPAAAEEVCFGKHG
VLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAPVSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIH
LGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKD
LRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=47.8723404255319, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI23308751, Length=286, Percent_Identity=29.3706293706294, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=36.8421052631579, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=33.8028169014084, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=30.6620209059233, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=28.5211267605634, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=27.3648648648649, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=37.2340425531915, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=28.6689419795222, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=28.6689419795222, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29869; Mature: 29869

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPV
CCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCC
TFAMLADPAAAEEVCFGKHGVLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAP
EEEECCCCHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCEEEECC
VSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIHLGDVGKGAEMKLVVNMVMGG
CCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHH
MMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKD
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHH
LRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPV
CCCCCEEEHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCC
TFAMLADPAAAEEVCFGKHGVLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAP
EEEECCCCHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEECCCEEEECC
VSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIHLGDVGKGAEMKLVVNMVMGG
CCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHEEEECCCCCCCHHHHHHHHHHHH
MMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKD
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEECCCCCCCCCHHHHHHH
LRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]