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The map label for this gene is typA [H]

Identifier: 78224206

GI number: 78224206

Start: 3397598

End: 3399394

Strand: Direct

Name: typA [H]

Synonym: Gmet_3013

Alternate gene names: 78224206

Gene position: 3397598-3399394 (Clockwise)

Preceding gene: 78224204

Following gene: 78224207

Centisome position: 84.99

GC content: 62.94

Gene sequence:

>1797_bases
ATGCAAGAACGGATCAGGAACATCGCCATCATCGCCCACGTCGACCACGGCAAAACCACGCTGGTCGACGCCATGCTGAA
GCACGCGGGGGTCTTCCGCGAGAATGAGGCCATCACCGAGCGGGTCATGGACTCCAACGACCTGGAGAAGGAGCGGGGGA
TCACCATCCTCGCCAAGAACCTCTCGGTGCACCATGGCCGCTACAAGATCAATATCATCGACACCCCTGGCCACGCCGAC
TTCGGCGGCGAGGTGGAGCGGGTGCTCAAGATGGTGGACTCGGTGCTCCTGCTGGTGGATGCCCTGGACGGCCCCATGCC
CCAGACCCGTTTCGTGCTCAAGAAATCCCTCGATCTGGGCCTGAAGCCCATCGTAGTCATCAACAAGATCGACCGCCCCG
GTTCCCGTCCCGACGAAGTCGTCGATATGGTCTTCGACCTCTTCTGTGAGCTGAACGCCAACGACGAGCAGCTGGATTTC
CCCATCGTCTACACCAGTGCCAAGCTCGGTTTCGCCAAACTGGACCTCACCTCCGACTCATCCAGCATGGAACCCCTCTT
CGCCGTGGTGGAATCCAATGTCCGCCCCCCCTCCGGCGATGCCAAATTACCGTTCCAGTTGCTGGTCACCAACATTGATT
ACAACGAATACATCGGCCGCATCGCCACGGGCAAGGTCTTCAACGGCAGCGTCAAGAGCGGCGAAACCGTGGCGCTGGTG
CGCCGCGACGGCAGCATCGTCAGGAGCCGCATCTCGAAACTCCTGGGCTACGAGGGGCTCAAGCAGGTAGAGGTTCCGGA
AGCGTGCACCGGCGACATCGTCACCGTGGCCGGCTTTGATGAGGTGGGTATCGGCGAAACCCTGGCAGCCGCCGACAATC
CCGTGGCCCTCCCCTACGTCTCCATCGACGAGCCGACCATCGCCATGAATTTCATCGTCAACTCCTCCCCCTTCGCCGGC
AAGGAGGGGAAATTCGTCACCTCCCGCAACATCCGTGACCGCCTCGACAAGGAGTTGCGGACCAACGTGTCGCTGCGCGT
CGAGGATACCGGGAACGCCGACACCTTCAAGGTCTCGGGTCGCGGCGAGCTCCACCTCTCCATCCTCATCGAGAACATGC
GGCGCGAAGGGTTCGAGATGGCGGTCTCCAAGCCCGAGGTCATCATGCGGGAGTTGGACGGCAAGAAGATGGAGCCCATG
GAGTACCTGGTGGTGGACGTCCCCTCCGAGTTCCAGGGGTCCATCATCGAGAAGATGGGACCCCGCAAGGGTGAGATGAC
CTCCATGCAGCCCATGGGGGAGACGGTGCGCCTTGAGTTCATCGTGCCGGCCCGGGGACTCATCGGCCTGCGGGGCGAGC
TCCTCACCGAGACCCGGGGCACCGCGGTCATGACCCACACCTTCCACGACTACGCCCCCTACAAGGGCGACATCCCGGGA
CGCAAGAACGGGGTCCTCATCGCCATGGAGAACGGCGAGACCACCGCCTACTCCCTGGACGGCCTCCAGCCCCGGGGCAT
CCTCTTCATCGGGGCAGGAGTCGAGGTCTACGGTGGCATGATCATCGGCCAGCACGCCAAGGACAACGACCTGGACGTGA
ACCCCTGCAAGGGGAAGAAGCTCACCAACGTCCGGGCCTCGGGCTCCGACGACGCCATCAAGCTCACCCCGCCCCGCATC
CTGACCCTGGAGCAGGCCCTGGAGTTCATCGACGACGATGAGCTGGTGGAGGTAACCCCCCAGTCGATCCGGCTCCGGAA
GAAGGAGCTGGACCCGAACCGGCGCAAGCGCAAGTAA

Upstream 100 bases:

>100_bases
ATACTATGGCGTTTTTTCAGACGAGCCGATGCTCGTCTTTTTCGTTTGCCTCCACCACCTTGAATCTATCGCCTCACGGC
AGAAGGAGCACGCACCACCC

Downstream 100 bases:

>100_bases
CGCATCTGCCGTCCCGCCCTCTGGGCGACTGTTGGCCCCAGGGGACGGGACGGAACTTTGCGTTGACTTTATCAGGGGAT
TTCACTACTTTTCCCCTGAT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIIDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNANDEQLDF
PIVYTSAKLGFAKLDLTSDSSSMEPLFAVVESNVRPPSGDAKLPFQLLVTNIDYNEYIGRIATGKVFNGSVKSGETVALV
RRDGSIVRSRISKLLGYEGLKQVEVPEACTGDIVTVAGFDEVGIGETLAAADNPVALPYVSIDEPTIAMNFIVNSSPFAG
KEGKFVTSRNIRDRLDKELRTNVSLRVEDTGNADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVIMRELDGKKMEPM
EYLVVDVPSEFQGSIIEKMGPRKGEMTSMQPMGETVRLEFIVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMENGETTAYSLDGLQPRGILFIGAGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNRRKRK

Sequences:

>Translated_598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIIDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNANDEQLDF
PIVYTSAKLGFAKLDLTSDSSSMEPLFAVVESNVRPPSGDAKLPFQLLVTNIDYNEYIGRIATGKVFNGSVKSGETVALV
RRDGSIVRSRISKLLGYEGLKQVEVPEACTGDIVTVAGFDEVGIGETLAAADNPVALPYVSIDEPTIAMNFIVNSSPFAG
KEGKFVTSRNIRDRLDKELRTNVSLRVEDTGNADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVIMRELDGKKMEPM
EYLVVDVPSEFQGSIIEKMGPRKGEMTSMQPMGETVRLEFIVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMENGETTAYSLDGLQPRGILFIGAGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNRRKRK
>Mature_598_residues
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKNLSVHHGRYKINIIDTPGHAD
FGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLGLKPIVVINKIDRPGSRPDEVVDMVFDLFCELNANDEQLDF
PIVYTSAKLGFAKLDLTSDSSSMEPLFAVVESNVRPPSGDAKLPFQLLVTNIDYNEYIGRIATGKVFNGSVKSGETVALV
RRDGSIVRSRISKLLGYEGLKQVEVPEACTGDIVTVAGFDEVGIGETLAAADNPVALPYVSIDEPTIAMNFIVNSSPFAG
KEGKFVTSRNIRDRLDKELRTNVSLRVEDTGNADTFKVSGRGELHLSILIENMRREGFEMAVSKPEVIMRELDGKKMEPM
EYLVVDVPSEFQGSIIEKMGPRKGEMTSMQPMGETVRLEFIVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
RKNGVLIAMENGETTAYSLDGLQPRGILFIGAGVEVYGGMIIGQHAKDNDLDVNPCKGKKLTNVRASGSDDAIKLTPPRI
LTLEQALEFIDDDELVEVTPQSIRLRKKELDPNRRKRK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=242, Percent_Identity=35.1239669421488, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=43.9393939393939, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=36.8055555555556, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI18390331, Length=165, Percent_Identity=37.5757575757576, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI310132016, Length=110, Percent_Identity=41.8181818181818, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310110807, Length=110, Percent_Identity=41.8181818181818, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310123363, Length=110, Percent_Identity=41.8181818181818, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923640, Length=161, Percent_Identity=34.1614906832298, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI25306287, Length=161, Percent_Identity=34.1614906832298, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI25306283, Length=161, Percent_Identity=34.1614906832298, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI34147630, Length=250, Percent_Identity=30.4, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI94966752, Length=83, Percent_Identity=44.578313253012, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=35, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI53729339, Length=152, Percent_Identity=33.5526315789474, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI53729337, Length=152, Percent_Identity=33.5526315789474, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI48994988, Length=599, Percent_Identity=57.9298831385643, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=504, Percent_Identity=28.5714285714286, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1789738, Length=153, Percent_Identity=36.6013071895425, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790412, Length=242, Percent_Identity=30.1652892561983, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789737, Length=240, Percent_Identity=30.4166666666667, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.7241379310345, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789559, Length=165, Percent_Identity=31.5151515151515, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=289, Percent_Identity=31.4878892733564, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=42.3076923076923, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=42.3076923076923, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=165, Percent_Identity=38.7878787878788, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17556745, Length=143, Percent_Identity=37.7622377622378, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=260, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=34.8148148148148, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=130, Percent_Identity=36.1538461538462, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=516, Percent_Identity=28.4883720930233, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324707, Length=144, Percent_Identity=39.5833333333333, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=144, Percent_Identity=39.5833333333333, Blast_Score=113, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=40.2684563758389, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323098, Length=150, Percent_Identity=36.6666666666667, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=35.5555555555556, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=270, Percent_Identity=28.8888888888889, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324550, Length=177, Percent_Identity=31.638418079096, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78706572, Length=518, Percent_Identity=27.4131274131274, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=39.2857142857143, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24582462, Length=177, Percent_Identity=37.8531073446328, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=35.7615894039735, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=38.0597014925373, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281363316, Length=268, Percent_Identity=29.8507462686567, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864358, Length=268, Percent_Identity=29.8507462686567, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI221458488, Length=164, Percent_Identity=37.1951219512195, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19921738, Length=231, Percent_Identity=30.7359307359307, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28572034, Length=286, Percent_Identity=25.1748251748252, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 65999; Mature: 65999

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSVHHGRYKINIIDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
CEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKIDRPGSRPDEVVDMVFDLFCELNANDEQLDFPIVYTSAKLGFAKLDLTSDS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCC
SSMEPLFAVVESNVRPPSGDAKLPFQLLVTNIDYNEYIGRIATGKVFNGSVKSGETVALV
CCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHCCEECCCEECCCCCCCCEEEEE
RRDGSIVRSRISKLLGYEGLKQVEVPEACTGDIVTVAGFDEVGIGETLAAADNPVALPYV
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEECCCCCCEEEEEE
SIDEPTIAMNFIVNSSPFAGKEGKFVTSRNIRDRLDKELRTNVSLRVEDTGNADTFKVSG
ECCCCEEEEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVIMRELDGKKMEPMEYLVVDVPSEFQGSIIEKMG
CCCEEEEEEEHHHHHCCHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCC
PRKGEMTSMQPMGETVRLEFIVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCC
RKNGVLIAMENGETTAYSLDGLQPRGILFIGAGVEVYGGMIIGQHAKDNDLDVNPCKGKK
CCCCEEEEEECCCEEEEEECCCCCCCEEEEECCHHHHCCEEEECCCCCCCCCCCCCCCCE
LTNVRASGSDDAIKLTPPRILTLEQALEFIDDDELVEVTPQSIRLRKKELDPNRRKRK
EEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MQERIRNIAIIAHVDHGKTTLVDAMLKHAGVFRENEAITERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHCCEEEEEEC
LSVHHGRYKINIIDTPGHADFGGEVERVLKMVDSVLLLVDALDGPMPQTRFVLKKSLDLG
CEEECCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LKPIVVINKIDRPGSRPDEVVDMVFDLFCELNANDEQLDFPIVYTSAKLGFAKLDLTSDS
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCC
SSMEPLFAVVESNVRPPSGDAKLPFQLLVTNIDYNEYIGRIATGKVFNGSVKSGETVALV
CCCCHHHHHHHCCCCCCCCCCCCCEEEEEEECCHHHHHCCEECCCEECCCCCCCCEEEEE
RRDGSIVRSRISKLLGYEGLKQVEVPEACTGDIVTVAGFDEVGIGETLAAADNPVALPYV
ECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEECCCCCCEEEEEE
SIDEPTIAMNFIVNSSPFAGKEGKFVTSRNIRDRLDKELRTNVSLRVEDTGNADTFKVSG
ECCCCEEEEEEEEECCCCCCCCCCEEECCCHHHHHHHHHHCCEEEEEECCCCCCEEEECC
RGELHLSILIENMRREGFEMAVSKPEVIMRELDGKKMEPMEYLVVDVPSEFQGSIIEKMG
CCCEEEEEEEHHHHHCCHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHCC
PRKGEMTSMQPMGETVRLEFIVPARGLIGLRGELLTETRGTAVMTHTFHDYAPYKGDIPG
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCHHEECCCCCEEEEEECCCCCCCCCCCCC
RKNGVLIAMENGETTAYSLDGLQPRGILFIGAGVEVYGGMIIGQHAKDNDLDVNPCKGKK
CCCCEEEEEECCCEEEEEECCCCCCCEEEEECCHHHHCCEEEECCCCCCCCCCCCCCCCE
LTNVRASGSDDAIKLTPPRILTLEQALEFIDDDELVEVTPQSIRLRKKELDPNRRKRK
EEEEECCCCCCEEEECCCCEEEHHHHHHHCCCCCEEEECCHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]